Small interfering RNA-mediated knockdown of protein kinase C zeta attenuates domoic acid-induced cognitive deficits in mice

Toxicological Sciences

Volumn 128, Issue 1, 2012, Pages 209-222

  Wu, Dong Mei ^a,b   Lu, Jun ^b   Zheng, Yuan Lin ^b   Zhang, Yan Qiu ^a   Hu, Bin ^b   Cheng, Wei ^a   Zhang, Zi Feng ^b   Li, Meng Qiu ^b  

^a CHINA UNIVERSITY OF MINING AND TECHNOLOGY   (China)

^b JIANGSU NORMAL UNIVERSITY   (China)

Author keywords

Cognitive deficits; Domoic acid; PKC ; ROS SAPK JNK pathway; SAPK JNK FoxO1 FasL Fas pathway

Indexed keywords

ANTHRA[1,9 CD]PYRAZOL 6(2H) ONE; CASPASE 3; CASPASE 8; DOMOIC ACID; FAS LIGAND; MITOGEN ACTIVATED PROTEIN KINASE KINASE 4; NITROUS OXIDE; PROTEIN KINASE C ZETA; PROTEIN P47; PROTEIN P85; REACTIVE OXYGEN METABOLITE; SMALL INTERFERING RNA; STRESS ACTIVATED PROTEIN KINASE; TRANSCRIPTION FACTOR FKHR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; COGNITIVE DEFECT; CONTROLLED STUDY; ENZYME ACTIVITY; EXCITOTOXICITY; FEMALE; GENE SILENCING; HIPPOCAMPUS; MOLECULAR BIOLOGY; MOUSE; NERVE CELL; NONHUMAN; PROTEIN CARBONYLATION; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION;

ANIMALS; BASE SEQUENCE; BEHAVIOR, ANIMAL; COGNITION DISORDERS; DNA PRIMERS; GENE KNOCKDOWN TECHNIQUES; KAINIC ACID; MALE; MICE; MICE, INBRED ICR; PROTEIN KINASE C; RNA, SMALL INTERFERING;

MUS;

EID: 84864124443     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfs124     Document Type: Article

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