Investigations on the 1-(2-biphenyl)piperazine motif: Identification of new potent and selective ligands for the serotonin 7 (5-HT 7) receptor with agonist or antagonist action in vitro or ex vivo

Journal of Medicinal Chemistry

Volumn 55, Issue 14, 2012, Pages 6375-6380

  Lacivita, Enza ^a   Patarnello, Daniela ^a   Stroth, Nikolas ^d   Caroli, Antonia ^b   Niso, Mauro ^a   Contino, Marialessandra ^a   De Giorgio, Paola ^a   Di Pilato, Pantaleo ^a   Colabufo, Nicola A ^a   Berardi, Francesco ^a   Perrone, Roberto ^a   Svenningsson, Per ^d   Hedlund, Peter B ^c   Leopoldo, Marcello ^a  

^a UNIVERSITY OF BARI   (Italy)

^b SAPIENZA UNIVERSITY OF ROME   (Italy)

^c SCRIPPS RESEARCH INSTITUTE   (United States)

^d KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

1 (2 BIPHENYL)PIPERAZINE DERIVATIVE; 1 (3 BIPHENYL)PIPERAZINE DERIVATIVE; 1 [2 (4 METHOXYPHENYL)PHENYL]PIPERAZINE; ALPHA 1 ADRENERGIC RECEPTOR; PHENTOLAMINE; PIPERAZINE DERIVATIVE; SEROTONIN; SEROTONIN 7 RECEPTOR; SEROTONIN AGONIST; SEROTONIN ANTAGONIST; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; DRUG DESIGN; DRUG RECEPTOR BINDING; DRUG SELECTIVITY; DRUG SYNTHESIS; EX VIVO STUDY; GUINEA PIG; HELA CELL; IN VITRO STUDY; NONHUMAN; RECEPTOR AFFINITY;

ANIMALS; GUINEA PIGS; HELA CELLS; HUMANS; ILEUM; LIGANDS; MODELS, MOLECULAR; MOLECULAR WEIGHT; PIPERAZINES; PROTEIN CONFORMATION; RECEPTORS, ADRENERGIC, ALPHA-1; RECEPTORS, SEROTONIN; SEROTONIN ANTAGONISTS; SEROTONIN RECEPTOR AGONISTS; STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTRATE SPECIFICITY;

EID: 84864210624     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm3003679     Document Type: Article

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