Pharmacokinetics, tissue distribution and metabolism of senkyunolide I, a major bioactive component in Ligusticum chuanxiong Hort. (Umbelliferae)

Journal of Ethnopharmacology

Volumn 142, Issue 3, 2012, Pages 706-713

  He, Chun Yong ^a   Wang, Shuo ^a   Feng, Yi ^a   Liang, Shuang ^a   Lin, Xiao ^a   Xu, De Sheng ^b   Ruan, Ke Feng ^a  

^a SHANGHAI UNIVERSITY OF TRADITIONAL CHINESE MEDICINE   (China)

^b SHUGUANG HOSPITAL AFFILIATED TO SHANGHAI UNIVERSITY OF TRADITIONAL CHINESE MEDICINE   (China)

Author keywords

Bioavailability; Metabolism; Pharmacokinetics; Senkyunolide I; Tissue distribution

Indexed keywords

PHTHALIDE DERIVATIVE; SENKYUNOLIDE I; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; BLOOD BRAIN BARRIER; BLOOD SAMPLING; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG ELIMINATION; DRUG HALF LIFE; DRUG METABOLISM; DRUG TISSUE LEVEL; FIRST PASS EFFECT; GLUCURONIDATION; GLUTATHIONE METABOLISM; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IN VIVO STUDY; LIGUSTICUM CHUANXIONG; MALE; METHYLATION; NONHUMAN; RAT; SIGNAL TRANSDUCTION; TANDEM MASS SPECTROMETRY; TISSUE DISTRIBUTION;

ANIMALS; BENZOFURANS; BILE; LIGUSTICUM; MALE; RATS; RATS, SPRAGUE-DAWLEY; TISSUE DISTRIBUTION;

APIACEAE; LIGUSTICUM CHUANXIONG; RATTUS;

EID: 84863990304     PISSN: 03788741     EISSN: 18727573     Source Type: Journal    
DOI: 10.1016/j.jep.2012.05.047     Document Type: Article

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