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Bioorganic and Medicinal Chemistry Letters

Volumn 22, Issue 15, 2012, Pages 5134-5140

Hit-to-lead investigation of a series of novel combined dopamine D 2 and muscarinic M1 receptor ligands with putative antipsychotic and pro-cognitive potential

(8) Sams, Anette Graven a,b Larsen, Krestian a Mikkelsen, Gitte Kobberoe a Hentzer, Morten a Christoffersen, Claus Tornby a Jensen, Klaus Gjervig a Frederiksen, Kristen a Bang Andersen, Benny a

a H LUNDBECK A S (Denmark)

b LEO PHARMA A S (Denmark)

Author keywords

Cognition; D2; M1; Schizophrenia

Indexed keywords

1 [3 [4 (2 OXO 2,3 DIHYDROBENZOIMIDAZOL 1 YL)PIPERIDIN 1 YL]PROPYL] 3,4 DIHYDRO 1H QUINOLIN 2 ONE; DOPAMINE 2 RECEPTOR; DOPAMINE 2 RECEPTOR BLOCKING AGENT; MUSCARINIC M1 RECEPTOR; MUSCARINIC M1 RECEPTOR AGONIST; UNCLASSIFIED DRUG;

ARTICLE; DRUG MECHANISM; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; REACTION ANALYSIS; RECEPTOR AFFINITY; RECEPTOR BINDING; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS;

ANTIPSYCHOTIC AGENTS; ETHER-A-GO-GO POTASSIUM CHANNELS; HALF-LIFE; HUMANS; LIGANDS; MICROSOMES, LIVER; QUINOLONES; RECEPTOR, MUSCARINIC M1; RECEPTORS, DOPAMINE D2; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84863981454 PISSN: 0960894X EISSN: 14643405 Source Type: Journal
DOI: 10.1016/j.bmcl.2012.05.048 Document Type: Article

Times cited : (9)

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