Imaging for endovascular stroke therapy

Acute Ischemic Stroke: Imaging and Intervention

Volumn , Issue , 2006, Pages 245-265

  Yoo, Albert J ^a   Nogueira, Raul G ^a   Hakimelahi, Reza ^a   Gilberto Gonzalez R ^a   Hirsch, Joshua A ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 84864226940     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1007/978-3-642-12751-9_12     Document Type: Chapter

References (167)

1. Hirsch J, Yoo AJ, Nogueira RG, Verduzco LA, Schwamm LH, Pryor JC, Rabinov JD, Gonzalez RG (2009) Case volumes of intra-arterial and intravenous treatment of ischemic stroke in the U. S. J NeuroInterv Surg 1:27-31
2. Lloyd-Jones D, Adams R, Carnethon M et al (2009) Heart disease and stroke statistics-2009 update: a report from the American Heart Association Statistics Committee and Stroke Statistics Subcommittee. Circulation 119:e21-e181
3. Higashida RT, Furlan AJ, Roberts H et al (2003) Trial design and reporting standards for intra-arterial cerebral thrombolysis for acute ischemic stroke. Stroke 34:e109-e137
4. Torres-Mozqueda F, He J, Yeh IB et al (2008) An acute ischemic stroke classification instrument that includes CT or MR angiography: the Boston Acute Stroke Imaging Scale. AJNR Am J Neuroradiol 29:1111-1117
5. Smith WS, Tsao JW, Billings ME et al (2006) Prognostic significance of angiographically confirmed large vessel intracranial occlusion in patients presenting with acute brain ischemia. Neurocrit Care 4:14-17
6. Smith WS, Sung G, Saver J et al (2008) Mechanical thrombectomy for acute ischemic stroke: final results of the Multi MERCI trial. Stroke 39:1205-1212
7. Lindsberg PJ, Mattle HP (2006) Therapy of basilar artery occlusion: a systematic analysis comparing intra-arterial and intravenous thrombolysis. Stroke 37:922-928
8. Smith WS (2007) Intra-arterial thrombolytic therapy for acute basilar occlusion: pro. Stroke 38:701-703
9. Rha JH, Saver JL (2007) The impact of recanalization on ischemic stroke outcome: a meta-analysis. Stroke 38:967-973
10. Lisboa RC, Jovanovic BD, Alberts MJ (2002) Analysis of the safety and efficacy of intra-arterial thrombolytic therapy in ischemic stroke. Stroke 33:2866-2871
11. Wolpert SM, Bruckmann H, Greenlee R et al (1993) Neuroradiologic evaluation of patients with acute stroke treated with recombinant tissue plasminogen activator. The rt-PA Acute Stroke Study Group. AJNR Am J Neuroradiol 14:3-13
12. Furlan A, Higashida R, Wechsler L et al (1999) Intra-arterial prourokinase for acute ischemic stroke. The PROACT II study: a randomized controlled trial. Prolyse in Acute Cerebral Thromboembolism. JAMA 282:2003-2011
13. Lee KY, Han SW, Kim SH et al (2007) Early recanalization after intravenous administration of recombinant tissue plasminogen activator as assessed by pre- and post-thrombolytic angiography in acute ischemic stroke patients. Stroke 38:192-193
14. Smith WS, Sung G, Starkman S et al (2005) Safety and efficacy of mechanical embolectomy in acute ischemic stroke: results of the MERCI trial. Stroke 36:1432-1438
15. Penumbra Pivotal Stroke Trial Investigators (2009) The penumbra pivotal stroke trial: safety and effectiveness of a new generation of mechanical devices for clot removal in intracranial large vessel occlusive disease. Stroke 40:2761-2768
16. Wechsler LR (2006) Does the Merci Retriever work? Against. Stroke 37:1341-1342; discussion 1342-1343
17. Ciccone A, Valvassori L, Gasparotti R et al (2007) Debunking 7 myths that hamper the realization of randomized controlled trials on intra-arterial thrombolysis for acute ischemic stroke. Stroke 38:2191-2195
18. Gonzalez RG (2006) Imaging-guided acute ischemic stroke therapy: from "time is brain" to "physiology is brain". AJNR Am J Neuroradiol 27:728-735
19. Caplan LR (2006) Stroke thrombolysis: slow progress. Circulation 114:187-190
20. Schellinger PD, Fiebach JB, Mohr A et al (2001) Thrombolytic therapy for ischemic stroke-a review. Part II-Intra-arterial thrombolysis, vertebrobasilar stroke, phase IV trials, and stroke imaging. Crit Care Med 29:1819-1825
21. Davis SM, Donnan GA (2006) Basilar artery thrombosis: recanalization is the key. Stroke 37:2440
22. Maas MB, Furie KL, Lev MH et al (2009) National Institutes of Health Stroke Scale score is poorly predictive of proximal occlusion in acute cerebral ischemia. Stroke 40:2988-2993
23. Smith WS, Lev MH, English JD et al (2009) Significance of large vessel intracranial occlusion causing acute ischemic stroke and TIA. Stroke 40(12):3834-3840
24. Sims JR, Rordorf G, Smith EE et al (2005) Arterial occlusion revealed by CT angiography predicts NIH stroke score and acute outcomes after IV tPA treatment. AJNR Am J Neuroradiol 26:246-251
25. Latchaw RE, Alberts MJ, Lev MH et al (2009) Recommendations for imaging of acute ischemic stroke. A Scientific Statement From the American Heart Association. Stroke 40(11):3646-3678
26. Lev MH, Farkas J, Rodriguez VR et al (2001) CT angiography in the rapid triage of patients with hyperacute stroke to intraarterial thrombolysis: accuracy in the detection of large vessel thrombus. J Comput Assist Tomogr 25:520-528
27. Bash S, Villablanca JP, Jahan R et al (2005) Intracranial vascular stenosis and occlusive disease: evaluation with CT angiography, MR angiography, and digital subtraction angiography. AJNR Am J Neuroradiol 26:1012-1021
28. Tomanek AI, Coutts SB, Demchuk AM et al (2006) MR angiography compared to conventional selective angiography in acute stroke. Can J Neurol Sci 33:58-62
29. Cipriano LE, Steinberg ML, Gazelle GS et al (2009) Comparing and predicting the costs and outcomes of patients with major and minor stroke using the Boston Acute Stroke Imaging Scale Neuroimaging Classification System. AJNR Am J Neuroradiol 30(4):703-709
30. Staroselskaya IA, Chaves C, Silver B et al (2001) Relationship between magnetic resonance arterial patency and perfusion-diffusion mismatch in acute ischemic stroke and its potential clinical use. Arch Neurol 58:1069-1074
31. Arnold M, Nedeltchev K, Brekenfeld C et al (2004) Outcome of acute stroke patients without visible occlusion on early arteriography. Stroke 35:1135-1138
32. Arnold M, Nedeltchev K, Mattle HP et al (2003) Intraarterial thrombolysis in 24 consecutive patients with internal carotid artery T occlusions. J Neurol Neurosurg Psychiatr 74:739-742
33. Eckert B, Kucinski T, Neumaier-Probst E et al (2003) Local intra-arterial fibrinolysis in acute hemispheric stroke: effect of occlusion type and fibrinolytic agent on recanalization success and neurological outcome. Cerebrovasc Dis 15:258-263
34. Barreto AD, Albright KC, Hallevi H et al (2008) Thrombus burden is associated with clinical outcome after intra-arterial therapy for acute ischemic stroke. Stroke 39:3231-3235
35. Tan IY, Demchuk AM, Hopyan J et al (2009) CT angiography clot burden score and collateral score: correlation with clinical and radiologic outcomes in acute middle cerebral artery infarct. AJNR Am J Neuroradiol 30:525-531
36. Zaidat OO, Suarez JI, Santillan C et al (2002) Response to intra-arterial and combined intravenous and intra-arterial thrombolytic therapy in patients with distal internal carotid artery occlusion. Stroke 33:1821-1826
37. Gupta R, Vora NA, Horowitz MB et al (2006) Multimodal reperfusion therapy for acute ischemic stroke: factors predicting vessel recanalization. Stroke 37:986-990
38. Fiehler J, Knudsen K, Thomalla G et al (2005) Vascular occlusion sites determine differences in lesion growth from early apparent diffusion coefficient lesion to final infarct. AJNR Am J Neuroradiol 26:1056-1061
39. Nakano S, Iseda T, Kawano H et al (2001) Correlation of early CT signs in the deep middle cerebral artery territories with angiographically confirmed site of arterial occlusion. AJNR Am J Neuroradiol 22:654-659
40. Liebeskind DS (2003) Collateral circulation. Stroke 34:2279-2284
41. Derex L, Hermier M, Adeleine P et al (2004) Influence of the site of arterial occlusion on multiple baseline hemodynamic MRI parameters and post-thrombolytic recanalization in acute stroke. Neuroradiology 46:883-887
42. Kucinski T, Naumann D, Knab R et al (2005) Tissue at risk is overestimated in perfusion-weighted imaging: MR imaging in acute stroke patients without vessel recanalization. AJNR Am J Neuroradiol 26:815-819
43. Yoo AJ, Verduzco LA, Schaefer PW et al (2009) MRIbased selection for intra-arterial stroke therapy: value of pretreatment diffusion-weighted imaging lesion volume in selecting patients with acute stroke who will benefit from early recanalization. Stroke 40:2046-2054
44. Arenillas JF, Rovira A, Molina CA et al (2002) Prediction of early neurological deterioration using diffusion- and perfusion-weighted imaging in hyperacute middle cerebral artery ischemic stroke. Stroke 33:2197-2203
45. Parsons MW, Christensen S, McElduff P et al (2010) Pretreatment diffusion- and perfusion-MR lesion volumes have a crucial influence on clinical response to stroke thrombolysis. J Cereb Blood Flow Metab 30:1214-1225
46. Gasparotti R, Grassi M, Mardighian D et al (2009) Perfusion CT in patients with acute ischemic stroke treated with intraarterial thrombolysis: predictive value of infarct core size on clinical outcome. AJNR Am J Neuroradiol 30:722-727
47. Cloft HJ, Rabinstein A, Lanzino G et al (2009) Intra-arterial stroke therapy: an assessment of demand and available work force. AJNR Am J Neuroradiol 30:453-458
48. van der Zwan A, Hillen B, Tulleken CA et al (1993) A quantitative investigation of the variability of the major cerebral arterial territories. Stroke 24:1951-1959
49. Hakimelahi R, Copen WA, Schaefer PW, Wu O, Yoo AJ, Schwamm LH, Gonzalez RG (2009) A small DWI lesion in the setting of an anterior circulation proximal artery occlusion predicts the presence of a large diffusion-perfusion mismatch. American Society of Neuroradiology Annual Meeting, Vancouver, British Columbia
50. Jovin TG, Yonas H, Gebel JM et al (2003) The cortical ischemic core and not the consistently present penumbra is a determinant of clinical outcome in acute middle cerebral artery occlusion. Stroke 34:2426-2433
51. Thomalla GJ, Kucinski T, Schoder V et al (2003) Prediction of malignant middle cerebral artery infarction by early perfusionand diffusion-weighted magnetic resonance imaging. Stroke 34:1892-1899
52. Oppenheim C, Samson Y, Manai R et al (2000) Prediction of malignant middle cerebral artery infarction by diffusionweighted imaging. Stroke 31:2175-2181
53. Albers GW, Thijs VN, Wechsler L et al (2006) Magnetic resonance imaging profiles predict clinical response to early reperfusion: the diffusion and perfusion imaging evaluation for understanding stroke evolution (DEFUSE) study. Ann Neurol 60:508-517
54. Lansberg MG, Thijs VN, Bammer R et al (2008) The MRADWI mismatch identifies patients with stroke who are likely to benefit from reperfusion. Stroke 39:2491-2496
55. Lo EH, Dalkara T, Moskowitz MA (2003) Mechanisms, challenges and opportunities in stroke. Nat Rev Neurosci 4:399-415
56. Mullins ME, Schaefer PW, Sorensen AG et al (2002) CT and conventional and diffusion-weighted MR imaging in acute stroke: study in 691 patients at presentation to the emergency department. Radiology 224:353-360
57. Gonzalez RG, Schaefer PW, Buonanno FS et al (1999) Diffusion-weighted MR imaging: diagnostic accuracy in patients imaged within 6 hours of stroke symptom onset. Radiology 210:155-162
58. Fiebach JB, Schellinger PD, Jansen O et al (2002) CT and diffusion-weighted MR imaging in randomized order: diffusionweighted imaging results in higher accuracy and lower interrater variability in the diagnosis of hyperacute ischemic stroke. Stroke 33:2206-2210
59. Heiss WD, Sobesky J, Smekal U et al (2004) Probability of cortical infarction predicted by flumazenil binding and diffusionweighted imaging signal intensity: a comparative positron emission tomography/magnetic resonance imaging study in early ischemic stroke. Stroke 35:1892-1898
60. Grant PE, He J, Halpern EF et al (2001) Frequency and clinical context of decreased apparent diffusion coefficient reversal in the human brain. Radiology 221:43-50
61. Kidwell CS, Saver JL, Starkman S et al (2002) Late secondary ischemic injury in patients receiving intraarterial thrombolysis. Ann Neurol 52:698-703
62. Schaefer PW, Hassankhani A, Putman C et al (2004) Characterization and evolution of diffusion MR imaging abnormalities in stroke patients undergoing intra-arterial thrombolysis. AJNR Am J Neuroradiol 25:951-957
63. Kidwell CS, Saver JL, Mattiello J et al (2000) Thrombolytic reversal of acute human cerebral ischemic injury shown by diffusion/perfusion magnetic resonance imaging. Ann Neurol 47:462-469
64. Fiehler J, Knudsen K, Kucinski T et al (2004) Predictors of apparent diffusion coefficient normalization in stroke patients. Stroke 35:514-519
65. Olivot JM, Mlynash M, Thijs VN et al (2009) Relationships between cerebral perfusion and reversibility of acute diffusion lesions in DEFUSE: insights from RADAR. Stroke 40:1692-1697
66. Chalela JA, Kang DW, Luby M et al (2004) Early magnetic resonance imaging findings in patients receiving tissue plasminogen activator predict outcome: insights into the pathophysiology of acute stroke in the thrombolysis era. Ann Neurol 55:105-112
67. Wintermark M, Flanders AE, Velthuis B et al (2006) Perfusion-CT assessment of infarct core and penumbra: receiver operating characteristic curve analysis in 130 patients suspected of acute hemispheric stroke. Stroke 37:979-985
68. Kohrmann M, Schellinger PD (2009) Acute stroke triage to intravenous thrombolysis and other therapies with advanced CT or MR imaging: pro MR imaging. Radiology 251:627-633
69. von Kummer R, Bourquain H, Bastianello S et al (2001) Early prediction of irreversible brain damage after ischemic stroke at CT. Radiology 219:95-100
70. Barber PA, Demchuk AM, Zhang J et al (2000) Validity and reliability of a quantitative computed tomography score in predicting outcome of hyperacute stroke before thrombolytic therapy. ASPECTS Study Group. Alberta Stroke Programme Early CT Score. Lancet 355:1670-1674
71. Hill MD, Rowley HA, Adler F et al (2003) Selection of acute ischemic stroke patients for intra-arterial thrombolysis with pro-urokinase by using ASPECTS. Stroke 34:1925-1931
72. Hill MD, Demchuk AM, Tomsick TA et al (2006) Using the baseline CT scan to select acute stroke patients for IV-IA therapy. AJNR Am J Neuroradiol 27:1612-1616
73. Wintermark M, Reichhart M, Cuisenaire O et al (2002) Comparison of admission perfusion computed tomography and qualitative diffusion- and perfusion-weighted magnetic resonance imaging in acute stroke patients. Stroke 33:2025-2031
74. Kucinski T, Vaterlein O, Glauche V et al (2002) Correlation of apparent diffusion coefficient and computed tomography density in acute ischemic stroke. Stroke 33:1786-1791
75. Pexman JH, Barber PA, Hill MD et al (2001) Use of the Alberta Stroke Program Early CT Score (ASPECTS) for assessing CT scans in patients with acute stroke. AJNR Am J Neuroradiol 22:1534-1542
76. Butcher KS, Lee SB, Parsons MW et al (2007) Differential prognosis of isolated cortical swelling and hypoattenuation on CT in acute stroke. Stroke 38:941-947
77. Parsons MW, Pepper EM, Bateman GA et al (2007) Identification of the penumbra and infarct core on hyperacute noncontrast and perfusion CT. Neurology 68:730-736
78. Wintermark M, Fischbein NJ, Smith WS et al (2005) Accuracy of dynamic perfusion CT with deconvolution in detecting acute hemispheric stroke. AJNR Am J Neuroradiol 26:104-112
79. Scharf J, Brockmann MA, Daffertshofer M et al (2006) Improvement of sensitivity and interrater reliability to detect acute stroke by dynamic perfusion computed tomography and computed tomography angiography. J Comput Assist Tomogr 30:105-110
80. Muir KW, Halbert HM, Baird TA et al (2006) Visual evaluation of perfusion computed tomography in acute stroke accurately estimates infarct volume and tissue viability. J Neurol Neurosurg Psychiatry 77:334-339
81. Murphy BD, Fox AJ, Lee DH et al (2008) White matter thresholds for ischemic penumbra and infarct core in patients with acute stroke: CT perfusion study. Radiology 247:818-825
82. Schaefer PW, Barak ER, Kamalian S et al (2008) Quantitative assessment of core/penumbra mismatch in acute stroke. CT and MR perfusion imaging are strongly correlated when sufficient brain volume is imaged. Stroke 39(11):2986-2992
83. Konstas AA, Goldmakher GV, Lee TY et al (2009) Theoretic basis and technical implementations of CT perfusion in acute ischemic stroke, part 2: technical implementations. AJNR Am J Neuroradiol 30:885-892
84. Youn SW, Kim JH, Weon YC et al (2008) Perfusion CT of the brain using 40-mm-wide detector and toggling table technique for initial imaging of acute stroke. AJR Am J Roentgenol 191:W120-W126
85. Calamante F, Gadian DG, Connelly A (2000) Delay and dispersion effects in dynamic susceptibility contrast MRI: simulations using singular value decomposition. Magn Reson Med 44:466-473
86. Kudo K, Sasaki M, Ogasawara K et al (2009) Difference in tracer delay-induced effect among deconvolution algorithms in CT perfusion analysis: quantitative evaluation with digital phantoms. Radiology 251:241-249
87. Calamante F, Gadian DG, Connelly A (2002) Quantification of perfusion using bolus tracking magnetic resonance imaging in stroke: assumptions, limitations, and potential implications for clinical use. Stroke 33:1146-1151
88. Takasawa M, Jones PS, Guadagno JV et al (2008) How reliable is perfusion MR in acute stroke? Validation and determination of the penumbra threshold against quantitative PET. Stroke 39:870-877
89. Fiorella D, Heiserman J, Prenger E et al (2004) Assessment of the reproducibility of postprocessing dynamic CT perfusion data. AJNR Am J Neuroradiol 25:97-107
90. Hacke W, Furlan AJ, Al-Rawi Y et al (2009) Intravenous desmoteplase in patients with acute ischaemic stroke selected by MRI perfusion-diffusion weighted imaging or perfusion CT (DIAS-2): a prospective, randomised, doubleblind, placebo-controlled study. Lancet Neurol 8:141-150
91. Ezzeddine MA, Lev MH, McDonald CT et al (2002) CT angiography with whole brain perfused blood volume imaging: added clinical value in the assessment of acute stroke. Stroke 33:959-966
92. Camargo EC, Furie KL, Singhal AB et al (2007) Acute brain infarct: detection and delineation with CT angiographic source images versus nonenhanced CT scans. Radiology 244:541-548
93. Hamberg LM, Hunter GJ, Kierstead D et al (1996) Measurement of cerebral blood volume with subtraction three-dimensional functional CT. AJNR Am J Neuroradiol 17:1861-1869
94. Hunter GJ, Silvennoinen HM, Hamberg LM et al (2003) Whole-brain CT perfusion measurement of perfused cerebral blood volume in acute ischemic stroke: probability curve for regional infarction. Radiology 227:725-730
95. Schramm P, Schellinger PD, Fiebach JB et al (2002) Comparison of CT and CT angiography source images with diffusion-weighted imaging in patients with acute stroke within 6 hours after onset. Stroke 33:2426-2432
96. Lev MH, Segal AZ, Farkas J et al (2001) Utility of perfusionweighted CT imaging in acute middle cerebral artery stroke treated with intra-arterial thrombolysis: prediction of final infarct volume and clinical outcome. Stroke 32:2021-2028
97. Hu R, Yoo AJ, Hakimelahi R, Lev MH, Nogueira RG, Hirsch JA, Gonzalez RG, Schaefer PW (2010) CTA source images in the era of fast, volume CT scanning: are they still "DWI" weighted? International Stroke Conference, San Antonio, TX
98. Fiebach J, Jansen O, Schellinger P et al (2001) Comparison of CT with diffusion-weighted MRI in patients with hyperacute stroke. Neuroradiology 43:628-632
99. Marchal G, Beaudouin V, Rioux P et al (1996) Prolonged persistence of substantial volumes of potentially viable brain tissue after stroke: a correlative PET-CT study with voxel-based data analysis. Stroke 27:599-606
100. Baird AE, Benfield A, Schlaug G et al (1997) Enlargement of human cerebral ischemic lesion volumes measured by diffusion-weighted magnetic resonance imaging. Ann Neurol 41:581-589
101. Furlan M, Marchal G, Viader F et al (1996) Spontaneous neurological recovery after stroke and the fate of the ischemic penumbra. Ann Neurol 40:216-226
102. Jones TH, Morawetz RB, Crowell RM et al (1981) Thresholds of focal cerebral ischemia in awake monkeys. J Neurosurg 54:773-782
103. Baron JC (2001) Perfusion thresholds in human cerebral ischemia: historical perspective and therapeutic implications. Cerebrovasc Dis 11 Suppl 1:2-8
104. Heiss WD, Kracht LW, Thiel A et al (2001) Penumbral probability thresholds of cortical flumazenil binding and blood flow predicting tissue outcome in patients with cerebral ischaemia. Brain 124:20-29
105. Christoforidis GA, Mohammad Y, Kehagias D et al (2005) Angiographic assessment of pial collaterals as a prognostic indicator following intra-arterial thrombolysis for acute ischemic stroke. AJNR Am J Neuroradiol 26:1789-1797
106. Kucinski T, Koch C, Eckert B et al (2003) Collateral circulation is an independent radiological predictor of outcome after thrombolysis in acute ischaemic stroke. Neuroradiology 45:11-18
107. Bang OY, Saver JL, Buck BH et al (2008) Impact of collateral flow on tissue fate in acute ischaemic stroke. J Neurol Neurosurg Psychiatr 79:625-629
108. Davalos A, Blanco M, Pedraza S et al (2004) The clinical-DWI mismatch: a new diagnostic approach to the brain tissue at risk of infarction. Neurology 62:2187-2192
109. Prosser J, Butcher K, Allport L et al (2005) Clinicaldiffusion mismatch predicts the putative penumbra with high specificity. Stroke 36:1700-1704
110. Warach S (2001) Tissue viability thresholds in acute stroke: the 4-factor model. Stroke 32:2460-2461
111. Konstas AA, Goldmakher GV, Lee TY et al (2009) Theoretic basis and technical implementations of CT perfusion in acute ischemic stroke, part 1: theoretic basis. AJNR Am J Neuroradiol 30:662-668
112. Butcher KS, Parsons M, MacGregor L et al (2005) Refining the perfusion-diffusion mismatch hypothesis. Stroke 36:1153-1159
113. Kane I, Carpenter T, Chappell F et al (2007) Comparison of 10 different magnetic resonance perfusion imaging processing methods in acute ischemic stroke: effect on lesion size, proportion of patients with diffusion/perfusion mismatch, clinical scores, and radiologic outcomes. Stroke 38:3158-3164
114. Ostergaard L, Weisskoff RM, Chesler DA et al (1996) High resolution measurement of cerebral blood flow using intravascular tracer bolus passages. Part I: mathematical approach and statistical analysis. Magn Reson Med 36:715-725
115. Yamada K, Wu O, Gonzalez RG et al (2002) Magnetic resonance perfusion-weighted imaging of acute cerebral infarction: effect of the calculation methods and underlying vasculopathy. Stroke 33:87-94
116. Christensen S, Mouridsen K, Wu O et al (2009) Comparison of 10 perfusion MRI parameters in 97 sub-6-hour stroke patients using voxel-based receiver operating characteristics analysis. Stroke 40:2055-2061
117. Grandin CB, Duprez TP, Smith AM et al (2002) Which MR-derived perfusion parameters are the best predictors of infarct growth in hyperacute stroke? Comparative study between relative and quantitative measurements. Radiology 223:361-370
118. Schellinger PD, Thomalla G, Fiehler J et al (2007) MRIbased and CT-based thrombolytic therapy in acute stroke within and beyond established time windows: an analysis of 1210 patients. Stroke 38:2640-2645
119. Thomalla G, Schwark C, Sobesky J et al (2006) Outcome and symptomatic bleeding complications of intravenous thrombolysis within 6 hours in MRI-selected stroke patients: comparison of a German multicenter study with the pooled data of ATLANTIS, ECASS, and NINDS tPA trials. Stroke 37:852-858
120. Schlaug G, Benfield A, Baird AE et al (1999) The ischemic penumbra: operationally defined by diffusion and perfusion MRI. Neurology 53:1528-1537
121. Sorensen AG, Buonanno FS, Gonzalez RG et al (1996) Hyperacute stroke: evaluation with combined multisection diffusion-weighted and hemodynamically weighted echoplanar MR imaging. Radiology 199:391-401
122. Sunshine JL, Tarr RW, Lanzieri CF, Landis D M D, Selman WR, Lewin JS (1999) Hyperacute stroke: ultrafast MR imaging to triage patients prior to therapy. Radiology 212:325-332
123. Barber PA, Darby DG, Desmond PM et al (1998) Prediction of stroke outcome with echoplanar perfusion- and diffusionweighted MRI. Neurology 51:418-426
124. Davis SM, Donnan GA, Parsons MW et al (2008) Effects of alteplase beyond 3 h after stroke in the Echoplanar Imaging Thrombolytic Evaluation Trial (EPITHET): a placebo-controlled randomised trial. Lancet Neurol 7:299-309
125. Olivot JM, Mlynash M, Thijs VN et al (2008) Relationships between infarct growth, clinical outcome, and early recanalization in diffusion and perfusion imaging for understanding stroke evolution (DEFUSE). Stroke 39:2257-2263
126. Wintermark M, Meuli R, Browaeys P et al (2007) Comparison of CT perfusion and angiography and MRI in selecting stroke patients for acute treatment. Neurology 68:694-697
127. Schramm P, Schellinger PD, Klotz E et al (2004) Comparison of perfusion computed tomography and computed tomography angiography source images with perfusionweighted imaging and diffusion-weighted imaging in patients with acute stroke of less than 6 hours' duration. Stroke 35:1652-1658
128. Hacke W, Albers G, Al-Rawi Y et al (2005) The Desmoteplase in Acute Ischemic Stroke Trial (DIAS): a phase II MRI-based 9-hour window acute stroke thrombolysis trial with intravenous desmoteplase. Stroke 36:66-73
129. Ribo M, Molina CA, Rovira A et al (2005) Safety and efficacy of intravenous tissue plasminogen activator stroke treatment in the 3-to 6-hour window using multimodal transcranial Doppler/MRI selection protocol. Stroke 36:602-606
130. Rother J, Schellinger PD, Gass A et al (2002) Effect of intravenous thrombolysis on MRI parameters and functional outcome in acute stroke <6 hours. Stroke 33:2438-2445
131. Kane I, Sandercock P, Wardlaw J (2007) Magnetic resonance perfusion diffusion mismatch and thrombolysis in acute ischaemic stroke: a systematic review of the evidence to date. J Neurol Neurosurg Psychiatr 78:485-491
132. Schabitz WR (2009) MR mismatch is useful for patient selection for thrombolysis: no. Stroke 40:2908-2909
133. Furlan AJ, Eyding D, Albers GW et al (2006) Dose escalation of desmoteplase for acute ischemic stroke (DEDAS): evidence of safety and efficacy 3 to 9 hours after stroke onset. Stroke 37:1227-1231
134. Davis SM, Donnan GA (2009) MR mismatch and thrombolysis: appealing but validation required. Stroke 40:2910
135. Kakuda W, Lansberg MG, Thijs VN et al (2008) Optimal definition for PWI/DWI mismatch in acute ischemic stroke patients. J Cereb Blood Flow Metab 28:887-891
136. Butcher KS, Parsons MW, Davis S et al (2003) PWI/DWI mismatch: better definition required. Stroke 34:e215-e216; author reply e215-e216
137. Coutts SB, Simon JE, Tomanek AI et al (2003) Reliability of assessing percentage of diffusion-perfusion mismatch. Stroke 34:1681-1683
138. Sobesky J, Zaro Weber O, Lehnhardt FG et al (2005) Does the mismatch match the penumbra? Magnetic resonance imaging and positron emission tomography in early ischemic stroke. Stroke 36:980-985
139. Heiss WD, Sobesky J, Hesselmann V (2004) Identifying thresholds for penumbra and irreversible tissue damage. Stroke 35:2671-2674
140. Olivot JM, Mlynash M, Thijs VN et al (2009) Optimal Tmax threshold for predicting penumbral tissue in acute stroke. Stroke 40:469-475
141. Kidwell CS, Alger JR, Saver JL (2004) Evolving paradigms in neuroimaging of the ischemic penumbra. Stroke 35:2662-2665
142. Parsons MW, Yang Q, Barber PA et al (2001) Perfusion magnetic resonance imaging maps in hyperacute stroke: relative cerebral blood flow most accurately identifies tissue destined to infarct. Stroke 32:1581-1587
143. Neumann-Haefelin T, Wittsack HJ, Wenserski F et al (1999) Diffusion- and perfusion-weighted MRI. The DWI/PWI mismatch region in acute stroke. Stroke 30:1591-1597
144. Shih LC, Saver JL, Alger JR et al (2003) Perfusion-weighted magnetic resonance imaging thresholds identifying core, irreversibly infarcted tissue. Stroke 34:1425-1430
145. Sobesky J, Zaro Weber O, Lehnhardt FG et al (2004) Which time-to-peak threshold best identifies penumbral flow? A comparison of perfusion-weighted magnetic resonance imaging and positron emission tomography in acute ischemic stroke. Stroke 35:2843-2847
146. Neumann-Haefelin T, Wittsack HJ, Fink GR et al (2000) Diffusion- and perfusion-weighted MRI: influence of severe carotid artery stenosis on the DWI/PWI mismatch in acute stroke. Stroke 31:1311-1317
147. Kim SJ, Seok JM, Bang OY et al (2009) MR mismatch profiles in patients with intracranial atherosclerotic stroke: a comprehensive approach comparing stroke subtypes. J Cereb Blood Flow Metab 29:1138-1145
148. Hirano T, Read SJ, Abbott DF et al (2001) Prediction of the final infarct volume within 6 h of stroke using single photon emission computed tomography with technetium-99m hexamethylpropylene amine oxime. Cerebrovasc Dis 11:119-127
149. Thijs VN, Adami A, Neumann-Haefelin T et al (2001) Relationship between severity of MR perfusion deficit and DWI lesion evolution. Neurology 57:1205-1211
150. Bandera E, Botteri M, Minelli C et al (2006) Cerebral blood flow threshold of ischemic penumbra and infarct core in acute ischemic stroke: a systematic review. Stroke 37:1334-1339
151. Janjua N, El-Gengaihy A, Pile-Spellman J et al (2009) Late endovascular revascularization in acute ischemic stroke based on clinical-diffusion mismatch. AJNR Am J Neuroradiol 30:1024-1027
152. Natarajan SK, Snyder KV, Siddiqui AH et al (2009) Safety and effectiveness of endovascular therapy after 8 hours of acute ischemic stroke onset and wake-up strokes. Stroke 40:3269-3274
153. Khatri P, Wechsler LR, Broderick JP (2007) Intracranial hemorrhage associated with revascularization therapies. Stroke 38:431-440
154. Berger C, Fiorelli M, Steiner T et al (2001) Hemorrhagic transformation of ischemic brain tissue: asymptomatic or symptomatic? Stroke 32:1330-1335
155. Anon (1995) Tissue plasminogen activator for acute ischemic stroke. The National Institute of Neurological Disorders and Stroke rt-PA Stroke Study Group. N Engl J Med 333:1581-1587
156. Trouillas P, von Kummer R (2006) Classification and pathogenesis of cerebral hemorrhages after thrombolysis in ischemic stroke. Stroke 37:556-561
157. Paciaroni M, Agnelli G, Corea F et al (2008) Early hemorrhagic transformation of brain infarction: rate, predictive factors, and influence on clinical outcome: results of a prospective multicenter study. Stroke 39:2249-2256
158. Fiorelli M, Bastianello S, von Kummer R et al (1999) Hemorrhagic transformation within 36 hours of a cerebral infarct: relationships with early clinical deterioration and 3-month outcome in the European Cooperative Acute Stroke Study I (ECASS I) cohort. Stroke 30:2280-2284
159. Brekenfeld C, Remonda L, Nedeltchev K et al (2007) Symptomatic intracranial haemorrhage after intra-arterial thrombolysis in acute ischaemic stroke: assessment of 294 patients treated with urokinase. J Neurol Neurosurg Psychiatry 78:280-285
160. Larrue V, von Kummer RR, Muller A et al (2001) Risk factors for severe hemorrhagic transformation in ischemic stroke patients treated with recombinant tissue plasminogen activator: a secondary analysis of the European-Australasian Acute Stroke Study (ECASS II). Stroke 32:438-441
161. Anon (1997) Intracerebral hemorrhage after intravenous t-PA therapy for ischemic stroke. The NINDS t-PA Stroke Study Group. Stroke 28:2109-2118
162. Demchuk AM, Hill MD, Barber PA et al (2005) Importance of early ischemic computed tomography changes using ASPECTS in NINDS rtPA Stroke Study. Stroke 36:2110-2115
163. Patel SC, Levine SR, Tilley BC et al (2001) Lack of clinical significance of early ischemic changes on computed tomography in acute stroke. JAMA 286:2830-2838
164. Lansberg MG, Thijs VN, Bammer R et al (2007) Risk factors of symptomatic intracerebral hemorrhage after tPA therapy for acute stroke. Stroke 38:2275-2278
165. Singer OC, Humpich MC, Fiehler J et al (2008) Risk for symptomatic intracerebral hemorrhage after thrombolysis assessed by diffusion-weighted magnetic resonance imaging. Ann Neurol 63:52-60
166. Singer OC, Kurre W, Humpich MC et al (2009) Risk assessment of symptomatic intracerebral hemorrhage after thrombolysis using DWI-ASPECTS. Stroke 40:2743-2748
167. Selim M, Fink JN, Kumar S et al (2002) Predictors of hemorrhagic transformation after intravenous recombinant tissue plasminogen activator: prognostic value of the initial apparent diffusion coefficient and diffusion-weighted lesion volume. Stroke 33:2047-2052