TIGAR induces p53-mediated cell-cycle arrest by regulation of RB-E2F1 complex

British Journal of Cancer

Volumn 107, Issue 3, 2012, Pages 516-526

  Madan, E ^a,b   Gogna, R ^b   Kuppusamy, P ^c   Bhatt, M ^a   Pati, U ^b   Mahdi, A A ^a  

^a KING GEORGE'S MEDICAL UNIVERSITY   (India)

^b JAWAHARLAL NEHRU UNIVERSITY   (India)

^c THE OHIO STATE UNIVERSITY WEXNER MEDICAL CENTER   (United States)

Author keywords

CDK; cell cycle arrest; cyclins; hypoxia; p53; RB; TIGAR; tumour regression

Indexed keywords

CYCLIN D; CYCLIN DEPENDENT KINASE 2; CYCLIN DEPENDENT KINASE 4; CYCLIN DEPENDENT KINASE 6; CYCLIN E; LUCIFERASE; PROTEIN P21; PROTEIN P53; REGULATOR PROTEIN; RETINOBLASTOMA PROTEIN; TP53 INDUCED GLYCOLYSIS AND APOPTOSIS REGULATOR PROTEIN; TRANSCRIPTION FACTOR E2F1; UNCLASSIFIED DRUG;

ARTICLE; CELL CYCLE ARREST; CELL CYCLE G1 PHASE; CELL CYCLE PROGRESSION; CELL CYCLE S PHASE; CHROMATIN IMMUNOPRECIPITATION; CONTROLLED STUDY; GENE CONTROL; GENE EXPRESSION REGULATION; GLYCOLYSIS; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN DEPHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; PROTEIN STABILITY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TUMOR XENOGRAFT; WESTERN BLOTTING;

CELL CYCLE CHECKPOINTS; CELL LINE, TUMOR; CELL PROLIFERATION; CYCLIN-DEPENDENT KINASE INHIBITOR P21; CYCLIN-DEPENDENT KINASES; E2F1 TRANSCRIPTION FACTOR; G1 PHASE; GENE EXPRESSION; GLYCOLYSIS; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; KB CELLS; PHOSPHORYLATION; PROTEIN INTERACTION DOMAINS AND MOTIFS; RETINAL NEOPLASMS; RETINOBLASTOMA; S PHASE; TAMOXIFEN; TUMOR SUPPRESSOR PROTEIN P53;

EID: 84864354801     PISSN: 00070920     EISSN: 15321827     Source Type: Journal    
DOI: 10.1038/bjc.2012.260     Document Type: Article

References (48)

1. Adams PD, Kaelin Jr WG (1995) Transcriptional control by E2F. Semin Cancer Biol 6: 99-108
2. Bensaad K, Tsuruta A, Selak MA, Vidal MN, Nakano K, Bartrons R, Gottlieb E, Vousden KH (2006) TIGAR, a p53-inducible regulator of glycolysis and apoptosis. Cell 126: 107-120
3. Brady G, Boggan L, Bowie A, O'Neill LA (2005) Schlafen-1 causes a cell cycle arrest by inhibiting induction of cyclin D1. J Biol Chem 280: 30723-30734
4. Brooks RF (1977) Continuous protein synthesis is required to maintain the probability of entry into S phase. Cell 12: 311-317
5. Bryant CS, Kumar S, Chamala S, Shah J, Pal J, Haider M, Seward S, Qazi AM, Morris R, Semaan A, Shammas MA, Steffes C, Potti RB, Prasad M, Weaver DW, Batchu RB (2010) Sulforaphane induces cell cycle arrest by protecting RB-E2F-1 complex in epithelial ovarian cancer cells. Mol Cancer 9: 47
6. Claudio PP, Howard CM, Fu Y, Cinti C, Califano L, Micheli P, Mercer EW, Caputi M, Giordano A (2000) Mutations in the retinoblastoma-related gene RB2/p130 in primary nasopharyngeal carcinoma. Cancer Res 60: 8-12
7. De Luca A, MacLachlan TK, Bagella L, Dean C, Howard CM, Claudio PP, Baldi A, Khalili K, Giordano A (1997) A unique domain of pRb2/p130 acts as an inhibitor of Cdk2 kinase activity. J Biol Chem 272: 20971-20974
8. Dowdy SF, Hinds PW, Louie K, Reed SI, Arnold A, Weinberg RA (1993) Physical interaction of the retinoblastoma protein with human D cyclins. Cell 73: 499-511
9. Duronio RJ (2004) A breath of fresh air for cyclin D/Cdk4: triggering growth via Hph. Dev Cell 6: 163-164
10. Ellederova Z, Cais O, Susor A, Uhlirova K, Kovarova H, Jelinkova L, Tomek W, Kubelka M (2008) ERK1/2 map kinase metabolic pathway is responsible for phosphorylation of translation initiation factor eIF4E during in vitro maturation of pig oocytes. Mol Reprod Dev 75: 309-317
11. Geng Y, Yu Q, Whoriskey W, Dick F, Tsai KY, Ford HL, Biswas DK, Pardee AB, Amati B, Jacks T, Richardson A, Dyson N, Sicinski P (2001) Expression of cyclins E1 and E2 during mouse development and in neoplasia. Proc Natl Acad Sci USA 98: 13138-13143
12. Griffin SV, Pichler R, Wada T, Vaughan M, Durvasula R, Shankland SJ (2003) The role of cell cycle proteins in glomerular disease. Semin Nephrol 23: 569-582
13. Hartwell LH, Kastan MB (1994) Cell cycle control and cancer. Science 266: 1821-1828
14. Herzig RP, Scacco S, Scarpulla RC (2000) Sequential serum-dependent activation of CREB and NRF-1 leads to enhanced mitochondrial respiration through the induction of cytochrome c. J Biol Chem 275: 13134-13141
15. Hsieh JK, Fredersdorf S, Kouzarides T, Martin K, Lu X (1997) E2F1-induced apoptosis requires DNA binding but not transactivation and is inhibited by the retinoblastoma protein through direct interaction. Genes Dev 11: 1840-1852
16. Hu X, Zhang X, Zhong Q, Fisher AB, Bryington M, Zuckerman KS (2001) Differential effects of transforming growth factor on cell cycle regulatory molecules in human myeloid leukemia cells. Oncogene 20: 6840-6850
17. Jackman M, Firth M, Pines J (1995) Human cyclins B1 and B2 are localized to strikingly different structures: B1 to microtubules, B2 primarily to the Golgi apparatus. EMBO J 14: 1646-1654
18. Kim DM, Yang K, Yang BS (2003) Biochemical characterizations reveal different properties between CDK4/cyclin D1 and CDK2/cyclin A. Exp Mol Med 35: 421-430
19. Korzeniewski B (2006) AMP deamination delays muscle acidification during heavy exercise and hypoxia. J Biol Chem 281: 3057-3066
20. Lauricella M, Calvaruso G, Carabillo M, D'Anneo A, Giuliano M, Emanuele S, Vento R, Tesoriere G (2001) pRb suppresses camptothecin-induced apoptosis in human osteosarcoma Saos-2 cells by inhibiting c-Jun N-terminal kinase. FEBS Lett 499: 191-197
21. Law BK, Chytil A, Dumont N, Hamilton EG, Waltner-Law ME, Aakre ME, Covington C, Moses HL (2002) Rapamycin potentiates transforming growth factor beta-induced growth arrest in nontransformed, oncogenetransformed, and human cancer cells. Mol Cell Biol 22: 8184-8198
22. Li H, Jogl G (2009) Structural and biochemical studies of TIGAR (TP53-induced glycolysis and apoptosis regulator). J Biol Chem 284: 1748-1754
23. Lim JH, Lee YM, Chun YS, Park JW (2008) Reactive oxygen speciesmediated cyclin D1 degradation mediates tumor growth retardation in hypoxia, independently of p21cip1 and hypoxia-inducible factor. Cancer Sci 99: 1798-1805
24. Macaluso M, Montanari M, Cinti C, Giordano A (2005) Modulation of cell cycle components by epigenetic and genetic events. Semin Oncol 32: 452-457
25. MacLachlan TK, Sang N, Giordano A (1995) Cyclins, cyclin-dependent kinases and cdk inhibitors: implications in cell cycle control and cancer. Crit Rev Eukaryot Gene Expr 5: 127-156
26. Malumbres M, Barbacid M (2009) Cell cycle, CDKs and cancer: a changing paradigm. Nat Rev Cancer 9: 153-166
27. Mandal S, Guptan P, Owusu-Ansah E, Banerjee U (2005) Mitochondrial regulation of cell cycle progression during development as revealed by the tenured mutation in Drosophila. Dev Cell 9: 843-854
28. Masamha CP, Benbrook DM (2009) Cyclin D1 degradation is sufficient to induce G1 cell cycle arrest despite constitutive expression of cyclin E2 in ovarian cancer cells. Cancer Res 69: 6565-6572
29. Matoba S, Kang JG, Patino WD, Wragg A, Boehm M, Gavrilova O, Hurley PJ, Bunz F, Hwang PM (2006) p53 regulates mitochondrial respiration. Science 312: 1650-1653
30. Mittnacht S (1998) Control of pRB phosphorylation. Curr Opin Genet Dev 8: 21-27
31. Modestou M, Puig-Antich V, Korgaonkar C, Eapen A, Quelle DE (2001) The alternative reading frame tumor suppressor inhibits growth through p21-dependent and p21-independent pathways. Cancer Res 61: 3145-3150
32. Mouysset J, Deichsel A, Moser S, Hoege C, Hyman AA, Gartner A, Hoppe T (2008) Cell cycle progression requires the CDC-48UFD-1/NPL-4 complex for efficient DNA replication. Proc Natl Acad Sci USA 105: 12879-12884
33. Muta D, Makino K, Nakamura H, Yano S, Kudo M, Kuratsu J (2011) Inhibition of eIF4E phosphorylation reduces cell growth and proliferation in primary central nervous system lymphoma cells. J Neurooncol 101: 33-39
34. Nevins JR (1992) E2F: a link between the Rb tumor suppressor protein and viral oncoproteins. Science 258: 424-429
35. Sheaff RJ, Groudine M, Gordon M, Roberts JM, Clurman BE (1997) Cyclin E-CDK2 is a regulator of p27Kip1. Genes Dev 11: 1464-1478
36. Sherr CJ (1996) Cancer cell cycles. Science 274: 1672-1677
37. Sherr CJ, Roberts JM (1995) Inhibitors of mammalian G1 cyclin-dependent kinases. Genes Dev 9: 1149-1163
38. Sweet S, Singh G (1995) Accumulation of human promyelocytic leukemic (HL-60) cells at two energetic cell cycle checkpoints. Cancer Res 55: 5164-5167
39. Thalmann I, Marcus NY, Thalmann R (1982) Adenine nucleotides of the organ of Corti under metabolic stress. Laryngoscope 92: 199-203
40. Thalmann R, Marcus NY, Thalmann I (1978) Adenylate energy charge, energy status, and phosphorylation state of stria vascularis under metabolic stress. Laryngoscope 88: 1985-1988
41. Touny LH, Banerjee PP (2006) Identification of both Myt-1 and Wee-1 as necessary mediators of the p21-independent inactivation of the cdc-2/cyclin B1 complex and growth inhibition of TRAMP cancer cells by genistein. Prostate 66: 1542-1555
42. Varshavsky A (1997) The ubiquitin system. Trends Biochem Sci 22: 383-387
43. Viticchi C, Moresi R, Piantanelli L (1996) Assay of total protein kinase activity in mouse brain cortex. Boll Soc Ital Biol Sper 72: 317-324
44. Vogelstein B, Lane D, Levine AJ (2000) Surfing the p53 network. Nature 408: 307-310
45. Wang S, Nath N, Minden A, Chellappan S (1999) Regulation of Rb and E2F by signal transduction cascades: divergent effects of JNK1 and p38 kinases. Embo J 18: 1559-1570
46. Weinberg RA (1995) The retinoblastoma protein and cell cycle control. Cell 81: 323-330
47. Zhang HS, Postigo AA, Dean DC (1999) Active transcriptional repression by the Rb-E2F complex mediates G1 arrest triggered by p16INK4a, TGFbeta, and contact inhibition. Cell 97: 53-61
48. Zhu X, Kwon CH, Schlosshauer PW, Ellenson LH, Baker SJ (2001) PTEN induces G(1) cell cycle arrest and decreases cyclin D3 levels in endometrial carcinoma cells. Cancer Res 61: 4569-4575