Cell cycle arrest through inhibition of tubulin polymerization by withaphysalin F, a bioactive compound isolated from Acnistus arborescens

Investigational New Drugs

Volumn 30, Issue 3, 2012, Pages 959-966

  Rocha, Danilo D ^a   Balgi, Aruna ^b   Maia, Ana Isabel V ^a   Pessoa, Otilia D ^a   Silveira, Edilberto R ^a   Costa Lotufo, Letícia V ^a   Roberge, Michel ^b   Pessoa, Claudia ^a,b  

^a FEDERAL UNIVERSITY OF CEARÁ   (Brazil)

^b UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

Acnistus arborescens; Antiproliferative; Cell cycle; Microtubule; Withaphysalin

Indexed keywords

ANTINEOPLASTIC AGENT; DOXORUBICIN; UNCLASSIFIED DRUG; WITHAPHYSALIN F;

ANTIPROLIFERATIVE ACTIVITY; ARTICLE; CELL CYCLE ARREST; CELL CYCLE G2 PHASE; CELL CYCLE M PHASE; CELL CYCLE PROGRESSION; CELL MEMBRANE DEPOLARIZATION; CONTROLLED STUDY; DNA FRAGMENTATION; DRUG CYTOTOXICITY; DRUG MECHANISM; DRUG STRUCTURE; HUMAN; HUMAN CELL; MICROTUBULE ASSEMBLY; MITOCHONDRIAL MEMBRANE; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOSIS INHIBITION; PRIORITY JOURNAL;

ANTINEOPLASTIC AGENTS; CELL CYCLE CHECKPOINTS; CELL LINE, TUMOR; CELL PROLIFERATION; ERGOSTEROL; HUMANS; MEMBRANE POTENTIAL, MITOCHONDRIAL; REACTIVE OXYGEN SPECIES; SECOSTEROIDS; SOLANACEAE; TUBULIN;

EID: 84864331609     PISSN: 01676997     EISSN: 15730646     Source Type: Journal    
DOI: 10.1007/s10637-011-9649-x     Document Type: Article

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