DNA interstrand cross-linking and in vivo antitumor activity of the extended pyrrolo[2,1-c][1,4]benzodiazepine dimer SG2057

Investigational New Drugs

Volumn 30, Issue 3, 2012, Pages 950-958

  Hartley, John A ^a   Hamaguchi, Anzu ^a   Suggitt, Marie ^a   Gregson, Stephen J ^b   Thurston, David E ^b   Howard, Philip W ^b  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b ASTRAZENECA   (United Kingdom)

Author keywords

DNA interstrand cross linking; DNA minor groove binding agent; Pyrrolobenzodiazepine dimer; SG2057

Indexed keywords

ANTINEOPLASTIC AGENT; CYTOTOXIC AGENT; DOXORUBICIN; IRINOTECAN; PACLITAXEL; SG 2000; SG 2057; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; COLON CANCER; CONTROLLED STUDY; DNA CROSS LINKING; DOSAGE SCHEDULE COMPARISON; DOSE RESPONSE; DRUG CYTOTOXICITY; DRUG MECHANISM; DRUG POTENCY; DRUG STRUCTURE; FEMALE; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MELANOMA; MOUSE; NONHUMAN; OVARY CANCER; PRIORITY JOURNAL; PROMYELOCYTIC LEUKEMIA; SINGLE DRUG DOSE; TUMOR XENOGRAFT;

ANIMALS; ANTINEOPLASTIC AGENTS; BENZODIAZEPINONES; CELL LINE, TUMOR; CELL PROLIFERATION; CROSS-LINKING REAGENTS; DNA; FEMALE; HUMANS; MICE; MICE, NUDE; MICE, SCID; NEOPLASMS; TUMOR BURDEN; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84864364277     PISSN: 01676997     EISSN: 15730646     Source Type: Journal    
DOI: 10.1007/s10637-011-9647-z     Document Type: Article

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