Visualization of substrate binding and translocation by the ATP-dependent protease, ClpXP

Molecular Cell

Volumn 6, Issue 6, 2000, Pages 1515-1521

  Ortega, Joaquin ^a   Singh, Satyendra K ^b   Ishikawa, Takashi ^a   Maurizi, Michael R ^b   Steven, Alasdair C ^a  

^a NATIONAL INSTITUTES OF HEALTH   (United States)

^b NATIONAL CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATE; PROTEINASE;

ARTICLE; COMPLEX FORMATION; ELECTRON MICROSCOPY; ENZYME SUBSTRATE; ESCHERICHIA COLI; INTERNALIZATION; NONHUMAN; PROTEIN BINDING;

ESCHERICHIA COLI;

EID: 0034502532     PISSN: 10972765     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1097-2765(00)00148-9     Document Type: Article

References (36)

1. At sixes and sevens: Characterization of the symmetry mismatch of the ClpAP chaperone-assisted protease
2. The structure of HsIU and the ATP-dependent protease HSIU-HsIV
3. The effects of radiation damage on the structure of frozen hydrated HSV-1 capsids
4. Scanning transmission electron microscopy and small-angle scattering provide evidence that native Escherichia coli ClpP is a tetradecamer with an axial pore
5. A subcomplex of the proteasome regulatory particle required for ubiquitin-conjugate degradation and related to the COP9-signalosome and elF3
6. Recognition, targeting, and hydrolysis of λO replication protein by ClpP/ClpX protease
7. Selective, energy-dependent proteolysis in Escherichia coli
8. Enzymatic and structural similarities between the Escherichia coli ATP-dependent proteases, ClpXP and ClpAP
9. Chaperone rings in protein folding and degradation
10. The role of the ClpA chaperone in preteolysis by ClpAP
11. Docking of components in a bacterial complex
12. Homology in structural organization between E. coli ClpAP protease and the eukaryotic 26S proteasome
13. Six-fold rotational symmetry of ClpQ, the E. coli homolog of the 20S proteasome, and its ATP-dependent activator, ClpY
14. Dynamics of substrate denaturation and translocation by the ClpXP degradation machine
15. Improved methods for determination of rotational symmetries in macromolecules
16. Crystal structure of the hexamerization domain of N-ethylmaleimide-sensitive fusion protein
17. Crystal structure of the 20S proteasome from the archaeon T. acidophilum at 3.4 Å resolution
18. Self-compartmentalizing proteases
19. ClpP represents a unique family of serine proteases
20. Endopeptidase Clp: The ATP-dependent Clp protease from Escherichia coli
21. Molecular properties of ClpAP protease of Escherichia coli: ATP-dependent association of ClpA and clpP
22. +: A class of chaperone-like ATPases associated with the assembly, operation, and disassembly of protein complexes
23. The ATP-dependent HsIVU protease from Escherichia coli is a four-ring structure resembling the proteasome
24. ClpA and ClpP remain associated during multiple rounds of ATP-dependent protein degradation by ClpAP protease
25. Unfolding and internalization of proteins by ClpXP and ClpAP
26. Lon and Clp family proteases and chaperones share homologous substrate-recognition domains
27. Digital image processing of electron micrographs: The PIC system-II
28. Digital image processing of electron micrographs: The PIC system-III
29. A new resolution criterion based on spectral signal-to-noise ratios
30. The structure of ClpP at 2.3 Å resolution suggests a model for ATP-dependent proteolysis
31. The Clp ATPases define a novel class of molecular chaperones
32. Global unfolding of a substrate protein by the Hsp100 chaperone ClpA
33. Conformational constraints in protein degradation by 20S proteasome
34. Post-translational quality control: Folding, refolding, and degrading proteins
35. Structure of the ATP-dependent oligomerization domain of the N-ethylmaleimide sensitive factor complexed with ATP
36. Disassembly lines: The proteasome and related ATPase-assisted proteases