Evidence for 5-HT1-like receptor-mediated vasoconstriction in human pulmonary artery

British Journal of Pharmacology

Volumn 119, Issue 2, 1996, Pages 277-282

  MacLean, Margaret R ^a   Clayton, Robin A ^a   Templeton, Alison G B ^a   Morecroft, Ian ^a  

^a UNIVERSITY OF GLASGOW   (United Kingdom)

Author keywords

5 hydroxytryptamine receptors; Human pulmonary arteries; Vasoconstriction

Indexed keywords

2 DIPROPYLAMINO 8 HYDROXYTETRALIN; 3 (3 DIMETHYLAMINOPROPYL) 4 HYDROXY N [4 (4 PYRIDINYL)PHENYL]BENZAMIDE; 5 CARBAMOYLTRYPTAMINE; KETANSERIN; METITEPINE; SEROTONIN; SEROTONIN 1 RECEPTOR; SEROTONIN ANTAGONIST; SUMATRIPTAN; UNCLASSIFIED DRUG; 3 (3 (DIMETHYLAMINO)PROPYL) 4 HYDROXY N (4 (4 PYRIDINYL)PHENYL)BENZAMIDE; 3-(3-(DIMETHYLAMINO)PROPYL)-4-HYDROXY-N-(4-(4-PYRIDINYL)PHENYL)BENZAMIDE; BENZAMIDE DERIVATIVE; PYRIDINE DERIVATIVE; SEROTONIN AGONIST; SEROTONIN RECEPTOR;

ARTICLE; CONTROLLED STUDY; DRUG POTENCY; HUMAN; HUMAN TISSUE; PRIORITY JOURNAL; PULMONARY ARTERY; VASOCONSTRICTION; DRUG EFFECT; IN VITRO STUDY; KINETICS; PHYSIOLOGY; ULTRASTRUCTURE;

8-HYDROXY-2-(DI-N-PROPYLAMINO)TETRALIN; BENZAMIDES; HUMANS; KETANSERIN; KINETICS; METHIOTHEPIN; PULMONARY ARTERY; PYRIDINES; RECEPTORS, SEROTONIN; SEROTONIN; SEROTONIN AGONISTS; SEROTONIN ANTAGONISTS; VASOCONSTRICTION;

EID: 0029658365     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1476-5381.1996.tb15982.x     Document Type: Article

References (21)

1. BRADLEY, P.B., ENGEL, G., FENIUK, W., FOZARD, J.R, HUMPHREY, P.P.A., MIDDLEMAS, D.N., MIDDLEMISS, E.J., MYLECHARNE, E.J., RICHARDSON, B.P. & SAXENA, P.R. (1986). Proposals for the classification and nomenclature of functional receptors for 5-hydroxytryptamine. Neuropharmacology, 25, 563-576.
2. BRENOT, F., HERVÉ, P., PETITPRETZ, P., PARENT, F., DUROUX, P. & SIMONNEAU, G. (1993). Primary pulmonary hypertension and fenfluramine use. Br. Heart J., 70, 537-541.
3. 1D receptor subtypes mediating cerebral vasoconstriction. Cephalalgia, 15 (suppl 14), 99.
4. 2 receptor activation. Eur. J. Pharmacol., 161, 91-94.
5. 2 receptors in the pulmonary and coronary arteries of calf. Naunyn-Schmiedeberg's Arch. Pharmacol., 326, 334-339.
6. HERVÉ, P., DROUET, L., DOSQUET, C., LAUNAY, J-M., RAIN, B., SIMONNEAU, G., CAEN, J. & DUROUX, P. (1990). Primary pulmonary hypertension in a patient with familial storage pool disease: role of serotonin. Am. J. Med., 89, 117-120.
7. HERVÉ, P., LAUNAY, J-M., SCROBOHACI, M-L., BRENOT, F., SIMONNEAU, G., PETITPRETZ, P., POUBEAU, P., CERRINA, J., DUROUX, P. & DROUET, L. (1995). Increased plasma serotonin in primary pulmonary hypertension. Am. J. Med., 99, 249-254.
8. HOYER, D., CLARKE, D.E., FOZARD, J.R., HARTIG, P.R., MARTIN, G.R., MYLECHARANE, E.J., SAXENA, P.R. & HUMPHREY, P.P.A. (1994). International Union of pharmacology classification of receptors for 5-hydroxytryptamine (serotonin). Pharmacol. Rev., 46, 157-203.
9. 1-like receptor on dog saphenous vein. Br. J. Pharmacol., 94, 1123-1132.
10. JOHNSON, D.E. & GEORGIEFF, M.K. (1989). Pulmonary neuroendocrine cells. Their secretory products and their potential roles in health and chronic lung disease in infancy. Am. Rev. Respir. Dis., 140, 1807-1812.
11. KLIMIUK, P.S., GRENNAN, A., WEINKOVE, C & JAYSON, M.I.V. (1989). Platelet serotonin in systemic sclerosis. Ann. Rheum. Dis., 48, 586-589.
12. 1-receptor-mediated vasoconstriction in bovine isolated pulmonary arteries: influence of vascular endothelium and tone. Pulm. Pharmacol., 7, 65-72.
13. MCINTYRE, P.E., BHARGAVA, B., HOGG, K.J., GEMMILL, J.D. & HILLIS, W.S. (1992). The effect of i.v. sumatriptan, a selective 5-HT1-receptor agonist on central haemodynamics and the coronary circulation. Br. J. Clin. Pharmacol., 34, 541-546.
14. 1-like receptors in rabbit isolated basilar arteries. Eur. J. Pharmacol., 174, 189-196.
15. 1-like receptors mediate 5-hydroxytryptamine-induced contraction of human basilar artery. Br. J. Pharmacol., 96, 434-449.
16. PITTMAN, R.N. & DULING, B.R. (1973). Oxygen sensitivity of vascular smooth muscle. Microvasc. Res., 6, 202-211.
17. TEMPLETON, A.G.B., CLAYTON, R.A. & MACLEAN, M.R. (1994). Contractile responses of human pulmonary artery to 5-HT and sumatriptan. Thorax, 49, 425P.
18. TEMPLETON, A.G.B., CLAYTON, R.A., MCINTYRE, P.D., HILLIS, W.S., PEACOCK, A.J. & MACLEAN, M.R. (1993). Sensitivity of human, bovine and rabbit pulmonary arteries to sumatriptan: comparison with 5-HT. Br. J. Pharmacol., 110, 113P.
19. 1D receptor subtypes. J. Receptor Signal Transduction Res., 15, 199-211.
20. 1D receptors and uses thereof. International Patent, No. WO 91/17174.
21. 1Dβ. Proc. Natl. Acad. Sci. U.S.A., 89, 3630-3634.