Regulation of mesenchymal stem cell differentiation and insulin secretion by differential expression of Pdx-1

Molecular Biology Reports

Volumn 39, Issue 7, 2012, Pages 7777-7783

  Yuan, Huijuan ^a   Liu, Hongmei ^b   Tian, Rui ^a   Li, Jie ^c   Zhao, Zhigang ^a  

^a HENAN PROVINCIAL PEOPLE'S HOSPITAL   (China)

^b Zhengzhou Central Hospital   (China)

^c ZHENGZHOU UNIVERSITY   (China)

Author keywords

Differentiation; Glucose stimulated insulin secretion; MSC; Pdx 1; Transfection

Indexed keywords

INSULIN; MESSENGER RNA; TRANSCRIPTION FACTOR PDX 1;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; ASSAY; CELL DIFFERENTIATION; CELL LINE; CONTROLLED STUDY; GENE EXPRESSION; GENETIC TRANSFECTION; INSULIN RELEASE; MALE; MESENCHYMAL STEM CELL; NONHUMAN; PANCREAS ISLET BETA CELL; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TRANSGENE;

CELL DIFFERENTIATION; CELL LINE; CELL PROLIFERATION; HOMEODOMAIN PROTEINS; HUMANS; INSULIN; INSULIN-SECRETING CELLS; MESENCHYMAL STROMAL CELLS; RNA, MESSENGER; TISSUE ENGINEERING; TRANS-ACTIVATORS;

EID: 84864284007     PISSN: 03014851     EISSN: 15734978     Source Type: Journal    
DOI: 10.1007/s11033-012-1619-7     Document Type: Article

References (28)

1. Yuan HJ, Li J, Xin N, Zhao ZG, Qin GJ (2010) Expression of Pdx-1 mediates differentiation from mesenchymal stem cells into insulin-producing cells. Mol Biol Rep 37:4023-4031
2. Zhou Q, Melton DA (2008) Pathways to New {beta} Cells. Cold Spring Harb Symp Quant Biol 73:175-181
3. Newgard CB (2002) While tinkering with the beta-cell metabolic regulatory mechanisms and new therapeutic strategies. American Diabetes Association Lilly Lecture. Diabetes 51:3141-3150 (Pubitemid 35246959)
4. Fiorina P, Voltarelli J, Zavazava N (2011) Immunological applications of stem cells in type 1 diabetes. Endocr Rev. doi: 10.1210/er.2011-0008
5. Kelly C, Flatt CC, McClenaghan NH (2011) Stem cell-based approaches for the treatment of diabetes. Stem Cells Int. doi: 10.4061/2011/424986
6. Michels AW, Eisenbarth GS (2011) Immune intervention in type 1 diabetes. Semin Immunol 23(3):214-219
7. Flier JS (2004) Obesity wars: molecular progress confronts an expanding epidemic. Cell 116:337-350 (Pubitemid 38167322)
8. Spiegelman BM, Flier JS (2001) Obesity and the regulation of energy balance. Cell 104:531-543 (Pubitemid 32201948)
9. Borowiak M, Melton DA (2009) How to make beta cells? Curr Opin Cell Biol 21:727-732
10. Maehr R, Chen S, Snitow M, Ludwig T, Yagasaki L, Goland R, Leibel RL, Melton DA (2009) Generation of pluripotent stem cells from patients with type 1 diabetes. Proc Natl Acad Sci USA 106:15768-15773
11. Melton DA (2011) Using stem cells to study and possibly treat type 1 diabetes. Philos Trans R Soc Lond B Biol Sci 366: 2307-2311
12. Zhou Q, Brown J, Kanarek A, Rajagopal J, Melton DA (2008) In vivo reprogramming of adult pancreatic exocrine cells to beta-cells. Nature 455:627-632
13. Feanny MA, Fagan SP, Ballian N, Liu SH, Li Z, Wang X, Fisher W, Brunicardi FC, Belaguli NS (2008) PDX-1 expression is associated with islet proliferation in vitro and in vivo. J Surg Res 144:8-16 (Pubitemid 350234965)
14. Hui H, Perfetti R (2002) Pancreas duodenum homeobox-1 regulates pancreas development during embryogenesis and islet cell function in adulthood. Eur J Endocrinol 146:129-141 (Pubitemid 34162905)
15. Kaneto H, Matsuoka TA, Katakami N, Matsuhisa M (2009) Combination of Maf A, PDX-1 and NeuroD is a useful tool to efficiently induce insulin-producing surrogate beta-cells. Curr Med Chem 16:3144-3151
16. Kaneto H, Matsuoka TA, Miyatsuka T, Kawamori D, Katakami N, Yamasaki Y, Matsuhisa M (2008) PDX-1 functions as a master factor in the pancreas. Front Biosci 13:6406-6420
17. Yoshida S, Kajimoto Y, Yasuda T, Watada H, Fujitani Y, Kosaka H, Gotow T, Miyatsuka T, Umayahara Y, Yamasaki Y, Hori M (2002) PDX-1 induces differentiation of intestinal epithelioid IEC-6 into insulin-producing cells. Diabetes 51:2505-2513 (Pubitemid 34827400)
18. Guo W, Miao C, Liu S, Qiu Z, Li J, Duan E (2009) Efficient differentiation of insulin-producing cells from skin-derived stem cells. Cell Prolif 42:49-62
19. Yang JH, Lee SH, Heo YT, Uhm SJ, Lee HT (2010) Generation of insulin-producing cells from gnotobiotic porcine skin-derived stem cells. Biochem Biophys Res Commun 397:679-684
20. Sun NZ, Ji HS (2009) In vitro differentiation of human placenta-derived adherent cells into insulin-producing cells. J Int Med Res 37:400-406
21. Trovato L, De Fazio R, Annunziata M, Sdei S, Favaro E, Ponti R, Marozio L, Ghigo E, Benedetto C, Granata R (2009) Pluripotent stem cells isolated from human amniotic fluid and differentiation into pancreatic beta-cells. J Endocrinol Invest 32:873-876
22. Oliver-Krasinski JM, Kasner MT, Yang J, Crutchlow MF, Rustgi AK, Kaestner KH, Stoffers DA (2009) The diabetes gene Pdx1 regulates the transcriptional network of pancreatic endocrine progenitor cells in mice. J Clin Invest 119:1888-1898
23. Overbergh L, Giulietti A, Valckx D, Decallonne R, Bouillon R, Mathieu C (2003) The use of real-time reverse transcriptase PCR for the quantification of cytokine gene expression. J Biomol Tech 14:33-43
24. -DDCT method. Methods 25:402-408 (Pubitemid 34164012)
25. Cai HQ, Xu SQ, Men XL, Sui WG, Zhang WJ, Li QD, Yang WY, Lou JN (2009) Isolation, purification, and functional evaluation of human pancreatic islet. Zhonghua Yi Xue Za Zhi 89:836-840
26. Liu SH, Patel S, Gingras MC, Nemunaitis J, Zhou G, Chen C, Li M, Fisher W, Gibbs R, Brunicardi FC (2011) PDX-1: demonstration of oncogenic properties in pancreatic cancer. Cancer 117: 723-733
27. Takahashi K, Yamanaka S (2006) Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell 126:663-676 (Pubitemid 44233629)
28. Gannon M, Ables ET, Crawford L, Lowe D, Offield MF, Mag-nuson MA, Wright CV (2008) pdx-1 function is specifically required in embryonic beta cells to generate appropriate numbers of endocrine cell types and maintain glucose homeostasis. Dev Biol 314:406-417