Adjunctive daptomycin attenuates brain damage and hearing loss more efficiently than rifampin in infant rat pneumococcal meningitis

Antimicrobial Agents and Chemotherapy

Volumn 56, Issue 8, 2012, Pages 4289-4295

  Grandgirard, Denis ^a   Burri, Melchior ^a   Agyeman, Philipp ^a,b   Leib, Stephen L ^a,c  

^a UNIVERSITY OF BERN   (Switzerland)

^b UNIVERSITY OF BERN   (Switzerland)

^c SPIEZ LABORATORY   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

CEFTRIAXONE; DAPTOMYCIN; INTERLEUKIN 10; INTERLEUKIN 6; MACROPHAGE INFLAMMATORY PROTEIN 1ALPHA; MONOCYTE CHEMOTACTIC PROTEIN 1; RIFAMPICIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BRAIN DAMAGE; CEREBROSPINAL FLUID; CONTROLLED STUDY; DRUG EFFICACY; HEARING LOSS; MORPHOMETRICS; NONHUMAN; OUTCOME ASSESSMENT; PNEUMOCOCCAL MENINGITIS; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; RAT; TREATMENT OUTCOME; WISTAR RAT;

ANIMALS; ANTI-BACTERIAL AGENTS; APOPTOSIS; BRAIN DAMAGE, CHRONIC; CEFTRIAXONE; CHEMOKINES; CYTOKINES; DAPTOMYCIN; DRUG ADMINISTRATION SCHEDULE; DRUG THERAPY, COMBINATION; HEARING LOSS; INFLAMMATION; MENINGITIS, PNEUMOCOCCAL; RANDOM ALLOCATION; RATS; RATS, WISTAR; RIFAMPIN;

EID: 84864390312     PISSN: 00664804     EISSN: 10986596     Source Type: Journal    
DOI: 10.1128/AAC.00674-12     Document Type: Article

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