Ortho-Carbaborane derivatives of indomethacin as cyclooxygenase (COX)-2 selective inhibitors

Bioorganic and Medicinal Chemistry

Volumn 20, Issue 15, 2012, Pages 4830-4837

  Scholz, Matthias ^a   Blobaum, Anna L ^b   Marnett, Lawrence J ^b,c   Hey Hawkins, Evamarie ^a  

^a UNIVERSITY OF LEIPZIG   (Germany)

^b VANDERBILT UNIVERSITY   (United States)

^c VANDERBILT INGRAM CANCER CENTER   (United States)

Author keywords

Carbaborane; Carborane; Cyclooxygenase; Indomethacin; Nonsteroidal anti inflammatory drugs

Indexed keywords

1 (1 ADAMANTYL) 5 METHOXY 2 METHYL 1H INDOLE 3 ACETIC ACID; 1 (1 ADAMANTYL) 5 METHOXY 2 METHYL 1H INDOLE 3 ACETIC ACID TERT BENZYL ESTER; 1 (1 ADAMANTYL) 5 METHOXY 2 METHYL 1H INDOLE 3 ACETIC ACID TERT BUTYL ESTER; 1 (1 CARBOXY 1,12 DICARBA CLOSO DODECABORAN[12]YL) 5 METHOXY 2 METHYL 1H INDOLE 3 ACETIC ACID; 1 (1 CARBOXY 1,12 DICARBA CLOSO DODECABORAN[12]YL) 5 METHOXY 2 METHYL 1H INDOLE 3 ACETIC ACID TERT BENZYL ESTER; 1 (1 CARBOXY 1,12 DICARBA CLOSO DODECABORAN[12]YL) 5 METHOXY 2 METHYL 1H INDOLE 3 ACETIC ACID TERT BUTYL ESTER; 1 (1 CARBOXY 1,12 DICARBA CLOSO DODECABORAN[12]YL) 5 METHOXY 2 METHYL 1H INDOLE 3 ACETIC ACID TERT METHYL ESTER; 1 (1 CARBOXY 1,2 DICARBA CLOSO DODECABORAN[12]YL) 5 METHOXY 2 METHYL 1H INDOLE 3 ACETIC ACID; 1 (1 CARBOXY 1,2 DICARBA CLOSO DODECABORAN[12]YL) 5 METHOXY 2 METHYL 1H INDOLE 3 ACETIC ACID TERT BENZYL ESTER; 1 (1 CARBOXY 1,2 DICARBA CLOSO DODECABORAN[12]YL) 5 METHOXY 2 METHYL 1H INDOLE 3 ACETIC ACID TERT BUTYL ESTER; 1 (1 CARBOXY 1,2 DICARBA CLOSO DODECABORAN[12]YL) 5 METHOXY 2 METHYL 1H INDOLE 3 ACETIC ACID TERT METHYL ESTER; 1 (1 CARBOXY 1,7 DICARBA CLOSO DODECABORAN[12]YL) 5 METHOXY 2 METHYL 1H INDOLE 3 ACETIC ACID; 1 (1 CARBOXY 1,7 DICARBA CLOSO DODECABORAN[12]YL) 5 METHOXY 2 METHYL 1H INDOLE 3 ACETIC ACID TERT BENZYL ESTER; 1 (1 CARBOXY 1,7 DICARBA CLOSO DODECABORAN[12]YL) 5 METHOXY 2 METHYL 1H INDOLE 3 ACETIC ACID TERT BUTYL ESTER; 1 (1 CARBOXY 1,7 DICARBA CLOSO DODECABORAN[12]YL) 5 METHOXY 2 METHYL 1H INDOLE 3 ACETIC ACID TERT METHYL ESTER; 2 CARBABORANE DERIVATIVE; 5 METHOXY 2 METHYL 1H INDOLE 3 ACETIC ACID; 5 METHOXY 2 METHYL 1H INDOLE 3 ACETIC ACID BENZYL ESTER; 5 METHOXY 2 METHYL 1H INDOLE 3 ACETIC ACID TERT BENZYL ESTER; 5 METHOXY 2 METHYL 1H INDOLE 3 ACETIC ACID TERT BUTYL ESTER; ADAMANTANE DERIVATIVE; CYCLOOXYGENASE 2 INHIBITOR; INDOMETACIN DERIVATIVE; PROSTAGLANDIN SYNTHASE; UNCLASSIFIED DRUG;

ARTICLE; CONCENTRATION RESPONSE; DRUG SYNTHESIS; ENZYME ACTIVITY; ENZYME INHIBITION; IC 50; SUBSTITUTION REACTION;

BORANES; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITORS; DOSE-RESPONSE RELATIONSHIP, DRUG; INDOMETHACIN; MODELS, MOLECULAR; MOLECULAR STRUCTURE; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84863987411     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2012.05.063     Document Type: Article

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