-
2
-
-
33947476062
-
5-Benzyl-2,4-diaminopyrimidines as Antibacterial Agents.1.Synthesis and Antibacterial Activity in Vitro
-
Roth, B. A.; Falco, E. A.; Hitchings, G. H.; Bushby, R. M. 5-Benzyl-2,4-diaminopyrimidines as Antibacterial Agents.1.Synthesis and Antibacterial Activity in Vitro J. Med. Pharm. Chem. 1962, 5, 1103-1123
-
(1962)
J. Med. Pharm. Chem.
, vol.5
, pp. 1103-1123
-
-
Roth, B.A.1
Falco, E.A.2
Hitchings, G.H.3
Bushby, R.M.4
-
3
-
-
0015738592
-
Metabolism of Trimethoprim in Man and Measurement of a New Metabolite: A New Fluorescence Assay
-
Carl, W. S.; Michael, E. G.; Charles, A. N. Metabolism of Trimethoprim in Man and Measurement of a New Metabolite: A New Fluorescence Assay J. Infect. Dis. 1973, 128, S580-S583
-
(1973)
J. Infect. Dis.
, vol.128
-
-
Carl, W.S.1
Michael, E.G.2
Charles, A.N.3
-
4
-
-
33745464490
-
Fluorinated Pyrimidines, a New Class of Tumour Inhibitory Compounds
-
Heidelberger, C.; Chaudhuri, N. K.; Danneberg, P.; Mooren, D.; Griesbach, L.; Duschinsky, K.; Schnitzer, R.; Pleven, E.; Scheiner, J. Fluorinated Pyrimidines, a New Class of Tumour Inhibitory Compounds Nature 1957, 179, 663-666
-
(1957)
Nature
, vol.179
, pp. 663-666
-
-
Heidelberger, C.1
Chaudhuri, N.K.2
Danneberg, P.3
Mooren, D.4
Griesbach, L.5
Duschinsky, K.6
Schnitzer, R.7
Pleven, E.8
Scheiner, J.9
-
5
-
-
84864243751
-
-
Anticancer activity of 5-fluorouracil available in NCI data base, NSC 19893
-
Anticancer activity of 5-fluorouracil available in NCI data base (www.dtp.nci.nih.gov), NSC 19893.
-
-
-
-
6
-
-
84864243755
-
-
Anticancer activity of methotrexate available in NCI data base, NSC 740
-
Anticancer activity of methotrexate available in NCI data base (www.dtp.nci.nih.gov), NSC 740.
-
-
-
-
8
-
-
0019951735
-
Synthesis, Retention and Biological Activity of Methotrexate Polyglutamates in Cultured Human Breast Cancer Cells
-
Jolivet, J.; Schilsky, R. L.; Bailey, B. D.; Drake, J. C.; Chabner, B. A. Synthesis, Retention and Biological Activity of Methotrexate Polyglutamates in Cultured Human Breast Cancer Cells J. Clin. Invest. 1982, 70, 351-360
-
(1982)
J. Clin. Invest.
, vol.70
, pp. 351-360
-
-
Jolivet, J.1
Schilsky, R.L.2
Bailey, B.D.3
Drake, J.C.4
Chabner, B.A.5
-
9
-
-
0034645774
-
Three-Dimensional Structure of M. tuberculosis Dihydrofolate Reductase Reveals Opportunities for the Design of Novel Tuberculosis Drugs
-
Li, R.; Sirawaraporn, R.; Chitnumsub, P.; Sirawaraporn, W.; Wooden, J.; Athappilly, F.; Turley, S.; Hol, W. G. J. Three-Dimensional Structure of M. tuberculosis Dihydrofolate Reductase Reveals Opportunities for the Design of Novel Tuberculosis Drugs J. Mol. Biol. 2000, 295, 307-323
-
(2000)
J. Mol. Biol.
, vol.295
, pp. 307-323
-
-
Li, R.1
Sirawaraporn, R.2
Chitnumsub, P.3
Sirawaraporn, W.4
Wooden, J.5
Athappilly, F.6
Turley, S.7
Hol, W.G.J.8
-
10
-
-
62549149036
-
Increased Hydrophobic Interactions of Iclaprim with Staphylococcus aureus Dihydrofolate Reductase Are Responsible for the Increase in Affinity and Antibacterial Activity
-
Oefner, C.; Bandera, M.; Haldimann, A.; Laue, H.; Schulz, H.; Mukhija, S.; Parisi, S.; Weiss, L.; Lociuro, S.; Dale, G. E. Increased Hydrophobic Interactions of Iclaprim with Staphylococcus aureus Dihydrofolate Reductase Are Responsible for the Increase in Affinity and Antibacterial Activity J. Antimicrob. Chemother. 2009, 63, 687-698
-
(2009)
J. Antimicrob. Chemother.
, vol.63
, pp. 687-698
-
-
Oefner, C.1
Bandera, M.2
Haldimann, A.3
Laue, H.4
Schulz, H.5
Mukhija, S.6
Parisi, S.7
Weiss, L.8
Lociuro, S.9
Dale, G.E.10
-
11
-
-
68049130004
-
Structural Comparison of Chromosomal and Exogenous Dihydrofolate Reductase from Staphylococcus aureus in Complex with the Potent Inhibitor Trimethoprim
-
Heaslet, H.; Harris, M.; Fahnoe, K.; Sarver, R.; Putz, H.; Chang, J.; Subramanyam, C.; Barreiro, G.; Miller, J. R. Structural Comparison of Chromosomal and Exogenous Dihydrofolate Reductase from Staphylococcus aureus in Complex with the Potent Inhibitor Trimethoprim Proteins 2009, 76, 706-717
-
(2009)
Proteins
, vol.76
, pp. 706-717
-
-
Heaslet, H.1
Harris, M.2
Fahnoe, K.3
Sarver, R.4
Putz, H.5
Chang, J.6
Subramanyam, C.7
Barreiro, G.8
Miller, J.R.9
-
12
-
-
0038121754
-
Synthesis and DHFR Inhibitory Activity of a Series of 6-Substituted-2,4-diaminothieno[2,3- d ]pyrimidines
-
Donkor, I. O.; Li, H.; Queener, S. F. Synthesis and DHFR Inhibitory Activity of a Series of 6-Substituted-2,4-diaminothieno[2,3- d ]pyrimidines Eur. J. Med. Chem. 2003, 38, 605-611
-
(2003)
Eur. J. Med. Chem.
, vol.38
, pp. 605-611
-
-
Donkor, I.O.1
Li, H.2
Queener, S.F.3
-
13
-
-
0035821589
-
Synthesis, Antifolate and Antitumour Activities of Classical and Nonclassical 2-Amino-4-oxo-5-substituted-pyrrolo[2,3- d ]pyrimidines
-
Gangjee, A.; Vidwans, A.; Elzein, E.; McGuire, J. J.; Queener, S. F.; Kisliuk, R. L. Synthesis, Antifolate and Antitumour Activities of Classical and Nonclassical 2-Amino-4-oxo-5-substituted-pyrrolo[2,3- d ]pyrimidines J. Med. Chem. 2001, 44, 1993-2003
-
(2001)
J. Med. Chem.
, vol.44
, pp. 1993-2003
-
-
Gangjee, A.1
Vidwans, A.2
Elzein, E.3
McGuire, J.J.4
Queener, S.F.5
Kisliuk, R.L.6
-
14
-
-
0038101420
-
Novel Dihydrofolate Reductase Inhibitors. Structure-Based versus Diversity-Based Library Design and High-Throughput Synthesis and Screening
-
Wyss, P. C.; Gerber, P.; Hartman, P. G.; Hubschwerlen, C.; Locher, H.; Marty, H. P.; Stahl, M. Novel Dihydrofolate Reductase Inhibitors. Structure-Based versus Diversity-Based Library Design and High-Throughput Synthesis and Screening J. Med. Chem. 2003, 46, 2304-2312
-
(2003)
J. Med. Chem.
, vol.46
, pp. 2304-2312
-
-
Wyss, P.C.1
Gerber, P.2
Hartman, P.G.3
Hubschwerlen, C.4
Locher, H.5
Marty, H.P.6
Stahl, M.7
-
15
-
-
52449089998
-
Potent Dual Thymidylate Synthase and Dihydrofolate Reductase Inhibitors: Classical and Nonclasssical 2-Amino-4-oxo-5-arylthio-substituted-6- methylthieno[2,3- d ]pyrimidine Antifolates
-
Gangjee, A.; Qiu, Y.; Li, W.; Kisliuk, R. L. Potent Dual Thymidylate Synthase and Dihydrofolate Reductase Inhibitors: Classical and Nonclasssical 2-Amino-4-oxo-5-arylthio-substituted-6-methylthieno[2,3- d ]pyrimidine Antifolates J. Med. Chem. 2008, 51, 5789-5797
-
(2008)
J. Med. Chem.
, vol.51
, pp. 5789-5797
-
-
Gangjee, A.1
Qiu, Y.2
Li, W.3
Kisliuk, R.L.4
-
16
-
-
2342468066
-
Synthesis of 2,4-Diamino-6-[2′- O -(ω-carboxyalkyl)oxydibenz[ b, f ]azepin-5-yl]-methylpteridines as Potent and Selective Inhibitors of Pneumocystis carnii, Toxoplasma gondii, and Mycobacterium avium Dihydrofolate Reductase
-
Rosowsky, A.; Fu, H.; Chan, D. C. M.; Queener, S. F. Synthesis of 2,4-Diamino-6-[2′- O -(ω-carboxyalkyl)oxydibenz[ b, f ]azepin-5-yl]-methylpteridines as Potent and Selective Inhibitors of Pneumocystis carnii, Toxoplasma gondii, and Mycobacterium avium Dihydrofolate Reductase J. Med. Chem. 2004, 47, 2475-2485
-
(2004)
J. Med. Chem.
, vol.47
, pp. 2475-2485
-
-
Rosowsky, A.1
Fu, H.2
Chan, D.C.M.3
Queener, S.F.4
-
17
-
-
68549132469
-
Design, Synthesis and X-ray Crystal Structure of Classical and Nonclassical 2-Amino-4-oxo-5-substituted-pyrrolo[2,3- d ]pyrimidines as Dual Thymidylate Synthase and Dihydrofolate Reductase Inhibitors and as Potential Antitumour Agents
-
Gangjee, A.; Li, W.; Kisliuk, R.; Cody, V.; Pace, J.; Piraino, J.; Makin, J. Design, Synthesis and X-ray Crystal Structure of Classical and Nonclassical 2-Amino-4-oxo-5-substituted-pyrrolo[2,3- d ]pyrimidines as Dual Thymidylate Synthase and Dihydrofolate Reductase Inhibitors and as Potential Antitumour Agents J. Med. Chem. 2009, 52, 4892-4902
-
(2009)
J. Med. Chem.
, vol.52
, pp. 4892-4902
-
-
Gangjee, A.1
Li, W.2
Kisliuk, R.3
Cody, V.4
Pace, J.5
Piraino, J.6
Makin, J.7
-
18
-
-
80051936025
-
Structure Based Design of New DHFR-Based Antibacterial Agents: 7-Aryl-2,4-diaminoquinazolines
-
Li, X.; Hilgers, M.; Cunningham, M.; Chen, Z.; Trzoss, M.; Zhang, J.; Kohnen, L.; Lam, T.; Creighton, C.; Kedar, G. C.; Nelson, K.; Kwan, B.; Stidham, M.; Brown-Driver, M.; Shaw, K. J.; Finn, J. Structure Based Design of New DHFR-Based Antibacterial Agents: 7-Aryl-2,4-diaminoquinazolines Bioorg. Med. Chem. Lett. 2011, 21, 5171-5176
-
(2011)
Bioorg. Med. Chem. Lett.
, vol.21
, pp. 5171-5176
-
-
Li, X.1
Hilgers, M.2
Cunningham, M.3
Chen, Z.4
Trzoss, M.5
Zhang, J.6
Kohnen, L.7
Lam, T.8
Creighton, C.9
Kedar, G.C.10
Nelson, K.11
Kwan, B.12
Stidham, M.13
Brown-Driver, M.14
Shaw, K.J.15
Finn, J.16
-
19
-
-
0242569143
-
Iclaprim, a Novel Diamino Pyrimidine with Potant Activity on Trimethoprim Sensitive and Resistant Bacteria
-
Schneider, P.; Hawser, S.; Islam, K. Iclaprim, a Novel Diamino Pyrimidine with Potant Activity on Trimethoprim Sensitive and Resistant Bacteria Bioorg. Med. Chem. Lett. 2003, 13, 4217-4221
-
(2003)
Bioorg. Med. Chem. Lett.
, vol.13
, pp. 4217-4221
-
-
Schneider, P.1
Hawser, S.2
Islam, K.3
-
20
-
-
0017160006
-
Antimalarial Activity of Some Novel Derivatives of 2,4-Diamino-(5- p -chlorophenyl)-6-ethylpyrimidine (Pyrimethamine)
-
Rees, R. W. A.; Chai, S. Y.; Winkley, M. W.; Russel, P. B. Antimalarial Activity of Some Novel Derivatives of 2,4-Diamino-(5- p -chlorophenyl)-6- ethylpyrimidine (Pyrimethamine) J. Med. Chem. 1976, 19 (5) 723-725
-
(1976)
J. Med. Chem.
, vol.19
, Issue.5
, pp. 723-725
-
-
Rees, R.W.A.1
Chai, S.Y.2
Winkley, M.W.3
Russel, P.B.4
-
21
-
-
0021288986
-
Properties of Brodimoprim as an Inhibitor of Dihydrofolate Reductases
-
Then, R. L.; Hermann, F. Properties of Brodimoprim as an Inhibitor of Dihydrofolate Reductases Chemotherapy 1984, 30 (1) 18-25
-
(1984)
Chemotherapy
, vol.30
, Issue.1
, pp. 18-25
-
-
Then, R.L.1
Hermann, F.2
-
22
-
-
0032881830
-
Metabolism of Trimethoprim to a Reactive Iminioquinone Methide by Activated Human Neutrophils and Hepatic Microsomes
-
Lai, W. G.; Zahid, N.; Uetrecht, J. P. Metabolism of Trimethoprim to a Reactive Iminioquinone Methide by Activated Human Neutrophils and Hepatic Microsomes J. Pharmacol. Expt. Ther 1999, 291, 292-299
-
(1999)
J. Pharmacol. Expt. Ther
, vol.291
, pp. 292-299
-
-
Lai, W.G.1
Zahid, N.2
Uetrecht, J.P.3
-
23
-
-
84864227767
-
-
Developmental Therapeutics Program, NCI/NIH
-
Developmental Therapeutics Program, NCI/NIH. www.dtp.nci.nih.gov.
-
-
-
-
24
-
-
84864243756
-
-
Anticancer activity of indomethacin available in NCI data base, NSC 77541
-
Anticancer activity of indomethacin available in NCI data base (www.dtp.nci.nih.gov), NSC 77541.
-
-
-
-
25
-
-
85069327761
-
-
-5 M
-
-5 M.
-
-
-
-
26
-
-
33746190548
-
A Spectrophotometric Investigation of the Interaction of Iodine with Aromatic Hydrocarbons
-
Hildebrand, J. H.; Benesi, H. A. A Spectrophotometric Investigation of the Interaction of Iodine with Aromatic Hydrocarbons J. Am. Chem. Soc. 1949, 71, 2703-2707
-
(1949)
J. Am. Chem. Soc.
, vol.71
, pp. 2703-2707
-
-
Hildebrand, J.H.1
Benesi, H.A.2
|