Impaired dephosphorylation renders G6PD-knockdown HepG2 cells more susceptible to H2O2-induced apoptosis

Free Radical Biology and Medicine

Volumn 49, Issue 3, 2010, Pages 361-373

  Lin, Chang Jun ^a,b   Ho, Hung Yao ^a   Cheng, Mei Ling ^a,c   Cheng, Tsai Hong ^a   Yu, Jau Song ^a   Chiu, Daniel Tsun Yee ^a,c  

^a CHANG GUNG UNIVERSITY   (Taiwan)

^b LANZHOU UNIVERSITY   (China)

^c CHANG GUNG MEMORIAL HOSPITAL   (Taiwan)

Author keywords

Apoptosis; Dephosphorylation; G6PD; MKP 1; Oxidative stress

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; ACETYLCYSTEINE; ANTHRA[1,9 CD]PYRAZOL 6(2H) ONE; GLUCOSE 6 PHOSPHATE DEHYDROGENASE; GLUCOSE OXIDASE; HYDROGEN PEROXIDE; MITOGEN ACTIVATED PROTEIN KINASE PHOSPHATASE 1; PROTEIN TYROSINE PHOSPHATASE; SMALL INTERFERING RNA; STRESS ACTIVATED PROTEIN KINASE INHIBITOR; SYNAPTOPHYSIN; 2-(2-AMINO-3-METHOXYPHENYL)-4H-1-BENZOPYRAN-4-ONE; ANTHRA(1,9-CD)PYRAZOL-6(2H)-ONE; ANTHRACENE DERIVATIVE; DUSP1 PROTEIN, HUMAN; FLAVONOID; IMIDAZOLE DERIVATIVE; MITOGEN ACTIVATED PROTEIN KINASE; PYRIDINE DERIVATIVE;

APOPTOSIS; ARTICLE; CELL STRAIN HEPG2; CONTROLLED STUDY; DEPHOSPHORYLATION; ENZYME ACTIVATION; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; GLUCOSE 6 PHOSPHATE DEHYDROGENASE DEFICIENCY; GROWTH RETARDATION; HUMAN; HUMAN CELL; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; RNA INTERFERENCE; SIGNAL TRANSDUCTION; ANTAGONISTS AND INHIBITORS; DRUG EFFECTS; GENE SILENCING; GENETICS; HEPG2 CELL LINE; METABOLISM;

ACETYLCYSTEINE; ANTHRACENES; APOPTOSIS; DUAL SPECIFICITY PHOSPHATASE 1; FLAVONOIDS; GENE KNOCKDOWN TECHNIQUES; GLUCOSEPHOSPHATE DEHYDROGENASE; HEP G2 CELLS; HUMANS; HYDROGEN PEROXIDE; IMIDAZOLES; MITOGEN-ACTIVATED PROTEIN KINASES; PROTEIN TYROSINE PHOSPHATASES; PYRIDINES;

EID: 77954142727     PISSN: 08915849     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2010.04.019     Document Type: Article

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