Inhibition of forebrain μ-opioid receptor signaling by low concentrations of rimonabant does not require cannabinoid receptors and directly involves μ-opioid receptors

Neurochemistry International

Volumn 61, Issue 3, 2012, Pages 378-388

  Zádor, Ferenc ^a   Ötvös, Ferenc ^a   Benyhe, Sándor ^a   Zimmer, Andreas ^b   Páldy, Eszter ^a,c  

^a INSTITUTE OF EXPERIMENTAL MEDICINE   (Hungary)

^b UNIVERSITY OF BONN   (Germany)

^c UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

Opioid receptor; 35S GTP S binding; CB1 cannabinoid receptor; CB1 receptor knockout mouse; CB1 CB2 receptor double knockout mouse; Docking; Forebrain; Radioligand binding; Rimonabant

Indexed keywords

CANNABINOID 1 RECEPTOR; CANNABINOID 2 RECEPTOR; ENKEPHALIN[2 DEXTRO ALANINE 4 METHYLPHENYLALANINE 5 GLYCINE]; MU OPIATE RECEPTOR; NOLADIN ETHER; RIMONABANT; SR 14716; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; BINDING COMPETITION; BRAIN MEMBRANE; CONTROLLED STUDY; DRUG BINDING SITE; DRUG RECEPTOR BINDING; FEMALE; FOREBRAIN; IN VITRO STUDY; IN VIVO STUDY; KNOCKOUT MOUSE; LIGAND BINDING; MATHEMATICAL ANALYSIS; MOLECULAR DOCKING; MOUSE; NONHUMAN; PRIORITY JOURNAL; RECEPTOR BLOCKING; RECEPTOR DOWN REGULATION;

ANIMALS; CANNABINOID RECEPTOR ANTAGONISTS; CHO CELLS; CRICETINAE; CRICETULUS; ENKEPHALIN, ALA(2)-MEPHE(4)-GLY(5)-; MICE; MICE, KNOCKOUT; PIPERIDINES; PROSENCEPHALON; PYRAZOLES; RECEPTORS, CANNABINOID; RECEPTORS, OPIOID, MU; SIGNAL TRANSDUCTION;

ANIMALIA; CRICETULUS GRISEUS; MUS;

EID: 84864212959     PISSN: 01970186     EISSN: 18729754     Source Type: Journal    
DOI: 10.1016/j.neuint.2012.05.015     Document Type: Article

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