Distribution, metabolism and excretion of butylidenephthalide of Ligustici chuanxiong rhizoma in hairless mouse after dermal application

Journal of Ethnopharmacology

Volumn 71, Issue 3, 2000, Pages 401-409

  Sekiya, Kouji ^a   Tezuka, Yasuhiro ^a   Tanaka, Ken ^c   Prasain, Jeevan Kumar ^a   Namba, Tsuneo ^a   Katayama, Kazunori ^a   Koizumi, Tamotsu ^a   Maeda, Masatoshi ^b   Kondo, Takashi ^b   Kadota, Shigetoshi ^a  

^a UNIVERSITY OF TOYAMA   (Japan)

^b TOYAMA MEDICAL AND PHARMACEUTICAL UNIVERSITY   (Japan)

^c NATIONAL RESEARCH INSTITUTE OF POLICE SCIENCE   (Japan)

Author keywords

Cysteine conjugate; Dermal application; Hairless mouse; Liquid chromatography mass spectrometry mass spectrometry (LC MS MS); 8 14C Butylidenephthalide

Indexed keywords

BUTYLIDENEPHTHALIDE; PHTHALIDE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; AUTORADIOGRAPHY; DRUG ABSORPTION; DRUG DISTRIBUTION; DRUG EXCRETION; DRUG METABOLISM; DRUG PENETRATION; FEMALE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; LIQUID CHROMATOGRAPHY; LIQUID SCINTILLATION COUNTING; MASS SPECTROMETRY; MOUSE; NONHUMAN;

EID: 0033868994     PISSN: 03788741     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-8741(00)00169-0     Document Type: Article

References (10)

1. L.J Fischer M.D Green A.W Harman Studies on the fate of the glutathione and cysteine conjugates of acetaminophen in mice Journal of Pharmacology and Experimental Therapeutics 13 1985 121 126
2. K Katayama O Takahashi R Matsui S Morigaki T Aiba M Kakemi Effect of l-menthol on the permeation of indomethacin, mannitol and cortisone through excised hairless mouse skin Chemical and Pharmaceutical Bulletin 40 1992 3097 3099
3. H Mori Fragrance Journal Special Issue No. 6 Fragrance Journal Ltd Tokyo 177–190 1986 219 223
4. T Namba Colored Illustrations Wakan-Yaku 1 1980 Hoikusha Co Osaka, Japan 23 24
5. T Namba K Sekiya K Kadota M Hattori K Katayama T Koizumi Study on baths with crude drug: the effect of Senkyu extracts as skin penetration enhancer Yakugaku Zasshi 112 1992 638 644
6. N Patel Y Kumagai S.E Unger J.M Fukuko A.K Cho Transformation of dopamine and alpha-methyldopamine by NG108-15 cells: formation of thiol adducts Chemical Research in Toxicology 4 1991 421 426
7. K Sekiya S Kadota K Katayama T Koizumi T Namba Study on baths with crude drug. III. The effect of Ligustici Chuanxiong Rhizoma extract on the percutaneous absorption of some natural compounds Biological and Pharmaceutical Bulletin 20 1997 983 987
8. C.H Wang Y.P Feng Y.L Wu A study on the metabolites of dl -3-butylphthalide in rats Acta Pharmaceutica Sinica 32 1997 641 646
9. H Yorozu H Sato Y Komoto The effect of crude drug extracts bathing. III. The effect of phthalides from Cnidii Rhizoma Japanese Journal Association of Physical Medicine Balneolocy and Clinitolocy 57 1994 123 128
10. L Zhou R.R Erickson J.P Hardwick S.S Park S.A Wrighton J.L Holtzman Catalysis of the cysteine conjugation and protein binding of acetaminophen by microsomes from a human lymphoblast line transfected with the cDNAs of various forms of human cytochrome P450 Journal of Pharmacology and Experimental Therapeutics 281 1997 785 790