Vasoconstrictor 5-HT receptors in the smooth muscle of the rat middle cerebral artery

European Journal of Pharmacology

Volumn 689, Issue 1-3, 2012, Pages 160-164

  Kovács, Anikó ^a   Hársing Jr , László G ^a,b   Szénási, Gábor ^a,b  

^a EGIS PHARMACEUTICALS LTD   (Hungary)

^b SEMMELWEIS UNIVERSITY   (Hungary)

Author keywords

5 HT2A receptor; Functional 5 HT1B receptor; Middle cerebral artery; Smooth muscle

Indexed keywords

5 CARBAMOYLTRYPTAMINE; RITANSERIN; SB 216641; SEROTONIN; SEROTONIN 1B ANTAGONIST; SEROTONIN 1B RECEPTOR; SEROTONIN 2A RECEPTOR; SUMATRIPTAN SUCCINATE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD FLOW VELOCITY; BRAIN BLOOD FLOW; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG ANTAGONISM; DRUG POTENCY; DRUG RECEPTOR BINDING; IN VITRO STUDY; MALE; MIDDLE CEREBRAL ARTERY; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN LOCALIZATION; RAT; SMOOTH MUSCLE; TISSUE DISTRIBUTION; VASOCONSTRICTION;

ANIMALS; MALE; MIDDLE CEREBRAL ARTERY; MUSCLE, SMOOTH, VASCULAR; ORGAN CULTURE TECHNIQUES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTOR, SEROTONIN, 5-HT1B; RECEPTOR, SEROTONIN, 5-HT2A; VASOCONSTRICTION;

EID: 84864280815     PISSN: 00142999     EISSN: 18790712     Source Type: Journal    
DOI: 10.1016/j.ejphar.2012.05.031     Document Type: Article

References (45)

1. 2A receptor antagonist Eur. J. Pharmacol. 586 2008 234 243
2. 1D beta receptor Mol. Pharmacol. 41 1992 1 7
3. H. Ahnstedt, H. Saveland, O. Nilsson, and L. Edvinsson Human cerebrovascular contractile receptors are upregulated via a B-Raf/MEK/ERK- sensitive signaling pathway BMC Neurosci. 12 2011 5
4. M.S. Asghar, A.E. Hansen, F.M. Amin, R.J. van der Geest, P. Koning, H.B. Larsson, J. Olesen, and M. Ashina Evidence for a vascular factor in migraine Ann. Neurol. 69 2011 635 645
5. J.H. Ashton, C.R. Benedict, C. Fitzgerald, S. Raheja, A. Taylor, W.B. Campbell, L.M. Buja, and J.T. Willerson Serotonin as a mediator of cyclic flow variations in stenosed canine coronary arteries Circulation 73 1986 572 578 (Pubitemid 16133036)
6. 1B receptor cell line Eur. J. Pharmacol. 360 1998 117 121 (Pubitemid 28531943)
7. 2A receptor antagonist Thromb. Haemost. 85 2001 521 528 (Pubitemid 32233029)
8. 2A receptor residues Phe339(6.51) and Phe340(6.52) with superpotent N-benzyl phenethylamine agonists Mol. Pharmacol. 70 2006 1956 1964 (Pubitemid 44771911)
9. 2 receptor activation Eur. J. Pharmacol. 161 1989 91 94 (Pubitemid 19058852)
10. 2 receptors predominantly mediate the contraction of the rat basilar artery to 5-hydroxytryptamine Eur. J. Pharmacol. 221 1992 17 25
11. 1B receptor) responses in human cerebral and coronary arteries: relationship to clinical effect Clin. Sci. (Lond) 109 2005 335 342 (Pubitemid 41337139)
12. J. Hansen-Schwartz, N.L. Hoel, C.B. Xu, N.A. Svendgaard, and L. Edvinsson Subarachnoid hemorrhage-induced upregulation of the 5-HT1B receptor in cerebral arteries in rats J. Neurosurg. 99 2003 115 120 (Pubitemid 36753884)
13. J. Hansen-Schwartz, H.N. Lovland, E. Nilsson, P. Tfelt-Hansen, and L. Edvinsson Endothelium-dependent relaxant responses to selective 5-HT(1B/1D) receptor agonists in the isolated middle cerebral artery of the rat J. Vasc. Res. 40 2003 561 566 (Pubitemid 38186467)
14. A.J. Kaumann, and F.O. Levy 5-hydroxytryptamine receptors in the human cardiovascular system Pharmacol. Ther. 111 2006 674 706 (Pubitemid 44118434)
15. 2C receptors Naunyn-Schmiedeberg's Arch. Pharmacol. 370 2004 114 123 (Pubitemid 39222863)
16. C.C. Larsen, G.K. Povlsen, M.N. Rasmussen, and L. Edvinsson Improvement in neurological outcome and abolition of cerebrovascular endothelin B and 5-hydroxytryptamine 1B receptor upregulation through mitogen-activated protein kinase kinase 1/2 inhibition after subarachnoid hemorrhage in rats J. Neurosurg. 114 2011 1143 1153
17. V. Limmroth, A. Bischoff, C. Fetscher, D. Wermelskirchen, H. Diener, and M.C. Michel Effects of alniditan on neurogenic oedema in the rat dura mater and on contraction of rat basilar artery Eur. J. Pharmacol. 382 1999 103 109 (Pubitemid 29488742)
18. 2A receptor-mediated contraction in rat aorta J. Physiol. 586 2008 3855 3869
19. 1 receptors with other receptors: clinical implications Neuropharmacology 55 2008 986 993
20. M.R. MacLean, R.A. Clayton, A.G. Templeton, and I. Morecroft Evidence for 5-HT1-like receptor-mediated vasoconstriction in human pulmonary artery Br. J. Pharmacol. 119 1996 277 282 (Pubitemid 26326459)
21. A. Maddahi, and L. Edvinsson Enhanced expressions of microvascular smooth muscle receptors after focal cerebral ischemia occur via the MAPK MEK/ERK pathway BMC Neurosci. 9 2008 85
22. S. Mehrotra, S. Gupta, I.M. Garrelds, C.M. Villalon, P.R. Saxena, A.J. Bogers, and A. Maassenvandenbrink Effects of current and prospective antimigraine drugs on the porcine isolated meningeal artery Naunyn Schmiedeberg's Arch. Pharmacol. 374 2006 163 175 (Pubitemid 44819250)
23. K. Miyata, H. Shimokawa, T. Higo, T. Yamawaki, N. Katsumata, T. Kandabashi, E. Tanaka, Y. Takamura, K. Yogo, K. Egashira, and A. Takeshita Sarpogrelate, a selective 5-HT2A serotonergic receptor antagonist, inhibits serotonin-induced coronary artery spasm in a porcine model J. Cardiovasc. Pharmacol. 35 2000 294 301 (Pubitemid 30073823)
24. L. Monassier, M.A. Laplante, T. Ayadi, S. Doly, and L. Maroteaux Contribution of gene-modified mice and rats to our understanding of the cardiovascular pharmacology of serotonin Pharmacol. Ther. 128 2010 559 567
25. M.J. Mulvany, and W. Halpern Contractile properties of small arterial resistance vessels in spontaneously hypertensive and normotensive rats Circ. Res. 41 1977 19 26 (Pubitemid 8132079)
26. S. Nagai, T. Tsurumaki, H. Abe, and H. Higuchi Functional serotonin and histamine receptor subtypes in porcine ciliary artery in comparison with middle cerebral artery Eur. J. Pharmacol. 570 2007 159 166 (Pubitemid 47247685)
27. 1B receptor/G-protein stoichiometry Mol. Pharmacol. 58 2000 1042 1049
28. Y. Nishimura Characterization of 5-hydroxytryptamine receptors mediating contractions in basilar arteries from stroke-prone spontaneously hypertensive rats Br. J. Pharmacol. 117 1996 1325 1333 (Pubitemid 26105358)
29. 1E 5-hydroxytryptamine receptors J. Neurochem. 67 1996 2096 2103 (Pubitemid 26349687)
30. 1B-receptors and vascular reactivity in human isolated blood vessels: assessment of the potential craniovascular selectivity of sumatriptan Br. J. Clin. Pharmacol. 53 2002 266 274 (Pubitemid 34226969)
31. K.I. Roon, A. MaassenVanDenBrink, M.D. Ferrari, and P.R. Saxena Bovine isolated middle cerebral artery contractions to antimigraine drugs Naunyn-Schmiedeberg's Arch. Pharmacol. 360 1999 591 596
32. H. Sandhu, S. Ansar, and L. Edvinsson Comparison of MEK/ERK pathway inhibitors on the upregulation of vascular G-protein coupled receptors in rat cerebral arteries Eur. J. Pharmacol. 644 2010 128 137
33. H. Sandhu, C.B. Xu, and L. Edvinsson Alteration in contractile G-protein coupled receptor expression by moist snuff and nicotine in rat cerebral arteries Toxicol. Appl. Pharmacol. 252 2011 138 149
34. D. Sarsero, T. Fujiwara, P. Molenaar, and J.A. Angus Human vascular to cardiac tissue selectivity of L- and T-type calcium channel antagonists Br. J. Pharmacol. 125 1998 109 119 (Pubitemid 28418762)
35. P.R. Saxena, and P. Tfelt-Hansen Triptans, 5-HT1B/1D receptor agonists in the acute treatment of migraine J. Olesen, P. Tfelt-Hansen, K.M.A. Welch, The Headaches 2000 Lippincott Williams & Wilkins New York, NY 411 438
36. E. Schlicker, K. Fink, G.J. Molderings, G.W. Price, M. Duckworth, L. Gaster, D.N. Middlemiss, J. Zentner, J. Likungu, and M. Gothert Effects of selective h5-HT1B (SB-216641) and h5-HT1D (BRL-15572) receptor ligands on guinea-pig and human 5-HT auto- and heteroreceptors Naunyn Schmiedeberg's Arch. Pharmacol. 356 1997 321 327 (Pubitemid 27376462)
37. D.A. Shapiro, K. Kristiansen, W.K. Kroeze, and B.L. Roth Differential modes of agonist binding to 5-hydroxytryptamine(2A) serotonin receptors revealed by mutation and molecular modeling of conserved residues in transmembrane region 5 Mol. Pharmacol. 58 2000 877 886
38. S.A. Silva, and C.A. Ribeiro Tachyphylaxis to the sumatriptan-induced contractile effect in the human uterine artery but not in human cerebral blood vessels: pharmacological demonstration of the 5-HT(1B) receptor functionality loss Pharmacology 89 2012 29 36
39. A.J. Sleight, N.J. Stam, V. Mutel, and P.M. Vanderheyden Radiolabelling of the human 5-HT2A receptor with an agonist, a partial agonist and an antagonist: effects on apparent agonist affinities Biochem. Pharmacol. 51 1996 71 76
40. 7 receptor mediating smooth muscle relaxation in canine cerebral arteries Br. J. Pharmacol. 127 1999 609 616 (Pubitemid 29276645)
41. 7 receptor-mediated dilatation in the middle meningeal artery of anesthetized rats Eur. J. Pharmacol. 560 2007 56 60
42. J.D. Urban, W.P. Clarke, M. von Zastrow, D.E. Nichols, B. Kobilka, H. Weinstein, J.A. Javitch, B.L. Roth, A. Christopoulos, P.M. Sexton, K.J. Miller, M. Spedding, and R.B. Mailman Functional selectivity and classical concepts of quantitative pharmacology J. Pharmacol. Exp. Ther. 320 2007 1 13 (Pubitemid 46025713)
43. P. Vikman, and L. Edvinsson Gene expression profiling in the human middle cerebral artery after cerebral ischemia Eur. J. Neurol. 13 2006 1324 1332 (Pubitemid 44736642)
44. S.W. Watts, and J.M. Thompson Characterization of the contractile 5-hydroxytryptamine receptor in the renal artery of the normotensive rat J. Pharmacol. Exp. Ther. 309 2004 165 172 (Pubitemid 38393127)
45. 1Dβ Proc. Natl. Acad. Sci. USA 89 1992 3630 3634