Tocopherols and tocotrienols plasma levels are associated with cognitive impairment

Neurobiology of Aging

Volumn 33, Issue 10, 2012, Pages 2282-2290

  Mangialasche, Francesca ^a,b   Xu, Weili ^a   Kivipelto, Miia ^a   Costanzi, Emanuela ^b   Ercolani, Sara ^b   Pigliautile, Martina ^b   Cecchetti, Roberta ^b   Baglioni, Mauro ^b   Simmons, Andrew ^c,d   Soininen, Hilkka ^e   Tsolaki, Magda ^f   Kloszewska, Iwona ^g   Vellas, Bruno ^h   Lovestone, Simon ^c   Mecocci, Patrizia ^b  

^a KAROLINSKA INSTITUTE   (Sweden)

^b UNIVERSITY OF PERUGIA   (Italy)

^c SOUTH LONDON AND MAUDSLEY NHS FOUNDATION TRUST   (United Kingdom)

^d KING'S COLLEGE LONDON   (United Kingdom)

^e UNIVERSITY OF EASTERN FINLAND   (Finland)

^f ARISTOTLE UNIVERSITY OF THESSALONIKI   (Greece)

^g MEDICAL UNIVERSITY OF LODZ   (Poland)

^h TOULOUSE UNIVERSITY HOSPITAL   (France)

Author keywords

Alzheimer's disease; Mild cognitive impairment; Nitrosative stress; Oxidative stress; Tocopherol; Tocotrienol; Vitamin E

Indexed keywords

5 NITRO GAMMA TOCOPHEROL; ALPHA TOCOPHERYLQUINONE; ALPHA TOCOTRIENOL; BETA CAROTENE; GAMMA TOCOPHEROL; REACTIVE NITROGEN SPECIES; RETINOL; TOCOPHEROL; UNCLASSIFIED DRUG;

AGED; ALZHEIMER DISEASE; ARTICLE; BLOOD SAMPLING; COGNITIVE DEFECT; CONTROLLED STUDY; DISEASE ACTIVITY; DISEASE ASSOCIATION; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MALE; MOLECULAR INTERACTION; MOLECULAR PATHOLOGY; OXIDATIVE STRESS; PRIORITY JOURNAL; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; VITAMIN BLOOD LEVEL;

AGED; AGED, 80 AND OVER; ALZHEIMER DISEASE; FEMALE; HUMANS; MALE; MILD COGNITIVE IMPAIRMENT; TOCOPHEROLS; TOCOTRIENOLS;

EID: 84864382037     PISSN: 01974580     EISSN: 15581497     Source Type: Journal    
DOI: 10.1016/j.neurobiolaging.2011.11.019     Document Type: Article

References (57)

1. Diagnostic and Statistical Manual of Mental Disorders 1994, American Psychiatric Association, American Psychiatric Publishing, Washington DC. 4th Edition.
2. Bourdel-Marchasson I., Delmas-Beauvieux M.C., Peuchant E., Richard-Harston S., Decamps A., Reignier B., Emeriau J.P., Rainfray M. Antioxidant defences and oxidative stress markers in erythrocytes and plasma from normally nourished elderly Alzheimer patients. Age Ageing 2001, 30:235-241.
3. Bruno R.S., Traber M.G. Vitamin E biokinetics, oxidative stress and cigarette smoking. Pathophysiology 2006, 13:143-149.
4. Craft N.E., Haitema T.B., Garnett K.M., Fitch K.A., Dorey C.K. Carotenoid, tocopherol, and retinol concentrations in elderly human brain. J. Nutr. Health Aging 2004, 8:156-162.
5. Cummings J.L., Mega M., Gray K., Rosenberg-Thompson S., Carusi D.A., Gornbein J. The Neuropsychiatric Inventory: comprehensive assessment of psychopathology in dementia. Neurology 1994, 44:2308-2314.
6. Devore E.E., Grodstein F., van Rooij F.J., Hofman A., Stampfer M.J., Witteman J.C., Breteler M.M. Dietary antioxidants and long-term risk of dementia. Arch. Neurol 2010, 67:819-825.
7. Engelhart M.J., Ruitenberg A., Meijer J., Kiliaan A., van Swieten J.C., Hofman A., Witteman J.C., Breteler M.M. Plasma levels of antioxidants are not associated with Alzheimer's disease or cognitive decline. Dement. Geriatr. Cogn. Disord 2005, 19:134-139.
8. Folstein M.F., Folstein S.E., McHugh P.R. "Mini-mental state". A practical method for grading the cognitive state of patients for the clinician. J. Psychiatr. Res 1975, 12:189-198.
9. Galasko D., Bennett D., Sano M., Ernesto C., Thomas R., Grundman M., Ferris S. An inventory to assess activities of daily living for clinical trials in Alzheimer's disease. The Alzheimer's Disease Cooperative Study. Alzheimer Dis. Assoc. Disord 1997, 11:S33-S39.
10. Hachinski V.C., Iliff L.D., Zilhka E., Du Boulay G.H., McAllister V.L., Marshall J., Russell R.W., Symon L. Cerebral blood flow in dementia. Arch. Neurol 1975, 32:632-637.
11. Helmer C., Peuchant E., Letenneur L., Bourdel-Marchasson I., Larrieu S., Dartigues J.F., Dubourg L., Thomas M.J., Barberger-Gateau P. Association between antioxidant nutritional indicators and the incidence of dementia: results from the PAQUID prospective cohort study. Eur. J. Clin. Nutr 2003, 57:1555-1561.
12. Hensley K., Barnes L.L., Christov A., Tangney C., Honer W.G., Schneider J.A., Bennett D.A., Morris M.C. Analysis of postmortem ventricular cerebrospinal fluid from patients with and without dementia indicates association of vitamin E with neuritic plaques and specific measures of cognitive performance. J. Alzheimers Dis 2011, 24:767-774.
13. Hu P., Bretsky P., Crimmins E.M., Guralnik J.M., Reuben D.B., Seeman T.E. Association between serum beta-carotene levels and decline of cognitive function in high-functioning older persons with or without apolipoprotein E 4 alleles: MacArthur studies of successful aging. Journals Gerontology 2006, 61:616-620.
14. Huang H.Y., Appel L.J. Supplementation of diets with alpha-tocopherol reduces serum concentrations of gamma- and delta-tocopherol in humans. J. Nutr 2003, 133:3137-3140.
15. Hughes C.P., Berg L., Danziger W.L., Coben L.A., Martin R.L. A new clinical scale for the staging of dementia. Br. J. Psychiatry 1982, 140:566-572.
16. Human Tissue Distribution of Orally Supplemented Natural Vitamin E Tocotrienol. Study NCT00678834 http://clinicaltrials.gov/ct2/show/record/NCT00678834?term=tocotrienol%26rank=12.
17. The AddNeuroMed Study. Scientific aims and objectives of AddNeuroMed Innovative Medicine Initiative. http://www.innomed-addneuromed.com.
18. Isaac M.G., Quinn R., Tabet N. Vitamin E for Alzheimer's disease and mild cognitive impairment. Cochrane Database Syst. Rev 2008, CD002854.
19. Kang J.H., Grodstein F. Plasma carotenoids and tocopherols and cognitive function: a prospective study. Neurobiol. Aging 2008, 29:1394-1403.
20. Khanna S., Parinandi N.L., Kotha S.R., Roy S., Rink C., Bibus D., Sen C.K. Nanomolar vitamin E alpha-tocotrienol inhibits glutamate-induced activation of phospholipase A2 and causes neuroprotection. J. Neurochem 2010, 112:1249-1260.
21. Khanna S., Patel V., Rink C., Roy S., Sen C.K. Delivery of orally supplemented alpha-tocotrienol to vital organs of rats and tocopherol-transport protein deficient mice. Free Radic. Biol. Med 2005, 39:1310-1319.
22. Lee H.P., Casadesus G., Zhu X., Lee H.G., Perry G., Smith M.A., Gustaw-Rothenberg K., Lerner A. All-trans retinoic acid as a novel therapeutic strategy for Alzheimer's disease. Expert Review Neurother 2009, 9:1615-1621.
23. Lovestone S., Francis P., Kloszewska I., Mecocci P., Simmons A., Soininen H., Spenger C., Tsolaki M., Vellas B., Wahlund L.O., Ward M. AddNeuroMed-the European collaboration for the discovery of novel biomarkers for Alzheimer's disease. Ann. N. Y. Acad. Sci 2009, 1180:36-46. AddNeuroMed Consortium.
24. Lovestone S., Francis P., Strandgaard K. Biomarkers for disease modification trials-the innovative medicines initiative and AddNeuroMed. J. Nutr. Health Aging 2007, 11:359-361.
25. Mangialasche F., Kivipelto M., Mecocci P., Rizzuto D., Palmer K., Winblad B., Fratiglioni L. High plasma levels of vitamin E forms and reduced Alzheimer's disease risk in advanced age. J. Alzheimers Dis 2010, 20:1029-1037.
26. Mangialasche F., Polidori M.C., Monastero R., Ercolani S., Camarda C., Cecchetti R., Mecocci P. Biomarkers of oxidative and nitrosative damage in Alzheimer's disease and mild cognitive impairment. Ageing Res. Rev 2009, 8:285-305.
27. McKhann G., Drachman D., Folstein M., Katzman R., Price D., Stadlan E.M. Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease. Neurology 1984, 34:939-944.
28. Morris J.C., Heyman A., Mohs R.C., Hughes J.P., van Belle G., Fillenbaum G., Mellits E.D., Clark C. The Consortium to Establish a Registry for Alzheimer's Disease (CERAD). Part I. Clinical and neuropsychological assessment of Alzheimer's disease. Neurology 1989, 39:1159-1165.
29. Morris M.C., Evans D.A., Tangney C.C., Bienias J.L., Wilson R.S., Aggarwal N.T., Scherr P.A. Relation of the tocopherol forms to incident Alzheimer disease and to cognitive change. Am. J. Clin. Nutr 2005, 81:508-514.
30. Muller D.P., Goss-Sampson M.A. Neurochemical, neurophysiological, and neuropathological studies in vitamin E deficiency. Crit. Rev. Neurobiol 1990, 5:239-263.
31. Nesaretnam K. Multitargeted therapy of cancer by tocotrienols. Cancer Lett 2008, 269:388-395.
32. Neuroprotective and Cardioprotective Effects Of Palm Vitamin E Tocotrienols; Study NCT00753532 http://clinicaltrials.gov/ct2/show/record/NCT00753532?term=tocotrienol%26rank=11.
33. Niki E. Tocopherylquinone and tocopherylhydroquinone. Redox Rep 2007, 12:204-210.
34. Parks E., Traber M.G. Mechanisms of vitamin E regulation: research over the past decade and focus on the future. Antioxid. Redox Signal 2000, 2:405-412.
35. Perkins A.J., Hendrie H.C., Callahan C.M., Gao S., Unverzagt F.W., Xu Y., Hall K.S., Hui S.L. Association of antioxidants with memory in a multiethnic elderly sample using the Third National Health and Nutrition Examination Survey. Am. J. Epidemiol 1999, 150:37-44.
36. Petersen R.C., Doody R., Kurz A., Mohs R.C., Morris J.C., Rabins P.V., Ritchie K., Rossor M., Thal L., Winblad B. Current concepts in mild cognitive impairment. Arch. Neurol 2001, 58:1985-1992.
37. Petersen R.C., Smith G.E., Waring S.C., Ivnik R.J., Tangalos E.G., Kokmen E. Mild cognitive impairment: clinical characterization and outcome. Arch. Neurol 1999, 56:303-308.
38. Praticò D., Sung S. Lipid peroxidation and oxidative imbalance: early functional events in Alzheimer's disease. J. Alzheimers Dis 2004, 6:171-175.
39. Ravaglia G., Forti P., Lucicesare A., Pisacane N., Rietti E., Mangialasche F., Cecchetti R., Patterson C., Mecocci P. Plasma tocopherols and risk of cognitive impairment in an elderly Italian cohort. Am. J. Clin. Nutr 2008, 87:1306-1313.
40. Reddy P.H. Mitochondrial dysfunction in aging and Alzheimer's disease: strategies to protect neurons. Antioxid. Redox Signal 2007, 9:1647-1658.
41. Reiter E., Jiang Q., Christen S. Anti-inflammatory properties of alpha- and gamma-tocopherol. Mol. Aspects Med 2007, 28:668-691.
42. Ricciarelli R., Argellati F., Pronzato M.A., Domenicotti C. Vitamin E and neurodegenerative diseases. Mol. Aspects Med 2007, 28:591-606.
43. Rinaldi P., Polidori M.C., Metastasio A., Mariani E., Mattioli P., Cherubini A., Catani M., Cecchetti R., Senin U., Mecocci P. Plasma antioxidants are similarly depleted in mild cognitive impairment and in Alzheimer's disease. Neurobiol. Aging 2003, 24:915-919.
44. Rosen W.G., Mohs R.C., Davis K.L. A new rating scale for Alzheimer's disease. Am. J. Psychiatry 1984, 141:1356-1364.
45. Schmidt R., Hayn M., Reinhart B., Roob G., Schmidt H., Schumacher M., Watzinger N., Launer L.J. Plasma antioxidants and cognitive performance in middle-aged and older adults: results of the Austrian Stroke Prevention Study. J. Am. Geriatr. Soc'Y 1998, 46:1407-1410.
46. Schurks M., Glynn R.J., Rist P.M., Tzourio C., Kurth T. Effects of vitamin E on stroke subtypes: meta-analysis of randomised controlled trials. BMJ Clin. Res. Ed 2010, 341:c5702.
47. Sen C.K., Khanna S., Rink C., Roy S. Tocotrienols: the emerging face of natural vitamin E. Vitam. Horm 2007, 76:203-261.
48. Sen C.K., Rink C., Khanna S. Palm oil-derived natural vitamin E alpha-tocotrienol in brain health and disease. J. Am. Coll. Nutr 2010, 29(3 suppl):314S-323S.
49. Suzuki Y.J., Tsuchiya M., Wassall S.R., Choo Y.M., Govil G., Kagan V.E., Packer L. Structural and dynamic membrane properties of alpha-tocopherol and alpha-tocotrienol: implication to the molecular mechanism of their antioxidant potency. Biochemistry 1993, 32:10692-10699.
50. Traber M.G., Jialal I. Measurement of lipid-soluble vitamins-further adjustment needed?. Lancet 2000, 355:2013-2014.
51. Vogel S., Contois J.H., Tucker K.L., Wilson P.W., Schaefer E.J., Lammi-Keefe C.J. Plasma retinol and plasma and lipoprotein tocopherol and carotenoid concentrations in healthy elderly participants of the Framingham Heart Study. Am. J. Clin. Nutr 1997, 66:950-958.
52. White E., Kristal A.R., Shikany J.M., Wilson A.C., Chen C., Mares-Perlman J.A., Masaki K.H., Caan B.J. Correlates of serum alpha- and gamma-tocopherol in the Women's Health Initiative. Ann. Epidemiol 2001, 11:136-144.
53. Williamson K.S., Gabbita S.P., Mou S., West M., Pye Q.N., Markesbery W.R., Cooney R.V., Grammas P., Reimann-Philipp U., Floyd R.A., Hensley K. The nitration product 5-nitro-gamma-tocopherol is increased in the Alzheimer brain. Nitric Oxide 2002, 6:221-227.
54. Wright M.E., Lawson K.A., Weinstein S.J., Pietinen P., Taylor P.R., Virtamo J., Albanes D. Higher baseline serum concentrations of vitamin E are associated with lower total and cause-specific mortality in the Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study. Am. J. Clin. Nutr 2006, 84:1200-1207.
55. Wyss-Coray T. Inflammation in Alzheimer disease: driving force, bystander or beneficial response?. Nat. Med 2006, 12:1005-1015.
56. Yesavage J., Sheik J. Geriatric Depression Scale (GDS): recent evidence and development of a shorter version. Clin. Gerontol 1986, 5:165-173.
57. Zingg J.M. Molecular and cellular activities of vitamin E analogues. Mini Rev. Med. Chem 2007, 7:543-558.