Munc18-1 regulates first-phase insulin release by promoting granule docking to multiple syntaxin isoforms

Journal of Biological Chemistry

Volumn 287, Issue 31, 2012, Pages 25821-25833

  Oh, Eunjin ^a   Kalwat, Michael A ^a   Kim, Min Jung ^b   Verhage, Matthijs ^c   Thurmond, Debbie C ^a  

^a INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b Korea Food and Drug Administration   (South Korea)

^c VU UNIVERSITY AMSTERDAM   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

CELL LYSATES; ELEVATED LEVEL; HUMAN ISLETS; INSULIN GRANULES; INSULIN RELEASE; INSULIN SECRETION; ISOFORMS; KNOCK OUTS; NORMAL COMPONENT; SECRETORY GRANULES; SYNTAXIN; TYPE-2 DIABETES;

CELL MEMBRANES; CYTOLOGY; DOCKING; GRANULATION; PHYSIOLOGY;

INSULIN;

MUNC18 1 PROTEIN; MUNC18 PROTEIN; SYNAPTOBREVIN 2; SYNTAXIN; SYNTAXIN 1; SYNTAXIN 4; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; BINDING SITE; CELL COUNT; CELL LYSATE; COMPLEX FORMATION; CONTROLLED STUDY; GLUCOSE HOMEOSTASIS; HUMAN; HUMAN CELL; INSULIN RELEASE; MALE; MOLECULAR DOCKING; MOLECULAR DYNAMICS; MOUSE; NONHUMAN; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; SECRETORY GRANULE; UPREGULATION;

ANIMALS; CELL MEMBRANE; CELLS, CULTURED; GLUCOSE; HAPLOINSUFFICIENCY; HOMEOSTASIS; HUMANS; INSULIN; ISLETS OF LANGERHANS; MALE; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; MUNC18 PROTEINS; PROTEIN ISOFORMS; QA-SNARE PROTEINS; RATS; SECRETORY PATHWAY; SECRETORY VESICLES; SNARE PROTEINS; VESICLE-ASSOCIATED MEMBRANE PROTEIN 2;

MUS;

EID: 84864390278     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.361501     Document Type: Article

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