-
1
-
-
20344394437
-
Cell-replacement therapy for diabetes: Generating functional insulin-producing tissue from adult human liver cells
-
DOI 10.1073/pnas.0405277102
-
T Sapir K Shternhall I Meivar-Levy T Blumenfeld H Cohen E Skutelsky S Eventov-Friedman I Barshack I Goldberg S Pri-Chen L Ben-Dor S Polak-Charcon A Karasik I Shimon E Mor S Ferber 2005 Cell-replacement therapy for diabetes: generating functional insulin-producing tissue from adult human liver cells Proc Natl Acad Sci USA 102 7964 7969 1:CAS:528:DC%2BD2MXkvF2ju7k%3D 10.1073/pnas.0405277102 15899968 (Pubitemid 40781046)
-
(2005)
Proceedings of the National Academy of Sciences of the United States of America
, vol.102
, Issue.22
, pp. 7964-7969
-
-
Sapir, T.1
Shternhall, K.2
Meivar-Levy, I.3
Blumenfeld, T.4
Cohen, H.5
Skutelsky, E.6
Eventov-Friedman, S.7
Barshack, I.8
Goldberg, I.9
Pri-Chen, S.10
Ben-Dor, L.11
Polak-Charcon, S.12
Karasik, A.13
Shimon, I.14
Mor, E.15
Ferber, S.16
-
2
-
-
68849091103
-
The diabetes gene Pdx1 regulates the transcriptional network of pancreatic endocrine progenitor cells in mice
-
1:CAS:528:DC%2BD1MXosVCrsr4%3D 10.1172/JCI37028 19487809
-
JM Oliver-Krasinski MT Kasner J Yang MF Crutchlow AK Rustgi KH Kaestner DA Stoffers 2009 The diabetes gene Pdx1 regulates the transcriptional network of pancreatic endocrine progenitor cells in mice J Clin Invest 119 1888 1898 1:CAS:528:DC%2BD1MXosVCrsr4%3D 10.1172/JCI37028 19487809
-
(2009)
J Clin Invest
, vol.119
, pp. 1888-1898
-
-
Oliver-Krasinski, J.M.1
Kasner, M.T.2
Yang, J.3
Crutchlow, M.F.4
Rustgi, A.K.5
Kaestner, K.H.6
Stoffers, D.A.7
-
3
-
-
2942594624
-
Adult bone marrow-derived cells trans differentiating into insulin-producing cells for the treatment of type I diabetes
-
DOI 10.1038/labinvest.3700074
-
SH Oh TM Muzzonigro SH Bae JM LaPlante HM Hatch BE Petersen 2004 Adult bone marrow-derived cells trans-differentiating into insulin-producing cells for the treatment of type I diabetes Lab Invest 84 607 617 1:CAS:528: DC%2BD2cXmtF2isbk%3D 10.1038/labinvest.3700074 15034596 (Pubitemid 38858470)
-
(2004)
Laboratory Investigation
, vol.84
, Issue.5
, pp. 607-617
-
-
Oh, S.-H.1
Muzzonigro, T.M.2
Bae, S.-H.3
LaPlante, J.M.4
Hatch, H.M.5
Petersen, B.E.6
-
4
-
-
0034068602
-
Pancreatic and duodenal homeobox gene 1 induces expression of insulin genes in liver and ameliorates streptozotocin-induced hyperglycemia
-
DOI 10.1038/75050
-
S Ferber A Halkin H Cohen I Ber Y Einav I Goldberg I Barshack R Seijffers J Kopolovic N Kaiser A Karasik 2000 Pancreatic and duodenal homeobox gene 1 induces expression of insulin genes in liver and ameliorates streptozotocin-induced hyperglycemia Nat Med 6 568 572 1:CAS:528: DC%2BD3cXjtFyhtrc%3D 10.1038/75050 10802714 (Pubitemid 30305908)
-
(2000)
Nature Medicine
, vol.6
, Issue.5
, pp. 568-572
-
-
Ferber, S.1
Halkin, A.2
Cohen, H.3
Ber, I.4
Einav, Y.5
Goldberg, I.6
Barshack, I.7
Seijffers, R.8
Kopolovic, J.9
Kaiser, N.10
Karasik, A.11
-
5
-
-
53349178722
-
In vivo reprogramming of adult pancreatic exocrine cells to beta-cells
-
1:CAS:528:DC%2BD1cXhtF2hsbvI 10.1038/nature07314 18754011
-
Q Zhou J Brown A Kanarek J Rajagopal DA Melton 2008 In vivo reprogramming of adult pancreatic exocrine cells to beta-cells Nature 455 627 632 1:CAS:528:DC%2BD1cXhtF2hsbvI 10.1038/nature07314 18754011
-
(2008)
Nature
, vol.455
, pp. 627-632
-
-
Zhou, Q.1
Brown, J.2
Kanarek, A.3
Rajagopal, J.4
Melton, D.A.5
-
6
-
-
1442279880
-
PDX-1 and the Pancreas
-
DOI 10.1097/00006676-200403000-00001
-
S Ashizawa FC Brunicardi XP Wang 2004 PDX-1 and the pancreas Pancreas 28 109 120 10.1097/00006676-200403000-00001 15028942 (Pubitemid 38269770)
-
(2004)
Pancreas
, vol.28
, Issue.2
, pp. 109-120
-
-
Ashizawa, S.1
Brunicardi, F.C.2
Wang, X.-P.3
-
7
-
-
0032525981
-
Beta-cell-specific inactivation of the mouse Ipf1/Pdx1 gene results in loss of the beta-cell phenotype and maturity onset diabetes
-
1:CAS:528:DyaK1cXktl2isbw%3D 10.1101/gad.12.12.1763 9637677
-
U Ahlgren J Jonsson L Jonsson K Simu H Edlund 1998 Beta-cell-specific inactivation of the mouse Ipf1/Pdx1 gene results in loss of the beta-cell phenotype and maturity onset diabetes Genes Dev 12 1763 1768 1:CAS:528:DyaK1cXktl2isbw%3D 10.1101/gad.12.12.1763 9637677
-
(1998)
Genes Dev
, vol.12
, pp. 1763-1768
-
-
Ahlgren, U.1
Jonsson, J.2
Jonsson, L.3
Simu, K.4
Edlund, H.5
-
8
-
-
10744233909
-
Little evidence of transdifferentiation of bone marrow-derived cells into pancreatic beta cells
-
DOI 10.1007/s00125-003-1182-9
-
JB Choi H Uchino K Azuma N Iwashita Y Tanaka H Mochizuki M Migita T Shimada R Kawamori H Watada 2003 Little evidence of transdifferentiation of bone marrow-derived cells into pancreatic beta cells Diabetologia 46 1366 1374 1:STN:280:DC%2BD3svmvVSitw%3D%3D 10.1007/s00125-003-1182-9 12898006 (Pubitemid 37297207)
-
(2003)
Diabetologia
, vol.46
, Issue.10
, pp. 1366-1374
-
-
Choi, J.B.1
Uchino, H.2
Azuma, K.3
Iwashita, N.4
Tanaka, Y.5
Mochizuki, H.6
Migita, M.7
Shimada, T.8
Kawamori, R.9
Watada, H.10
-
9
-
-
1442326000
-
No Evidence for Significant Transdifferentiation of Bone Marrow Into Pancreatic β-Cells in Vivo
-
DOI 10.2337/diabetes.53.3.616
-
A Lechner YG Yang RA Blacken L Wang AL Nolan JF Habener 2004 No evidence for significant transdifferentiation of bone marrow into pancreatic beta-cells in vivo Diabetes 53 616 623 1:CAS:528:DC%2BD2cXhvFelu74%3D 10.2337/diabetes.53. 3.616 14988245 (Pubitemid 38270630)
-
(2004)
Diabetes
, vol.53
, Issue.3
, pp. 616-623
-
-
Lechner, A.1
Yang, Y.-G.2
Blacken, R.A.3
Wang, L.4
Nolan, A.L.5
Habener, J.F.6
-
10
-
-
33644779820
-
Failure of transplanted bone marrow cells to adopt a pancreatic β-cell fate
-
DOI 10.2337/diabetes.55.02.06.db05-1212
-
J Taneera A Rosengren E Renstrom JM Nygren P Serup P Rorsman SE Jacobsen 2006 Failure of transplanted bone marrow cells to adopt a pancreatic beta-cell fate Diabetes 55 290 296 1:CAS:528:DC%2BD28XhsFajsr4%3D 10.2337/diabetes.55.02. 06.db05-1212 16443759 (Pubitemid 43343255)
-
(2006)
Diabetes
, vol.55
, Issue.2
, pp. 290-296
-
-
Taneera, J.1
Rosengren, A.2
Renstrom, E.3
Nygren, J.M.4
Serup, P.5
Rorsman, P.6
Jacobsen, S.E.W.7
-
11
-
-
51849144706
-
Co-expression of Pdx1 and betacellulin in mesenchymal stem cells could promote the differentiation of nestin-positive epithelium-like progenitors and pancreatic islet-like spheroids
-
1:CAS:528:DC%2BD1cXhtFaisrzI 10.1089/scd.2008.0060 18439098
-
L Li F Li H Qi G Feng K Yuan H Deng H Zhou 2008 Co-expression of Pdx1 and betacellulin in mesenchymal stem cells could promote the differentiation of nestin-positive epithelium-like progenitors and pancreatic islet-like spheroids Stem Cells Dev 17 815 823 1:CAS:528:DC%2BD1cXhtFaisrzI 10.1089/scd.2008.0060 18439098
-
(2008)
Stem Cells Dev
, vol.17
, pp. 815-823
-
-
Li, L.1
Li, F.2
Qi, H.3
Feng, G.4
Yuan, K.5
Deng, H.6
Zhou, H.7
-
12
-
-
77954936480
-
Isolation, purification, and functional evaluation of human pancreatic islet
-
1:CAS:528:DC%2BD1MXhtlemtL3O 19595125
-
HQ Cai SQ Xu XL Men WG Sui WJ Zhang QD Li WY Yang JN Lou 2009 Isolation, purification, and functional evaluation of human pancreatic islet Zhonghua Yi Xue Za Zhi 89 836 840 1:CAS:528:DC%2BD1MXhtlemtL3O 19595125
-
(2009)
Zhonghua Yi Xue Za Zhi
, vol.89
, pp. 836-840
-
-
Cai, H.Q.1
Xu, S.Q.2
Men, X.L.3
Sui, W.G.4
Zhang, W.J.5
Li, Q.D.6
Yang, W.Y.7
Lou, J.N.8
-
13
-
-
0035710746
-
-ΔΔCT method
-
DOI 10.1006/meth.2001.1262
-
KJ Livak TD Schmittgen 2001 Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method Methods 25 402 408 1:CAS:528:DC%2BD38XhtFelt7s%3D 10.1006/meth.2001.1262 11846609 (Pubitemid 34164012)
-
(2001)
Methods
, vol.25
, Issue.4
, pp. 402-408
-
-
Livak, K.J.1
Schmittgen, T.D.2
-
14
-
-
0014261390
-
Heterotopic of bone marrow. Analysis of precursor cells for osteogenic and hematopoietic tissues
-
1:STN:280:DyaF1c3ns1Ciug%3D%3D 10.1097/00007890-196803000-00009 5654088
-
AJ Friedenstein KV Petrakova AI Kurolesova GP Frolova 1968 Heterotopic of bone marrow. Analysis of precursor cells for osteogenic and hematopoietic tissues Transplantation 6 230 247 1:STN:280:DyaF1c3ns1Ciug%3D%3D 10.1097/00007890-196803000-00009 5654088
-
(1968)
Transplantation
, vol.6
, pp. 230-247
-
-
Friedenstein, A.J.1
Petrakova, K.V.2
Kurolesova, A.I.3
Frolova, G.P.4
-
15
-
-
77953164714
-
Use of polyamidoamine dendrimers to engineer BDNF-producing human mesenchymal stem cells
-
doi: 10.1007/s11033-009-9651-y
-
Shakhbazau A, Shcharbin D, Seviaryn I, Goncharova N, Kosmacheva S, Potapnev M, Gabara B, Ionov M, Bryszewska M (2009) Use of polyamidoamine dendrimers to engineer BDNF-producing human mesenchymal stem cells. Mol Biol Rep. doi: 10.1007/s11033-009-9651-y
-
(2009)
Mol Biol Rep.
-
-
Shakhbazau, A.1
Shcharbin, D.2
Seviaryn, I.3
Goncharova, N.4
Kosmacheva, S.5
Potapnev, M.6
Gabara, B.7
Ionov, M.8
Bryszewska, M.9
-
16
-
-
68149181573
-
Effects of the different culture and isolation methods on the growth, proliferation and biology characteristics of rat bone marrow mesenchymal stem cells
-
19764582
-
GQ Jia MM Zhang P Yang JQ Cheng YR Lu XT Wu 2009 Effects of the different culture and isolation methods on the growth, proliferation and biology characteristics of rat bone marrow mesenchymal stem cells Sichuan Da Xue Xue Bao Yi Xue Ban 40 719 723 19764582
-
(2009)
Sichuan da Xue Xue Bao Yi Xue Ban
, vol.40
, pp. 719-723
-
-
Jia, G.Q.1
Zhang, M.M.2
Yang, P.3
Cheng, J.Q.4
Lu, Y.R.5
Wu, X.T.6
-
17
-
-
58149462473
-
Mesenchymal stem cells and their use as cell replacement therapy and disease modelling tool
-
10.1111/j.1582-4934.2008.00516.x 19210755
-
J García-Castro C Trigueros J Madrenas JA Pérez- Simón R Rodriguez P Menendez 2008 Mesenchymal stem cells and their use as cell replacement therapy and disease modelling tool J Cell Mol Med 12 2552 2565 10.1111/j.1582-4934.2008.00516.x 19210755
-
(2008)
J Cell Mol Med
, vol.12
, pp. 2552-2565
-
-
García-Castro, J.1
Trigueros, C.2
Madrenas, J.3
Pérez- Simón, J.A.4
Rodriguez, R.5
Menendez, P.6
-
18
-
-
13144281727
-
Embryonic stem cells differentiate into insulin-producing cells without selection of nestin-expressing cells
-
DOI 10.1387/ijdb.041904pb
-
P Blyszczuk C Asbrand A Rozzo G Kania L St-Onge M Rupnik AM Wobus 2004 Embryonic stem cells differentiate into insulin-producing cells without selection of nestin-expressing cells Int J Dev Biol 48 1095 1104 1:CAS:528:DC%2BD2MXit1Wmt7c%3D 10.1387/ijdb.041904pb 15602695 (Pubitemid 40179576)
-
(2004)
International Journal of Developmental Biology
, vol.48
, Issue.10
, pp. 1095-1104
-
-
Blyszczuk, P.1
Asbrand, C.2
Rozzo, A.3
Kania, G.4
St.-Onge, L.5
Rupnik, M.6
Wobus, A.M.7
-
19
-
-
34547857040
-
Generation of insulin-producing islet-like clusters from human embryonic stem cells
-
DOI 10.1634/stemcells.2006-0761
-
J Jiang M Au K Lu A Eshpeter G Korbutt G Fisk AS Majumdar 2007 Generation of insulin-producing islet-like clusters from human embryonic stem cells Stem Cells 25 1940 1953 1:CAS:528:DC%2BD2sXhtVSqsbbI 10.1634/stemcells.2006-0761 17510217 (Pubitemid 47258172)
-
(2007)
Stem Cells
, vol.25
, Issue.8
, pp. 1940-1953
-
-
Jiang, J.1
Au, M.2
Lu, K.3
Eshpeter, A.4
Korbutt, G.5
Fisk, G.6
Majumdar, A.S.7
-
20
-
-
20444457464
-
Differentiation of in vitro-modified human peripheral blood monocytes into hepatocyte-like and pancreatic islet-like cells
-
DOI 10.1053/j.gastro.2005.03.029, PII S0016508505004464
-
M Ruhnke H Ungefroren A Nussler F Martin M Brulport W Schormann JG Hengstler W Klapper K Ulrichs JA Hutchinson B Soria RM Parwaresch P Heeckt B Kremer F Fändrich 2005 Differentiation of in vitro-modified human peripheral blood monocytes into hepatocyte-like and pancreatic islet-like cells Gastroenterology 128 1774 1786 1:CAS:528:DC%2BD2MXlvFKlsrY%3D 10.1053/j.gastro.2005.03.029 15940611 (Pubitemid 40824688)
-
(2005)
Gastroenterology
, vol.128
, Issue.7
, pp. 1774-1786
-
-
Ruhnke, M.1
Ungefroren, H.2
Nussler, A.3
Martin, F.4
Brulport, M.5
Schormann, W.6
Hengstler, J.G.7
Klapper, W.8
Ulrichs, K.9
Hutchinson, J.A.10
Soria, B.11
Parwaresch, R.M.12
Heeckt, P.13
Kremer, B.14
Fandrich, F.15
-
21
-
-
58149314073
-
Transplantation of insulin-producing clusters derived from adult bone marrow stem cells to treat diabetes in rats
-
18954303
-
MM Gabr MM Sobh MM Zakaria AF Refaie MA Ghoneim 2008 Transplantation of insulin-producing clusters derived from adult bone marrow stem cells to treat diabetes in rats Exp Clin Transplant 6 236 243 18954303
-
(2008)
Exp Clin Transplant
, vol.6
, pp. 236-243
-
-
Gabr, M.M.1
Sobh, M.M.2
Zakaria, M.M.3
Refaie, A.F.4
Ghoneim, M.A.5
-
22
-
-
33750542712
-
Differentiation of embryonic stem cells conditionally expressing neurogenin 3
-
DOI 10.1634/stemcells.2006-0082
-
NR Treff RK Vincent ML Budde VL Browning JF Magliocca V Kapur JS Odorico 2006 Differentiation of embryonic stem cells conditionally expressing neurogenin 3 Stem Cells 24 2529 2537 1:CAS:528:DC%2BD28Xht12hsbfP 10.1634/stemcells.2006- 0082 16809427 (Pubitemid 44674314)
-
(2006)
Stem Cells
, vol.24
, Issue.11
, pp. 2529-2537
-
-
Treff, N.R.1
Vincent, R.K.2
Budde, M.L.3
Browning, V.L.4
Magliocca, J.F.5
Kapur, V.6
Odorico, J.S.7
-
23
-
-
0033534620
-
Glucose stimulates translocation of the homeodomain transcription factor PDX1 from the cytoplasm to the nucleus in pancreatic β-cells
-
DOI 10.1074/jbc.274.2.1011
-
WM Macfarlane CM McKinnon ZA Felton-Edkins H Cragg RF James K Docherty 1999 Glucose stimulates translocation of the homeodomain transcription Factor PDX1 from the cytoplasm to the nucleus in pancreatic β-cells J Biol Chem 274 1011 1016 1:CAS:528:DyaK1MXmt1entw%3D%3D 10.1074/jbc.274.2.1011 9873045 (Pubitemid 29058074)
-
(1999)
Journal of Biological Chemistry
, vol.274
, Issue.2
, pp. 1011-1016
-
-
Macfarlane, W.M.1
McKinnon, C.M.2
Felton-Edkins, Z.A.3
Cragg, H.4
James, R.F.L.5
Docherty, K.6
-
24
-
-
0036340074
-
Direct evidence for the pancreatic lineage: NGN3+ cells are islet progenitors and are distinct from duct progenitors
-
1:CAS:528:DC%2BD38XksFWnur0%3D 11973276
-
G Gu J Dubauskaite DA Melton 2002 Direct evidence for the pancreatic lineage: NGN3+ cells are islet progenitors and are distinct from duct progenitors Development 129 2447 2457 1:CAS:528:DC%2BD38XksFWnur0%3D 11973276
-
(2002)
Development
, vol.129
, pp. 2447-2457
-
-
Gu, G.1
Dubauskaite, J.2
Melton, D.A.3
-
25
-
-
0034121735
-
Adult insulin- and glucagon-producing cells differentiate from two independent cell lineages
-
1:CAS:528:DC%2BD3cXksVKmsrg%3D 10804174
-
PL Herrera 2000 Adult insulin- and glucagon-producing cells differentiate from two independent cell lineages Development 127 2317 2322 1:CAS:528:DC%2BD3cXksVKmsrg%3D 10804174
-
(2000)
Development
, vol.127
, pp. 2317-2322
-
-
Herrera, P.L.1
-
26
-
-
35349021929
-
Expression of the notch signaling pathway and effect on exocrine cell proliferation in adult rat pancreas
-
DOI 10.2353/ajpath.2006.050926
-
I Rooman N De Medts L Baeyens J Lardon S De Breuck H Heimberg L Bouwens 2006 Expression of the Notch signaling pathway and effect on exocrine cell proliferation in adult rat pancreas Am J Pathol 169 1206 1214 1:CAS:528:DC%2BD28XhtFeitLjP 10.2353/ajpath.2006.050926 17003479 (Pubitemid 351194357)
-
(2006)
American Journal of Pathology
, vol.169
, Issue.4
, pp. 1206-1214
-
-
Rooman, I.1
De Medts, N.2
Baeyens, L.3
Lardon, J.4
De Breuck, S.5
Heimberg, H.6
Bouwens, L.7
-
27
-
-
72849124907
-
Insulin but not glucagon gene is silenced in human pancreas-derived mesenchymal stem cells
-
1:CAS:528:DC%2BC3cXlsFyltA%3D%3D 10.1002/stem.229 19785038
-
LM Wilson SH Wong N Yu E Geras-Raaka BM Raaka MC Gershengorn 2009 Insulin but not glucagon gene is silenced in human pancreas-derived mesenchymal stem cells Stem Cells 27 2703 2711 1:CAS:528:DC%2BC3cXlsFyltA%3D%3D 10.1002/stem.229 19785038
-
(2009)
Stem Cells
, vol.27
, pp. 2703-2711
-
-
Wilson, L.M.1
Wong, S.H.2
Yu, N.3
Geras-Raaka, E.4
Raaka, B.M.5
Gershengorn, M.C.6
-
28
-
-
51849111124
-
Generation of high-level stable transgene expressing human embryonic stem cell lines using Chinese hamster elongation factor-1 alpha promoter system
-
1:CAS:528:DC%2BD1cXhtFaisrjE 10.1089/scd.2007.0233 18788934
-
KK Chan SM Wu PM Nissom SK Oh AB Choo 2008 Generation of high-level stable transgene expressing human embryonic stem cell lines using Chinese hamster elongation factor-1 alpha promoter system Stem Cells Dev 17 825 836 1:CAS:528:DC%2BD1cXhtFaisrjE 10.1089/scd.2007.0233 18788934
-
(2008)
Stem Cells Dev
, vol.17
, pp. 825-836
-
-
Chan, K.K.1
Wu, S.M.2
Nissom, P.M.3
Oh, S.K.4
Choo, A.B.5
-
29
-
-
59249084751
-
Sustained transgene expression using MAR elements
-
1:CAS:528:DC%2BD1cXhsFemt7%2FJ 10.2174/156652308786071032 18855632
-
N Harraghy A Gaussin N Mermod 2008 Sustained transgene expression using MAR elements Curr Gene Ther 8 353 366 1:CAS:528:DC%2BD1cXhsFemt7%2FJ 10.2174/156652308786071032 18855632
-
(2008)
Curr Gene Ther
, vol.8
, pp. 353-366
-
-
Harraghy, N.1
Gaussin, A.2
Mermod, N.3
|