Inhibition of eIF4E phosphorylation reduces cell growth and proliferation in primary central nervous system lymphoma cells

Journal of Neuro-Oncology

Volumn 101, Issue 1, 2011, Pages 33-39

  Muta, Daisuke ^a   Makino, Keishi ^a   Nakamura, Hideo ^a   Yano, Shigetoshi ^a   Kudo, Mareina ^a   Kuratsu, Jun Ichi ^a  

^a KUMAMOTO UNIVERSITY   (Japan)

Author keywords

eIF4E; MNK1; MNK1 inhibitor; Phosphorylation; Primary central nervous system lymphoma

Indexed keywords

CYCLIN D1; INITIATION FACTOR 4E; MAP KINASE INTERACTING KINASE 1; MAP KINASE INTERACTING KINASE 1 INHIBITOR; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; B CELL LYMPHOMA; CANCER CHEMOTHERAPY; CANCER INHIBITION; CELL SURVIVAL; CELL TRANSFORMATION; CONTROLLED STUDY; DRUG EFFECT; DRUG EFFICACY; HUMAN; HUMAN CELL; HUMAN TISSUE; LYMPHOMA CELL; MALE; MOUSE; NONHUMAN; PRIMARY CENTRAL NERVOUS SYSTEM LYMPHOMA; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; TREATMENT DURATION;

ANIMALS; BLOTTING, WESTERN; CELL PROLIFERATION; CENTRAL NERVOUS SYSTEM NEOPLASMS; ENZYME INHIBITORS; EUKARYOTIC INITIATION FACTOR-4E; HUMANS; IMMUNOHISTOCHEMISTRY; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; LYMPHOMA; MALE; MICE; MICE, SCID; PHOSPHORYLATION; PROTEIN-SERINE-THREONINE KINASES; SIGNAL TRANSDUCTION; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 78651282683     PISSN: 0167594X     EISSN: 15737373     Source Type: Journal    
DOI: 10.1007/s11060-010-0233-6     Document Type: Article

References (24)

1. K Makino H Nakamura T Kino H Takeshima J Kuratsu 2006 Rising incidence of primary central nervous system lymphoma in Kumamoto, Japan Surg Neurol 66 503 506 10.1016/j.surneu.2006.05.055 17084198
2. JD Richter N Sonenberg 2005 Regulation of cap-dependent translation by eIF4E inhibitory proteins Nature 433 477 480 1:CAS:528:DC%2BD2MXpt1Cnug%3D%3D 10.1038/nature03205 15690031
3. D Rousseau AC Gingras A Pause N Sonenberg 1996 The eIF4E-binding proteins 1 and 2 are negative regulators of cell growth Oncogene 13 2415 2420 1:CAS:528:DyaK2sXns12i 8957083
4. SG Zimmer A DeBenedetti JR Graff 2000 Translational control of malignancy: the mRNA cap-binding protein, eIF-4E, as a central regulator of tumor formation, growth, invasion and metastasis Anticancer Res 20 1343 1351 1:CAS:528:DC%2BD3cXlvVOqtLc%3D 10928042
5. A De Benedetti JR Graff 2004 eIF-4E expression and its role in malignancies and metastases Oncogene 23 3189 3199 10.1038/sj.onc.1207545 15094768
6. K Byrnes S White Q Chu, et al. 2006 High eIF4E, VEGF, and microvessel density in stage I to III breast cancer Ann Surg 243 684 690 10.1097/01.sla.0000216770.23642.d8 16633004 (discussion 691-692)
7. T Khoury S Alrawi N Ramnath, et al. 2009 Eukaryotic initiation factor-4E and cyclin D1 expression associated with patient survival in lung cancer Clin Lung Cancer 10 58 66 1:CAS:528:DC%2BD1MXjslalu7Y%3D 10.3816/CLC.2009.n.009 19289374
8. D Ruggero L Montanaro L Ma, et al. 2004 The translation factor eIF-4E promotes tumor formation and cooperates with c-Myc in lymphomagenesis Nat Med 10 484 486 1:CAS:528:DC%2BD2cXjsF2jtLY%3D 10.1038/nm1042 15098029
9. HG Wendel E De Stanchina JS Fridman, et al. 2004 Survival signalling by Akt and eIF4E in oncogenesis and cancer therapy Nature 428 332 337 1:CAS:528:DC%2BD2cXitFCntbY%3D 10.1038/nature02369 15029198
10. Y Mamane E Petroulakis L Rong K Yoshida LW Ler N Sonenberg 2004 eIF4E-from translation to transformation Oncogene 23 3172 3179 1:CAS:528:DC%2BD2cXjtFOmsbY%3D 10.1038/sj.onc.1207549 15094766
11. AJ Waskiewicz A Flynn CG Proud JA Cooper 1997 Mitogen-activated protein kinases activate the serine/threonine kinases Mnk1 and Mnk2 EMBO J 16 1909 1920 1:CAS:528:DyaK2sXjt1Wlt7s%3D 10.1093/emboj/16.8.1909 9155017
12. S Pyronnet 2000 Phosphorylation of the cap-binding protein eIF4E by the MAPK-activated protein kinase Mnk1 Biochem Pharmacol 60 1237 1243 1:CAS:528:DC%2BD3cXmslOjtrY%3D 10.1016/S0006-2952(00)00429-9 11007962
13. GC Scheper CG Proud 2002 Does phosphorylation of the cap-binding protein eIF4E play a role in translation initiation? Eur J Biochem 269 5350 5359 1:CAS:528:DC%2BD38XptVymtro%3D 10.1046/j.1432-1033.2002.03291.x 12423333
14. T Ueda R Watanabe-Fukunaga H Fukuyama S Nagata R Fukunaga 2004 Mnk2 and Mnk1 are essential for constitutive and inducible phosphorylation of eukaryotic initiation factor 4E but not for cell growth or development Mol Cell Biol 24 6539 6549 1:CAS:528:DC%2BD2cXmtlKltLw%3D 10.1128/MCB.24.15.6539-6549.2004 15254222
15. HG Wendel RL Silva A Malina, et al. 2007 Dissecting eIF4E action in tumorigenesis Genes Dev 21 3232 3237 1:CAS:528:DC%2BD2sXhsVOrsb7K 10.1101/gad.1604407 18055695
16. A Bianchini M Loiarro P Bielli, et al. 2008 Phosphorylation of eIF4E by MNKs supports protein synthesis, cell cycle progression and proliferation in prostate cancer cells Carcinogenesis 29 2279 2288 1:CAS:528:DC%2BD1cXhsVOgsLnP 10.1093/carcin/bgn221 18809972
17. K Koga T Todaka M Morioka, et al. 2001 Expression of angiopoietin-2 in human glioma cells and its role for angiogenesis Cancer Res 61 6248 6254 1:CAS:528:DC%2BD3MXmt12kur0%3D 11507079
18. N Shinojima K Tada S Shiraishi, et al. 2003 Prognostic value of epidermal growth factor receptor in patients with glioblastoma multiforme Cancer Res 63 6962 6970 1:CAS:528:DC%2BD3sXosVGnsLg%3D 14583498
19. S Wang IB Rosenwald MJ Hutzler, et al. 1999 Expression of the eukaryotic translation initiation factors 4E and 2alpha in non-Hodgkin's lymphomas Am J Pathol 155 247 255 1:CAS:528:DyaK1MXkslegtbo%3D 10393856
20. A Noske JL Lindenberg S Darb-Esfahani, et al. 2008 Activation of mTOR in a subgroup of ovarian carcinomas: correlation with p-eIF-4E and prognosis Oncol Rep 20 1409 1417 1:CAS:528:DC%2BD1MXjs1Ghtw%3D%3D 19020722
21. IB Rosenwald A Lazaris-Karatzas N Sonenberg EV Schmidt 1993 Elevated levels of cyclin D1 protein in response to increased expression of eukaryotic initiation factor 4E Mol Cell Biol 13 7358 7363 1:CAS:528:DyaK2cXltFSmug%3D%3D 8246956
22. I Topisirovic M Ruiz-Gutierrez KL Borden 2004 Phosphorylation of the eukaryotic translation initiation factor eIF4E contributes to its transformation and mRNA transport activities Cancer Res 64 8639 8642 1:CAS:528: DC%2BD2cXhtVCjs73L 10.1158/0008-5472.CAN-04-2677 15574771
23. B Culjkovic I Topisirovic L Skrabanek M Ruiz-Gutierrez KL Borden 2005 eIF4E promotes nuclear export of cyclin D1 mRNAs via an element in the 3'UTR J Cell Biol 169 245 256 1:CAS:528:DC%2BD2MXjslartr4%3D 10.1083/jcb.200501019 15837800
24. A Soni A Akcakanat G Singh, et al. 2008 eIF4E knockdown decreases breast cancer cell growth without activating Akt signaling Mol Cancer Ther 7 1782 1788 1:CAS:528:DC%2BD1cXoslCgtLw%3D 10.1158/1535-7163.MCT-07-2357 18644990