Involvement of mucosal addressin cell adhesion molecule-1 (MAdCAM-1) in the pathogenesis of granulomatous colitis in rats

Clinical and Experimental Immunology

Volumn 126, Issue 2, 2001, Pages 259-265

  Hokari, R ^a   Kato, S ^a   Matsuzaki, K ^a   Iwai, A ^a   Kawaguchi, A ^a   Nagao, S ^a   Miyahara, T ^a   Itoh, K ^a   Sekizuka, E ^b   Nagata, H ^c   Ishii, H ^b   Iizuka, T ^d   Miyasaka, M ^e   Miura, S ^a  

^a NATIONAL DEFENSE MEDICAL COLLEGE   (Japan)

^b SAITAMA NATIONAL HOSPITAL   (Japan)

^c KEIO UNIVERSITY   (Japan)

^d TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

^e OSAKA UNIVERSITY MEDICAL SCHOOL   (Japan)

Author keywords

Adhesion molecules; Colitis; Lymphocytes; PG PS

Indexed keywords

CD4 ANTIGEN; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY OST 2; MUCOSAL ADDRESSIN CELL ADHESION MOLECULE 1; PEPTIDOGLYCAN POLYSACCHARIDE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL INFILTRATION; COLITIS; COLON INJURY; COLON MUCOSA; CONTROLLED STUDY; FEMALE; GRANULOMA; GRANULOMATOUS INFLAMMATION; IMMUNOHISTOCHEMISTRY; LYMPHOCYTE; MACROPHAGE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SUBMUCOSA; VENULE;

ANIMALS; ANTIBODIES, MONOCLONAL; CD4-POSITIVE T-LYMPHOCYTES; CELL ADHESION MOLECULES; CELL MOVEMENT; CHRONIC DISEASE; CROHN DISEASE; ENDOTHELIUM, VASCULAR; FEMALE; IMMUNOGLOBULINS; IMMUNOHISTOCHEMISTRY; INTESTINAL MUCOSA; MUCOPROTEINS; PEPTIDOGLYCAN; POLYSACCHARIDES; RATS; RATS, INBRED LEW;

EID: 20244389692     PISSN: 00099104     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2249.2001.01690.x     Document Type: Article

References (24)

1. Lymphocyte homing and homeostasis
2. High endothelial venules (HEVs): Specialized endothelium for lymphocyte migration
3. α4β7 integrin mediates lymphocyte binding to the mucosal vascular addressin MAdCAM-1
4. Role of α4-integrins in lymphocyte homing to mucosal tissues in vivo
5. Endotoxin stimulates lymphocyte-endothelial interactions in rat intestinal Peyer's patches and villus mucosa
6. Human mucosal addressin cell adhesion molecule-1 is preferentially expressed in intestinal tract and associated lymphoid tissue
7. Expression of lymphocyte-endothelial receptor-ligand pairs, alpha4beta7/MAdCAM-1 and OX40/OX40 ligand in the colon and jejunum of patients with inflammatory bowel disease
8. Phlogistic properties of peptidoglycan-polysaccharide polymers from cell walls of pathogenic and normal-flora bacteria which colonize humans
9. Selective kallikrein-kinin system activation in inbred rats differentially susceptible to granulomatous enterocolitis
10. Effects of streptococcal components on immunity
11. Interleukin 10 suppresses experimental chronic, granulomatous inflammation induced by bacterial cell wall polymers
12. Role of the thymus in streptococcal cell wall-induced arthritis and hepatic granuloma formation. Comparative studies of pathology and cell wall distribution in athymic and euthymic rats
13. Stage-specific expression of mucosal addressin cell adhesion molecule-1 during embryogenesis in rats
14. Mucosal injury and inflammation in a model of chronic granulomatous colitis in rats
15. Expression of mucosal addressin cell adhesion molecule-1 (MAdCAM-1) in acute and chronic inflammation
16. + T cells
17. Amelioration of murine experimental colitis by inhibition of mucosal addressin cell adhesion molecule-1
18. Cytokines in intestinal inflammation: Pathophysiological and clinical considerations
19. The role of IL-10 in crossregulation of TH1 and TH2 responses
20. The Peyer's patch high endothelial receptor for lymphocytes, the mucosal vascular addressin, is induced on a murine endothelial cell line by tumor necrosis factor-alpha and IL-1
21. Interaction of monocytoid cells with the mucosal addressin MAdCAM-1 via the integrins VLA-4 and LPAM-1
22. VCAM-1 and ICAM-1 mediate leukocyte-endothelial cell adhesion in rat experimental colitis
23. Rapid resolution of chronic colitis in the cotton-top tamarin with an antibody to a gut-homing integrin alpha 4 beta 7
24. VCAM-1, but not ICAM-1 or MAdCAM-1, immunoblockade ameliorates DSS-induced colitis in mice