Expansion of CD4+CD25+FOXP3+ regulatory T cells in infants of mothers with type 1 diabetes

Pediatric Diabetes

Volumn 13, Issue 5, 2012, Pages 400-407

  Luopajärvi, Kristiina ^a   Nieminen, JanneK ^a   Ilonen, Jorma ^b,c   Åkerblom, Hans K ^d   Knip, Mikael ^d,e,f   Vaarala, Outi ^a  

^a NATIONAL PUBLIC HEALTH INSTITUTE   (Finland)

^b UNIVERSITY OF EASTERN FINLAND   (Finland)

^c UNIVERSITY OF TURKU   (Finland)

^d UNIVERSITY OF HELSINKI   (Finland)

^e FOLKHÄLSAN RESEARCH CENTER   (Finland)

^f TAMPERE UNIVERSITY HOSPITAL   (Finland)

Author keywords

CB; Insulin treatment; Regulatory T cells; T1D

Indexed keywords

INSULIN; INTERLEUKIN 10; MESSENGER RNA; STROMAL INTERACTION MOLECULE 1; TRANSCRIPTION FACTOR FOXP3; TRANSCRIPTION FACTOR NFAT; TRANSFORMING GROWTH FACTOR BETA;

ADULT; ARTICLE; CD4+ CD25+ T LYMPHOCYTE; CD4+CD25+FOXP3+ T LYMPHOCYTE; CELL EXPANSION; CLINICAL ARTICLE; CONTROLLED STUDY; CORD BLOOD MONONUCLEAR CELL; FEMALE; FLOW CYTOMETRY; GENE EXPRESSION; GENETIC ANALYSIS; GENOTYPING TECHNIQUE; GESTATIONAL AGE; HLA SYSTEM; HUMAN; IN VITRO STUDY; INFANT; INSULIN DEPENDENT DIABETES MELLITUS; INSULIN TREATMENT; MALE; MATERNAL AGE; PRENATAL EXPOSURE; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; T LYMPHOCYTE; UMBILICAL CORD BLOOD;

ANTIGENS, CD4; DIABETES MELLITUS, TYPE 1; FEMALE; FETAL BLOOD; FORKHEAD TRANSCRIPTION FACTORS; HUMANS; INFANT; INFANT, NEWBORN; INSULIN; INTERLEUKIN-2 RECEPTOR ALPHA SUBUNIT; MALE; MOTHERS; T-LYMPHOCYTES, REGULATORY;

EID: 84864382360     PISSN: 1399543X     EISSN: 13995448     Source Type: Journal    
DOI: 10.1111/j.1399-5448.2012.00852.x     Document Type: Article

References (34)

1. Warram JH, Krolewski AS, Gottlieb MS, Kahn CR. Differences in risk of insulin-dependent diabetes in offspring of diabetic mothers and diabetic fathers. N Engl J Med 1984: 311: 149-152.
2. Tuomilehto J, Podar T, Tuomilehto-Wolf E, Virtala E. Evidence for importance of gender and birth cohort for risk of IDDM in offspring of IDDM parents. Diabetologia 1995: 38: 975-982.
3. The EURODIAB ACE Study Group and the EURODIAB ACE Substudy 2 Study Group. Familial risk of type I diabetes in European children. Diabetologia 1998: 41: 1151-1156.
4. Harjutsalo V, Reunanen A, Tuomilehto J. Differential transmission of type 1 diabetes from diabetic fathers and mothers to their offspring. Diabetes 2006: 55: 1517-1524.
5. Palmer JP, Asplin CM, Clemons P et al. Insulin antibodies in insulin-dependent diabetics before insulin treatment. Science 1983: 222: 1337-1339.
6. Greenbaum CJ, Palmer JP. Insulin antibodies and insulin autoantibodies. Diabet Med 1991: 8: 97-105.
7. Fineberg SE, Kawabata TT, Finco-Kent D, Fountaine RJ, Finch GL, Krasner AS. Immunological responses to exogenous insulin. Endocr Rev 2007: 28: 625-652.
8. Knip M, Lautala P, Leppäluoto J, Åkerblom HK, Kouvalainen K. Relation of enteroinsular hormones at birth to macrosomia and neonatal hypoglycemia in infants of diabetic mothers. J Pediatr 1983: 103: 603-611.
9. DiMario U, Fallucca F, Gargiulo P et al. Insulin-anti-insulin complexes in diabetic women and their neonates. Diabetologia 1984: 27 (Suppl.): 83-86.
10. Paronen J, Knip M, Savilahti E et al. Effect of cow's milk exposure and maternal type 1 diabetes on cellular and humoral immunization to dietary insulin in infants at genetic risk for type 1 diabetes. Finnish trial to reduce IDDM in the genetically at risk study group. Diabetes 2000: 49: 1657-1665.
11. Sakaguchi S, Sakaguchi N, Asano M, Itoh M, Toda M. Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases. J Immunol 1995: 155: 1151-1164.
12. Sakaguchi S, Yamaguchi T, Nomura T, Ono M. Regulatory T cells and immune tolerance. Cell 2008: 133: 775-787.
13. Pugliese A, Zeller M, Fernandez A et al. The insulin gene is transcribed in the human thymus and transcription levels correlated with allelic variation at the INS VNTR-IDDM2 susceptibility locus for type 1 diabetes. Nat Genet 1997: 15: 293-297.
14. Pugliese A, Brown D, Garza D et al. Self-antigen-presenting cells expressing diabetes-associated autoantigens exist in both thymus and peripheral lymphoid organs. J Clin Invest 2001: 107: 555-564.
15. Walker MR, Kasprowicz DJ, Gersuk V et al. Induction of FoxP3 and acquisition of T regulatory activity by stimulated human CD4+CD25- T cells. J Clin Invest 2003: 112: 1437-1443.
16. Fontenot JD, Gavin MA, Rudensky AY. Foxp3 programs the development and function of CD4+CD25+ regulatory T cells. Nat Immunol 2003: 4: 330-336.
17. Hori S, Nomura T, Sakaguchi S. Control of regulatory T cell development by the transcription factor Foxp3. Science 2003: 299: 1057-1061.
18. Rudensky AY, Gavin M, Zheng Y. FOXP3 and NFAT: partners in tolerance. Cell 2006: 126: 253-256.
19. Oh-hora M, Yamashita M, Hogan PG et al. Dual functions for the endoplasmic reticulum calcium sensors STIM1 and STIM2 in T cell activation and tolerance. Nat Immunol 2008: 9: 432-443.
20. TRIGR Study Group. Study design of the trial to reduce IDDM in the genetically at risk (TRIGR). Pediatr Diabetes 2007: 8: 117-137.
21. Hölttä V, Klemetti P, Sipponen T et al. IL-23/IL-17 immunity as a hallmark of crohn's disease. Inflamm Bowel Dis 2008: 14: 1175-1184.
22. Kukko M, Virtanen SM, Toivonen A et al. Geographical variation in risk HLA-DQB1 genotypes for type 1 diabetes and signs of beta-cell autoimmunity in a high-incidence country. Diabetes Care 2004: 27: 676-681.
23. Sjöroos M, Iitiä A, Ilonen J, Reijonen H, Lövgren T. Triple-label hybridization assay for type-1 diabetes-related HLA alleles. BioTechniques 1995: 18: 870-877.
24. Laaksonen M, Pastinen T, Sjöroos M et al. HLA class II associated risk and protection against multiple sclerosis-a Finnish family study. J Neuroimmunol 2002: 122: 140-145.
25. Laine AP, Holmberg H, Nilsson A et al. Two insulin gene single nucleotide polymorphisms associated with type 1 diabetes risk in the Finnish and Swedish populations. Dis Markers 2007: 23: 139-145.
26. Hermann R, Lipponen K, Kiviniemi M et al. Lymphoid tyrosine phosphatase (LYP/PTPN22) Arg620Trp variant regulates insulin autoimmunity and progression to type 1 diabetes. Diabetologia 2006: 49: 1198-1208.
27. Kiviniemi M, Nurmi J, Turpeinen H, Lövgren T, Ilonen J. A homogeneous high-throughput genotyping method based on competitive hybridization. Clin Biochem 2003: 36: 633-640.
28. Menon RK, Cohen RM, Sperling MA, Cutfield WS, Mimouni F, Khoury JC. Transplacental passage of insulin in pregnant women with insulin-dependent diabetes mellitus. Its role in fetal macrosomia. N Engl J Med 1990: 323: 309-315.
29. Potter KN, Wilkin TJ. The molecular specificity of insulin autoantibodies. Diabetes Metab Res Rev 2000: 16: 338-353.
30. Warram JH, Martin BC, Krolewski AS. Risk of IDDM in children of diabetic mothers decreases with increasing maternal age at pregnancy. Diabetes 1991: 40: 1679-1684.
31. Vang T, Congia M, Macis MD et al. Autoimmune-associated lymphoid tyrosine phosphatase is a gain-of-function variant. Nat Genet 2005: 37: 1317-1319.
32. Aarnisalo J, Treszl A, Svec P et al. Reduced CD4+ T cell activation in children with type 1 diabetes carrying the PTPN22/Lyp 620Trp variant. J Autoimmun 2008: 31: 13-21.
33. Tanaka S, Maeda S, Hashimoto M et al. Graded attenuation of TCR signaling elicits distinct autoimmune diseases by altering thymic T cell selection and regulatory T cell function. J Immunol 2010: 185: 2295-2305.
34. Stanford S, Mustelin T, Bottini N. Lymphoid tyrosine phosphatase and autoimmunity: human genetics rediscovers tyrosine phosphatases. Semin Immunopathol 2010: 32: 127-136.