메뉴 건너뛰기




Volumn 61, Issue 8, 2012, Pages 2074-2083

Oxidation of fatty acids is the source of increased mitochondrial reactive oxygen species production in kidney cortical tubules in early diabetes

Author keywords

[No Author keywords available]

Indexed keywords

CARNITINE PALMITOYLTRANSFERASE I; PYRUVIC ACID; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE (UBIQUINONE); UBIQUINOL CYTOCHROME C REDUCTASE; UBIQUINONE;

EID: 84864387242     PISSN: 00121797     EISSN: 1939327X     Source Type: Journal    
DOI: 10.2337/db11-1437     Document Type: Article
Times cited : (152)

References (50)
  • 1
    • 2342519703 scopus 로고    scopus 로고
    • USRDS: The United States Renal Data System
    • USRDS
    • USRDS. USRDS: the United States Renal Data System. Am J Kidney Dis 2003;42(6 Suppl. 5):1-230
    • (2003) Am J Kidney Dis , vol.42 , Issue.6 SUPPL. 5 , pp. 1-230
  • 3
  • 4
    • 0037166338 scopus 로고    scopus 로고
    • Role of sterol regulatory element-binding protein 1 in regulation of renal lipid metabolism and glomerulosclerosis in diabetes mellitus
    • DOI 10.1074/jbc.M110650200
    • Sun L, Halaihel N, Zhang W, Rogers T, Levi M. Role of sterol regulatory element-binding protein 1 in regulation of renal lipid metabolism and glomerulosclerosis in diabetes mellitus. J Biol Chem 2002;277:18919-18927 (Pubitemid 34952453)
    • (2002) Journal of Biological Chemistry , vol.277 , Issue.21 , pp. 18919-18927
    • Sun, L.1    Halaihel, N.2    Zhang, W.3    Rogers, H.4    Levi, M.5
  • 5
    • 33750580307 scopus 로고    scopus 로고
    • Regulation of renal fatty acid and cholesterol metabolism, inflammation, and fibrosis in Akita and OVE26 mice with type 1 diabetes
    • DOI 10.2337/db05-0603
    • Proctor G, Jiang T, Iwahashi M, Wang Z, Li J, Levi M. Regulation of renal fatty acid and cholesterol metabolism, inflammation, and fibrosis in Akita and OVE26 mice with type 1 diabetes. Diabetes 2006;55:2502-2509 (Pubitemid 44871150)
    • (2006) Diabetes , vol.55 , Issue.9 , pp. 2502-2509
    • Proctor, G.1    Jiang, T.2    Iwahashi, M.3    Wang, Z.4    Li, J.5    Levi, M.6
  • 6
    • 0035166933 scopus 로고    scopus 로고
    • Effect of lipid reduction on the progression of renal disease: A meta-analysis
    • DOI 10.1046/j.1523-1755.2001.00487.x
    • Fried LF, Orchard TJ, Kasiske BL. Effect of lipid reduction on the progression of renal disease: a meta-analysis. Kidney Int 2001;59:260-269 (Pubitemid 32055234)
    • (2001) Kidney International , vol.59 , Issue.1 , pp. 260-269
    • Fried, L.F.1    Orchard, T.J.2    Kasiske, B.L.3
  • 7
    • 11144321456 scopus 로고    scopus 로고
    • Effect of low-density lipoprotein apheresis on urinary protein and podocyte excretion in patients with nephrotic syndrome due to diabetic nephropathy
    • DOI 10.1053/j.ajkd.2004.09.013, PII S0272638604013113
    • Nakamura T, Kawagoe Y, Ogawa H, et al. Effect of low-density lipoprotein apheresis on urinary protein and podocyte excretion in patients with nephrotic syndrome due to diabetic nephropathy. Am J Kidney Dis 2005;45:48-53 (Pubitemid 40038044)
    • (2005) American Journal of Kidney Diseases , vol.45 , Issue.1 , pp. 48-53
    • Nakamura, T.1    Kawagoe, Y.2    Ogawa, H.3    Ueda, Y.4    Hara, M.5    Shimada, N.6    Ebihara, I.7    Koide, H.8
  • 8
    • 0027462148 scopus 로고
    • Renal interstitial expansion in insulin-dependent diabetes mellitus
    • Lane PH, Steffes MW, Fioretto P, Mauer SM. Renal interstitial expansion in insulin-dependent diabetes mellitus. Kidney Int 1993;43:661-667 (Pubitemid 23071950)
    • (1993) Kidney International , vol.43 , Issue.3 , pp. 661-667
    • Lane, P.H.1    Steffes, M.W.2    Fioretto, P.3    Mauer, S.M.4
  • 9
    • 0033843758 scopus 로고    scopus 로고
    • Type 2 diabetic patients with nephropathy show structural-functional relationships that are similar to type 1 disease
    • White KE, Bilous RW. Type 2 diabetic patients with nephropathy show structural-functional relationships that are similar to type 1 disease. J Am Soc Nephrol 2000;11:1667-1673
    • (2000) J Am Soc Nephrol , vol.11 , pp. 1667-1673
    • White, K.E.1    Bilous, R.W.2
  • 10
    • 0025829825 scopus 로고
    • The pathogenesis of chronic renal failure in diabetic nephropathy. Investigation of 488 cases of diabetic glomerulosclerosis
    • Bohle A, Wehrmann M, Bogenschütz O, Batz C, Müller CA, Müller GA. The pathogenesis of chronic renal failure in diabetic nephropathy. Investigation of 488 cases of diabetic glomerulosclerosis. Pathol Res Pract 1991;187:251-259
    • (1991) Pathol Res Pract , vol.187 , pp. 251-259
    • Bohle, A.1    Wehrmann, M.2    Bogenschütz, O.3    Batz, C.4    Müller, C.A.5    Müller, G.A.6
  • 11
    • 15744400877 scopus 로고    scopus 로고
    • Multiple metabolic hits converge on CD36 as novel mediator of tubular epithelial apoptosis in diabetic nephropathy
    • Susztak K, Ciccone E, McCue P, Sharma K, Böttinger EP. Multiple metabolic hits converge on CD36 as novel mediator of tubular epithelial apoptosis in diabetic nephropathy. PLoS Med 2005;2:e45
    • (2005) PLoS Med , vol.2
    • Susztak, K.1    Ciccone, E.2    McCue, P.3    Sharma, K.4    Böttinger, E.P.5
  • 12
    • 0028795359 scopus 로고
    • Metabolic effects of fatty acid-bearing albumin on a proximal tubule cell line
    • Thomas ME, Morrison AR, Schreiner GF. Metabolic effects of fatty acid-bearing albumin on a proximal tubule cell line. Am J Physiol 1995;268:F1177-F1184
    • (1995) Am J Physiol , vol.268
    • Thomas, M.E.1    Morrison, A.R.2    Schreiner, G.F.3
  • 14
    • 0022568530 scopus 로고
    • Metabolic fuels along the nephron: Pathways and intracellular mechanisms of interaction
    • Guder WG, Wagner S, Wirthensohn G. Metabolic fuels along the nephron: pathways and intracellular mechanisms of interaction. Kidney Int 1986;29:41-45 (Pubitemid 16148554)
    • (1986) Kidney International , vol.29 , Issue.1 , pp. 41-45
    • Guder, W.G.1    Wagner, S.2    Wirthensohn, G.3
  • 15
    • 84944298809 scopus 로고
    • Carbohydrate and lipid metabolism of the renal tubule in diabetes mellitus
    • Guder WG, Schmolke M, Wirthensohn G. Carbohydrate and lipid metabolism of the renal tubule in diabetes mellitus. Eur J Clin Chem Clin Biochem 1992;30:669-674
    • (1992) Eur J Clin Chem Clin Biochem , vol.30 , pp. 669-674
    • Guder, W.G.1    Schmolke, M.2    Wirthensohn, G.3
  • 16
    • 33748308770 scopus 로고    scopus 로고
    • Diabetic nephropathy is associated with gene expression levels of oxidative phosphorylation and related pathways
    • DOI 10.2337/db05-1438
    • Huang C, Kim Y, Caramori ML, et al. Diabetic nephropathy is associated with gene expression levels of oxidative phosphorylation and related pathways. Diabetes 2006;55:1826-1831 (Pubitemid 44324139)
    • (2006) Diabetes , vol.55 , Issue.6 , pp. 1826-1831
    • Huang, C.1    Kim, Y.2    Caramori, M.L.3    Moore, J.H.4    Rich, S.S.5    Mychaleckyj, J.C.6    Walker, P.C.7    Mauer, M.8
  • 17
    • 20044376702 scopus 로고    scopus 로고
    • The pathobiology of diabetic complications: A unifying mechanism
    • DOI 10.2337/diabetes.54.6.1615
    • Brownlee M. The pathobiology of diabetic complications: a unifying mechanism. Diabetes 2005;54:1615-1625 (Pubitemid 40770750)
    • (2005) Diabetes , vol.54 , Issue.6 , pp. 1615-1625
    • Brownlee, M.1
  • 19
    • 0344012015 scopus 로고    scopus 로고
    • Hyperglycemia increases mitochondrial superoxide in retina and retinal cells
    • DOI 10.1016/j.freeradbiomed.2003.08.018
    • Du Y, Miller CM, Kern TS. Hyperglycemia increases mitochondrial superoxide in retina and retinal cells. Free Radic Biol Med 2003;35:1491-1499 (Pubitemid 37452474)
    • (2003) Free Radical Biology and Medicine , vol.35 , Issue.11 , pp. 1491-1499
    • Du, Y.1    Miller, C.M.2    Kern, T.S.3
  • 20
    • 0037245335 scopus 로고    scopus 로고
    • Preventing superoxide formation in epineurial arterioles of the sciatic nerve from diabetic rats restores endothelium-dependent vasodilation
    • DOI 10.1080/1071576021000028442
    • CoppeyLJ, Gellett JS, Davidson EP, Yorek MA. Preventing superoxide formation in epineurial arterioles of the sciatic nerve from diabetic rats restores endothelium-dependent vasodilation. Free Radic Res 2003;37:33-40 (Pubitemid 36124328)
    • (2003) Free Radical Research , vol.37 , Issue.1 , pp. 33-40
    • Coppey, L.J.1    Gellett, J.S.2    Davidson, E.P.3    Yorek, M.A.4
  • 21
    • 33644637265 scopus 로고    scopus 로고
    • Decreased complex II respiration and HNE-modified SDH subunit in diabetic heart
    • DOI 10.1016/j.freeradbiomed.2005.10.040, PII S0891584905006350
    • Lashin OM, Szweda PA, Szweda LI, Romani AM. Decreased complex II respiration and HNE-modified SDH subunit in diabetic heart. Free Radic Biol Med 2006;40:886-896 (Pubitemid 43327322)
    • (2006) Free Radical Biology and Medicine , vol.40 , Issue.5 , pp. 886-896
    • Lashin, O.M.1    Szweda, P.A.2    Szweda, L.I.3    Romani, A.M.P.4
  • 22
    • 78649755150 scopus 로고    scopus 로고
    • -(AkitaJ) mice by the mitochondria-targeted therapy MitoQ
    • -(AkitaJ) mice by the mitochondria-targeted therapy MitoQ. Biochem J 2010;432:9-19
    • (2010) Biochem J , vol.432 , pp. 9-19
    • Chacko, B.K.1    Reily, C.2    Srivastava, A.3
  • 23
    • 78751486039 scopus 로고    scopus 로고
    • Diminished superoxide generation is associated with respiratory chain dysfunction and changes in the mitochondrial proteome of sensory neurons from diabetic rats
    • Akude E, Zherebitskaya E, Chowdhury SK, Smith DR, Dobrowsky RT, Fernyhough P. Diminished superoxide generation is associated with respiratory chain dysfunction and changes in the mitochondrial proteome of sensory neurons from diabetic rats. Diabetes 2011;60:288-297
    • (2011) Diabetes , vol.60 , pp. 288-297
    • Akude, E.1    Zherebitskaya, E.2    Chowdhury, S.K.3    Smith, D.R.4    Dobrowsky, R.T.5    Fernyhough, P.6
  • 24
    • 65249138943 scopus 로고    scopus 로고
    • Triglyceride synthesis in epididymal adipose tissue: Contribution of glucose and non-glucose carbon sources
    • Bederman IR, Foy S, Chandramouli V, Alexander JC, Previs SF. Triglyceride synthesis in epididymal adipose tissue: contribution of glucose and non-glucose carbon sources. J Biol Chem 2009;284:6101-6108
    • (2009) J Biol Chem , vol.284 , pp. 6101-6108
    • Bederman, I.R.1    Foy, S.2    Chandramouli, V.3    Alexander, J.C.4    Previs, S.F.5
  • 25
    • 0018185366 scopus 로고
    • Isolation and characterization of rat glomerular epithelial cells in vitro
    • Kreisberg JI, Hoover RL, Karnovsky MJ. Isolation and characterization of rat glomerular epithelial cells in vitro. Kidney Int 1978;14:21-30 (Pubitemid 8396235)
    • (1978) Kidney International , vol.14 , Issue.1 , pp. 21-30
    • Kreisberg, J.I.1    Hoover, R.L.2    Karnovsky, M.J.3
  • 27
    • 0018399518 scopus 로고
    • Riboflavin and rat hepatic cell structure and function. Mitochondrial oxidative metabolism in deficiency states
    • Hoppel C, DiMarco JP, Tandler B. Riboflavin and rat hepatic cell structure and function. Mitochondrial oxidative metabolism in deficiency states. J Biol Chem 1979;254:4164-4170 (Pubitemid 9178641)
    • (1979) Journal of Biological Chemistry , vol.254 , Issue.10 , pp. 4164-4170
    • Hoppel, C.1    DiMarco, J.P.2    Tandler, B.3
  • 28
    • 77049249588 scopus 로고
    • Respiratory enzymes in oxidative phosphorylation. III. The steady state
    • Chance B, Williams GR. Respiratory enzymes in oxidative phosphorylation. III. The steady state. J Biol Chem 1955;217:409-427
    • (1955) J Biol Chem , vol.217 , pp. 409-427
    • Chance, B.1    Williams, G.R.2
  • 29
    • 0032483331 scopus 로고    scopus 로고
    • The malonyl-CoA-sensitive form of carnitine palmitoyltransferase is not localized exclusively in the outer membrane of rat liver mitochondria
    • DOI 10.1074/jbc.273.36.23495
    • Hoppel CL, Kerner J, Turkaly P, Turkaly J, Tandler B. The malonyl-CoA-sensitive form of carnitine palmitoyltransferase is not localized exclusively in the outer membrane of rat liver mitochondria. J Biol Chem 1998;273:23495-23503 (Pubitemid 28417541)
    • (1998) Journal of Biological Chemistry , vol.273 , Issue.36 , pp. 23495-23503
    • Hoppel, C.L.1    Kerner, J.2    Turkaly, P.3    Turkaly, J.4    Tandler, B.5
  • 30
    • 65449129608 scopus 로고    scopus 로고
    • Post-translational modifications of mitochondrial outer membrane proteins
    • Distler AM, Kerner J, Lee K, Hoppel CL. Post-translational modifications of mitochondrial outer membrane proteins. Methods Enzymol 2009;457:97-115
    • (2009) Methods Enzymol , vol.457 , pp. 97-115
    • Distler, A.M.1    Kerner, J.2    Lee, K.3    Hoppel, C.L.4
  • 31
    • 0035881548 scopus 로고    scopus 로고
    • Rat liver mitochondrial contact sites and carnitine palmitoyltransferase- I
    • DOI 10.1006/abbi.2001.2463
    • Hoppel C, Kerner J, Turkaly P, Tandler B. Rat liver mitochondrial contact sites and carnitine palmitoyltransferase-I. Arch Biochem Biophys 2001;392:321-325 (Pubitemid 32757045)
    • (2001) Archives of Biochemistry and Biophysics , vol.392 , Issue.2 , pp. 321-325
    • Hoppel, C.1    Kerner, J.2    Turkaly, P.3    Tandler, B.4
  • 32
    • 70349134016 scopus 로고    scopus 로고
    • Tissue-specific remodeling of the mitochondrial proteome in type 1 diabetic akita mice
    • Bugger H, Chen D, Riehle C, et al. Tissue-specific remodeling of the mitochondrial proteome in type 1 diabetic akita mice. Diabetes 2009;58:1986-1997
    • (2009) Diabetes , vol.58 , pp. 1986-1997
    • Bugger, H.1    Chen, D.2    Riehle, C.3
  • 33
  • 34
    • 0031043030 scopus 로고    scopus 로고
    • The mitochondrial carnitine palmitoyltransferase system. From concept to molecular analysis
    • McGarry JD, Brown NF. The mitochondrial carnitine palmitoyltransferase system. From concept to molecular analysis. Eur J Biochem 1997;244:1-14 (Pubitemid 27079689)
    • (1997) European Journal of Biochemistry , vol.244 , Issue.1 , pp. 1-14
    • McGarry, J.D.1    Brown, N.F.2
  • 35
    • 78651497653 scopus 로고    scopus 로고
    • Angiotensin-converting enzyme (ACE) 2 overexpression ameliorates glomerular injury in a rat model of diabetic nephropathy: A comparison with ACE inhibition
    • Liu CX, Hu Q, Wang Y, et al. Angiotensin-converting enzyme (ACE) 2 overexpression ameliorates glomerular injury in a rat model of diabetic nephropathy: a comparison with ACE inhibition. Mol Med 2011;17:59-69
    • (2011) Mol Med , vol.17 , pp. 59-69
    • Liu, C.X.1    Hu, Q.2    Wang, Y.3
  • 36
    • 77956627992 scopus 로고    scopus 로고
    • Enhanced expression of naofen in kidney of streptozotocin-induced diabetic rats: Possible correlation to apoptosis of tubular epithelial cells
    • Sato Y, Feng GG, Huang L, et al. Enhanced expression of naofen in kidney of streptozotocin-induced diabetic rats: possible correlation to apoptosis of tubular epithelial cells. Clin Exp Nephrol 2010;14:205-212
    • (2010) Clin Exp Nephrol , vol.14 , pp. 205-212
    • Sato, Y.1    Feng, G.G.2    Huang, L.3
  • 37
    • 0037983739 scopus 로고    scopus 로고
    • Starvation and diabetes reduce the amount of pyruvate dehydrogenase phosphatase in rat heart and kidney
    • DOI 10.2337/diabetes.52.6.1371
    • Huang B, Wu P, Popov KM, Harris RA. Starvation and diabetes reduce the amount of pyruvate dehydrogenase phosphatase in rat heart and kidney. Diabetes 2003;52:1371-1376 (Pubitemid 36666190)
    • (2003) Diabetes , vol.52 , Issue.6 , pp. 1371-1376
    • Huang, B.1    Wu, P.2    Popov, K.M.3    Harris, R.A.4
  • 38
    • 0016795356 scopus 로고
    • Control of pyruvate dehydrogenase activity in intact cardiac mitochondria. Regulation of the inactivation and activation of the dehydrogenase
    • Chiang PK, Sacktor B. Control of pyruvate dehydrogenase activity in intact cardiac mitochondria. Regulation of the inactivation and activation of the dehydrogenase. J Biol Chem 1975;250:3399-3408
    • (1975) J Biol Chem , vol.250 , pp. 3399-3408
    • Chiang, P.K.1    Sacktor, B.2
  • 39
    • 76449100708 scopus 로고    scopus 로고
    • PPARs: Diverse regulators in energy metabolism and metabolic diseases
    • Wang YX. PPARs: diverse regulators in energy metabolism and metabolic diseases. Cell Res 2010;20:124-137
    • (2010) Cell Res , vol.20 , pp. 124-137
    • Wang, Y.X.1
  • 40
    • 47949094965 scopus 로고    scopus 로고
    • Integration of metabolism and inflammation by lipid-activated nuclear receptors
    • Bensinger SJ, Tontonoz P. Integration of metabolism and inflammation by lipid-activated nuclear receptors. Nature 2008;454:470-477
    • (2008) Nature , vol.454 , pp. 470-477
    • Bensinger, S.J.1    Tontonoz, P.2
  • 41
    • 0031731244 scopus 로고    scopus 로고
    • Dietary lipids regulate beta-oxidation enzyme gene expression in the developing rat kidney
    • Ouali F, Djouadi F, Merlet-Bénichou C, Bastin J. Dietary lipids regulate beta-oxidation enzyme gene expression in the developing rat kidney. Am J Physiol 1998;275:F777-F784
    • (1998) Am J Physiol , vol.275
    • Ouali, F.1    Djouadi, F.2    Merlet-Bénichou, C.3    Bastin, J.4
  • 42
    • 38149090083 scopus 로고    scopus 로고
    • Renal mitochondrial impairment is attenuated by AT1 blockade in experimental Type I diabetes
    • de Cavanagh EM, Ferder L, Toblli JE, et al. Renal mitochondrial impairment is attenuated by AT1 blockade in experimental Type I diabetes. Am J Physiol Heart Circ Physiol 2008;294:H456-H465
    • (2008) Am J Physiol Heart Circ Physiol , vol.294
    • De Cavanagh, E.M.1    Ferder, L.2    Toblli, J.E.3
  • 43
    • 0037160091 scopus 로고    scopus 로고
    • Topology of superoxide production from different sites in the mitochondrial electron transport chain
    • DOI 10.1074/jbc.M207217200
    • St-Pierre J, Buckingham JA, Roebuck SJ, Brand MD. Topology of superoxide production from different sites in the mitochondrial electron transport chain. J Biol Chem 2002;277:44784-44790 (Pubitemid 36159072)
    • (2002) Journal of Biological Chemistry , vol.277 , Issue.47 , pp. 44784-44790
    • St-Pierre, J.1    Buckingham, J.A.2    Roebuck, S.J.3    Brand, M.D.4
  • 45
    • 33645509709 scopus 로고    scopus 로고
    • Insulin resistance reduces arterial prostacyclin synthase and eNOS activities by increasing endothelial fatty acid oxidation
    • Du X, Edelstein D, Obici S, Higham N, Zou MH, Brownlee M. Insulin resistance reduces arterial prostacyclin synthase and eNOS activities by increasing endothelial fatty acid oxidation. J Clin Invest 2006;116:1071-1080
    • (2006) J Clin Invest , vol.116 , pp. 1071-1080
    • Du, X.1    Edelstein, D.2    Obici, S.3    Higham, N.4    Zou, M.H.5    Brownlee, M.6
  • 46
    • 0035816639 scopus 로고    scopus 로고
    • Leptin induces mitochondrial superoxide production and monocyte chemoattractant protein-1 expression in aortic endothelial cells by increasing fatty acid oxidation via protein kinase A
    • Yamagishi SI, Edelstein D, Du XL, Kaneda Y, Guzmán M, Brownlee M. Leptin induces mitochondrial superoxide production and monocyte chemoattractant protein-1 expression in aortic endothelial cells by increasing fatty acid oxidation via protein kinase A. J Biol Chem 2001;276:25096-25100
    • (2001) J Biol Chem , vol.276 , pp. 25096-25100
    • Yamagishi, S.I.1    Edelstein, D.2    Du, X.L.3    Kaneda, Y.4    Guzmán, M.5    Brownlee, M.6
  • 47
    • 10344221083 scopus 로고    scopus 로고
    • Complex III releases superoxide to both sides of the inner mitochondrial membrane
    • DOI 10.1074/jbc.M407715200
    • Muller FL, Liu Y, Van Remmen H. Complex III releases superoxide to both sides of the inner mitochondrial membrane. J Biol Chem 2004;279:49064-49073 (Pubitemid 39625788)
    • (2004) Journal of Biological Chemistry , vol.279 , Issue.47 , pp. 49064-49073
    • Muller, F.L.1    Liu, Y.2    Van Remmen, H.3
  • 48
    • 0019332510 scopus 로고
    • Studies on electron transfer from general acyl-CoA dehydrogenase to electron transfer flavoprotein
    • Hall CL, Lambeth JD. Studies on electron transfer from general acyl-CoA dehydrogenase to electron transfer flavoprotein. J Biol Chem 1980;255:3591-3595
    • (1980) J Biol Chem , vol.255 , pp. 3591-3595
    • Hall, C.L.1    Lambeth, J.D.2
  • 49
    • 0019977781 scopus 로고
    • The effect of tetrahydrofolate on the reduction of electron transfer flavoprotein by sarcosine and dimethylglycine dehydrogenases
    • Steenkamp DJ, Husain M. The effect of tetrahydrofolate on the reduction of electron transfer flavoprotein by sarcosine and dimethylglycine dehydrogenases. Biochem J 1982;203:707-715 (Pubitemid 12018134)
    • (1982) Biochemical Journal , vol.203 , Issue.3 , pp. 707-715
    • Steenkamp, D.J.1    Husain, M.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.