Plasmids with a mammalian replication origin and a matrix attachment region initiate the event similar to gene amplification

Cancer Research

Volumn 61, Issue 19, 2001, Pages 6987-6990

  Shimizu, N ^a   Miura, Y ^a   Sakamoto, Y ^a   Tsutsui, K ^a  

^a HIROSHIMA UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; CELL NUCLEUS MATRIX; CHROMOSOME REPLICATION; DOUBLE MINUTE CHROMOSOME; GENE AMPLIFICATION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; PLASMID; PRIORITY JOURNAL; TUMOR GROWTH;

COLORECTAL NEOPLASMS; DNA REPLICATION; GENE AMPLIFICATION; HELA CELLS; HUMANS; NUCLEAR MATRIX; PLASMIDS; REPLICATION ORIGIN; TRANSFECTION; TUMOR CELLS, CULTURED;

EID: 0035476928     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (24)

1. Double minute chromosomes and homogeneously staining regions in tumors taken directly from patients versus in human tumor cell lines
2. Loss of amplified c-myc genes in the spontaneously differentiated HL-60 cells
3. Elimination of extrachromosomally amplified MYC genes from human tumor cells reduces their tumorigenicity
4. Induction of differentiation in HL60 cells by the reduction of extrachromosomally amplified c-myc
5. Selective capture of acentric fragments by micronuclei provides a rapid method for purifying extrachromosomally amplified DNA
6. Selective elimination of acentric double minutes from cancer cells through the extrusion of micronuclei
7. Induced detachment of acentric chromatin from mitotic chromosomes leads to their cytoplasmic localization at G I and the micronucleation by lamin reorganization at S phase
8. Have double minutes functioning centromeres?
9. Histone-GFP fusion protein enables sensitive analysis of chromosome dynamics in living mammalian cells
10. Segregation of viral plasmids depends on tethering to chromosomes and is regulated by phosphorylation
11. Mapping EBNA-1 domains involved in binding to metaphase chromosomes
12. Efficient persistence of extrachromosomal KSHV DNA mediated by latency-associated nuclear antigen
13. Mitotic stability of an episomal vector containing a human scaffold/matrix-attached region is provided by association with nuclear matrix
14. Mitotic segregation of viral and cellular acentric extrachromosomal molecules by chromosome tethering
15. On the relationship of matrix association and DNA replication
16. Matrix attachment regions are positioned near replication initiation sites, genes, and an interamplicon junction in the amplified dihydrofolate reductase domain of Chinese hamster ovary cells
17. Autonomous replication of a DNA fragment containing the chromosomal replication origin of the human c-myc gene
18. Identification within the simian virus 40 genome of a chromosomal loop attachment site that contains topoisomerase II cleavage sites
19. Identification and characterization of a nuclear scaffold protein that binds the matrix attachment region DNA
20. Selective entrapment of extrachromosomally amplified DNA by nuclear budding and micronucleation during S-phase
21. DNA replication-dependent intranuclear relocation of double minute chromatin
22. Computer-assisted search for sites of nuclear matrix attachment
23. The importance of circular DNA in mammalian gene amplification
24. Extrachromosomal circular DNAs and genomic sequence plasticity in eukaryotic cells