Effect of LNA- and OMeN-modified oligonucleotide probes on the stability and discrimination of mismatched base pairs of duplexes

Journal of Biosciences

Volumn 37, Issue 2, 2012, Pages 233-241

  Yan, Ying ^a,b   Yan, Jing ^a   Piao, Xianyu ^a   Zhang, Tianbiao ^a   Guan, Yifu ^a  

^a CHINA MEDICAL UNIVERSITY   (China)

^b SHENYANG NORTHERN HOSPITAL   (China)

Author keywords

Discrimination; Hybridization; Mismatch; Nucleotide analogue

Indexed keywords

2' O METHYL NUCLEOTIDE; COMPLEMENTARY DNA; DOUBLE STRANDED DNA; LOCKED NUCLEIC ACID; OLIGONUCLEOTIDE; PYRIMIDINE DERIVATIVE; UNCLASSIFIED DRUG;

DIGESTION; DNA; HYBRIDIZATION; NUCLEIC ACID; RNA;

ARTICLE; BASE MISPAIRING; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; DNA DETERMINATION; DNA HYBRIDIZATION; DNA MODIFICATION; DNA STRUCTURE; MELTING POINT; MOLECULAR STABILITY; OLIGONUCLEOTIDE PROBE; THERMODYNAMICS;

BASE PAIR MISMATCH; DNA; DNA, COMPLEMENTARY; NUCLEIC ACID DENATURATION; NUCLEIC ACID HYBRIDIZATION; NUCLEOTIDES; OLIGONUCLEOTIDE PROBES; OLIGONUCLEOTIDES; TEMPERATURE;

EID: 84864340201     PISSN: 02505991     EISSN: 09737138     Source Type: Journal    
DOI: 10.1007/s12038-012-9196-4     Document Type: Article

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