The KCl cotransporter, KCC2, is highly expressed in the vicinity of excitatory synapses in the rat hippocampus

European Journal of Neuroscience

Volumn 13, Issue 12, 2001, Pages 2205-2217

  Gulyas A I ^a   Sik A ^a   Payne, J A ^b   Kaila, K ^c   Freund, T F ^a  

^a INSTITUTE OF EXPERIMENTAL MEDICINE   (Hungary)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF HELSINKI   (Finland)

Author keywords

Chloride regulation; Dendritic spine; Interneuron; Thorny excrescence; Volume regulation

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR; CALBINDIN; CALRETININ; CARRIER PROTEIN; METABOTROPIC RECEPTOR; POTASSIUM CHLORIDE COTRANSPORTER; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELLULAR DISTRIBUTION; CONTROLLED STUDY; DENTATE GYRUS; HIPPOCAMPUS; IMMUNOCYTOCHEMISTRY; IMMUNOREACTIVITY; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PYRAMIDAL NERVE CELL; RAT; SYNAPSE;

ANIMALS; ANIMALS, NEWBORN; CALCIUM-BINDING PROTEIN, VITAMIN D-DEPENDENT; CARRIER PROTEINS; CHLORIDE CHANNELS; CHLORIDES; DENDRITES; DENTATE GYRUS; EXCITATORY POSTSYNAPTIC POTENTIALS; HIPPOCAMPUS; IMMUNOHISTOCHEMISTRY; INTERNEURONS; MALE; MEMBRANE POTENTIALS; MICROSCOPY, ELECTRON; NEURONS; PARVALBUMINS; POTASSIUM; PYRAMIDAL CELLS; RATS; RATS, WISTAR; RECEPTORS, METABOTROPIC GLUTAMATE; SYMPORTERS; SYNAPSES;

EID: 0034913071     PISSN: 0953816X     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.0953-816X.2001.01600.x     Document Type: Article

References (69)

1. GABAergic cells are the major postsynaptic targets of mossy fibers in the rat hippocampus
2. Kinetic differences between synaptic and extrasynaptic GABA (A) receptors in CA1 pyramidal cells
3. International Union of Pharmacology. XV. Subtypes of gamma-aminobutyric acidA receptors: Classification on the basis of subunit structure and receptor function
4. The role of swelling-induced anion channels during neuronal volume regulation
5. The metabotropic glutamate receptor (mGluR1a) is concentrated at perisynaptic membrane of neuronal subpopulations as detected by immunogold reaction
6. 3H-thymidine autoradiography
7. Giant synaptic potentials in immature rat CA3 hippocampal neurones
8. A receptors
9. Adaptive regulation of neuronal excitability by a voltage-independent potassium conductance
10. +)-ATPase, cytochrome oxidase, and total protein in temporal lobe epilepsy
11. Excitotoxic cell death dependent on inhibitory receptor activation
12. GABA: An excitatory transmitter in early postnatal life
13. - cotransporter expression in rat neocortex
14. Synaptic patterns on different cell types in the different laminae of the cat visual cortex. An electron microscope study
15. Impact of network activity on the integrative properties of neocortical pyramidal neurons in vivo
16. Transient changes in the size of the extracellular space in the sensorimotor cortex of cats in relation to stimulus-reduced changes in potassium concentration
17. - regulation
18. Relationship of neuronal vulnerability and calcium binding protein immunoreactivity in ischemia
19. Pattern of neuronal death in the rat hippocampus after status epilepticus. Relationship to calcium binding protein content and ischemic vulnerability
20. An autoradiographic study of the development of the entorhinal and commissural afferents to the dentate gyrus of the rat
21. A receptors containing the alpha 1 subunit to neurochemically distinct subpopulations of rat hippocampal interneurons
22. The control of rate and timing of spikes in the deep cerebellar nuclei by inhibition
23. Molecular cloning and functional expression of the K-Cl cotransporter from rabbit, rat, and human. A new member of the cation-chloride cotransporter family
24. Immunohistochemical visualization of a metabotropic glutamate receptor
25. Pyramidal cell dendrites are the primary targets of calbindin D28k-immunoreactive interneurons in the hippocampus
26. Total number and ratio of excitatory and inhibitory synapses converging onto single interneurons of different types in the CA1 area of the rat hippocampus
27. Calretinin-immunoreactive cells in the rat hippocampus. I. A new type of neuron-specifically associated with the mossy fibre system-revealed
28. Calretinin is present in non-pyramidal cells of the rat hippocampus-I. A new type of neuron specifically associated with the mossy fibre system
29. - cotransporter
30. Membrane mechanisms and intracellular signalling in cell volume regulation
31. - accumulation and depletion in cultured rat midbrain neurons
32. Interpretation of intrinsic optical signals and calcein fluorescence during acute excitotoxic insult in the hippocampal slice
33. A receptor channel function in the nervous system
34. Regulation of intracellular chloride by cotransporters in developing lateral superior olive neurons
35. Synaptic GABA (A) activation inhibits AMPA-kainate receptor-mediated bursting in the newborn (P0-P2) rat hippocampus
36. Functional significance of cell volume regulatory mechanisms
37. GABA and glutamate depolarize cortical progenitor cells and inhibit DNA synthesis
38. Developmental regulation of the neuronal-specific isoform of K-Cl cotransporter KCC2 in postnatal rat brains
39. GABAergic stimulation regulates the phenotype of hippocampal interneurons through the regulation of brain-derived neurotrophic factor
40. Regional variation of extracellular space in the hippocampus
41. Total number and distribution of inhibitory and excitatory synapses on hippocampal CA1 pyramidal cells
42. Isoforms of the Na-K-2Cl cotransporter in murine TAL I. Molecular characterization and intrarenal localization
43. Subcellular distribution of amino acid neurotransmitter receptors and voltage-gated channels
44. Cell type and pathway dependence of synaptic AMPA receptor number and variability in the hippocampus
45. A receptor in relation to specific GABAergic synapses in the dentate gyrus
46. A receptors on cerebellar granule cells as determined by a quantitative immunogold method
47. A receptor is concentrated in both inhibitory and excitatory synapses on cerebellar granule cells
48. Changing properties of GABA (A) receptor-mediated signaling during early neocortical development
49. Molecular characterization of a putative K-Cl cotransporter in rat brain. A neuronalspecific isoform
50. Primary structure, functional expression, and chromosomal localization of the bumetanide-sensitive Na-K-Cl cotransporter in human colon
51. A Golgi-electron microscopic study of fusiform neurons in the hilar region of the dentate gyrus
52. - co-transporter KCC2 renders GABA hyperpolarizing during neuronal maturation
53. Developmental regulation of K-Cl cotransporter (KCC2 and KCC1) mRNA in early postnatal rat hippocampus
54. + imaging in spines and fine dendrites of central neurons
55. The neurotoxicity of excitatory amino acids is produced by passive chloride influx
56. Selective vulnerability of the hippocampus in brain ischemia
57. Calcium-binding protein (calbindin-D28k) and parvalbumin immunocytochemistry: Localization in the rat hippocampus with specific reference to the selective vulnerability of hippocampal neurons to seizure activity
58. A receptor function following gene transfer of the CLC-2 chloride channel
59. Involvement of distinct pioneer neurons in the formation of layer-specific connections in the hippocampus
60. The organization of the embryonic and early postnatal murine hippocampus. II. Development of entorhinal, commissural, and septal connections studied with the lipophilic tracer DiI
61. Development of afferent fiber lamination in the infrapyramidal blade of the rat dentate gyrus
62. Mechanisms of sodium pump regulation
63. - in hippocampal CA3 neurons
64. Calbindin D28k-containing nonpyramidal cells in the rat hippocampus: Their immunoreactivity for GABA and projection to the medial septum
65. Evidence that different cation chloride cotransporters in retinal neurons allow opposite responses to GABA
66. Localization and developmental expression patterns of the neuronal K-Cl cotransporter (KCC2) in the rat retina
67. The neuron-specific K-Cl cotransporter, KCC2. Antibody development and initial characterization of the protein
68. Anterograde neuroanatomical tracing with Phaseolus vulgaris-leucoagglutinin combined with immunocytochemistry of gammaamino butyric acid, choline acetyltransferase or serotonin
69. Molecular cloning and functional expression of the bumetanide-sensitive Na-K-Cl cotransporter