Synthesis and DHFR inhibitory activity of a series of 6-substituted-2,4-diaminothieno[2,3-d]pyrimidines

European Journal of Medicinal Chemistry

Volumn 38, Issue 6, 2003, Pages 605-611

  Donkor, Isaac O ^a   Li, Hui ^a   Queener, Sherry F ^b  

^a UNIVERSITY OF TENNESSEE HEALTH SCIENCE CENTER   (United States)

^b INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

DHFR; Diaminothieno 2,3 d pyrimidines; Opportunistic infections; Pneumocystis carinii; Pneumonia

Indexed keywords

5 METHYL 6 (2 NAPHTHALEN 1 YLETHYL)THIENO[2,3 D]PYRIMIDINE 2,4 DIAMINE; 5 METHYL 6 (2 NAPHTHALEN 2 YLETHYL)THIENO[2,3 D]PYRIMIDINE 2,4 DIAMINE; 5 METHYL 6 (3 NAPHTHALEN 1 YLPROPYL)THIENO[2,3 D]PYRIMIDINE 2,4 DIAMINE; 5 METHYL 6 (3 NAPHTHALEN 2 YLPROPYL)THIENO[2,3 D]PYRIMIDINE 2,4 DIAMINE; 5 METHYL 6 (3 PHENYLPROPYL)THIENO[2,3 D]PYRIMIDINE 2,4 DIAMINE; 5 METHYL 6 (4 PHENYLBUTYL)THIENO[2,3 D]PYRIMIDINE 2,4 DIAMINE; 5 METHYL 6 (5 PHENYLPENTYL)THIENO[2,3 D]PYRIMIDINE 2,4 DIAMINE; 5 METHYL 6 PHENETHYLTHIENO[2,3 D]PYRIMIDINE 2,4 DIAMINE; CARBENE; DIHYDROFOLATE REDUCTASE; POLYCYCLIC AROMATIC HYDROCARBON DERIVATIVE; PYRIMIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG SELECTIVITY; DRUG SYNTHESIS; IC 50; INFRARED SPECTROSCOPY; LIVER; MYCOBACTERIUM AVIUM; NONHUMAN; PNEUMOCYSTIS CARINII; PROTON NUCLEAR MAGNETIC RESONANCE; RAT; THIN LAYER CHROMATOGRAPHY; TOXOPLASMA GONDII;

EID: 0038121754     PISSN: 02235234     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0223-5234(03)00101-6     Document Type: Article

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