Cyclooxygenase-1 and-2 differentially modulate lipopolysaccharide-induced blood-brain barrier disruption through matrix metalloproteinase activity

Journal of Cerebral Blood Flow and Metabolism

Volumn 30, Issue 2, 2010, Pages 370-380

  Aid, Saba ^a   Silva, Afonso C ^b   Candelario Jalil, Eduardo ^c   Choi, Sang Ho ^a   Rosenberg, Gary A ^c   Bosetti, Francesca ^a  

^a NATIONAL INSTITUTE ON AGING   (United States)

^b NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE   (United States)

^c UNIVERSITY OF NEW MEXICO HEALTH SCIENCES CENTER   (United States)

Author keywords

Blood brain barrier; Cyclooxygenases; Lipopolysaccharide; Matrix metalloproteinases; MRI; Neuroinflammation

Indexed keywords

CD45 ANTIGEN; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; GAMMA INTERFERON INDUCIBLE PROTEIN 10; GELATINASE B; INTERCELLULAR ADHESION MOLECULE 1; LIPOPOLYSACCHARIDE; MATRIX METALLOPROTEINASE; MESSENGER RNA; STROMELYSIN; TOLL LIKE RECEPTOR 4;

ANIMAL EXPERIMENT; ARTICLE; BLOOD BRAIN BARRIER; BRAIN CORTEX; CELL INTERACTION; CONTROLLED STUDY; ENZYME ACTIVITY; GENE EXPRESSION; HIPPOCAMPUS; IMMUNOSTIMULATION; INNATE IMMUNITY; MALE; MOUSE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; PERMEABILITY; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; WILD TYPE;

ANIMALS; BLOOD-BRAIN BARRIER; CAPILLARY PERMEABILITY; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; FLUORESCENCE RESONANCE ENERGY TRANSFER; GENE EXPRESSION; HIPPOCAMPUS; INFLAMMATION; INJECTIONS, INTRAVENTRICULAR; LIPOPOLYSACCHARIDES; MAGNETIC RESONANCE IMAGING; MATRIX METALLOPROTEINASE 3; MATRIX METALLOPROTEINASE 9; MICE; MICE, KNOCKOUT; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION;

EID: 76349091357     PISSN: 0271678X     EISSN: None     Source Type: Journal    
DOI: 10.1038/jcbfm.2009.223     Document Type: Article

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