S-ketamine concentrations are greatly increased by grapefruit juice

European Journal of Clinical Pharmacology

Volumn 68, Issue 6, 2012, Pages 979-986

  Peltoniemi, Marko A ^a,b   Saari, Teijo I ^c   Hagelberg, Nora M ^a,b   Laine, Kari ^a   Neuvonen, Pertti J ^b,d,e   Olkkola, Klaus T ^a,b  

^a UNIVERSITY OF TURKU   (Finland)

^b TURKU UNIVERSITY HOSPITAL   (Finland)

^c UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

^d UNIVERSITY OF HELSINKI   (Finland)

^e HELSINKI UNIVERSITY CENTRAL HOSPITAL   (Finland)

Author keywords

Analgesics; Citrus paradisi (grapefruit juice); Cytochrome P450 CYP3A; Drug interaction; Ketamine; Oral administration

Indexed keywords

CYTOCHROME P450 2B6; CYTOCHROME P450 3A; DRUG METABOLITE; ESKETAMINE; KETAMINE; NORKETAMINE; UNCLASSIFIED DRUG;

ABSENCE OF SIDE EFFECTS; ADULT; ANALGESIC ACTIVITY; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; CROSSOVER PROCEDURE; DRUG BLOOD LEVEL; DRUG ELIMINATION; DRUG HALF LIFE; DRUG METABOLISM; DRUG TARGETING; FEMALE; FLUID INTAKE; FOOD DRUG INTERACTION; FOOD INTAKE; GRAPEFRUIT JUICE; HUMAN; HUMAN EXPERIMENT; MALE; MAXIMUM PLASMA CONCENTRATION; NORMAL HUMAN; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL;

ADULT; AGED; ARYL HYDROCARBON HYDROXYLASES; BEVERAGES; CITRUS PARADISI; CROSS-OVER STUDIES; CYTOCHROME P-450 CYP3A; FEMALE; FOOD-DRUG INTERACTIONS; HUMANS; KETAMINE; MALE; MIDDLE AGED; OXIDOREDUCTASES, N-DEMETHYLATING; YOUNG ADULT;

EID: 84864284736     PISSN: 00316970     EISSN: 14321041     Source Type: Journal    
DOI: 10.1007/s00228-012-1214-9     Document Type: Article

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