Identification of the ortho-benzoquinone intermediate of 5-O-caffeoylquinic acid in vitro and in vivo: Comparison of bioactivation under normal and pathological situations

Drug Metabolism and Disposition

Volumn 40, Issue 8, 2012, Pages 1628-1640

  Xie, Cen ^a   Zhong, Dafang ^a   Chen, Xiaoyan ^a  

^a SHANGHAI INSTITUTE OF MATERIA MEDICA   (China)

Author keywords

[No Author keywords available]

Indexed keywords

5 O CAFFEOYLQUINIC ACID DERIVATIVE; BENZOQUINONE DERIVATIVE; CARBONYL DERIVATIVE; CATECHOL METHYLTRANSFERASE; CHLOROGENIC ACID; CUMENE HYDROPEROXIDE; CYTOCHROME P450; CYTOCHROME P450 2E1; CYTOCHROME P450 3A4; DRUG METABOLITE; DRUG METABOLIZING ENZYME; GLUTATHIONE; GLUTATHIONE TRANSFERASE; MYELOPEROXIDASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; S ADENOSYLMETHIONINE; TOLCAPONE; UNCLASSIFIED DRUG;

ARTICLE; BIOACTIVATION; CONTROLLED STUDY; DRUG ACTIVATION; DRUG CONJUGATION; DRUG OXIDATION; HUMAN; HUMAN CELL; HUMAN TISSUE; LEUKOCYTE; LIVER MICROSOME; PRIORITY JOURNAL;

ANIMALS; BENZOQUINONES; CHLOROGENIC ACID; HUMANS; MALE; MASS SPECTROMETRY; QUINIC ACID; RATS; RATS, WISTAR;

RATTUS;

EID: 84863913079     PISSN: 00909556     EISSN: 1521009X     Source Type: Journal    
DOI: 10.1124/dmd.112.045641     Document Type: Article

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