Changes in gene expression profile in human subcutaneous adipose tissue during significant weight loss

Obesity Facts

Volumn 5, Issue 3, 2012, Pages 440-451

  Leyvraz, Céline ^a   Verdumo, Chantal ^a   Suter, Michel ^a   Paroz, Alexandre ^a   Calmes, Jean Marie ^a   Marques Vidal, Pedro M ^b   Giusti, Vittorio ^a  

^a LAUSANNE UNIVERSITY HOSPITAL   (Switzerland)

^b UNIVERSITY OF LAUSANNE   (Switzerland)

Author keywords

11 HSD1; PPAR ; Roux en Y gastric bypass; Subcutaneous adipose tissue

Indexed keywords

11BETA HYDROXYSTEROID DEHYDROGENASE; CHOLESTEROL; GLUCOSE; HIGH DENSITY LIPOPROTEIN; LEPTIN; LOW DENSITY LIPOPROTEIN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA 1; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA 2; TRIACYLGLYCEROL; UNCLASSIFIED DRUG; URATE;

11BETA HYDROXYSTEROID DEHYDROGENASE GENE; ADULT; ANTHROPOMETRIC PARAMETERS; ARTICLE; BODY MASS; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; GENE; GENE EXPRESSION PROFILING; GENE OVEREXPRESSION; GLUCOSE BLOOD LEVEL; HUMAN; HUMAN TISSUE; LEPTIN GENE; LIPOSUCTION; OBESITY; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA 1 GENE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA 2 GENE; POSTOPERATIVE PERIOD; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; ROUX Y ANASTOMOSIS; STOMACH BYPASS; SUBCUTANEOUS FAT; TREATMENT OUTCOME; WEIGHT REDUCTION;

11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1; ADULT; BODY MASS INDEX; FEMALE; GASTRIC BYPASS; HUMANS; LEPTIN; MIDDLE AGED; OBESITY; OBESITY, MORBID; PPAR GAMMA; SUBCUTANEOUS FAT; TRANSCRIPTOME; WEIGHT LOSS;

EID: 84863962246     PISSN: 16624025     EISSN: 16624033     Source Type: Journal    
DOI: 10.1159/000341137     Document Type: Article

References (56)

1. Bult MJ, van Dalen T, Muller AF: Surgical treatment of obesity. Eur J Endocrinol 2008; 158: 135-145.
2. Smith BR, Schauer P, Nguyen NT: Surgical approaches to the treatment of obesity: Bariatric surgery. Endocrinol Metab Clin North Am 2008; 37: 943-964.
3. Ballantyne GH, Farkas D, Laker S, Wasielewski A: Short-term changes in insulin resistance following weight loss surgery for morbid obesity: Laparoscopic adjustable gastric banding versus laparoscopic Roux-en-Y gastric bypass. Obes Surg 2006; 16: 1189-1197.
4. Gumbs AA, Modlin IM, Ballantyne GH: Changes in insulin resistance following bariatric surgery: Role of caloric restriction and weight loss. Obes Surg 2005; 15: 462-473.
5. Cottam DR, Mattar SG, Barinas-Mitchell E, Eid G, Kuller L, Kelley DE, Schauer PR: The chronic inflammatory hypothesis for the morbidity associated with morbid obesity: Implications and effects of weight loss. Obes Surg 2004; 14: 589-600.
6. Viguerie N, Poitou C, Cancello R, Stich V, Clement K, Langin D: Transcriptomics applied to obesity and caloric restriction. Biochimie 2005; 87: 117-123.
7. Kim K, Perroud B, Espinal G, Kachinskas D, Austrheim-Smith I, Wolfe BM, Warden CH: Genes and networks expressed in perioperative omental adipose tissue are correlated with weight loss from Roux-en-Y gastric bypass. Int J Obes 2008; 32: 1395-1406.
8. Auboeuf D, Rieusset J, Fajas L, Vallier P, Frering V, Riou JP, Staels B, Auwerx J, Laville M, Vidal H: Tissue distribution and quantification of the expression of mRNAs of peroxisome proliferator-activated receptors and liver X receptor-alpha in humans: No alteration in adipose tissue of obese and NIDDM patients. Diabetes 1997; 46: 1319-1327.
9. Giusti V, Verdumo C, Suter M, Gaillard RC, Burckhardt P, Pralong F: Expression of peroxisome proliferatoractivated receptor-gamma(1) and peroxisome proliferator-activated receptor-gamma(2) in visceral and subcutaneous adipose tissue of obese women. Diabetes 2003; 52: 1673-1676.
10. Vidal-Puig AJ, Considine RV, Jimenez-Linan M, Werman A, Pories WJ, Caro JF, Flier JS: Peroxisome proliferator- activated receptor gene expression in human tissues. Effects of obesity, weight loss, and regulation by insulin and glucocorticoids. J Clin Invest 1997; 99: 2416-3422.
11. Krempler F, Breban D, Oberkofler H, Esterbauer H, Hell E, Paulweber B, Patsch W: Leptin, peroxisome proliferator- activated receptor-gamma, and CCAAT/enhancer binding protein-alpha mRNA expression in adipose tissue of humans and their relation to cardiovascular risk factors. Arterioscler Thromb Vasc Biol 2000; 20: 443-449.
12. Rieusset J, Andreelli F, Auboeuf D, Roques M, Vallier P, Riou JP, Auwerx J, Laville M, Vidal H: Insulin acutely regulates the expression of the peroxisome proliferator-activated receptor-gamma in human adipocytes. Diabetes 1999; 48: 699-705.
13. Bortolotto JW, Margis R, Ferreira AC, Padoin AV, Mottin CC, Guaragna RM: Adipose tissue distribution and quantification of PPARbeta/delta and PPARgamma1-3 mRNAs: Discordant gene expression in subcutaneous, retroperitoneal and visceral adipose tissue of morbidly obese patients. Obes Surg 2007; 17: 934-940.
14. Lefebvre AM, Laville M, Vega N, Riou JP, van Gaal L, Auwerx J, Vidal H: Depot-specific differences in adipose tissue gene expression in lean and obese subjects. Diabetes 1998; 47: 98-103.
15. Viguerie N, Vidal H, Arner P, Holst C, Verdich C, Avizou S, Astrup A, Saris WH, Macdonald IA, Klimcakova E, Clément K, Martinez A, Hoffstedt J, Sørensen TI, Langin D: Adipose tissue gene expression in obese subjects during low-fat and high-fat hypocaloric diets. Diabetologia 2005; 48: 123-131.
16. Poulain-Godefroy O, Lecoeur C, Pattou F, Fruhbeck G, Froguel P: Inflammation is associated with a decrease of lipogenic factors in omental fat in women. Am J Physiol Regul Integr Comp Physiol 2008; 295:R1-7.
17. Rask E, Olsson T, Soderberg S, Andrew R, Livingstone DE, Johnson O, Walker BR: Tissue- specific dysregulation of cortisol metabolism in human obesity. J Clin Endocrinol Metab 2001; 86: 1418-1421.
18. Rask E, Walker BR, Soderberg S, Livingstone DE, Eliasson M, Johnson O, Andrew R, Olsson T: Tissue-specific changes in peripheral cortisol metabolism in obese women: Increased adipose 11beta-hydroxysteroid dehydrogenase type 1 activity. J Clin Endocrinol Metab 2002; 87: 3330-3336.
19. Paulmyer-Lacroix O, Boullu S, Oliver C, Alessi MC, Grino M: Expression of the mRNA coding for 11betahydroxysteroid dehydrogenase type 1 in adipose tissue from obese patients: An in situ hybridization study. J Clin Endocrinol Metab 2002; 87: 2701-2705.
20. Desbriere R, Vuaroqueaux V, Achard V, Boullu-Ciocca S, Labuhn M, Dutour A, Grino N: 11beta-hydroxysteroid dehydrogenase type 1 mRNA is increased in both visceral and subcutaneous adipose tissue of obese patients. Obesity 2006; 14: 794-798.
21. Svendsen PF, Madsbad S, Nilas L, Paulsen SK, Pedersen SB: Expression of 11beta-hydroxysteroid dehydrogenase 1 and 2 in subcutaneous adipose tissue of lean and obese women with and without polycystic ovary syndrome. Int J Obes 2009; 33: 1249-1256.
22. Mericq V, Medina P, Bouwman C, Johnson MC, Godoy J, Lopez T, Iniquez G: Expression and activity of 11betahydroxysteroid dehydrogenase type 1 enzyme in subcutaneous and visceral adipose tissue of prepubertal children. Horm Res 2009; 71: 89-93.
23. Tomlinson JW, Moore J, Cooper MS, Bujalska I, Shahmanesh M, Burt C, Strain A, Hewison M, Stewart PM: Regulation of expression of 11beta-hydroxysteroid dehydrogenase type 1 in adipose tissue: Tissue-specific induction by cytokines. Endocrinology 2001; 142: 1982-1989.
24. Tomlinson JW, Sinha B, Bujalska I, Hewison M, Stewart PM: Expression of 11beta- hydroxysteroid dehydrogenase type 1 in adipose tissue is not increased in human obesity. J Clin Endocrinol Metab 2002; 87: 5630-5635.
25. Tomlinson JW, Moore JS, Clark PM, Holder G, Shakespeare L, Stewart PM: Weight loss increases 11betahydroxysteroid dehydrogenase type 1 expression in human adipose tissue. J Clin Endocrinol Metab 2004; 89: 2711-16.
26. Yang YK, Chen M, Clements RH, Abrams GA, Aprahamian CJ, Harmon CM: Human mesenteric adipose tissue plays unique role versus subcutaneous and omental fat in obesity related diabetes. Cell Physiol Biochem 2008; 22: 531-538.
27. Munoz R, Carvajal C, Escalona A, Boza C, Perez G, Ibanez L, Fardella C: 11beta-hydroxysteroid dehydrogenase type 1 is overexpressed in subcutaneous adipose tissue of morbidly obese patients. Obes Surg 2009; 17: 764-770.
28. Hernandez-Morante JJ, Gomez-Santos C, Milagro F, Campion J, Martinez JA, Zamora S, Garaulet M: Expression of cortisol metabolism-related genes shows circadian rhythmic patterns in human adipose tissue. Int J Obes 2009; 33: 473-480.
29. Gomez-Abellan P, Gomez-Santos C, Madrid JA, Milagro FI, Campion J, Martinez JA, Ordovas JM, Garaulet M: Circadian expression of adiponectin and its receptors in human adipose tissue. Endocrinology 2010; 151: 115-122.
30. Gomez-Abellan P, Hernandez-Morante JJ, Lujan JA, Madrid JA, Garaulet M: Clock genes are implicated in the human metabolic syndrome. Int J Obes 2008; 32: 121-128.
31. Gomez-Santos C, Gomez-Abellan P, Madrid JA, Hernandez-Morante JJ, Lujan JA, Ordovas JM, Garaulet M: Circadian rhythm of clock genes in human adipose explants. Obesity 2009; 17: 1481-1485.
32. Giusti V, Suter M, Verdumo C, Gaillard RC, Burckhardt P, Pralong FP: Molecular determinants of human adipose tissue: Differences between visceral and subcutaneous compartments in obese women. J Clin Endocrinol Metab 2004; 89: 1379-1384.
33. Knerr I, Herzog D, Rauh M, Rascher W, Horbach T: Leptin and ghrelin expression in adipose tissues and serum levels in gastric banding patients. Eur J Clin Invest 2006; 36: 389-394.
34. Bastard JP, Hainque B, Dusserre E, Bruckert E, Robin D, Vallier P, Perche S, Robin P, Turpin G, Jardel C, Laville M, Forest C, Vidal H: Peroxisome proliferator activated receptor-gamma, leptin and tumor necrosis factoralpha mRNA expression during very low calorie diet in subcutaneous adipose tissue in obese women. Diabetes Metab Res Rev 1999; 15: 92-98.
35. Schoof E, Stuppy A, Harig F, Singer H, Carbon R, Horbach T, Kratzsch J, Rascher W, Dötsch J: No influence of surgical stress on postoperative leptin gene expression in different adipose tissues and soluble leptin receptor plasma levels. Horm Res 2003; 59: 184-190.
36. Coupaye M, Bouillot JL, Coussieu C, Guy-Grand B, Basdevant A, Oppert JM: One-year changes in energy expenditure and serum leptin following adjustable gastric banding in obese women. Obes Surg 2005; 15: 827-833.
37. Holdstock C, Engstrom BE, Ohrvall M, Lind L, Sundbom M, Karlsson FA: Ghrelin and adipose tissue regulatory peptides: Effect of gastric bypass surgery in obese humans. J Clin Endocrinol Metab 2003; 88: 3177-3183.
38. Infanger D, Baldinger R, Branson R, Barbier T, Steffen R, Horber FF: Effect of significant intermediate-term weight loss on serum leptin levels and body composition in severely obese subjects. Obes Surg 2003; 13: 879-888.
39. Swarbrick MM, Stanhope KL, Austrheim-Smith IT, Van Loan MD, Ali MR, Wolfe BM, Havel PJ: Longitudinal changes in pancreatic and adipocyte hormones following Roux-en-Y gastric bypass surgery. Diabetologia 2008; 51: 1901-1911.
40. Bastard JP, Jardel C, Bruckert E, Blondy P, Capeau J, Laville M, Vidal H, Hainque B: Elevated levels of interleukin 6 are reduced in serum and subcutaneous adipose tissue of obese women after weight loss. J Clin Endocrinol Metab 2000; 85: 3338-3342.
41. Polak J, Klimcakova E, Moro C, Viguerie N, Berlan M, Hejnova J, Richterova B, Kraus I, Langin D, Stich V: Effect of aerobic training on plasma levels and subcutaneous abdominal adipose tissue gene expression of adiponectin, leptin, interleukin 6, and tumor necrosis factor alpha in obese women. Metabolism 2006; 55: 1375-1381.
42. Guijarro A, Suzuki S, Chen C, Kirchner H, Middleton FA, Nadtochiy S, Brookes PS, Niijima A, Inui A, Meguid MM: Characterization of weight loss and weight regain mechanisms after Roux-en-Y gastric bypass in rats. Am J Physiol Regul Integr Comp Physiol 2007; 293:R1474-1489.
43. Meguid MM, Glade MJ, Middleton FA: Weight regain after Roux-en-Y: A significant 20% complication related to PYY. Nutrition 2008; 24: 832-842.
44. Garaulet M, Viguerie N, Porubsky S, Klimcakova E, Clement K, Langin D, Stich V: Adiponectin gene expression and plasma values in obese women during very-low-calorie diet. Relationship with cardiovascular risk factors and insulin resistance. J Clin Endocrinol Metab 2004; 89: 756-760.
45. Savu MK, Philips SA, Oh DK, Park K, Gerlan C, Ciaraldi TP, Henry RR: Response of adiponectin and its receptors to changes in metabolic state after gastric bypass surgery: Dissociation between adipose tissue expression and circulating levels. Surg Obes Relat Dis 2009; 5: 172-180.
46. Ricote M, Huang J, Fajas L, Li A, Welch J, Najib J, Witztum JL, Auwerx J, Palinski W, Glass CK: Expression of the peroxisome proliferator-activated receptor gamma (PPARgamma) in human atherosclerosis and regulation in macrophages by colony stimulating factors and oxidized low density lipoprotein. Proc Natl Acad Sci U S A 1998; 95: 7614-7619.
47. Ricote M, Li AC, Willson TM, Kelly CJ, Glass CK: The peroxisome proliferator-activated receptor-gamma is a negative regulator of macrophage activation. Nature 1998; 391: 79-82.
48. Temelkova-Kurktschiev T, Hanefeld M, Chinetti G, Zawadzki C, Haulon S, Kubaszek A, Koehler C, Leonhardt W, Staels B, Laakso M: Ala12Ala genotype of the peroxisome proliferator-activated receptor gamma2 protects against atherosclerosis. J Clin Endocrinol Metab 2004; 89: 4238-4242.
49. Lefebvre AM, Laville M, Vega N, Riou JP, van Gaal L, Auwerx J, Vidal H: Depot-specific differences in adipose tissue gene expression in lean and obese subjects. Diabetes 1998; 47: 98-103.
50. Vidal-Puig A, Jimenez-Linan M, Lowell BB, Hamann A, Hu E, Spiegelman B, Flier JS, Moller DE: Regulation of PPAR gamma gene expression by nutrition and obesity in rodents. J Clin Invest 1996; 97: 2553-2561.
51. Kintscher U, Law RE: PPARgamma-mediated insulin sensitization: The importance of fat versus muscle. Am J Physiol Endocrinol Metab 2005; 288:E287-291.
52. Moller DE, Berger JP: Role of PPARs in the regulation of obesity-related insulin sensitivity and inflammation. Int J Obes Relat Metab Disord 2003; 27(suppl 3):S17-21.
53. Sharma AM, Staels B: Review: Peroxisome proliferator-activated receptor gamma and adipose tissue- understanding obesity-related changes in regulation of lipid and glucose metabolism. J Clin Endocrinol Metab 2007; 92: 386-395.
54. He W, Barak Y, Hevener A, Olson P, Liao D, Le J, Nelson M, Ong E, Olefsky JM, Evans RM: Adipose-specific peroxisome proliferator-activated receptor gamma knockout causes insulin resistance in fat and liver but not in muscle. Proc Natl Acad Sci U S A 2003; 100: 15712-15717.
55. Jones JR, Barrick C, Kim KA, Lindner J, Blondeau B, Fujimoto Y, Shiota M, Kesterson RA, Kahn BB, Magnuson MA: Deletion of PPARgamma in adipose tissues of mice protects against high fat diet-induced obesity and insulin resistance. Proc Natl Acad Sci U S A 2005; 102: 6207-6212.
56. Paulsen SK, Pedersen SB, Fisker S, Richelsen B: 11Beta-HSD type 1 expression in human adipose tissue: Impact of gender, obesity, and fat localization. Obesity 2007; 15: 1954-1960.