메뉴 건너뛰기




Volumn 30, Issue 8, 2012, Pages 1756-1770

MicroRNA-181a regulates local immune balance by inhibiting proliferation and immunosuppressive properties of mesenchymal stem cells

Author keywords

IL 6; MAPK; Mesenchymal stem cells; MiR 181a; TGF

Indexed keywords

DEXTRAN SULFATE; INDOLEAMINE 2,3 DIOXYGENASE; INTERLEUKIN 6; MESSENGER RNA; MICRORNA; MICRORNA 181A; MITOGEN ACTIVATED PROTEIN KINASE P38; STRESS ACTIVATED PROTEIN KINASE; TRANSFORMING GROWTH FACTOR BETA; UNCLASSIFIED DRUG;

EID: 84864330589     PISSN: 10665099     EISSN: None     Source Type: Journal    
DOI: 10.1002/stem.1156     Document Type: Article
Times cited : (94)

References (74)
  • 1
    • 78149278320 scopus 로고    scopus 로고
    • SFRP2 suppression of bone morphogenic protein (BMP) and Wnt signaling mediates mesenchymal stem cell (MSC) self-renewal promoting engraftment and myocardial repair
    • Alfaro MP, Vincent A, Saraswati S et al. sFRP2 suppression of bone morphogenic protein (BMP) and Wnt signaling mediates mesenchymal stem cell (MSC) self-renewal promoting engraftment and myocardial repair. J Biol Chem 2010;285:35645-35653.
    • (2010) J Biol Chem , vol.285 , pp. 35645-35653
    • Alfaro, M.P.1    Vincent, A.2    Saraswati, S.3
  • 2
    • 13544249606 scopus 로고    scopus 로고
    • Human mesenchymal stem cells modulate allogeneic immune cell responses
    • DOI 10.1182/blood-2004-04-1559
    • Aggarwal S, Pittenger MF. Human mesenchymal stem cells modulate allogeneic immune cell responses. Blood 2005;105:1815-1822. (Pubitemid 40223708)
    • (2005) Blood , vol.105 , Issue.4 , pp. 1815-1822
    • Aggarwal, S.1    Pittenger, M.F.2
  • 5
    • 77955361735 scopus 로고    scopus 로고
    • Umbilical cord mesenchymal stem cell transplantation in severe and refractory systemic lupus erythematosus
    • Sun L, Wang D, Liang J et al. Umbilical cord mesenchymal stem cell transplantation in severe and refractory systemic lupus erythematosus. Arthritis Rheum 2010;62:2467-2475.
    • (2010) Arthritis Rheum , vol.62 , pp. 2467-2475
    • Sun, L.1    Wang, D.2    Liang, J.3
  • 6
    • 67649604299 scopus 로고    scopus 로고
    • Mesenchymal stem cell transplantation reverses multiorgan dysfunction in systemic lupus erythematosus mice and humans
    • Sun L, Akiyama K, Zhang H et al. Mesenchymal stem cell transplantation reverses multiorgan dysfunction in systemic lupus erythematosus mice and humans. Stem Cells 2009;27:1421-1432.
    • (2009) Stem Cells , vol.27 , pp. 1421-1432
    • Sun, L.1    Akiyama, K.2    Zhang, H.3
  • 7
    • 76249084930 scopus 로고    scopus 로고
    • Mesenchymal stem cells derived from human gingiva are capable of immunomodulatory functions and ameliorate inflammation-related tissue destruction in experimental colitis
    • Zhang Q, Shi S, Liu Y et al. Mesenchymal stem cells derived from human gingiva are capable of immunomodulatory functions and ameliorate inflammation-related tissue destruction in experimental colitis. J Immunol 2009;183:7787-7798.
    • (2009) J Immunol , vol.183 , pp. 7787-7798
    • Zhang, Q.1    Shi, S.2    Liu, Y.3
  • 8
    • 49149112861 scopus 로고    scopus 로고
    • Angiotensin receptor agonistic autoantibodies induce pre-eclampsia in pregnant mice
    • Zhou CC, Zhang YJ, Irani RA et al. Angiotensin receptor agonistic autoantibodies induce pre-eclampsia in pregnant mice. Nat Med 2008; 14:855-862.
    • (2008) Nat Med , vol.14 , pp. 855-862
    • Zhou, C.C.1    Zhang, Y.J.2    Irani, R.A.3
  • 9
    • 70349667016 scopus 로고    scopus 로고
    • The biology of preeclampsia
    • Kanasaki K, Kalluri R. The biology of preeclampsia. Kidney Int 2009;76:831-837.
    • (2009) Kidney Int , vol.76 , pp. 831-837
    • Kanasaki, K.1    Kalluri, R.2
  • 10
    • 36048934271 scopus 로고    scopus 로고
    • Examination of distinct fetal and maternal molecular pathways suggests a mechanism for the development of preeclampsia
    • DOI 10.1016/j.jri.2007.03.012, PII S0165037807000770, Proceedings of the 5th International Workshop on Reproductive Immunology, Immunological Tolerance and Immunology of Preeclampsia
    • Goldman-Wohl DS, Yagel S. Examination of distinct fetal and maternal molecular pathways suggests a mechanism for the development of preeclampsia. J Reprod Immunol 2007;76:54-60. (Pubitemid 350100879)
    • (2007) Journal of Reproductive Immunology , vol.76 , Issue.1-2 , pp. 54-60
    • Goldman-Wohl, D.S.1    Yagel, S.2
  • 11
    • 78650673843 scopus 로고    scopus 로고
    • Umbilical cord-derived mesenchymal stromal cells modulate monocyte function to suppress T cell proliferation
    • Cutler AJ, Limbani V, Girdlestone J et al. Umbilical cord-derived mesenchymal stromal cells modulate monocyte function to suppress T cell proliferation. J Immunol 2010;185:6617-6623.
    • (2010) J Immunol , vol.185 , pp. 6617-6623
    • Cutler, A.J.1    Limbani, V.2    Girdlestone, J.3
  • 12
    • 84875378915 scopus 로고    scopus 로고
    • Potential for mesenchymal stem cell isolation from human placenta
    • Atkinson K, Chatterjee K, Barlow S et al. Potential for mesenchymal stem cell isolation from human placenta. Blood 2005;106:158b-158b.
    • (2005) Blood , vol.106
    • Atkinson, K.1    Chatterjee, K.2    Barlow, S.3
  • 13
    • 38649133527 scopus 로고    scopus 로고
    • Co-expression of two perivascular cell markers isolates mesenchymal stem-like cells from human endometrium
    • DOI 10.1093/humrep/dem265
    • Schwab KE, Gargett CE. Co-expression of two perivascular cell markers isolates mesenchymal stem-like cells from human endometrium. Hum Reprod 2007;22:2903-2911. (Pubitemid 351709405)
    • (2007) Human Reproduction , vol.22 , Issue.11 , pp. 2903-2911
    • Schwab, K.E.1    Gargett, C.E.2
  • 14
    • 71649092049 scopus 로고    scopus 로고
    • Cytokine expression in placenta-derived mesenchymal stem cells in patients with pre-eclampsia and normal pregnancies
    • Hwang JH, Lee MJ, Seok OS et al. Cytokine expression in placenta-derived mesenchymal stem cells in patients with pre-eclampsia and normal pregnancies. Cytokine 2010;49:95-101.
    • (2010) Cytokine , vol.49 , pp. 95-101
    • Hwang, J.H.1    Lee, M.J.2    Seok, O.S.3
  • 16
    • 0035955366 scopus 로고    scopus 로고
    • An extensive class of small RNAs in Caenorhabditis elegans
    • DOI 10.1126/science.1065329
    • Lee RC, Ambros V. An extensive class of small RNAs in Caenorhabditis elegans. Science 2001;294:862-864. (Pubitemid 33032105)
    • (2001) Science , vol.294 , Issue.5543 , pp. 862-864
    • Lee, R.C.1    Ambros, V.2
  • 17
    • 0036544755 scopus 로고    scopus 로고
    • Micro RNAs are complementary to 30 UTR sequence motifs that mediate negative post-transcriptional regulation
    • Lai EC. Micro RNAs are complementary to 30 UTR sequence motifs that mediate negative post-transcriptional regulation. Nat Genet 2002; 30:363-364.
    • (2002) Nat Genet , vol.30 , pp. 363-364
    • Lai, E.C.1
  • 18
    • 70349631644 scopus 로고    scopus 로고
    • Differential expression of microRNAs in the placentae of Chinese patients with severe pre-eclampsia
    • Hu YL, Li PF, Hao S et al. Differential expression of microRNAs in the placentae of Chinese patients with severe pre-eclampsia. Clin Chem Lab Med 2009;47:923-929.
    • (2009) Clin Chem Lab Med , vol.47 , pp. 923-929
    • Hu, Y.L.1    Li, P.F.2    Hao, S.3
  • 19
    • 79952509217 scopus 로고    scopus 로고
    • Expression profile of MicroRNAs and mRNAs in human placentas from pregnancies complicated by preeclampsia and preterm labor
    • Mayor-Lynn K, Toloubeydokhti T, Cruz AC et al. Expression profile of MicroRNAs and mRNAs in human placentas from pregnancies complicated by preeclampsia and preterm labor. Reprod Sci 2011;18: 46-56.
    • (2011) Reprod Sci , vol.18 , pp. 46-56
    • Mayor-Lynn, K.1    Toloubeydokhti, T.2    Cruz, A.C.3
  • 20
    • 67349233035 scopus 로고    scopus 로고
    • Differential expression profile of microRNAs in human placentas from preeclamptic pregnancies vs normal pregnancies
    • Zhu XM, Han T, Sargent IL et al. Differential expression profile of microRNAs in human placentas from preeclamptic pregnancies vs normal pregnancies. Am J Obstet Gynecol 2009; 200.
    • (2009) Am J Obstet Gynecol , pp. 200
    • Zhu, X.M.1    Han, T.2    Sargent, I.L.3
  • 22
    • 56349133372 scopus 로고    scopus 로고
    • Pre-miRNA loop nucleotides control the distinct activities of mir-181a-1 and mir-181c in early T cell development
    • Liu G, Min HY, Yue SB et al. Pre-miRNA loop nucleotides control the distinct activities of mir-181a-1 and mir-181c in early T cell development. PLoS One 2008; 3.
    • (2008) PLoS One , pp. 3
    • Liu, G.1    Min, H.Y.2    Yue, S.B.3
  • 23
    • 70350435670 scopus 로고    scopus 로고
    • An endogenous positively selecting peptide enhances mature T cell responses and becomes an autoantigen in the absence of microRNA miR-181a
    • Ebert PJR, Jiang S, Xie JM et al. An endogenous positively selecting peptide enhances mature T cell responses and becomes an autoantigen in the absence of microRNA miR-181a. Nat Immunol 2009;10: 1162-1169.
    • (2009) Nat Immunol , vol.10 , pp. 1162-1169
    • Ebert, P.J.R.1    Jiang, S.2    Xie, J.M.3
  • 24
    • 34247648712 scopus 로고    scopus 로고
    • MicroRNA miR-181a correlates with morphological sub-class of acute myeloid leukaemia and the expression of its target genes in global genome-wide analysis
    • DOI 10.1038/sj.leu.2404605, PII 2404605
    • Debernardi S, Skoulakis S, Molloy G et al. MicroRNA miR-181a correlates with morphological sub-class of acute myeloid leukaemia and the expression of its target genes in global genome-wide analysis. Leukemia 2007;21:912-916. (Pubitemid 46672066)
    • (2007) Leukemia , vol.21 , Issue.5 , pp. 912-916
    • Debernardi, S.1    Skoulakis, S.2    Molloy, G.3    Chaplin, T.4    Dixon-McIver, A.5    Young, B.D.6
  • 25
    • 79955603055 scopus 로고    scopus 로고
    • Aberrant microRNA expression in Chinese patients with chronic lymphocytic leukemia
    • Zhu DX, Miao KR, Fang C et al. Aberrant microRNA expression in Chinese patients with chronic lymphocytic leukemia. Leukemia Res 2011;35:730-734.
    • (2011) Leukemia Res , vol.35 , pp. 730-734
    • Zhu, D.X.1    Miao, K.R.2    Fang, C.3
  • 26
    • 77954315239 scopus 로고    scopus 로고
    • Deregulated expression of miR-21, miR-143 and miR-181a in non small cell lung cancer is related to clinicopathologic characteristics or patient prognosis
    • Gao W, Yu Y, Cao HL et al. Deregulated expression of miR-21, miR-143 and miR-181a in non small cell lung cancer is related to clinicopathologic characteristics or patient prognosis. Biomed Pharmacother 2010;64:399-408.
    • (2010) Biomed Pharmacother , vol.64 , pp. 399-408
    • Gao, W.1    Yu, Y.2    Cao, H.L.3
  • 27
    • 66549107815 scopus 로고    scopus 로고
    • Deregulation of microRNA involved in hematopoiesis and the immune response in HTLV-I adult T-cell leukemia
    • Bellon M, Lepelletier Y, Hermine O et al. Deregulation of microRNA involved in hematopoiesis and the immune response in HTLV-I adult T-cell leukemia. Blood 2009;113:4914-4917.
    • (2009) Blood , vol.113 , pp. 4914-4917
    • Bellon, M.1    Lepelletier, Y.2    Hermine, O.3
  • 28
    • 77949445582 scopus 로고    scopus 로고
    • MicroRNA-181a sensitizes human malignant glioma U87MG cells to radiation by targeting Bcl-2
    • Chen G, Zhu W, Shi DZ et al. MicroRNA-181a sensitizes human malignant glioma U87MG cells to radiation by targeting Bcl-2. Oncol Rep 2010;23:997-1003.
    • (2010) Oncol Rep , vol.23 , pp. 997-1003
    • Chen, G.1    Zhu, W.2    Shi, D.Z.3
  • 29
    • 79151484006 scopus 로고    scopus 로고
    • MiR-181a shows tumor suppressive effect against oral squamous cell carcinoma cells by downregulating K-ras
    • Shin KH, Bae SD, Hong HS et al. miR-181a shows tumor suppressive effect against oral squamous cell carcinoma cells by downregulating K-ras. Biochem Biophys Res Commun 2011;404:896-902.
    • (2011) Biochem Biophys Res Commun , vol.404 , pp. 896-902
    • Shin, K.H.1    Bae, S.D.2    Hong, H.S.3
  • 30
    • 53049107572 scopus 로고    scopus 로고
    • Hsa-mir-181a and hsa-mir-181b function as tumor suppressors in human glioma cells
    • Shi L, Cheng ZH, Zhang JX et al. hsa-mir-181a and hsa-mir-181b function as tumor suppressors in human glioma cells. Brain Res 2008; 1236:185-193.
    • (2008) Brain Res , vol.1236 , pp. 185-193
    • Shi, L.1    Cheng, Z.H.2    Zhang, J.X.3
  • 31
    • 79961104904 scopus 로고    scopus 로고
    • 17beta-estradiol induces CD40 expression in dendritic cells via MAPK signaling pathways in a minichromosome maintenance protein 6-dependent manner
    • Xie H, Hua C, Sun L et al. 17beta-estradiol induces CD40 expression in dendritic cells via MAPK signaling pathways in a minichromosome maintenance protein 6-dependent manner. Arthritis Rheum 2011;63: 2425-2435.
    • (2011) Arthritis Rheum , vol.63 , pp. 2425-2435
    • Xie, H.1    Hua, C.2    Sun, L.3
  • 32
    • 77954281005 scopus 로고    scopus 로고
    • Mesenchymal stem cells derived from human gingiva are capable of immunomodulatory functions and ameliorate inflammation-related tissue destruction in experimental colitis (vol 183, pg 7787, 2009)
    • Zhang QZ, Shi SH, Liu Y et al. Mesenchymal stem cells derived from human gingiva are capable of immunomodulatory functions and ameliorate inflammation-related tissue destruction in experimental colitis (vol 183, pg 7787, 2009). J Immunol 2010;184:1656.
    • (2010) J Immunol , vol.184 , pp. 1656
    • Zhang, Q.Z.1    Shi, S.H.2    Liu, Y.3
  • 33
    • 1642298263 scopus 로고    scopus 로고
    • Introduction a mouse model for pre-eclampsia: Adoptive transfer of activated Th1 cells leads to pre-eclampsia-like symptoms exclusively in pregnant mice
    • DOI 10.1002/eji.200324469
    • Zenclussen AC, Fest S, Joachim R et al. Introducing a mouse model for pre-eclampsia: Adoptive transfer of activated Th1 cells leads to pre-eclampsia-like symptoms exclusively in pregnant mice. Eur J Immunol 2004;34:377-387. (Pubitemid 39255948)
    • (2004) European Journal of Immunology , vol.34 , Issue.2 , pp. 377-387
    • Zenclussen, A.C.1    Fest, S.2    Joachim, R.3    Klapp, B.F.4    Arck, P.C.5
  • 34
    • 66149099328 scopus 로고    scopus 로고
    • Functional alteration of the lymphoma stromal cell niche by the cytokine context: Role of indoleamine-2,3 dioxygenase
    • Maby-El Hajjami H, Ame-Thomas P, Pangault C et al. Functional alteration of the lymphoma stromal cell niche by the cytokine context: Role of indoleamine-2,3 dioxygenase. Cancer Res 2009;69: 3228-3237.
    • (2009) Cancer Res , vol.69 , pp. 3228-3237
    • Maby-El Hajjami, H.1    Ame-Thomas, P.2    Pangault, C.3
  • 36
    • 33749149462 scopus 로고    scopus 로고
    • Pressure-induced regulation of IL-6 in retinal glial cells: Involvement of the ubiquitin/proteasome pathway and NFkappaB
    • DOI 10.1167/iovs.05-1408
    • Sappington RM, Calkins DJ. Pressure-induced regulation of IL-6 in retinal glial cells: Involvement of the ubiquitin/proteasome pathway and NF kappa B. Invest Ophthalmol Vis Sci 2006;47:3860-3869. (Pubitemid 46044301)
    • (2006) Investigative Ophthalmology and Visual Science , vol.47 , Issue.9 , pp. 3860-3869
    • Sappington, R.M.1    Calkins, D.J.2
  • 37
    • 63649161069 scopus 로고    scopus 로고
    • Curcumin suppresses the induction of indoleamine 2,3-dioxygenase by blocking the Janus-activated kinase-protein kinase C delta-STAT1 signaling pathway in interferongamma-stimulated murine dendritic cells
    • Jeong YI, Kim SW, Jung ID et al. Curcumin suppresses the induction of indoleamine 2,3-dioxygenase by blocking the Janus-activated kinase-protein kinase C delta-STAT1 signaling pathway in interferongamma-stimulated murine dendritic cells. J Biol Chem 2009;284: 3700-3708.
    • (2009) J Biol Chem , vol.284 , pp. 3700-3708
    • Jeong, Y.I.1    Kim, S.W.2    Jung, I.D.3
  • 38
    • 33745654304 scopus 로고    scopus 로고
    • The signal transducer and activator of transcription 1alpha and interferon regulatory factor 1 are not essential for the induction of indoleamine 2,3-dioxygenase by lipopolysaccharide: Involvement of p38 mitogen-activated protein kinase and nuclear factor-kappaB pathways, and synergistic effect of several proinflammatory cytokines
    • DOI 10.1093/jb/mvj072
    • Fujigaki H, Saito K, Fujigaki S et al. The signal transducer and activator of transcription 1 alpha and interferon regulatory factor 1 are not essential for the induction of indoleamine 2,3-dioxygenase by lipopolysaccharide: Involvement of p38 mitogen-activated protein kinase and nuclear Factor-kappa B pathways, and synergistic effect of several proinflammatory cytokines. J Biochem 2006;139: 655-662. (Pubitemid 43973911)
    • (2006) Journal of Biochemistry , vol.139 , Issue.4 , pp. 655-662
    • Fujigaki, H.1    Saito, K.2    Fujigaki, S.3    Takemura, M.4    Sudo, K.5    Ishiguro, H.6    Seishima, M.7
  • 39
    • 33947532866 scopus 로고    scopus 로고
    • Differential regulation of indoleamine 2,3-dioxygenase by lipopolysaccharide and interferon gamma in murine bone marrow derived dendritic cells
    • DOI 10.1016/j.febslet.2007.02.073, PII S0014579307002487
    • Jung ID, Lee CM, Jeong YI et al. Differential regulation of indoleamine 2,3-dioxygenase by lipopolysaccharide and interferon gamma in murine bone marrow derived dendritic cells. FEBS Lett 2007;581: 1449-1456. (Pubitemid 46463960)
    • (2007) FEBS Letters , vol.581 , Issue.7 , pp. 1449-1456
    • Jung, I.D.1    Lee, C.-M.2    Jeong, Y.-I.3    Lee, J.S.4    Park, W.S.5    Han, J.6    Park, Y.-M.7
  • 40
    • 31144474775 scopus 로고    scopus 로고
    • Colonic subepithelial myofibroblasts in mucosal inflammation and repair: Contribution of bone marrow-derived stem cells to the gut regenerative response
    • DOI 10.1007/s00535-005-1727-4
    • Andoh A, Bamba S, Fujiyama Y et al. Colonic subepithelial myofibroblasts in mucosal inflammation and repair: Contribution of bone marrow- derived stem cells to the gut regenerative response. J Gastroenterol 2005;40:1089-1099. (Pubitemid 43124835)
    • (2005) Journal of Gastroenterology , vol.40 , Issue.12 , pp. 1089-1099
    • Andoh, A.1    Bamba, S.2    Fujiyama, Y.3    Brittan, M.4    Wright, N.A.5
  • 41
    • 67650093720 scopus 로고    scopus 로고
    • Enhancing epithelial engraftment of rat mesenchymal stem cells restores epithelial barrier integrity
    • Yabana T, Arimura Y, Tanaka H et al. Enhancing epithelial engraftment of rat mesenchymal stem cells restores epithelial barrier integrity. J Pathol 2009;218:350-359.
    • (2009) J Pathol , vol.218 , pp. 350-359
    • Yabana, T.1    Arimura, Y.2    Tanaka, H.3
  • 42
    • 0142104985 scopus 로고    scopus 로고
    • Smad-dependent and Smad-independent pathways in TGF-beta family signalling
    • DOI 10.1038/nature02006
    • Derynck R, Zhang YE. Smad-dependent and Smad-independent pathways in TGF-beta family signalling. Nature 2003;425:577-584. (Pubitemid 37280136)
    • (2003) Nature , vol.425 , Issue.6958 , pp. 577-584
    • Derynck, R.1    Zhang, Y.E.2
  • 43
    • 77953695161 scopus 로고    scopus 로고
    • Cellular and molecular basis for the regulation of inflammation by TGF-beta
    • Yoshimura A, Wakabayashi Y, Mori T. Cellular and molecular basis for the regulation of inflammation by TGF-beta. J Biochem 2010;147: 781-792.
    • (2010) J Biochem , vol.147 , pp. 781-792
    • Yoshimura, A.1    Wakabayashi, Y.2    Mori, T.3
  • 44
    • 0037013742 scopus 로고    scopus 로고
    • Mechanisms of TGF-beta signaling in regulation of cell growth and differentiation
    • DOI 10.1016/S0165-2478(02)00023-8, PII S0165247802000238
    • Moustakas A, Pardali K, Gaal A et al. Mechanisms of TGF-beta signaling in regulation of cell growth and differentiation. Immunol Lett 2002;82:85-91. (Pubitemid 34468039)
    • (2002) Immunology Letters , vol.82 , Issue.1-2 , pp. 85-91
    • Moustakas, A.1    Pardali, K.2    Gaal, A.3    Heldin, C.-H.4
  • 45
    • 33750322988 scopus 로고    scopus 로고
    • TGF-beta receptor-binding proteins: Complex interactions
    • DOI 10.1016/j.cellsig.2006.05.009, PII S089865680600101X
    • Runyan CE, Poncelet AC, Schnaper HW. TGF-beta receptor-binding proteins: Complex interactions. Cell Signal 2006;18:2077-2088. (Pubitemid 44636159)
    • (2006) Cellular Signalling , vol.18 , Issue.12 , pp. 2077-2088
    • Runyan, C.E.1    Poncelet, A.-C.2    Schnaper, H.W.3
  • 46
    • 0028603343 scopus 로고
    • Tgf-Beta induced transdifferentiation of mammary epithelial-cells to mesenchymal cells-Involvement of type-I receptors
    • Miettinen PJ, Ebner R, Lopez AR et al. Tgf-Beta induced transdifferentiation of mammary epithelial-cells to mesenchymal cells-Involvement of type-I receptors. J Cell Biol 1994;127:2021-2036.
    • (1994) J Cell Biol , vol.127 , pp. 2021-2036
    • Miettinen, P.J.1    Ebner, R.2    Lopez, A.R.3
  • 47
    • 33645007189 scopus 로고    scopus 로고
    • Smad3-dependent nuclear translocation of beta-catenin is required for TGF-beta 1-induced proliferation of bone marrow-derived adult human mesenchymal stem cells
    • Jian HY, Shen X, Liu I et al. Smad3-dependent nuclear translocation of beta-catenin is required for TGF-beta 1-induced proliferation of bone marrow-derived adult human mesenchymal stem cells. Gene Dev 2006;20:666-674.
    • (2006) Gene Dev , vol.20 , pp. 666-674
    • Jian, H.Y.1    Shen, X.2    Liu, I.3
  • 48
    • 33745082823 scopus 로고    scopus 로고
    • Role of transforming growth factor-beta in hematologic malignancies
    • DOI 10.1182/blood-2005-10-4169
    • Dong M, Blobe GC. Role of transforming growth factor-beta in hematologic malignancies. Blood 2006;107:4589-4596. (Pubitemid 43882602)
    • (2006) Blood , vol.107 , Issue.12 , pp. 4589-4596
    • Dong, M.1    Blobe, G.C.2
  • 49
    • 0035379649 scopus 로고    scopus 로고
    • Transforming growth factor-beta receptor-associated protein 1 is a Smad4 chaperone
    • Wurthner JU, Frank DB, Felici A et al. Transforming growth factor-beta receptor-associated protein 1 is a Smad4 chaperone. J Biol Chem 2001;276:19495-19502.
    • (2001) J Biol Chem , vol.276 , pp. 19495-19502
    • Wurthner, J.U.1    Frank, D.B.2    Felici, A.3
  • 50
    • 78650115940 scopus 로고    scopus 로고
    • ALK5 inhibition blocks TGFβ-induced CCN2 expression in gingival fibroblasts
    • Thompson K, Hamilton DW, Leask A. ALK5 inhibition blocks TGFβ-induced CCN2 expression in gingival fibroblasts. J Dent Res 2010;89:1450-1454.
    • (2010) J Dent Res , vol.89 , pp. 1450-1454
    • Thompson, K.1    Hamilton, D.W.2    Leask, A.3
  • 51
    • 78651102047 scopus 로고    scopus 로고
    • TbetaRI/Alk5-independent TbetaRII signaling to ERK1/2 in human skin cells according to distinct levels of TbetaRII expression
    • Bandyopadhyay B, Han A, Dai J et al. TbetaRI/Alk5-independent TbetaRII signaling to ERK1/2 in human skin cells according to distinct levels of TbetaRII expression. J Cell Sci 2011;124:19-24.
    • (2011) J Cell Sci , vol.124 , pp. 19-24
    • Bandyopadhyay, B.1    Han, A.2    Dai, J.3
  • 52
    • 2342547687 scopus 로고    scopus 로고
    • An Increased Transforming Growth Factor beta Receptor Type I:Type II Ratio Contributes to Elevated Collagen Protein Synthesis That Is Resistant to Inhibition via a Kinase-Deficient Transforming Growth Factor beta Receptor Type II in Scleroderma
    • DOI 10.1002/art.20225
    • Pannu J, Gore-Hyer E, Yamanaka M et al. An increased transforming growth factor beta receptor type I:type II ratio contributes to elevated collagen protein synthesis that is resistant to inhibition via a kinase-deficient transforming growth factor beta receptor type II in scleroderma. Arthritis Rheum 2004;50:1566-1577. (Pubitemid 38608079)
    • (2004) Arthritis and Rheumatism , vol.50 , Issue.5 , pp. 1566-1577
    • Pannu, J.1    Gore-Hyer, E.2    Yamanaka, M.3    Smith, E.A.4    Rubinchik, S.5    Dong, J.-Y.6    Jablonska, S.7    Blaszczyk, M.8    Trojanowska, M.9
  • 53
    • 0346727524 scopus 로고    scopus 로고
    • MicroRNAs Modulate Hematopoietic Lineage Differentiation
    • DOI 10.1126/science.1091903
    • Chen CZ, Li L, Lodish HF et al. MicroRNAs modulate hematopoietic lineage differentiation. Science 2004;303:83-86. (Pubitemid 38055775)
    • (2004) Science , vol.303 , Issue.5654 , pp. 83-86
    • Chen, C.-Z.1    Li, L.2    Lodish, H.F.3    Bartel, D.P.4
  • 55
    • 2942595706 scopus 로고    scopus 로고
    • Human bone marrow stromal cells inhibit allogeneic T-cell responses by indoleamine 2,3-dioxygenase-mediated tryptophan degradation
    • DOI 10.1182/blood-2003-11-3909
    • Meisel R, Zibert A, Laryea M et al. Human bone marrow stromal cells inhibit allogeneic T-cell responses by indoleamine 2,3-dioxygenase-mediated tryptophan degradation. Blood 2004;103:4619-4621. (Pubitemid 38745993)
    • (2004) Blood , vol.103 , Issue.12 , pp. 4619-4621
    • Meisel, R.1    Zibert, A.2    Laryea, M.3    Gobel, U.4    Daubener, W.5    Dilloo, D.6
  • 56
    • 77952923309 scopus 로고    scopus 로고
    • Immunomodulatory properties of mesenchymal stromal cells and their therapeutic consequences for immune-mediated disorders
    • Zhao SM, Wehner R, Bornhauser M et al. Immunomodulatory properties of mesenchymal stromal cells and their therapeutic consequences for immune-mediated disorders. Stem Cells Dev 2010;19:607-614.
    • (2010) Stem Cells Dev , vol.19 , pp. 607-614
    • Zhao, S.M.1    Wehner, R.2    Bornhauser, M.3
  • 57
    • 77952094325 scopus 로고    scopus 로고
    • Mesenchymal stem cells: A new strategy for immunosuppression and tissue repair
    • Shi YF, Hu GZ, Su JJ et al. Mesenchymal stem cells: A new strategy for immunosuppression and tissue repair. Cell Res 2010;20:510-518.
    • (2010) Cell Res , vol.20 , pp. 510-518
    • Shi, Y.F.1    Hu, G.Z.2    Su, J.J.3
  • 58
    • 34548833007 scopus 로고    scopus 로고
    • Human multipotent mesenchymal stromal cells inhibit proliferation of PBMCs independently of IFNgammaR1 signaling and IDO expression
    • DOI 10.1182/blood-2007-04-083162
    • Gieseke F, Schutt B, Viebahn S et al. Human multipotent mesenchymal stromal cells inhibit proliferation of PBMCs independently of IFN gamma R1 signaling and IDO expression. Blood 2007;110: 2197-2200. (Pubitemid 47443941)
    • (2007) Blood , vol.110 , Issue.6 , pp. 2197-2200
    • Gieseke, F.1    Schutt, B.2    Viebahn, S.3    Koscielniak, E.4    Friedrich, W.5    Handgretinger, R.6    Muller, I.7
  • 59
    • 24744435772 scopus 로고    scopus 로고
    • Directing transition from innate to acquired immunity: Defining a role for IL-6
    • Jones SA. Directing transition from innate to acquired immunity: Defining a role for IL-6. J Immunol 2005;175:3463-3468. (Pubitemid 41292002)
    • (2005) Journal of Immunology , vol.175 , Issue.6 , pp. 3463-3468
    • Jones, S.A.1
  • 60
    • 63849275584 scopus 로고    scopus 로고
    • Interleukin-6/STAT3 signaling regulates the ability of naive T cells to acquire B-cell help capacities
    • Eddahri F, Denanglaire S, Bureau F et al. Interleukin-6/STAT3 signaling regulates the ability of naive T cells to acquire B-cell help capacities. Blood 2009;113:2426-2433.
    • (2009) Blood , vol.113 , pp. 2426-2433
    • Eddahri, F.1    Denanglaire, S.2    Bureau, F.3
  • 61
    • 18544371666 scopus 로고    scopus 로고
    • Human mesenchymal stem cells inhibit differentiation and function of monocyte-derived dendritic cells
    • DOI 10.1182/blood-2004-02-0586
    • Jiang XX, Zhang Y, Liu B et al. Human mesenchymal stem cells inhibit differentiation and function of monocyte-derived dendritic cells. Blood 2005;105:4120-4126. (Pubitemid 40656164)
    • (2005) Blood , vol.105 , Issue.10 , pp. 4120-4126
    • Jiang, X.-X.1    Zhang, Y.2    Liu, B.3    Zhang, S.-X.4    Wu, Y.5    Yu, X.-D.6    Mao, N.7
  • 63
    • 69249227552 scopus 로고    scopus 로고
    • MSCs inhibit monocyte-derived DC maturation and function by selectively interfering with the generation of immature DCs: Central role of MSC-derived prostaglandin E2
    • Spaggiari GM, Abdelrazik H, Becchetti F et al. MSCs inhibit monocyte-derived DC maturation and function by selectively interfering with the generation of immature DCs: Central role of MSC-derived prostaglandin E2. Blood 2009;113:6576-6583.
    • (2009) Blood , vol.113 , pp. 6576-6583
    • Spaggiari, G.M.1    Abdelrazik, H.2    Becchetti, F.3
  • 64
    • 40749110247 scopus 로고    scopus 로고
    • Human mesenchymal stem cells license adult CD34+ hemopoietic progenitor cells to differentiate into regulatory dendritic cells through activation of the Notch pathway
    • Li YP, Paczesny S, Lauret E et al. Human mesenchymal stem cells license adult CD34+ hemopoietic progenitor cells to differentiate into regulatory dendritic cells through activation of the Notch pathway. J Immunol 2008;180:1598-1608.
    • (2008) J Immunol , vol.180 , pp. 1598-1608
    • Li, Y.P.1    Paczesny, S.2    Lauret, E.3
  • 65
    • 70849116391 scopus 로고    scopus 로고
    • Mesenchymal stromal cells promote or suppress the proliferation of T lymphocytes from cord blood and peripheral blood: The importance of low cell ratio and role of interleukin-6
    • Najar M, Rouas R, Raicevic G et al. Mesenchymal stromal cells promote or suppress the proliferation of T lymphocytes from cord blood and peripheral blood: The importance of low cell ratio and role of interleukin-6. Cytotherapy 2009;11:570-583.
    • (2009) Cytotherapy , vol.11 , pp. 570-583
    • Najar, M.1    Rouas, R.2    Raicevic, G.3
  • 66
    • 77955907279 scopus 로고    scopus 로고
    • The dual-specificity MAP kinase phosphatases: Critical roles in development and cancer
    • Bermudez O, Pages G, Gimond C. The dual-specificity MAP kinase phosphatases: Critical roles in development and cancer. Am J Physiol-Cell Physiol 2010;299:C189-C202.
    • (2010) Am J Physiol-Cell Physiol , vol.299
    • Bermudez, O.1    Pages, G.2    Gimond, C.3
  • 67
    • 77953626408 scopus 로고    scopus 로고
    • Small interfering RNA screen for phosphatases involved in IgE-mediated mast cell degranulation
    • Zhang J, Mendoza M, Guiraldelli MF et al. Small interfering RNA screen for phosphatases involved in IgE-mediated mast cell degranulation. J Immunol 2010;184:7178-7185.
    • (2010) J Immunol , vol.184 , pp. 7178-7185
    • Zhang, J.1    Mendoza, M.2    Guiraldelli, M.F.3
  • 69
    • 78651070199 scopus 로고    scopus 로고
    • Protein tyrosine phosphatase N2 regulates TNFalpha-induced signalling and cytokine secretion in human intestinal epithelial cells
    • Scharl M, McCole DF, Weber A et al. Protein tyrosine phosphatase N2 regulates TNFalpha-induced signalling and cytokine secretion in human intestinal epithelial cells. Gut 2011;60:189-197.
    • (2011) Gut , vol.60 , pp. 189-197
    • Scharl, M.1    McCole, D.F.2    Weber, A.3
  • 70
    • 0034108451 scopus 로고    scopus 로고
    • Cytoskeletal protein tyrosine phosphatase PTPH1 reduces T cell antigen receptor signaling
    • DOI 10.1002/(SICI)1521-4141(200005)30:5<1318::AID-IMMU1318>3.0. CO;2-G
    • Han S, Williams S, Mustelin T. Cytoskeletal protein tyrosine phosphatase PTPH1 reduces T cell antigen receptor signaling. Eur J Immunol 2000;30:1318-1325. (Pubitemid 30311960)
    • (2000) European Journal of Immunology , vol.30 , Issue.5 , pp. 1318-1325
    • Han, S.1    Williams, S.2    Mustelin, T.3
  • 72
    • 79551485270 scopus 로고    scopus 로고
    • Elevated maternal soluble Gp130 and IL-6 levels and reduced Gp130 and SOCS-3 expressions in women complicated with preeclampsia
    • Wang Y, Lewis DF, Gu Y et al. Elevated maternal soluble Gp130 and IL-6 levels and reduced Gp130 and SOCS-3 expressions in women complicated with preeclampsia. Hypertension 2011;57:336-342.
    • (2011) Hypertension , vol.57 , pp. 336-342
    • Wang, Y.1    Lewis, D.F.2    Gu, Y.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.