Efficient recombinant production in mammalian cells using a novel IR/MAR gene amplification method

PLoS ONE

Volumn 7, Issue 7, 2012, Pages

  Araki, Yoshio ^a   Hamafuji, Tetsuro ^b   Noguchi, Chiemi ^a   Shimizu, Noriaki ^a  

^a HIROSHIMA UNIVERSITY   (Japan)

^b Transgenic Inc   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

RECOMBINANT ANTIBODY;

ANIMAL CELL; ANTIBODY PRODUCTION; ARTICLE; CELL CLONE; CELL LINE; CELL TYPE; CONTROLLED STUDY; CULTURE MEDIUM; GENE AMPLIFICATION; GENE REPLICATION; HUMAN; HUMAN CELL; IR MAR GENE AMPLIFICATION; MATRIX ATTACHMENT REGION; NONHUMAN; PLASMID; PROTEIN EXPRESSION; RECOMBINANT DNA TECHNOLOGY; REPLICATION INITIATION REGION; STABLE EXPRESSION; SUSPENSION CELL CULTURE;

ANIMALS; CELL LINE, TUMOR; CHO CELLS; CRICETINAE; CRICETULUS; DNA REPLICATION; DNA, RECOMBINANT; GENETIC ENGINEERING; HUMANS; IMMUNOGLOBULIN G; MATRIX ATTACHMENT REGIONS; NUCLEIC ACID AMPLIFICATION TECHNIQUES; PLASMIDS; TRANSFECTION;

ANIMALIA; MAMMALIA;

EID: 84864262986     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0041787     Document Type: Article

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