Effects of purified Saccharomyces cerevisiae (1→3)-β-glucan on venous ulcer healing

International Journal of Molecular Sciences

Volumn 13, Issue 7, 2012, Pages 8142-8158

  Medeiros, Sarah Dantas Viana ^a   Cordeiro, Sara Lima ^a   Cavalcanti, Jéssica Escorel Chaves ^a   Melchuna, Karina Mendes ^a   Lima, Aleida Maria da Silva ^a   Filho, Irami Araújo ^a   Medeiros, Aldo Cunha ^a   Rocha, Keyla Borges Ferreira ^a   Oliveira, Elizabeth Maia ^a   Faria, Eduardo Dantas Baptista ^a   Sassaki, Guilherme Lanzi ^b   Rocha, Hugo Alexandre Oliveira ^a   Sales, Valéria Soraya Farias ^a  

^a FEDERAL UNIVERSITY OF RIO GRANDE DO NORTE   (Brazil)

^b FEDERAL UNIVERSITY OF PARANÁ   (Brazil)

Author keywords

Immunomodulator; Polysaccharide; Tissue repair; Water insoluble glucan; Yeast

Indexed keywords

BETA 1,3 GLUCAN; FUNGAL POLYSACCHARIDE; GLUCAN;

ADULT; AGED; ANGIOGENESIS; ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; CELL PROLIFERATION; CHRONIC VEIN INSUFFICIENCY; CLINICAL ARTICLE; CLINICAL TRIAL; DRUG PURIFICATION; DRUG STRUCTURE; EPITHELIUM HYPERPLASIA; FEMALE; FIBROBLAST; HETERONUCLEAR SINGLE QUANTUM COHERENCE; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; INFLAMMATORY CELL; LEG ULCER; MALE; PLASMA CELL; PROTON NUCLEAR MAGNETIC RESONANCE; SACCHAROMYCES CEREVISIAE; ULCER HEALING; CHEMISTRY; COMPARATIVE STUDY; DRUG EFFECTS; ISOLATION AND PURIFICATION; MIDDLE AGED; VARICOSE ULCER; WOUND HEALING;

SACCHAROMYCES CEREVISIAE;

ADULT; AGED; FEMALE; FUNGAL POLYSACCHARIDES; GLUCANS; HUMANS; MALE; MIDDLE AGED; SACCHAROMYCES CEREVISIAE; VARICOSE ULCER; WOUND HEALING;

EID: 84864350950     PISSN: 16616596     EISSN: 14220067     Source Type: Journal    
DOI: 10.3390/ijms13078142     Document Type: Article

References (37)

1. Rodero, M.P.; Khosrotehrani, K. Skin wound healing modulation by macrophages. Int. J. Clin. Exp. Pathol. 2010, 3, 643-653.
2. Gillitzer, R.; Goebeler, M. Chemokines in cutaneous wound healing. J. Leukocyte Biol. 2001, 69, 513-521.
3. Gurtner, G.C.; Werner, S.; Barrandon, Y.; Longaker, M.T. Wound repair and regeneration. Nature 2008, 453, 314-321.
4. Park, J.E.; Barbul, A. Understanding the role of immune regulation in wound healing. Am. J. Surg. 2004, 187, 11-16.
5. Singer, A.J.; Clark, R.A.F. Mechanisms of disease: Cutaneous wound healing. N. Engl. J. Med. 1999, 341, 738-746.
6. Werner, S.; Grose R. Regulation of wound healing by growth factors and cytokines. Physiol. Rev. 2003, 83, 835-870.
7. Boyce, D.E.; Jones, W.D.; Ruge, F.; Harding, K.G.; Moore, K. The role of lymphocytes in human dermal wound healing. Br. J. Dermatol. 2000, 143, 59-65.
8. Iwata, Y.; Yoshizaki, A.; Komura, K.; Shimizu, K.; Ogawa, F.; Hara, T.; Muroi, E.; Bae, S.; Takenaka, M.; Yukami T.; et al. CD19, A response regulator of b lymphocytes, regulates wound healing through hyaluronan-induced TLR4 signaling. Am. J. Pathol. 2009, 175, 649-660.
9. Chen, J.; Seviour, R. Medicinal importance of fungal β-(1→3),(1→6) glucans. Mycol. Res. 2007, 111, 635-652.
10. Manners, D.J.; Masson, A.J.; Patterson, J.C. The heterogeneity of glucan preparations from the walls of various yeasts. J. Gen. Microbiol. 1974, 80, 411-417.
11. Kim, Y.T.; Kim, E.H.; Cheong, C.; Williams, D.L.; Kim, C.W.; Lim, S.T. Structural characterization of β-D-(1→3,1→6)-linked Glucans using NMR spectroscopy. Carbohydr. Res. 2000, 328, 331-341.
12. Goodridge, H.S.; Wolf, A.J.; Underhill, D.M. β-Glucan Recognition by the Innate Immune System. Immunol. Rev. 2009, 230, 38-50.
13. Wei, D.; Williams, D.; Browder W. Activation of AP-1 and SP1 correlates with wound growth factor gene expression in glucan-treated human fibroblasts. Int. Immunopharmacol. 2002, 2, 1163-1172.
14. Berdal, M.; Appelbom, H.I.; Eikrem, J.H.; Lund, A.; Zykova, S.; Busund, L.T.; Seljelid, R.; Jenssen, T. Aminated β-1,3-D-glucan improves wound healing in diabetic db/db mice. Wound. Repair. Regen. 2007, 15, 825-832.
15. Lee, S.B.; Jeon, H.W.; Lee, Y.W.; Lee, Y.M.; Song, K.W.; Park, M.H.; Nam, Y.S.; Ahn, H.C. Bio-artificial skin composed of gelatin and (1→3),(1→6)-β-glucan. Biomaterials. 2003, 24, 2503-2511.
16. Toklu, H.Z.; Sener, G.; Jahovic, N.; Uslu, B.; Arbak, S.; Yegen, B.C. β-glucan protects against burn-induced oxidative organ damage in rats. Int. Immunopharmacol. 2006, 6, 156-169.
17. Delatte, S.J.; Evans, J.; Hebra, A.; Adamson, W.; Othersen, H.B.; Tagge, E.P. Effectiveness of beta-glucan collagen for treatment of partial-thickness burns in children. J. Pediatr. Surg. 2001, 36, 113-118.
18. Simon, D.A.; Dix, F.P.; McCollum, C.N. Management of venous leg ulcers. Br. Med. J. 2004, 328, 1358-1362.
19. Bi, H.; Ni, Z.; Liu, X.; Iteku, J.; Tai, G.; Zhou, Y.; Zhao, J. A novel water-soluble β-(1→6)-D-glucan isolated from the fruit bodies of Bulgaria inquinans (Fries). Carbohydr. Res. 2009, 344, 1254-1258.
20. Ensley, H.E.; Tobias, B.; Pretus, H.A.; McNamee, R.B.; Jones, E.L.; Browder, I.W.; Williams, D.L. NMR spectral analysis of a water-insoluble (1→3)-β-D-glucan isolated from Saccharomyces cerevisiae. Carbohydr. Res. 1994, 258, 307-311.
21. Freimund, S.; Sauter, M.; Käppeli, O.; Dutler, H. A new non-degrading isolation process for 1,3-β-D-glucan of high purity from baker's yeast Saccharomyces cerevisiae. Carbohydr. Polym. 2003, 54, 159-171.
22. Roubroeks, J.P.; Andersson, R.; Aman P. Structural features of (1→3),(1→4) β-D-glucan and arabinoxylan fractions isolated from rye bran. Carbohydr. Polym. 2000, 42, 3-11.
23. Tada, R.; Harada, T.; Nagi-Miura, N.; Adachi, Y.; Nakajima, M.; Yadomae, T.; Ohno, N. NMR characterization of the structure of a β-(1→3)-D-glucan isolate from cultured fruit bodies of Sparassis crispa. Carbohydr. Res. 2007, 342, 2611-2618.
24. Williams, D.L.; McNamee, R.B.; Jones, E.L.; Pretus, H.A.; Ensley, H.E.; Browder, I.W.; di Luzio, N.R. A method for the solubilization of a (1→3)-β-D-glucan isolated from Saccharomyces cerevisiae. Carbohydr. Res. 1991, 219, 203-213.
25. Shivakumar, S.; Vijayendra, S.V.N. Production of exopolysaccharides by Agrobacterium sp. CFR-24 using coconut water-a byproduct of food industry. Lett. Appl. Microbiol. 2006, 42, 477-482.
26. Kenyon, W.J.; Buller, C.S. Structural analysis of the curdlan-like exopolysaccharide produced by Cellulomonas flavigena KU. J. Ind. Microbiol. Biotechnol. 2002, 29, 200-203.
27. Wang, Y.; Zhang, M.; Ruan, D.; Shashkov, A.S.; Kilcoyne, M.; Savage, A.V.; Zhang, L. Chemical components and molecular mass of six polysaccharides isolated from the sclerotium of Poria cocos. Carbohydr. Res. 2004, 339, 327-334.
28. Coleridge-Smith, P.D. Leg ulcer treatment. J. Vasc. Surg. 2009, 49, 804-808.
29. O'Meara, S.; Cullum, N.A.; Nelson, E.A. Compression for venous leg ulcers. Cochrane Database Syst. Rev. 2009, 1, doi:10.1002/14651858.CD000265.pub2.
30. Leibovich, S.J.; Danon, D. Promotion of wound repair in mice by application of glucan. J. Reticuloendothel. Soc. 1980, 27, 1-11.
31. Wolk, M.; Danon, D. Promotion of wound healing by yeast glucan evaluated on single animals. Med. Biol. 1985, 63, 73-80.
32. Browder, W.; Williams, D.; Lucore, P.; Pretus, H.; Jones, E.; McNamee, R. Effect of enhanced macrophage function on early wound healing. Surgery 1988, 104, 224-230.
33. Portera, C.A.; Love, E.J.; Memore, L.; Zhang, L.; Muller, A.; Browder, W.; Williams, D.L. Effect of macrophage stimulation on collagen biosynthesis in the healing wound. Am. Surg. 1997, 63, 125-130.
34. Hassid, W.Z.; Joslyn, M.A.; McCready, R.M. The molecular constitution of an insoluble polysaccharide from yeast, Saccharomyces cerevisiae. J. Am. Chem. Soc. 1941, 63, 295-298.
35. Dubois, M.; Gilles, K.A.; Hamilton, J.K.; Rebers, P.A.; Smith, F. Colorimetric methods for determination of sugars and related substances. Anal. Chem. 1956, 28, 350-356.
36. Spector, J. Refinement of the comassie blue method of protein qualification. A simple and linear spectrofotometric assay of 0.5 to 50 μg of protein. Anal. Chem. 1978, 86, 142-146.
37. Melo-Silveira, R.F.; Fidelis, G.P.; Costa, M.S.S.P.; Telles, C.B.S.; Dantas-Santos, N.; Elias, S.O.; Ribeiro, V.B.; Barth, A.L.; Macedo, A.J.; Leite, E.L.; Rocha, H.A.O. In vitro antioxidant, anticoagulant and antimicrobial activity and in inhibition of cancer cell proliferation by xylan extracted from corn cobs. Int. J. Mol. Sci. 2012, 13, 409-426.