Insulin resistance in tetracycline-repressible Munc18c transgenic mice

Diabetes

Volumn 52, Issue 8, 2003, Pages 1910-1917

  Spurlin, Beth A ^a   Thomas, Rhonda M ^a   Nevins, Angela K ^a   Kim, Hyo Jeong ^b   Kim, Yoon Jung ^b   Noh, Hye Lim ^b   Shulman, Gerald I ^b   Kim, Jason K ^b   Thurmond, Debbie C ^a  

^a INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GLYCOGEN; INSULIN; PROTEIN; PROTEIN MUNC18C; SYNTAXIN; SYNTAXIN 4; TETRACYCLINE; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; CLAMP; CONTROLLED STUDY; EMBRYO; FEMALE; GLUCOSE TRANSPORT; GLYCOGEN SYNTHESIS; GLYCOLYSIS; HORMONE ACTION; HYPERINSULINEMIA; INSULIN BLOOD LEVEL; INSULIN RELEASE; INSULIN RESISTANCE; MOUSE; NONHUMAN; PANCREAS ISLET; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; SKELETAL MUSCLE; TRANSGENIC MOUSE; WHITE ADIPOSE TISSUE;

ADIPOSE TISSUE; ANIMALS; ANTI-BACTERIAL AGENTS; GENE EXPRESSION; GLUCOSE; GLUCOSE INTOLERANCE; HOMEOSTASIS; INSULIN; INSULIN RESISTANCE; MEMBRANE PROTEINS; MICE; MICE, TRANSGENIC; MUNC18 PROTEINS; MUSCLE, SKELETAL; NERVE TISSUE PROTEINS; PROTEINS; QA-SNARE PROTEINS; TETRACYCLINE; VESICULAR TRANSPORT PROTEINS;

EID: 0043268827     PISSN: 00121797     EISSN: None     Source Type: Journal    
DOI: 10.2337/diabetes.52.8.1910     Document Type: Article

References (50)

1. Olson AL, Pessin JE: Structure, function and regulation of the mammalian facilitative glucose transporter gene family. Ann Rev Nutr 16:235-256, 1996
2. Slot JW, Geuze HJ, Gigengack S, Lienhard GE, James DE: Immunolocalization of the insulin regulatable glucose transporter in brown adipose tissue of the rat. J Cell Biol 113:123-135, 1991
3. Czech MP: Molecular actions of insulin on glucose transport. Annu Rev Nutr 15:441-471, 1995
4. Kahn BB: Facilitative glucose transporters: regulatory mechanisms and dysregulation in diabetes. J Clin Invest 89:1367-1374, 1992
5. Kandror KV, Pilch PF: Compartmentalization of protein traffic in insulin-sensitive cells. Am J Physiol 271:E1-E14, 1996
6. Klip A, Tsakiridis T, Marette A, Ortiz PA: Regulation of expression of glucose transporters by glucose: a review of studies in vivo and in cell cultures. FASEB J 8:43-53, 1994
7. Thurmond DC, Pessin JE: Molecular machinery involved in the insulin-regulated fusion of GLUT4-containing vesicles with the plasma membrane (Review). Mol Membr Biol 18:237-245, 2001
8. White MF: The IRS-signalling system: a network of docking proteins that mediate insulin action. Mol Cell Biochem 182:3-11, 1998
9. Saltiel AR, Pessin JE: Insulin signaling pathways in time and space. Trends Cell Biol 12:65-71, 2002
10. Chen KS, Friel JC, Ruderman NB: Regulation of phosphatidylinositol 3-kinase by insulin in rat skeletal muscle. Am J Physiol 265:E736-E742, 1993
11. Folli F, Saad MJA, Backer JM, Kahn CR: Regulation of phosphatidylinositol 3-kinase activity in liver and muscle of ammal models of insulin-resistant and insulin-deficient diabetes-mellitus. J Clin Invest 92:1787-1794, 1993
12. Ruderman NB, Kapeller R, White MF, Cantley LC: Activation of phosphatidylinositol 3-kinase by insulin. Proc Natl Acad Sci U S A 87:1411-1415, 1990
13. Bandyopadhyay G, Standaert ML, Zhao L, Yu B, Avignon A, Galloway L, Karnam P, Moscat J, Farese RV: Activation of protein kinase C (alpha, beta, and zeta) by insulin in 3T3/L1 cells: transfection studies suggest a role for PKC-zeta in glucose transport. J Biol Chem 272:2551-2558, 1997
14. Kotani K, Ogawa W, Matsumoto M, Kitamura T, Sakaue H, Hino Y, Miyake K, Sano W, Akimoto K, Ohno S, Kasuga M: Requirement of atypical protein kinase Cλ for insulin stimulation of glucose uptake but not for Akt activation in 3T3-L1 adipocytes. Mol Cell Biol 18:6971-6982, 1998
15. Araki S, Tamori Y, Kawanishi M, Shinoda H, Masugi J, Mori H, Niki T, Okazawa H, Kubota T, Kasuga M: Inhibition of the binding of SNAP-23 to syntaxin 4 by Munc18c. Biochem Biophys Res Commun 234:257-262, 1997
16. Kawanishi M, Tamori Y, Okazawa H, Araki S, Shinoda H, Kasuga M: Role of SNAP23 in insulin-induced translocation of GLUT4 in 3T3-L1 adipocytes: mediation of complex formation between syntaxin4 and VAMP2. J Biol Chem 275:8240-8247, 2000
17. Olson AL, Knight JB, Pessin JE: Syntaxin 4, VAMP2, and/or VAMP3/cellubrevin are functional target membrane and vesicle SNAP receptors for insulin-stimulated GLUT4 translocation in adipocytes. Mol Cell Biol 17:2425-2435, 1997
18. Rea S, Martin LB, McIntosh S, Macaulay SL, Ramsdale T, Baldini G, James DE: Syndet, an adipocyte target SNARE involved in the insulin-induced translocation of GLUT4 to the cell surface. J Biol Chem 273:18784-18792, 1998
19. Volchuk A, Wang Q, Ewart HS, Liu Z, He L, Bennett MK, Klip A: Syntaxin 4 in 3T3-L1 adipocytes: regulation by insulin and participation in insulin-dependent glucose transport. Mol Biol Cell 7:1075-1082, 1996
20. Yang C, Coker KJ, Kim JK, Mora S, Thurmond DC, Davis AC, Yang B, Williamson RA, Shulman GI, Pessin JE: Syntaxin 4 heterozygous knockout mice develop muscle insulin resistance. J Clin Invest 107:1311-1318, 2001
21. Cain CC, Trimble WS, Lienhard GE: Members of the VAMP family of synaptic vesicle proteins are components of glucose transporter-containing vesicles from rat adipocytes. J Biol Chem 267:11681-11684, 1992
22. Cheatham B, Volchuk A, Kahn CR, Wang L, Rhodes CJ, Klip A: Insulin-stimulated translocation of GLUT4 glucose transporters requires SNARE-complex proteins. Proc Natl Acad Sci U S A 93:15169-15173, 1996
23. Tamori Y, Hashiramoto M, Araki S, Kamata Y, Takahashi M, Kozaki S, Kasuga M: Cleavage of vesicle-associated membrane protein (VAMP)-2 and cellubrevin on GLUT4-containing vesicles inhibits the translocation of GLUT4 in 3T3-L1 adipocytes. Biochem Biophys Res Commun 220:740-745, 1996
24. Volchuk A, Sargeant R, Sumitani S, Liu Z, He L, Klip A: Cellubrevin is a resident protein of insulin-sensitive GLUT4 glucose transporter vesicles in 3T3-L1 adipocytes. J Biol Chem 270:8233-8240, 1995
25. Gengyo-Ando K, Kamiya Y, Yamakawa A, Kodaira K, Nishiwaki K, Miwa J, Hori I, Hosono R: The C. elegans unc-18 gene encodes a protein expressed in motor neurons. Neuron 11:703-711, 1993
26. Salzberg A, Cohen N, Halachmi N, Kimchie Z, Lev Z: The Drosophila Ras2 and Rop gene pair: a dual homology with a yeast Ras-like gene and a suppressor of its loss-of-function phenotype. Development 117:1309-1319, 1993
27. Hosono R, Hekimi S, Kamiya Y, Sassa T, Murakami S, Nishiwaki K, Miwa J, Taketo A, Kodaira KI: The unc-18 gene encodes a novel protein affecting the kinetics of acetylcholine metabolism in the nematode Caenorhabditis elegans. J Neurochem 58:1517-1525, 1992
28. Garcia EP, Gatti E, Butler M, Burton J, De Camilli P: A rat brain Sec1 homologue related to Rop and UNC18 interacts with syntaxin. Proc Natl Acad Sci U S A 91:2003-2007, 1994
29. Pevsner J, Hsu SC, Scheller RH: n-Sec1: a neural-specific syntaxin-binding protein. Proc Natl Acad Sci U S A 91:1445-1449, 1994
30. Hata Y, Slaughter CA, Sudhof TC: Synaptic vesicle fusion complex contains unc-18 homologue bound to syntaxin. Nature 366:347-351, 1993
31. Tellam JT, McIntosh S, James DE: Molecular identification of two novel Munc-18 isoforms expressed in non-neuronal tissues. J Biol Chem 270:5857-5863, 1995
32. Tellam JT, Macaulay SL, McIntosh S, Hewish DR, Ward CW, James DE: Characterization of Munc-18c and syntaxin-4 in 3T3-L1 adipocytes: putative role in insulin-dependent movement of GLUT-4. J Biol Chem 272:6179-6186, 1997
33. Harrison SD, Broadie K, van de Goor J, Rubin GM: Mutations in the Drosophila Rop gene suggest a function in general secretion and synaptic transmission. Neuron 13:555-566, 1994
34. Verhage M, Maia AS, Plomp JJ, Brussaard AB, Heeroma JH, Vermeer H, Toonen RF, Hammer RE, van den Berg TK, Missler M, Geuze HJ, Sudhof TC, de Vries KJ, Geijtenbeek A, Brian EC, de Graan PN, Ghijsen WE: Synaptic assembly of the brain in the absence of neurotransmitter secretion: dynamics of Munc18-1 phosphorylation/dephosphorylation in rat brain nerve terminals. Science 287:864-869, 2000
35. Thurmond DC, Pessin JE: Discrimination of GLUT4 vesicle trafficking from fusion using a temperature-sensitive Munc18c mutant. EMBO J 19:3565-3575, 2000
36. Thurmond DC, Kanzaki M, Khan AH, Pessin JE: Munc18c function is required for insulin-stimulated plasma membrane fusion of GLUT4 and insulin-responsive amino peptidase storage vesicles. Mol Cell Biol 20:379-388, 2000
37. Schulze KL, Littleton JT, Salzberg A, Halachmi N, Stern M, Lev Z, Bellen HJ: rop, a Drosophila homolog of yeast Sec1 and vertebrate n-Sec1/Munc-18 proteins, is a negative regulator of neurotransmitter release in vivo. Neuron 13:1099-1108, 1994
38. Tamori Y, Kawanishi M, Niki T, Shinoda H, Araki S, Okazawa H, Kasuga M: Inhibition of insulin-induced GLUT4 translocation by Munc18c through interaction with syntaxin4 in 3T3-L1 adipocytes. J Biol Chem 273:19740-19746, 1998
39. Thurmond DC, Ceresa BP, Okada S, Elmendorf JS, Coker K, Pessin JE: Regulation of insulin-stimulated GLUT4 translocation by munc18c in 3T3L1 adipocytes. J Biol Chem 273:33876-33883, 1998
40. Khan AH, Thurmond DC, Yang C, Ceresa BP, Sigmund CD, Pessin JE: Munc18c regulates insulin-stimulated GLUT4 translocation to the transverse tubules in skeletal muscle. J Biol Chem 276:4063-4069, 2001
41. Fujita H, Tuma PL, Finnegan CM, Locco L, Hubbard AL: Endogenous syntaxins 2, 3 and 4 exhibit distinct but overlapping patterns of expression at the hepatocyte plasma membrane. Biochem J 329:527-538, 1998
42. Hickson GR, Chamberlain LH, Maier VH, Gould GW: Quantification of SNARE protein levels in 3T3-L1 adipocytes: implications for insulin-stimulated glucose transport. Biochem Biophys Res Commun 270:841-845, 2000
43. Schultze N, Burki Y, Lang Y, Certa U, Bluethmann H: Efficient control of gene expression by single step integration of the tetracycline system in transgenic mice. Nat Biotechnol 14:499-503, 1996
44. Kim JK, Gavrilova O, Chen Y, Reitman ML, Shulman GI: Mechanism of insulin resistance in A-ZIP/F-1 fatless mice. J Biol Chem 275:8456-8460, 2000
45. Lacy PE, Kostianovsky M: Method for the isolation of intact islets of Langerhans from the rat pancreas. Diabetes 16:35-39, 1967
46. Zhou M, Sevilla L, Vallega G, Chen P, Palacin M, Zorzano A, Pilch PF, Kandror KV: Insulin-dependent protein trafficking in skeletal muscle cells. Am J Physiol 275:E187-E196, 1998
47. Zisman A, Peroni OD, Abel ED, Michael MD, Mauvais-Jarvis F, Lowell BB, Wojtaszewski JF, Hirshman MF, Virkamaki A, Goodyear LJ, Kahn CR, Kahn BB: Targeted disruption of the glucose transporter 4 selectively in muscle causes insulin resistance and glucose intolerance. Nat Med 6:924-928, 2000
48. Rhodes CJ: Processing of the insulin molecule. In Diabetes mellitus: a fundamental and clinical text. LeRoith T, Olefsky E., Eds. Philadelphia, Lippincott Williams & Wilkins, 2000, p. 20-38
49. Zhang W, Efanov A, Yang SN, Fried G, Kolare S, Brown H, Zaitsev S, Berggren PO, Meister B: Munc-18 associates with syntaxin and serves as a negative regulator of exocytosis in the pancreatic beta-cell. J Biol Chem 275:41521-41527, 2000
50. Gaisano HY, Lutz MP, Leser J, Sheu L, Lynch G, Tang L, Tamori Y, Trimble WS, Salapatek AM: Supramaximal cholecystokinin displaces Munc18c from the pancreatic acinar basal surface, redirecting apical exocytosis to the basal membrane. J Clin Invest 108:1597-1611, 2001