Endothelium-dependent mechanisms of the vasodilatory effect of the endocannabinoid, anandamide, in the rat pulmonary artery

Pharmacological Research

Volumn 66, Issue 3, 2012, Pages 251-259

  Baranowska Kuczko, Marta ^a   MacLean, Margaret R ^b   Kozłowska, Hanna ^a   Malinowska, Barbara ^a  

^a MEDICAL UNIVERSITY OF BIALYSTOK   (Poland)

^b UNIVERSITY OF GLASGOW   (United Kingdom)

Author keywords

Abnormal cannabidiol; Anandamide; Endocannabinoid; Endothelium; Pulmonary artery

Indexed keywords

1 (2,4 DICHLOROPHENYL) 5 (4 IODOPHENYL) 4 METHYL N (1 PIPERIDYL) 1H PYRAZOLE 3 CARBOXAMIDE; 1,3 DIMETHOXY 5 METHYL 2 [3 METHYL 6 (1 METHYLETHENYL 2 CYCLOHEXEN 1 YL)]BENZENE; 15 HYDROXY 11ALPHA,9ALPHA EPOXYMETHANOPROSTA 5,13 DIENOIC ACID; 6 IODO 3 (4 METHOXYBENZOYL) 2 METHYL 1 (2 MORPHOLINOETHYL)INDOLE; ANANDAMIDE; APAMIN; CANNABIDIOL; CANNABINOID RECEPTOR ANTAGONIST; CAPSAZEPINE; CHARYBDOTOXIN; CYCLOHEXYLCARBAMIC ACID 3' CARBAMOYLBIPHENYL 3 YL ESTER; INDOMETACIN; N(G) NITROARGININE METHYL ESTER; O 1918; TETRYLAMMONIUM; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTERY ENDOTHELIUM; ARTERY TONE; ARTICLE; COMBINATION CHEMOTHERAPY; CONTROLLED STUDY; DRUG EFFICACY; DRUG MECHANISM; MALE; MONOTHERAPY; NONHUMAN; PRIORITY JOURNAL; PULMONARY ARTERY; RAT; VASOCONSTRICTION; VASODILATATION;

15-HYDROXY-11 ALPHA,9 ALPHA-(EPOXYMETHANO)PROSTA-5,13-DIENOIC ACID; AMIDOHYDROLASES; ANIMALS; ANISOLES; APAMIN; ARACHIDONIC ACIDS; BENZAMIDES; BENZYL COMPOUNDS; CANNABINOID RECEPTOR ANTAGONISTS; CAPSAICIN; CARBAMATES; CHARYBDOTOXIN; CYCLOHEXANES; ENDOCANNABINOIDS; ENDOTHELIUM, VASCULAR; IMIDAZOLES; INDOLES; INDOMETHACIN; MALE; NG-NITROARGININE METHYL ESTER; NITRIC OXIDE SYNTHASE; PIPERIDINES; POLYUNSATURATED ALKAMIDES; POTASSIUM CHANNEL BLOCKERS; POTASSIUM CHLORIDE; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES; PULMONARY ARTERY; PYRAZOLES; RATS; RATS, WISTAR; RECEPTORS, CANNABINOID; RECEPTORS, EPOPROSTENOL; TETRAETHYLAMMONIUM; TRPV CATION CHANNELS; VASODILATION;

EID: 84864280145     PISSN: 10436618     EISSN: 10961186     Source Type: Journal    
DOI: 10.1016/j.phrs.2012.05.004     Document Type: Article

References (37)

1. M. Begg, P. Pacher, S. Bátkai, D. Osei-Hyiaman, L. Offetáler, and M.F. Mo Evidence for novel cannabinoid receptors Pharmacology & Therapeutics 106 2005 133 145 (Pubitemid 40613055)
2. V.E. Mendizábal, and E. Adler-Graschinsky Cannabinoids as therapeutic agents in cardiovascular disease: a tale of passions and illusions British Journal of Pharmacology 151 2007 427 440 (Pubitemid 46905012)
3. F. Montecucco, and V. Di Marzo At the heart of the matter: the endocannabinoid system in cardiovascular function and dysfunction Trends in Pharmacological Sciences 2012 [Epub ahead of print]
4. B. Malinowska, S. Łupiński, G. Godlewski, U. Baranowska, and E. Schlicker Role of endocannabinoids in cardiovascular shock Journal of Physiology and Pharmacology 59 Suppl. 8 2008 S91 S107
5. S. Bátkai, and P. Pacher Endocannabinoids and cardiac contractile function: pathophysiological implications Pharmacological Research 60 2009 99 106
6. M.D. Randall, D.A. Kendall, and S. O'Sullivan The complexities of the cardiovascular actions of cannabinoids British Journal of Pharmacology 142 2004 20 26 (Pubitemid 38698188)
7. S.E. O'Sullivan, D.A. Kendall, and M.D. Randall Heterogeneity in the mechanisms of vasorelaxation to anandamide in resistance and conduit rat mesenteric arteries British Journal of Pharmacology 142 2004 435 442 (Pubitemid 38869856)
8. E. Herradón, M.I. Martín, and V. López-Miranda Characterization of the vasorelaxant mechanisms of the endocannabinoid anandamide in rat aorta British Journal of Pharmacology 152 2007 699 708 (Pubitemid 350034972)
9. L. Offertáler, F.M. Mo, S. Bátkai, J. Liu, M. Begg, and R.K. Razdan Selective ligands and cellular effectors of a G protein-coupled endothelial cannabinoid receptor Molecular Pharmacology 63 2003 699 705 (Pubitemid 36297343)
10. 2 receptors Proceedings of the National Academy of Sciences of the United States of America 96 1999 14136 14141
11. J.A. Wagner, K. Varga, Z. Járai, and G. Kunos Mesenteric vasodilation mediated by endothelial anandamide receptors Hypertension 33 1999 429 434 (Pubitemid 29065697)
12. W.S. Ho, and C.R. Hiley Vasodilator actions of abnormal-cannabidiol in rat isolated small mesenteric artery British Journal of Pharmacology 138 2003 1320 1332 (Pubitemid 36543130)
13. H. Kozłowska, M. Baranowska, E. Schlicker, M. Kozłowski, J. Laudański, and B. Malinowska Identification of the vasodilatory endothelial cannabinoid receptor in the human pulmonary artery Journal of Hypertension 25 2007 2240 2248 (Pubitemid 47537917)
14. W.S. Ho, and C.R. Hiley Vasorelaxant activities of the putative endocannabinoid virodhamine in rat isolated small mesenteric artery Journal of Pharmacy and Pharmacology 56 2004 869 875 (Pubitemid 38885980)
15. H. Kozłowska, M. Baranowska, E. Schlicker, M. Kozłowski, J. Laudański, and B. Malinowska Virodhamine relaxes the human pulmonary through the endothelial cannabinoid receptor and indirectly through a COX product British Journal of Pharmacology 155 2008 1034 1042
16. F.F. Lam, P.W. Luk, and E.S. Ng Pharmacological characterization of receptor types mediating the dilator action of anandamide on blood vessels of the rat knee joint Life Sciences 80 2007 1495 1502 (Pubitemid 46399746)
17. A. Zakrzeska, E. Schlicker, M. Baranowska, H. Kozłowska, G. Kwolek, and B. Malinowska A cannabinoid receptor, sensitive to O-1918, is involved in the delayed hypotension induced by anandamide in anaesthetized rats British Journal of Pharmacology 160 2010 574 584
18. B.E. Van Hoozen, and C.E. Cross Marijuana. Respiratory tract effects Clinical Reviews in Allergy and Immunology 15 1997 243 269
19. D.P. Tashkin Smoked marijuana as a cause of lung injury Monaldi Archives for Chest Disease 63 2005 93 100 (Pubitemid 41167514)
20. H. Wahn, J. Wolf, F. Kram, S. Frantz, and J.A. Wagner The endocannabinoid arachidonyl ethanolamide (anandamide) increases pulmonary arterial pressure via cyclooxygenase-2 products in isolated rabbit lungs American Journal of Physiology: Heart and Circulatory Physiology 289 2005 H2491 H2496
21. A. Calignano, I. Kátona, F. Désarnaud, A. Giuffrida, G. La Rana, and K. Mackie Bidirectional control of airway responsiveness by endogenous cannabinoids Nature 408 2000 96 101
22. 9-tetrahydrocannabinol in conscious and morphine-chloralose-anesthetized dogs: anesthetic influence on drug action European Journal of Pharmacology 53 1978 63 68
23. 2 receptor linked to phospholipase C in calf pulmonary endothelial cells British Journal of Pharmacology 140 2003 1351 1362 (Pubitemid 38067842)
24. J.Y. Su, and A.C. Vo 2-Arachidonylglyceryl ether and abnormal cannabidiol-induced vascular smooth muscle relaxation in rabbit pulmonary arteries via receptor-pertussis toxin sensitive G proteins-ERK1/2 signaling European Journal of Pharmacology 59 2007 189 195 (Pubitemid 46295410)
25. Y. Dempsie, and M.R. MacLean Pulmonary hypertension: therapeutic targets within the serotonin system British Journal of Pharmacology 155 2008 455 462
26. D. Shao, J.E. Park, and S.J. Wort The role of endothelin-1 in the pathogenesis of pulmonary arterial hypertension Pharmacological Research 63 2011 504 511
27. M.J. Mulvany, and W. Halpern Contractile properties of small arterial resistance vessels in spontaneously hypertensive and normotensive rats Circulation Research 41 1977 19 26 (Pubitemid 8132079)
28. S. Guimarães, and D. Moura Vascular adrenoceptors: an update Pharmacological Reviews 53 2001 319 356 (Pubitemid 32476119)
29. M. Bernareggi, G. Rossoni, and F. Berti Bronchopulmonary effects of 8-epi-PGF2A in anaesthetised guinea pigs Pharmacological Research 37 1998 75 80 (Pubitemid 28068684)
30. W.S. Ho, and M.D. Randall Endothelium-dependent metabolism by endocannabinoid hydrolases and cyclooxygenases limits vasorelaxation to anandamide and 2-arachidonoylglycerol British Journal of Pharmacology 150 2007 641 651 (Pubitemid 46355564)
31. D.G. Deutsch, M.S. Goligorsky, P.C. Schmid, R.J. Krebsbach, H.H. Schmid, and S.K. Das Production and physiological actions of anandamide in the vasculature of the rat kidney Journal of Clinical Investigation 100 1997 1538 1546 (Pubitemid 27425781)
32. S. Holt, B. Paylor, L. Boldrup, K. Alajakku, S. Vandevoorde, and A. Sundström Inhibition of fatty acid amide hydrolase, a key endocannabinoid metabolizing enzyme, by analogues of ibuprofen and indomethacin European Journal of Pharmacology 565 2007 26 36 (Pubitemid 46782775)
33. 1B receptor/SERT antagonist in experimental pulmonary hypertension Cardiovascular Research 85 2010 593 603
34. 9-tetrahydrocannabinol in rat mesenteric vasculature, and its interactions with the endocannabinoid anandamide British Journal of Pharmacology 145 2005 514 526 (Pubitemid 40966281)
35. N. Parmar, and W.S. Ho N-arachidonoyl glycine, an endogenous lipid that acts as a vasorelaxant via nitric oxide and large conductance calcium-activated potassium channels British Journal of Pharmacology 160 2010 594 603
36. A.J. Wheal, S.P. Alexander, and M.D. Randall Vasorelaxation to N-oleoylethanolamine in rat isolated arteries: mechanisms of action and modulation via cyclooxygenase activity British Journal of Pharmacology 160 2010 701 711
37. + channels Journal of Pharmacology and Experimental Therapeutics 328 2009 351 361