Betulinic acid derivatives: A new class of human immunodeficiency virus type 1 specific inhibitors with a new mode of action

Journal of Medicinal Chemistry

Volumn 39, Issue 5, 1996, Pages 1056-1068

  Evers, Michel ^a   Poujade, Christèle ^a   Soler, Françoise ^a   Ribeill, Yves ^a   James, Claude ^a   Lelièvre, Yves ^a   Gueguen, Jean Christophe ^a   Reisdorf, Daniel ^a   Morize, Isabelle ^a   Pauwels, Rudi ^b   De Clercq, Erik ^b   Hénin, Yvette ^a   Bousseau, Anne ^a   Mayaux, Jean François ^a   Le Pecq, Jean Bernard ^a   Dereu, Norbert ^a  

^a SANOFI   (France)

^b REGA INSTITUTE FOR MEDICAL RESEARCH   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

11 [3BETA HYDROXY 30 [(2 HYDROXYETHYL)THIO]LUP 20(29) EN 28 OYLAMINO]UNDECANOIC ACID; 11 [3BETA,30 DIHYDROXYLUP 20(29) EN 28 OYLAMINO]UNDECANOIC ACID; 11 [3BETA,30 HYDROXYLUP 20(29) EN 28 OYLAMINO]UNDECANOIC ACID; [7 CHLORO 5 (1H PYRROL 2 YL) 3H BENZO[E][1,4]DIAZEPIN 2 YL]METHYLAMINE; A 80987; ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT; BETULINIC ACID DERIVATIVE; DIDANOSINE; NEVIRAPINE; PROTEINASE; PROTEINASE INHIBITOR; RNA DIRECTED DNA POLYMERASE; RNA DIRECTED DNA POLYMERASE INHIBITOR; SAQUINAVIR; TRANSACTIVATOR PROTEIN; UNCLASSIFIED DRUG; ZALCITABINE; ZIDOVUDINE;

ANTIVIRAL ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG MECHANISM; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS 2; HUMAN IMMUNODEFICIENCY VIRUS INFECTION;

ANTIVIRAL AGENTS; ENZYME INHIBITORS; HIV-1; HIV-2; HUMANS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; REVERSE TRANSCRIPTASE INHIBITORS; STRUCTURE-ACTIVITY RELATIONSHIP; TRITERPENES; TUMOR CELLS, CULTURED;

EID: 13344284666     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm950670t     Document Type: Article

References (28)

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