MR mismatch and thrombolysis: Appealing but validation required

Stroke

Volumn 40, Issue 8, 2009, Pages 2910-

  Davis, Stephen M ^a   Donnan, Geoffrey A ^a  

^a ROYAL MELBOURNE HOSPITAL   (Australia)

Author keywords

Controversies; Diffusion weighted imaging; MR mismatch; Thrombolysis

Indexed keywords

TISSUE PLASMINOGEN ACTIVATOR;

BLOOD CLOT LYSIS; BRAIN INFARCTION SIZE; CLINICAL TRIAL; DIFFUSION WEIGHTED IMAGING; DISEASE SEVERITY; HUMAN; IMAGE ANALYSIS; PATIENT SELECTION; PERFUSION WEIGHTED IMAGING; PRIORITY JOURNAL; SHORT SURVEY; STROKE; VALIDATION PROCESS;

DIFFUSION MAGNETIC RESONANCE IMAGING; HUMANS; REPRODUCIBILITY OF RESULTS; STROKE; THROMBOLYTIC THERAPY;

EID: 68749087328     PISSN: 00392499     EISSN: None     Source Type: Journal    
DOI: 10.1161/STROKEAHA.109.552893     Document Type: Short Survey

References (8)

1. Symon L. The ischemic penumbra - the beginning. In Donnan GA, Baron JC, Davis SM, Sharp F, eds. The Ischemic Penumbra. New York: Informa Healthcare; 2007:1-6.
2. Donnan GA, Baron JC, Ma H, Davis SM. Penumbral selection for trials of acute stroke therapy. Lancet Neurology. In press.
3. Christensen S, Parsons M, DeSilva D, Ebinger M, Butcher K, Fink J, Davis SM. Optimal mismatch definitions for detecting treatment response in acute stroke. Cerebrovasc Dis. 2008;25:1-192.
4. Olivot JM, Mlynash M, Thijs VN, Kemp S, Lansberg MG, Wechsler L, Bammer R, Marks MP, Albers GW. Optimal Tmax threshold for predicting penumbral tissue in acute stroke. Stroke. 2009;40:469-475.
5. Singer OC, Humpich MC, Fiehler J, Albers GW, Lansberg MG, Kastrup A, Rovira A, Liebeskind DS, Gass A, Rosso C, Derex L, Kim JS, Neumann-Haefelin T. Risk for symptomatic intracerebral hemorrhage after thrombolysis assessed by diffusion-weighted magnetic resonance imaging. Ann Neurol. 2008;63:52-60.
6. Albers GW, Thijs VN, Wechsler L, Kemp S, Schlaug G, Skalabrin E, Bammer R, Kakuda W, Lansberg MG, Shuaib A, Coplin W, Hamilton S, Moseley M, Marks MP. Magnetic resonance imaging profiles predict clinical response to early reperfusion: The Diffusion and Perfusion Imaging Evaluation for Understanding Stroke Evolution (DEFUSE) study. Ann Neurol. 2006;60:508-517.
7. Davis SM, Donnan GA, Parsons MW, Levi C, Butcher KS, Peeters A, Barber PA, Bladin C, De Silva DA, Byrnes G, Chalk JB, Fink JN, Kimber TE, Schultz D, Hand PJ, Frayne J, Hankey G, Muir K, Gerraty R, Tress BM, Desmond PM. Effects of alteplase beyond 3 h after stroke in the Echoplanar Imaging Thrombolytic Evaluation Trial (Epithet): A placebocontrolled randomised trial. Lancet Neurol. 2008;7:299-309.
8. Hacke W, Kaste M, Bluhmki E, Brozman M, Davalos A, Guidetti D, Larrue V, Lees KR, Medeghri Z, Machnig T, Schneider D, von Kummer R, Wahlgren N, Toni D. Thrombolysis with alteplase 3 to 4.5 hours after acute ischemic stroke. N Engl J Med. 2008;359:1317-1329.