Crystallography and mutagenesis point to an essential role for the N-terminus of human mitochondrial ClpP

Journal of Structural Biology

Volumn 148, Issue 3, 2004, Pages 338-352

  Kang, Sung Gyun ^a   Maurizi, Michael R ^a   Thompson, Mark ^b   Mueser, Timothy ^b   Ahvazi, Bijan ^b,c  

^a NATIONAL CANCER INSTITUTE   (United States)

^b Lab of Structural Biology Research   (United States)

^c NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES   (United States)

Author keywords

ATP dependent protease; Clp Hsp100; Mitochondrial ClpP; X ray crystallography

Indexed keywords

ADENOSINE TRIPHOSPHATE; BACTERIAL ENZYME; CHAPERONE; ENDOPEPTIDASE CLP; PEPTIDE; PROTEIN SUBUNIT;

AMINO TERMINAL SEQUENCE; ARTICLE; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; CRYSTAL STRUCTURE; CRYSTALLOGRAPHY; HYDROPHOBICITY; MAMMAL; MITOCHONDRION; MUTAGENESIS; MUTATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN INTERACTION; PROTEIN STABILITY; PROTEIN STRUCTURE;

AMINO ACID SEQUENCE; BINDING SITES; CATALYSIS; CRYSTALLOGRAPHY, X-RAY; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOPEPTIDASE CLP; ESCHERICHIA COLI PROTEINS; GENE DELETION; HUMANS; KINETICS; MITOCHONDRIA; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; MUTATION; PEPTIDES; PROTEIN CONFORMATION; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; SEQUENCE HOMOLOGY, AMINO ACID;

BACTERIA (MICROORGANISMS); MAMMALIA;

EID: 7444254844     PISSN: 10478477     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jsb.2004.07.004     Document Type: Article

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