Importance of early ischemic computed tomography changes using ASPECTS in NINDS rtPA stroke study

Stroke

Volumn 36, Issue 10, 2005, Pages 2110-2115

  Demchuk, Andrew M ^a   Hill, Michael D ^b   Barber, Philip A ^b   Silver, Brian ^c   Patel, Suresh C ^c   Levine, Steven R ^d  

^a FOOTHILLS HOSPITAL   (Canada)

^b UNIVERSITY OF CALGARY   (Canada)

^c HENRY FORD HOSPITAL   (United States)

^d MOUNT SINAI SCHOOL OF MEDICINE   (United States)

Author keywords

Computed tomography; Diagnostic imaging; Ischemia; Stroke, acute; Thrombolytic therapy

Indexed keywords

TISSUE PLASMINOGEN ACTIVATOR;

ACUTE DISEASE; ADULT; AGED; ARTICLE; BRAIN HEMORRHAGE; BRAIN ISCHEMIA; COMPUTER ASSISTED TOMOGRAPHY; DIAGNOSTIC IMAGING; DISEASE SEVERITY; FEMALE; FIBRINOLYTIC THERAPY; FOLLOW UP; HUMAN; MAJOR CLINICAL STUDY; MALE; MIDDLE CEREBRAL ARTERY; OUTCOMES RESEARCH; PRIORITY JOURNAL; RISK BENEFIT ANALYSIS; STROKE;

AGED; BRAIN ISCHEMIA; CEREBRAL ANGIOGRAPHY; CEREBRAL HEMORRHAGE; CEREBROVASCULAR ACCIDENT; DOUBLE-BLIND METHOD; FEMALE; FOLLOW-UP STUDIES; HUMANS; ISCHEMIA; MALE; MIDDLE AGED; MIDDLE CEREBRAL ARTERY; MODELS, STATISTICAL; MULTIVARIATE ANALYSIS; OBSERVER VARIATION; PLACEBOS; PROSPECTIVE STUDIES; RECOMBINANT PROTEINS; RISK; THROMBOLYTIC THERAPY; TIME FACTORS; TISSUE PLASMINOGEN ACTIVATOR; TOMOGRAPHY, X-RAY COMPUTED; TREATMENT OUTCOME;

EID: 26044479507     PISSN: 00392499     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.STR.0000181116.15426.58     Document Type: Article

References (39)

1. The National Institute of Neurological Disorders and Stroke rt-PA Stroke Study Group. Tissue plasminogen activator for acute ischemic stroke. N Engl J Med. 1995;333:1581-1587.
2. Marler JR, Tilley BC, Lu M, Brott TG, Lyden PC, Grotta JC, et al. Early stroke treatment associated with better outcome: the NINDS rt-PA stroke study. Neurology. 2000;55:1649-1655.
3. The NINDS tPA Stroke Study Group. Generalized efficacy of tPA for Acute Stroke: subgroup analysis of the NINDS tPA Stroke Trial. Stroke. 1997;28:2119-2125.
4. Hacke W, Kaste M, Fieschi C, Toni D, Lesaffre E, von Kummer R, et al, for the ECASS Study Group. Intravenous thrombolysis with recombinant tissue plasminogen activator for acute hemispheric stroke: The European Cooperative Acute Stroke Study (ECASS). JAMA. 1995;274:1017-1025.
5. Barber PA, Demchuk AM, Zhang J, Buchan AM, for the ASPECTS Study Group. Validity and reliability of a quantitative computed tomography score in predicting outcome in hyperacute stroke before thrombolytic therapy. Lancet. 2000;355:1670-1674.
6. Silver B, Demaerschalk B, Merino JG, Wong E, Tamayo A, Devasenapathy A, et al. Improved outcomes in stroke thrombolysis with pre-specified imaging criteria. Can J Neurol Sci. 2001;28:113-119.
7. von Kummer R, Bourquain H, Bastianello S, Bozzao L, Manelfe C, Meier D, et al. Early prediction of irreversible brain damage after ischemic stroke at CT. Radiology. 2001;219:95-100.
8. Gilligan A, Markus R, Read S, Srikanth V, Hirano T, Fitt G, et al, Australian Streptokinase Trial Investigators. Baseline blood pressure but not early computed tomography changes predict major hemorrhage after streptokinase in acute ischemic stroke. Stroke. 2002;33:2236-2242.
9. The NINDS t-PA Stroke Study Group. Intracerebral hemorrhage after intravenous t-PA therapy for ischemic stroke. Stroke. 1997;28:2109-2118.
10. The National Institute of Neurological Disorders and Stroke (NINDS) rt-PA Stroke Study Group. Effect of intravenous recombinant tissue plasminogen activator on ischemic stroke lesion size measured by computed tomography. Stroke. 2000;31:2912-2919.
11. Hsieh FY. Sample size tables for logistic regression. Stat Med. 1989;8:795-802.
12. Rothman KJ, Greenland S. Modern Epidemiology, 2nd ed. Philadelphia: Lippincott Raven; 1998.
13. Altman DG. Confidence intervals for the number needed to treat. BMJ, 1998;317:1309-1312.
14. Broderick JP, Lu M, Kothari R, Levine SR, Lyden PD, Haley EC, et al. Finding the most powerful measures of the effectiveness of tissue plasminogen activator in the NINDS tPA stroke trial. Stroke. 2000;31:2335-2341.
15. Patel SC, Levine SR, Tilley BC, Grotta JC, Lu M, Frankel M, et al. Lack of clinical significance of early ischemic changes on computed tomography in acute stroke. JAMA. 2001;286:2830-2838.
16. Hacke W, Kaste M, Fieschi C, et al, for the ECASS Study Group. Intravenous thrombolysis with recombinant tissue plasminogen activator for acute hemispheric stroke: the European Cooperative Acute Stroke Study (ECASS). JAMA. 1995;274:1017-1025.
17. von Kummer R, Allen KL, Holle R, Bozzao L, Bastianello S, Manelfe C, et al. Acute stroke: usefulness of early CT findings before thrombolytic therapy. Radiology. 1997;205:327-333.
18. Adams HP Jr, Brott TG, Furlan AJ, Gomez CR, Grotta J, Helgason CM, et al. Guidelines for thrombolytic therapy for acute stroke: a supplement to the guidelines for the management of patients with acute ischemic stroke. A statement for healthcare professionals from a Special Writing Group of the Stroke Council, American Heart Association. Circulation. 1996;94:1167-1174.
19. Hacke W, Kaste M, Fieschi C, von Kummer R, Davalos A, Meier D, et al. Randomised double blind placebo-controlled trial of thrombolytic therapy with intravenous alteplase in acute ischaemic stroke (ECASS II). Lancet. 1998;352:1245-1251.
20. Dippel DWJ, Du RY, van Beest Holle M, van Kooten F, et al. The validity and reliability of early infarct signs on CT in acute ischaemic stroke. Cerebrovas Dis. 1997;7(suppl 4):15.
21. Schriger D, Kalafut M, Starkman S, et al. Cranial computed tomography interpretation in acute stroke. Physicians accuracy in determining eligibility for thrombolytic therapy. JAMA. 1998;279:1293-1297.
22. Grotta JC, Chiu D, Lu M, Patel S, Levine SR, Tilley BC, et al. Agreement and variability in the interpretation of early CT changes in stroke patients qualifying for intravenous rtPA therapy. Stroke. 1999;30:1528-1533.
23. Wardlaw JM, Dorman PJ, Lewis SC, Sandercock PAG. Can stroke physicians and neurologists identify signs of early cerebral infarction on CT? J Neurol Neurosurg Psychiatry. 1999;67:651-653.
24. Pexman JHW, Barber PA, Hill MD, Sevick RJ, Demchuk AM, Hudon M, et al. Use of the Alberta Stroke Program Early CT Score (ASPECTS) for assessing CT scans in patients with acute stroke. AJNR Am J Neuroradiol. 2001;22:1534-1542.
25. Coutts SB, Demchuk AM, Barber PA, Hu WY, Simon JE, Buchan AM, et al, VISION Study Group. Interobserver variation of ASPECTS in real time. Stroke. 2004;35:e103-105.
26. Barber PA, Hill MD, Eliasziw M, Demchuk AM, Pexman W, Hudon M, et al. A comparative analysis of CT with magnetic resonance diffusion weighted imaging in hyperacute stroke. J Neurol Neurosurg Psychiatry. In press.
27. Hill MD, Rowley HA, Adler F, Eliasziw M, Furlan A, Higashida RT, et al, for the PROACT-II Investigators. Selection of acute ischemic stroke patients for intra-arterial thrombolysis with pro-urokinase by using ASPECTS. Stroke. 2003;34:1925-1931.
28. Furlan A, Higashida R, Wechsler L, Gent M, Rowley H, Kase C, et al. Intra-arterial prourokinase for acute ischemic stroke. The PROACT II study: a randomized controlled trial. Prolyse in acute cerebral thromboembolism. JAMA. 1999;282:2003-2011.
29. Barber PA, Demchuk AM, Hill MD, Pexman JH, Hudon ME, Frayne R, et al. The probability of middle cerebral artery MRA flow signal abnormality with quantified CT ischaemic change: targets for future therapeutic studies. J Neurol Neurosurg Psychiatry. 2004;75:1426-1430.
30. Hacke W, Donnan G, Fieschi C, Kaste M, von Kummer R, Broderick JP, et al, ATLANTIS Trials Investigators, ECASS Trials Investigators, NINDS rt-PA Study Group Investigators. Association of outcome with early stroke treatment: pooled analysis of ATLANTIS, ECASS, and NINDS rt-PA stroke trials. Lancet. 2004;363:768-774.
31. Jaillard A, Hommel M, Baird AE, Linfante I, Llinas RH, Caplan LR, et al. Significance of early CT signs in acute stroke: a CT scan-diffusion MRI study. Cerebrovasc Dis. 2002;13:47-56.
32. Butcher KS, Lee SB, Parsons M, Fink J, Levi C, Allport L, et al, for the EPITHET Investigators, Increased blood volume maintains viability in tissue with isolated focal swelling on CT in acute stroke [Abstract]. Stroke. 2005;36:418.
33. Ezzeddine MA, Lev MH, McDonald CT, Rordorf G, Oliveira-Filho J, Aksoy FG, et al. CT angiography with whole brain perfused blood volume imaging: added clinical value in the assessment of acute stroke. Stroke. 2002;33:959-966.
34. Coutts SB, Lev MH, Eliasziw M, Roccatagliata L, Hill MD, Schwamm LH, et al. ASPECTS on CTA source images versus unenhanced CT: added value in predicting final infarct extent and clinical outcome. Stroke. 2004;35:2472-2476.
35. Wintermark M, Reichhart M, Thiran JP, Maeder P, Chalaron M, Schnyder P, et al. Prognostic accuracy of cerebral blood flow measurement by perfusion computed tomography, at the time of emergency room admission, in acute stroke patients. Ann Neurol. 2002;51:417-432.
36. Koenig M, Kraus M, Theek C, Klotz E, Gehlen W, Heuser L. Quantitative assessment of the ischemic brain by means of perfusion-related parameters derived from perfusion CT. Stroke. 2001;32:431-437.
37. Wintermark M, Fischbein NJ, Smith WS, Ko NU, Quist M, Dillon WP. Accuracy of dynamic perfusion CT with deconvolution in detecting acute hemispheric stroke. AJNR Am J Neuroradiol. 2005;26:104-112.
38. Schellinger PD, Fiebach JB, Hacke W. Imaging-based decision making in thrombolytic therapy for ischemic stroke: present status. Stroke. 2003;34:575-583.
39. Chalela JA, Kang DW, Luby M, Ezzeddine M, Latour LL, Todd JW, et al. Early magnetic resonance imaging findings in patients receiving tissue plasminogen activator predict outcome: insights into the pathophysiology of acute stroke in the thrombolysis era. Ann Neurol. 2004;55:105-112.