Specific cysteines in β3 are involved in disulfide bond exchange-dependent and -independent activation of αIIbβ3

Journal of Biological Chemistry

Volumn 283, Issue 28, 2008, Pages 19235-19244

  Mor Cohen, Ronit ^a,b   Rosenberg, Nurit ^a,b   Landau, Meytal ^b   Lahav, Judith ^b,c   Seligsohn, Uri ^a,b  

^a SHEBA MEDICAL CENTER   (Israel)

^b TEL AVIV UNIVERSITY   (Israel)

^c RABIN MEDICAL CENTER   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATION STATES; CONSTITUTIVELY ACTIVES; CYSTEINE RESIDUES; CYSTEINE SUBSTITUTIONS; DISULFIDE BONDS; DO-MAINS; EPIDERMAL GROWTH FACTORS; HAMSTER KIDNEYS; SULFHYDRYL; SURFACE EXPRESSIONS; TAIL DOMAINS;

ANTIBODIES; FLOW CYTOMETRY;

CHEMICAL ACTIVATION;

ALPHA IIB BETA3 INTEGRIN; ALPHA INTEGRIN; BENZOIC ACID DERIVATIVE; CYSTEINE; DISULFIDE; DUAL SPECIFICITY PHOSPHATASE 2; EPIDERMAL GROWTH FACTOR; EPIDERMAL GROWTH FACTOR 3; EPIDERMAL GROWTH FACTOR 4; MUTANT PROTEIN; PROTEIN P2; THIOL DERIVATIVE; UNCLASSIFIED DRUG; FIBRINOGEN RECEPTOR; MONOCLONAL ANTIBODY;

AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; CELL STRAIN BHK; DISULFIDE BOND; FLOW CYTOMETRY; MOLECULAR DYNAMICS; MOLECULAR INTERACTION; MUTATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FUNCTION; WILD TYPE; ANIMAL; CELL LINE; CHEMISTRY; GENETICS; HAMSTER; HUMAN; METABOLISM; PROTEIN QUATERNARY STRUCTURE; PROTEIN TERTIARY STRUCTURE;

CRICETINAE;

AMINO ACID SUBSTITUTION; ANIMALS; ANTIBODIES, MONOCLONAL; CELL LINE; CRICETINAE; CYSTEINE; DISULFIDES; HUMANS; PLATELET GLYCOPROTEIN GPIIB-IIIA COMPLEX; PROTEIN STRUCTURE, QUATERNARY; PROTEIN STRUCTURE, TERTIARY;

EID: 50349098094     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M802399200     Document Type: Article

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