Mechanisms involved in cellular ceramide homeostasis

Nutrition and Metabolism

Volumn 9, Issue , 2012, Pages

  Hussain, M Mahmood ^a   Jin, Weijun ^a   Jiang, Xian Cheng ^a  

^a Downstate Health Sciences University   (United States)

Author keywords

Ceramides; Endoplasmic reticulum; Gangliosides; Golgi; Lipoproteins; Plasma membrane; Sphingomyelin

Indexed keywords

APOLIPOPROTEIN B; CERAMIDE; GANGLIOSIDE GM3; GLUCOSYLCERAMIDE; SPHINGOLIPID; SPHINGOMYELIN; SPHINGOMYELIN SYNTHASE 1; SPHINGOMYELIN SYNTHASE 2; SYNTHETASE; TRIACYLGLYCEROL; UNCLASSIFIED DRUG;

BIOSYNTHESIS; CELL DAMAGE; CELL MEMBRANE; CELL ORGANELLE; CELLULAR CERAMIDE HOMEOSTASIS; ENDOPLASMIC RETICULUM; ENZYME DEFICIENCY; GOLGI COMPLEX; HOMEOSTASIS; HUMAN; LIPID METABOLISM; LIPOGENESIS; LYSOSOME; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; REVIEW; SEPSIS; SPHINGOMYELIN SYNTHASE 1 DEFICIENCY; SPHINGOMYELIN SYNTHASE 2 DEFICIENCY;

EID: 84864361823     PISSN: None     EISSN: 17437075     Source Type: Journal    
DOI: 10.1186/1743-7075-9-71     Document Type: Review

References (44)

1. An overview of sphingolipid metabolism: from synthesis to breakdown. Gault CR, Obeid LM, Hannun YA, Adv Exp Med Biol 2010 688 1 23 10.1007/978-1-4419-6741-1-1 20919643
2. Functions of sphingolipid metabolism in mammals-lessons from genetic defects. Sabourdy F, Kedjouar B, Sorli SC, Colie S, Milhas D, Salma Y, et al. Biochim Biophys Acta 2008 1781 145 183 10.1016/j.bbalip.2008.01.004 18294974
3. Nuclear sphingolipid metabolism. Lucki NC, Sewer MB, Annu Rev Physiol 2012 74 131 151 10.1146/annurev-physiol-020911-153321 21888508
4. Many ceramides. Hannun YA, Obeid LM, J Biol Chem 2011 286 27855 27862 10.1074/jbc.R111.254359 21693702
5. Functional rafts in cell membranes. Simons K, Ikonen E, Nature 1997 387 569 572 10.1038/42408 9177342
6. The complex life of simple sphingolipids. Futerman AH, Hannun YA, EMBO Rep 2004 5 777 782 10.1038/sj.embor.7400208 15289826
7. Lipid microdomains, lipid translocation and the organization of intracellular membrane transport (Review). Holthuis JC, van Meer G, Huitema K, Mol Membr Biol 2003 20 231 241 12893531
8. Physiological and pathophysiological aspects of ceramide. Gulbins E, Li PL, Am J Physiol Regul Integr Comp Physiol 2006 290 11 R26 10.1152/ajpregu. 00416.2005 16352856
9. Ceramide accumulation mediates inflammation, cell death and infection susceptibility in cystic fibrosis. Teichgraber V, Ulrich M, Endlich N, Riethmuller J, Wilker B, De Oliveira-Munding CC, et al. Nat Med 2008 14 382 391 10.1038/nm1748 18376404
10. Liver cell death and anemia in Wilson disease involve acid sphingomyelinase and ceramide. Lang PA, Schenck M, Nicolay JP, Becker JU, Kempe DS, Lupescu A, et al. Nat Med 2007 13 164 170 10.1038/nm1539 17259995
11. Plasma ceramides are elevated in obese subjects with type 2 diabetes and correlate with the severity of insulin resistance. Haus JM, Kashyap SR, Kasumov T, Zhang R, Kelly KR, Defronzo RA, et al. Diabetes 2009 58 337 343 19008343
12. Plasma ceramide and lysophosphatidylcholine inversely correlate with mortality in sepsis patients. Drobnik W, Liebisch G, Audebert FX, Frohlich D, Gluck T, Vogel P, et al. J Lipid Res 2003 44 754 761 10.1194/jlr.M200401-JLR200 12562829
13. Sphingolipids in atherosclerosis and vascular biology. Chatterjee S, Arterioscler Thromb Vasc Biol 1998 18 1523 1533 10.1161/01.ATV.18.10.1523 9763522
14. Gulbins E, Kolesnick R, Raft ceramide in molecular medicine. Oncogene 2003 22 7070 7077
15. Link between plasma ceramides, inflammation and insulin resistance: association with serum IL-6 concentration in patients with coronary heart disease. de Mello V, Lankinen M, Schwab U, Kolehmainen M, Lehto S, Seppanen-Laakso T, et al. Diabetologia 2009 52 2612 2615 10.1007/s00125-009- 1482-9 19669729
16. Effects of dietary cholesterol on tissue ceramides and oxidation products of apolipoprotein B-100 in ApoE-deficient mice. Ichi I, Takashima Y, Adachi N, Nakahara K, Kamikawa C, Harada-Shiba M, et al. Lipids 2007 42 893 900 10.1007/s11745-007-3067-z 17647040
17. Ceramides as modulators of cellular and whole-body metabolism. Bikman BT, Summers SA, J Clin Invest 2011 121 4222 4230 10.1172/JCI57144 22045572
18. Functions of ceramide in coordinating cellular responses to stress. Hannun YA, Science 1996 274 1855 1859 10.1126/science.274.5294.1855 8943189
19. Identification of a family of animal sphingomyelin synthases. Huitema K, van den Dikkenberg J, Brouwers JF, Holthuis JC, EMBO J 2004 23 33 44 10.1038/sj.emboj.7600034 14685263
20. Sphingomyelin synthase-related protein SMSr controls ceramide homeostasis in the ER. Vacaru AM, Tafesse FG, Ternes P, Kondylis V, Hermansson M, Brouwers JF, et al. J Cell Biol 2009 185 1013 1027 10.1083/jcb.200903152 19506037
21. Intracellular trafficking of ceramide by ceramide transfer protein. Hanada K, Proc Jpn Acad Ser B Phys Biol Sci 2010 86 426 437 10.2183/pjab.86.426 20431265
22. Molecular machinery for non-vesicular trafficking of ceramide. Hanada K, Kumagai K, Yasuda S, Miura Y, Kawano M, Fukasawa M, et al. Nature 2003 426 803 809 10.1038/nature02188 14685229
23. CERT-mediated trafficking of ceramide. Hanada K, Kumagai K, Tomishige N, Yamaji T, Biochim Biophys Acta 2009 1791 684 691 10.1016/j.bbalip.2009.01.006 19416656
24. Expression cloning of a human cDNA restoring sphingomyelin synthesis and cell growth in sphingomyelin synthase-defective lymphoid cells. Yamaoka S, Miyaji M, Kitano T, Umehara H, Okazaki T, J Biol Chem 2004 279 18688 18693 10.1074/jbc.M401205200 14976195
25. Impact of Sphingomyelin Synthase 1 Deficiency on Sphingolipid Metabolism and Atherosclerosis in Mice. Li Z, Fan Y, Liu J, Li Y, Quan C, Bui HH, et al. Arterioscler Thromb Vasc Biol 2012 32 1577 1584 10.1161/ATVBAHA.112.251538 22580896
26. Sphingomyelin Synthase 2 Is One of the Determinants for Plasma and Liver Sphingomyelin Levels in Mice. Liu J, Zhang H, Li Z, Hailemariam TK, Chakraborty M, Qiu D, et al. Arterioscler Thromb Vasc Biol 2009 29 850 856 10.1161/ATVBAHA.109.185223 19286635
27. Role of membrane sphingomyelin and ceramide in platform formation for Fas-mediated apoptosis. Miyaji M, Jin ZX, Yamaoka S, Amakawa R, Fukuhara S, Sato SB, et al. J Exp Med 2005 202 249 259 10.1084/jem.20041685 16009715
28. Resistance to alkyl-lysophospholipid-induced apoptosis due to downregulated sphingomyelin synthase 1 expression with consequent sphingomyelin- and cholesterol-deficiency in lipid rafts. van der Luit AH, Budde M, Zerp S, Caan W, Klarenbeek JB, Verheij M, et al. Biochem J 2007 401 541 549 10.1042/BJ20061178 17049047
29. Inhibition of sphingomyelin synthase (SMS) affects intracellular sphingomyelin accumulation and plasma membrane lipid organization. Li Z, Hailemariam TK, Zhou H, Li Y, Duckworth DC, Peake DA, et al. Biochim Biophys Acta 2007 1771 1186 1194 10.1016/j.bbalip.2007.05.007 17616479
30. Blood sphingolipidomics in healthy humans: impact of sample collection methodology. Hammad SM, Pierce JS, Soodavar F, Smith KJ, Al Gadban MM, Rembiesa B, et al. J Lipid Res 2010 51 3074 3087 10.1194/jlr.D008532 20660127
31. Clock genes, intestinal transport and plasma lipid homeostasis. Hussain MM, Pan X, Trends Endocrinol Metab 2009 20 177 185 10.1016/j.tem.2009.01.001 19349191
32. Chylomicron assembly and catabolism: role of apolipoproteins and receptors. Hussain MM, Kancha RK, Zhou Z, Luchoomun J, Zu H, Bakillah A, Biochim Biophys Acta 1996 1300 151 170 10.1016/0005-2760(96)00041-0 8679680
33. Targeted mutation of plasma phospholipid transfer protein gene markedly reduces high-density lipoprotein levels. Jiang XC, Bruce C, Mar J, Lin M, Ji Y, Francone OL, et al. J Clin Invest 1999 103 907 914 10.1172/JCI5578 10079112
34. The mammalian low-density lipoprotein receptor family. Hussain MM, Strickland DK, Bakillah A, Annu Rev Nutr 1999 19 141 172 10.1146/annurev.nutr. 19.1.141 10448520
35. The biogenesis of chylomicrons. Mansbach CM, Siddiqi SA, Annu Rev Physiol 2010 72 315 333 10.1146/annurev-physiol-021909-135801 20148678
36. Intracellular Trafficking and Secretion of VLDL. Tiwari S, Siddiqi SA, Arterioscler Thromb Vasc Biol 2012 32 1079 1086 10.1161/ATVBAHA.111.241471 22517366
37. Endotoxin and cytokines increase hepatic sphingolipid biosynthesis and produce lipoproteins enriched in ceramides and sphingomyelin. Memon RA, Holleran WM, Moser AH, Seki T, Uchida Y, Fuller J, et al. Arterioscler Thromb Vasc Biol 1998 18 1257 1265 10.1161/01.ATV.18.8.1257 9714132
38. Regulation of glycosphingolipid metabolism in liver during the acute phase response. Memon RA, Holleran WM, Uchida Y, Moser AH, Ichikawa S, Hirabayashi Y, et al. J Biol Chem 1999 274 19707 19713 10.1074/jbc.274.28.19707 10391911
39. Sphingolipid biosynthesis de novo by rat hepatocytes in culture. Ceramide and sphingomyelin are associated with, but not required for, very low density lipoprotein secretion. Merrill AH Jr, Lingrell S, Wang E, Nikolova-Karakashian M, Vales TR, Vance DE, J Biol Chem 1995 270 13834 13841 10.1074/jbc.270.23.13834 7775441
40. Microsomal triglyceride transfer protein and its role in apolipoprotein B-lipoprotein assembly. Hussain MM, Shi J, Dreizen P, J Lipid Res 2003 44 22 32 10.1194/jlr.R200014-JLR200 12518019
41. Multiple functions of microsomal triglyceride transfer protein. Hussain MM, Rava P, Walsh M, Rana M, Iqbal J, Nutr Metab (Lond) 2012 9 14 10.1186/1743-7075-9-14
42. Apolipoprotein B secretion and atherosclerosis are decreased in mice with phospholipid-transfer protein deficiency. Jiang XC, Qin S, Qiao C, Kawano K, Lin M, Skold A, et al. Nat Med 2001 7 847 852 10.1038/89977 11433351
43. Phospholipid transfer activity and apoB-containing lipoprotein metabolism. Jiang XC, Jin W, Hussain MM, Nutr Metab (Lond) 2012 In press
44. Efflux of sphingomyelin, cholesterol, and phosphatidylcholine by ABCG1. Kobayashi A, Takanezawa Y, Hirata T, Shimizu Y, Misasa K, Kioka N, et al. J Lipid Res 2006 47 1791 1802 10.1194/jlr.M500546-JLR200 16702602