Aminated β-1,3-d-glucan improves wound healing in diabetic db/db mice

Wound Repair and Regeneration

Volumn 15, Issue 6, 2007, Pages 825-832

  Berdal, Margrete ^a   Appelbom, Hege I ^a   Eikrem, Jorunn H ^a   Lund, Åse ^a   Zykova, Svetlana ^a   Busund, Lill Tove ^a,b   Seljelid, Rolf ^a   Jenssen, Trond ^a,c  

^a UNIVERSITY OF TROMSØ   (Norway)

^b UNIVERSITY HOSPITAL OF NORTH NORWAY   (Norway)

^c OSLO UNIVERSITY HOSPITAL   (Norway)

Author keywords

[No Author keywords available]

Indexed keywords

BETA 1,3 GLUCAN; INSULIN; PLACEBO;

AMINATION; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DIABETES MELLITUS; DIET RESTRICTION; DRUG EFFECT; GLUCOSE BLOOD LEVEL; HISTOLOGY; MACROPHAGE; MOUSE; NONHUMAN; PRIORITY JOURNAL; SCORING SYSTEM; WOUND HEALING;

ADMINISTRATION, TOPICAL; ANALYSIS OF VARIANCE; ANIMALS; BETA-GLUCANS; DIABETES MELLITUS, EXPERIMENTAL; INSULIN; INTERLEUKIN-1; MACROPHAGES; MICE; MICE, INBRED C57BL; STATISTICS, NONPARAMETRIC; TUMOR NECROSIS FACTOR-ALPHA; WOUND HEALING;

EID: 36248983653     PISSN: 10671927     EISSN: 1524475X     Source Type: Journal    
DOI: 10.1111/j.1524-475X.2007.00286.x     Document Type: Article

References (40)

1. Kontras SB, Bodenbender JG. Studies of the inflammatory cycle in juvenile diabetes. Am J Dis Child 1968 116 : 130 4.
2. Abbott CA, Garrow AP, Carrington AL, Morris J, Van Ross ER, Boulton AJ. Foot ulcer risk is lower in South-Asian and African-Caribbean compared with European diabetic patients in the UK The North-West Diabetes Foot Care Study. Diabetes Care 2005 28 : 1869 75.
3. Greenhalgh DG, Sprugel KH, Murray MJ, Ross R. PDGF and FGF stimulate wound healing in the genetically diabetic mouse. Am J Pathol 1990 136 : 1235 46.
4. Orlidge A, Hollis TM. Aortic endothelial and smooth-muscle histamine-metabolism in experimental diabetes. Arteriosclerosis 1982 2 : 142 50.
5. Hill HR, Augustine NH, Rallison ML, Santos JI. Defective monocyte chemotactic responses in diabetes mellitus. J Clin Immunol 1983 3 : 70 77.
6. Katz S, Klein B, Elian I, Fishman P, Djaldetti M. Phagocytotic activity of monocytes from diabetic patients. Diabetes Care 1983 6 : 479 82.
7. Luger A, Schernthaner G, Urbanski A, Luger TA. Cytokine production in patients with newly diagnosed insulin-dependent (type I) diabetes mellitus. Eur J Clin Invest 1988 18 : 233 6.
8. Leibovich SJ, Ross R. The role of the macrophage in wound repair. A study with hydrocortisone and antimacrophage serum. Am J Pathol 1975 78 : 71 100.
9. Ptak W, Klimek M, Bryniarski K, Ptak M, Majcher P. Macrophage function in alloxan diabetic mice: expression of adhesion molecules, generation of monokines and oxygen and NO radicals. Clin Exp Immunol 1998 114 : 13 18.
10. Doxey DL, Nares S, Park B, Trieu C, Cutler CW, Iacopino AM. Diabetes-induced impairment of macrophage cytokine release in a rat model: potential role of serum lipids. Life Sci 1998 63 : 1127 36.
11. Zykova SN, Jenssen TG, Berdal M, Olsen R, Myklebust R, Seljelid R. Altered cytokine and nitric oxide secretion in vitro by macrophages from diabetic type II-like db/db mice. Diabetes 2000 49 : 1451 8.
12. Kokoshis PL, Williams DL, Cook JA, Diluzio NR. Increased resistance to Staphylococcus-aureus infection and enhancement in serum lysozyme activity by glucan. Science 1978 199 : 1340 2.
13. Bogwald J, Seljelid R. Coupling of polysaccharides activated by means of chloroacetaldehyde dimethyl acetal to amines or proteins by reductive amination. Carbohydrate Res 1986 148 : 101 7.
14. Doita M, Rasmussen LT, Seljelid R, Lipsky PE. Effect of soluble aminated beta-1,3-d-polyglucose on human monocytes: stimulation of cytokine and prostaglandin E2 production but not antigen-presenting function. J Leukoc Biol 1991 49 : 342 51.
15. Rasmussen Busund LT, Konopski Z, Oian P, Seljelid R. Killing of Escherichia coli by mononuclear phagocytes and neutrophils stimulated in vitro with beta-1,3-d-polyglucose derivatives. Microbiol Immunol 1992 36 : 1173 88.
16. Browder W, Williams D, Pretus H, Olivero G, Enrichens F, Mao P, Franchello A. Beneficial effect of enhanced macrophage function in the trauma patient. Ann Surg 1990 211 : 605 12.
17. Suzuki T, Ohno N, Chiba N, Miura NN, Adachi Y, Yadomae T. Immunopharmacological activity of the purified insoluble glucan, zymocel, in mice. J Pharm Pharmacol 1996 48 : 1243 8.
18. Seljelid R, Figenschau Y, Bogwald J, Rasmussen LT, Austgulen R. Evidence that tumor necrosis induced by aminated beta 1-3d polyglucose is mediated by a concerted action of local and systemic cytokines. Scand J Immunol 1989 30 : 687 94.
19. Almdahl SM, Bogwald J, Hoffman J, Giercksky KE, Seljelid R. Protection by aminated glucan in experimental endogenous peritonitis. Eur Surg Res 1987 19 : 78 85.
20. Abel G, Czop JK. Stimulation of human monocyte beta-glucan receptors by glucan particles induces production of Tnf-Alpha and Il-1-Beta. Int J Immunopharmacol 1992 14 : 1363 73.
21. Lee GH, Proenca R, Montez JM, Carroll KM, Darvishzadeh JG, Lee JI, Friedman JM. Abnormal splicing of the leptin receptor in diabetic mice. Nature 1996 379 : 632 5.
22. Coleman DL. Diabetes-obesity syndromes in mice. Diabetes 1982 31 (Suppl. 1, Part 2) : 1 6.
23. Wang PY. Palmitic acid as an excipient in implants for sustained release of insulin. Biomaterials 1991 12 : 57 62.
24. Bland JM, Altman DG. Comparing methods of measurement: why plotting difference against standard method is misleading. Lancet 1995 346 : 1085 7.
25. Littell RC, Pendergast J, Natarajan R. Modelling covariance structure in the analysis of repeated measures data. Stat Med 2000 19 : 1793 819.
26. Gillies RJ, Didier N, Denton M. Determination of cell number in monolayer-cultures. Anal Biochem 1986 159 : 109 13.
27. Doxey DL, Ng MC, Dill RE, Iacopino AM. Platelet-derived growth factor levels in wounds of diabetic rats. Life Sci 1995 57 : 1111 23.
28. Wieman TJ, Smiell JM, Su Y. Efficacy and safety of a topical gel formulation of recombinant human platelet-derived growth factor-BB (becaplermin) in patients with chronic neuropathic diabetic ulcers. A phase III randomized placebo-controlled double-blind study. Diabetes Care 1998 21 : 822 7.
29. Bhide MV, Dunphy MJ, Mirkopulos N, Smith DJ. Promotion of wound collagen formation in normal and diabetic mice by quadrol. Immunopharmacol Immunotoxicol 1988 10 : 513 22.
30. Leibovich SJ, Danon D. Promotion of wound repair in mice by application of glucan. J Reticuloendothel Soc 1980 27 : 1 11.
31. Browder W, Williams D, Lucore P, Pretus H, Jones E, McNamee R. Effect of enhanced macrophage function on early wound healing. Surgery 1988 104 : 224 30.
32. Wei D, Zhang L, Williams DL, Browder IW. Glucan stimulates human dermal fibroblast collagen biosynthesis through a nuclear factor-1 dependent mechanism. Wound Repair Regen 2002 10 : 161 8.
33. Willment JA, Gordon S, Brown GD. Characterization of the human beta-glucan receptor and its alternatively spliced isoforms. J Biol Chem 2001 276 : 43818 23.
34. Konopski Z, Smedsrod B, Seljelid R, Eskeland T. A novel immunomodulator soluble aminated beta-1,3-d-glucan: binding characteristics to mouse peritoneal macrophages. Biochim Biophys Acta 1994 1221 : 61 65.
35. Witte MB, Kiyama T, Barbul A. Nitric oxide enhances experimental wound healing in diabetes. Br J Surg 2002 89 : 1594 601.
36. Patchen ML, Dalesandro MM, Brook I, Blakely WF, Macvittie TJ. Glucan - mechanisms involved in its radioprotective effect. J Leuk Biol 1987 42 : 95 105.
37. Piaggesi A, Baccetti F, Rizzo L, Romanelli M, Navalesi R, Benzi L. Sodium carboxyl-methyl-cellulose dressings in the management of deep ulcerations of diabetic foot. Diabet Med 2001 18 : 320 4.
38. Veves A, Sheehan P, Pham HT. A randomized, controlled trial of Promogran (a collagen/oxidized regenerated cellulose dressing) vs standard treatment in the management of diabetic foot ulcers. Arch Surg 2002 137 : 822 7.
39. Koenig RJ, Cerami A. Synthesis of hemoglobin AIc in normal and diabetic mice: potential model of basement membrane thickening. Proc Natl Acad Sci USA 1975 72 : 3687 91.
40. Day JF, Ingebretsen CG, Ingebretsen WR Jr., Baynes JW, Thorpe SR. Nonenzymatic glucosylation of serum proteins and hemoglobin: response to changes in blood glucose levels in diabetic rats. Diabetes 1980 29 : 524 7.