Glycolytic cancer cells lacking 6-phosphogluconate dehydrogenase metabolize glucose to induce senescence

FEBS Letters

Volumn 586, Issue 16, 2012, Pages 2389-2395

  Sukhatme, Vikas P ^a   Chan, Barden ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

Author keywords

6 Phosphogluconate dehydrogenase; Glucose metabolism; Glycolytic tumor; Senescence

Indexed keywords

FRUCTOSE; GLUCOSE; PHOSPHOGLUCONATE DEHYDROGENASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; RIBOSE PHOSPHATE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANCER CELL; CANCER INHIBITION; CELL GROWTH; CELL PROLIFERATION; CONTROLLED STUDY; CULTURE MEDIUM; ENZYME INHIBITION; ENZYME METABOLISM; GENE SILENCING; GLUCOSE METABOLISM; GLYCOLYTIC CANCER CELL; HUMAN; HUMAN CELL; HUMAN TISSUE; LUNG NON SMALL CELL CANCER; MOUSE; NONHUMAN; OXIDATION; PENTHOSE PHOSPHATE PATHWAY; PRIORITY JOURNAL; SENESCENCE; UPREGULATION;

ANIMALS; CELL AGING; CELL PROLIFERATION; GENE EXPRESSION REGULATION, NEOPLASTIC; GLUCOSE; GLYCOLYSIS; HUMANS; LUNG NEOPLASMS; MICE; MICE, NUDE; OXIDATIVE STRESS; OXYGEN; OXYGEN CONSUMPTION; PENTOSE PHOSPHATE PATHWAY; PHOSPHOGLUCONATE DEHYDROGENASE; TUMOR SUPPRESSOR PROTEIN P53;

EID: 84864284168     PISSN: 00145793     EISSN: 18733468     Source Type: Journal    
DOI: 10.1016/j.febslet.2012.05.052     Document Type: Article

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