-
1
-
-
0034814794
-
Inflammatory activation of prostaglandin production by microglial cells antagonized by amyloid peptide
-
DOI 10.1006/bbrc.2000.4156
-
Balboa MA, Balsinde J, Dennis EA (2001) Inflammatory activation of prostaglandin production by microglial cells antagonized by amyloid peptide. Biochem Biophys Res Commun 280:558-560 (Pubitemid 32912827)
-
(2001)
Biochemical and Biophysical Research Communications
, vol.280
, Issue.2
, pp. 558-560
-
-
Balboa, M.A.1
Balsinde, J.2
Dennis, E.A.3
-
2
-
-
0035053038
-
(2001) COX-2 as a multifunctional neuronal modulator
-
Bazan NG (2001) (2001) COX-2 as a multifunctional neuronal modulator. Nat Med 7(4):414-415
-
(2001)
Nat Med
, vol.7
, Issue.4
, pp. 414-415
-
-
Bazan, N.G.1
-
3
-
-
0028641246
-
Peroxynitrite versus hydroxyl radical: The role of nitric oxide in superoxide-dependent cerebral injury
-
Beckman JS (1994) Peroxynitrite versus hydroxyl radical: the role of nitric oxide in superoxide-dependent cerebral injury. Ann N Y Acad Sci 17:69-75
-
(1994)
Ann N Y Acad Sci
, vol.17
, pp. 69-75
-
-
Beckman, J.S.1
-
4
-
-
0030250376
-
Inflammatory processes and antiinflammatory drugs in Alzheimer's disease: A current appraisal
-
Breitner JC (1996) Inflammatory processes and antiinflammatory drugs in Alzheimer's disease: a current appraisal. Neurobiol Aging 17:789-794
-
(1996)
Neurobiol Aging
, vol.17
, pp. 789-794
-
-
Breitner, J.C.1
-
5
-
-
17044441129
-
Conformations of synthetic beta peptides in solid state and in aqueous solution: Relation to toxicity in PC12 cells
-
DOI 10.1016/0925-4439(95)00102-6
-
Buchet R, Tavitian E, Ristig D, Swoboda R, Stauss U, Gremlich HU, de La Fournière L, Staufenbiel M, Frey P, Lowe DA (1996) Conformations of synthetic beta peptides in solid state and in aqueous solution: relation to toxicity in PC12 cells. Biochim Biophys Acta 1315(1):40-46 (Pubitemid 26049979)
-
(1996)
Biochimica et Biophysica Acta - Molecular Basis of Disease
, vol.1315
, Issue.1
, pp. 40-46
-
-
Buchet, R.1
Tavitian, E.2
Ristig, D.3
Swoboda, R.4
Stauss, U.5
Gremlich, H.U.6
De La, F.L.7
Staufenbiel, M.8
Frey, P.9
Lowe, D.A.10
-
6
-
-
0036753272
-
Evidence that amyloid beta-peptide-induced lipid peroxidation and its sequelae in Alzheimer's disease brain contribute to neuronal death
-
DOI 10.1016/S0197-4580(01)00340-2, PII S0197458001003402
-
Butterfield DA, Castegna A, Lauderback CM, Drake J (2002a) Evidence that amyloid beta-peptide-induced lipid peroxidation and its sequelae in Alzheimer's disease brain contribute to neuronal death. Neurobiol Aging 23(5):655-664 (Pubitemid 35217687)
-
(2002)
Neurobiology of Aging
, vol.23
, Issue.5
, pp. 655-664
-
-
Allan, B.D.1
Castegna, A.2
Lauderback, C.M.3
Drake, J.4
-
7
-
-
0036592636
-
Amyloid beta-peptide and amyloid pathology are central to the oxidative stress and inflammatory cascades under which Alzheimer's disease brain exists
-
Butterfield DA, Griffin S, Munch G, Pasinetti GM (2002b) Amyloid beta-peptide and amyloid pathology are central to the oxidative stress and inflammatory cascades under which Alzheimer's disease brain exists. J Alzheimers Dis 4(3):193-201 (Pubitemid 35006051)
-
(2002)
Journal of Alzheimer's Disease
, vol.4
, Issue.3
, pp. 193-201
-
-
Butterfield, D.A.1
Griffin, S.2
Munch, G.3
Pasinetti, G.M.4
-
8
-
-
0034055035
-
Dominant negative effects of apolipoprotein E4 revealed in transgenic models of neurodegenerative disease
-
DOI 10.1016/S0306-4522(00)00069-5, PII S0306452200000695
-
Buttini M, Akeefe H, Lin C, Mahley RW, Pitas RE, Wyss-Coray T, Mucke (2000) Dominant negative effects of apolipoprotein E4 revealed in transgenic models of neurodegenerative disease. Neuroscience 97(2):207-210 (Pubitemid 30224757)
-
(2000)
Neuroscience
, vol.97
, Issue.2
, pp. 207-210
-
-
Buttini, M.1
Akeefe, H.2
Lin, C.3
Mahley, R.W.4
Pitas, R.E.5
Wyss-Coray, T.6
Mucke, L.7
-
9
-
-
0028178004
-
Brain interleukin-1 beta in Alzheimer's disease and vascular dementia
-
Cacabelos R, Alvarez XA, Fernández-Novoa L, Franco A, Mangues R, Pellicer A, Nishimura T (1994) Brain interleukin-1 beta in Alzheimer's disease and vascular dementia. Methods Find Exp Clin Pharmacol 16(2):141-151
-
(1994)
Methods Find Exp Clin Pharmacol
, vol.16
, Issue.2
, pp. 141-151
-
-
Cacabelos, R.1
Alvarez, X.A.2
Fernández-Novoa, L.3
Franco, A.4
Mangues, R.5
Pellicer, A.6
Nishimura, T.7
-
10
-
-
15944369995
-
The interaction of amyloid-beta with ApoE
-
Carter DB (2005) The interaction of amyloid-beta with ApoE. Subcell Biochem 38:255-272
-
(2005)
Subcell Biochem
, vol.38
, pp. 255-272
-
-
Carter, D.B.1
-
11
-
-
0038509216
-
APOE epsilon4 influences the pathological phenotype of Alzheimer's disease by favouring cerebrovascular over parenchymal accumulation of Abeta protein
-
DOI 10.1046/j.1365-2990.2003.00457.x
-
Chalmers K, Wilcock GK, Love S (2003) APOE epsilon 4 influences the pathological phenotype of Alzheimer's disease by favouring cerebrovascular over parenchymal accumulation of A beta protein. Neuropathol Appl Neurobiol 29(3):231-238 (Pubitemid 36718171)
-
(2003)
Neuropathology and Applied Neurobiology
, vol.29
, Issue.3
, pp. 231-238
-
-
Chalmers, K.1
Wilcock, G.K.2
Love, S.3
-
12
-
-
0037703255
-
RAGE mediates amyloid-beta peptide transport across the blood-brain barrier and accumulation in brain
-
DOI 10.1038/nm890
-
Deane R, Du Yan S, Submamaryan RK, LaRue B, Jovanovic S, Hogg E, Welch D, Manness L, Lin C, Yu J, Zhu H, Ghiso J, Frangione B, Stern A, Schmidt AM, Armstrong DL, Arnold B, Liliensiek B, Nawroth P, Hofman F, Kindy M, Stern D, Zlokovic B (2003) RAGE mediates amyloid-beta peptide transport across the bloodbrain barrier and accumulation in brain. Nat Med 9(7):907-913 (Pubitemid 36889934)
-
(2003)
Nature Medicine
, vol.9
, Issue.7
, pp. 907-913
-
-
Deane, R.1
Yan, S.D.2
Submamaryan, R.K.3
LaRue, B.4
Jovanovic, S.5
Hogg, E.6
Welch, D.7
Manness, L.8
Lin, C.9
Yu, J.10
Zhu, H.11
Ghiso, J.12
Frangione, B.13
Stern, A.14
Schmidt, A.M.15
Armstrong, D.L.16
Arnold, B.17
Liliensiek, B.18
Nawroth, P.19
Hofman, F.20
Kindy, M.21
Stern, D.22
Zlokovic, B.23
more..
-
13
-
-
57449084208
-
ApoE isoform-specific disruption of amyloid beta peptide clearance from mouse brain
-
Deane R, Sagare A, Hamm K, Parisi M, Lane S, Finn MB, Holtzman DM, Zlokovic BV (2008) apoE isoform-specific disruption of amyloid beta peptide clearance from mouse brain. J Clin Invest 118(12):4002-4013
-
(2008)
J Clin Invest
, vol.118
, Issue.12
, pp. 4002-4013
-
-
Deane, R.1
Sagare, A.2
Hamm, K.3
Parisi, M.4
Lane, S.5
Finn, M.B.6
Holtzman, D.M.7
Zlokovic, B.V.8
-
14
-
-
0035478595
-
2 is mediated by inducible nitric oxide synthase activation of the constitutive cyclooxygenase and induction of membrane-associated prostaglandin E synthase
-
Devaux Y, Seguin C, Grosjean S, Talance N, Camaeti V, Burlet A, Zannad F, Meistelman C, Mertes PM, Longrois D (2001) Lipopolysaccharide-induced increase of prostaglandin E(2) is mediated by inducible nitric oxide synthase activation of the constitutive cyclooxygenase and induction of membraneassociated prostaglandin E synthase. J Immunol 167:3962-3971 (Pubitemid 32910842)
-
(2001)
Journal of Immunology
, vol.167
, Issue.7
, pp. 3962-3971
-
-
Devaux, Y.1
Seguin, C.2
Grosjean, S.3
De Talance, N.4
Camaeti, V.5
Burlet, A.6
Zannad, F.7
Meistelman, C.8
Mertes, P.-M.9
Longrois, D.10
-
15
-
-
84863868582
-
Apolipoprotein E: Highavidity binding familial Alzheimer disease
-
Enghild J, Salvesen GS, Roses AD (1993) Apolipoprotein E: highavidity binding familial Alzheimer disease. Proc Natl Acad Sci USA 90:1977-1981
-
(1993)
Proc Natl Acad Sci USA
, vol.90
, pp. 1977-1981
-
-
Enghild, J.1
Salvesen, G.S.2
Roses, A.D.3
-
16
-
-
14944385354
-
Beta-amyloid-stimulated microglia induce neuron death via synergistic stimulation of tumor necrosis factor alpha and NMDA receptors
-
Floden AM, Li S, Combs CK (2005) Beta-amyloid-stimulated microglia induce neuron death via synergistic stimulation of tumor necrosis factor alpha and NMDA receptors. J Neurosci 25 (10):2566-2275
-
(2005)
J Neurosci
, vol.25
, Issue.10
, pp. 2566-12275
-
-
Floden, A.M.1
Li, S.2
Combs, C.K.3
-
17
-
-
0029866177
-
The interaction between apolipoprotein e and Alzheimer's amyloid β-peptide is dependent on-peptide conformation
-
Golabek AA, Soto C, Vogel T, Wisniewski T (1996) The interaction between apolipoprotein E and Alzheimer's amyloid β-peptide is dependent on-peptide conformation. J Biol Chem 271:10602-10606
-
(1996)
J Biol Chem
, vol.271
, pp. 10602-10606
-
-
Golabek, A.A.1
Soto, C.2
Vogel, T.3
Wisniewski, T.4
-
18
-
-
0030610936
-
2 synthesis is differentially affected by reactive nitrogen intermediates in cultured rat microglia and RAW 264.7 cells
-
DOI 10.1016/S0014-5793(97)00925-3, PII S0014579397009253
-
Guastadisegni C, Minghetti L, Nicolini A, Polazzi E, Ade P, Balduzzi M, Levi G (1997) Prostaglandin E2 synthesis is differentially affected by reactive nitrogen intermediates in cultured rat microglia and RAW 264.7 cells. FEBS Lett 413:314-318 (Pubitemid 27353291)
-
(1997)
FEBS Letters
, vol.413
, Issue.2
, pp. 314-318
-
-
Guastadisegni, C.1
Minghetti, L.2
Nicolini, A.3
Polazzi, E.4
Ade, P.5
Balduzzi, M.6
Levi, G.7
-
19
-
-
0035100231
-
Neuronal cyclooxygenase 2 expression in the hippocampal formation as a function of the clinical progression of Alzheimer disease
-
Ho L, Purohit D, Haroutunian V, Luterman JD, Willis F, Naslund J, Buxbaum JD, Mohs RC, Aisen PS, Pasinetti GM (2001) Neuronal cyclooxygenase 2 expression in the hippocampal formation as a function of the clinical progression of Alzheimer disease. Arch Neurol 58(3):487-892
-
(2001)
Arch Neurol
, vol.58
, Issue.3
, pp. 487-892
-
-
Ho, L.1
Purohit, D.2
Haroutunian, V.3
Luterman, J.D.4
Willis, F.5
Naslund, J.6
Buxbaum, J.D.7
Mohs, R.C.8
Aisen, P.S.9
Pasinetti, G.M.10
-
20
-
-
4243215848
-
Apolipoprotein E isoform-dependent amyloid deposition and neuritic degeneration in a mouse model of Alzheimer's disease
-
DOI 10.1073/pnas.050004797
-
Holtzman DM, Bales KR, Tenkova T, Fagan AM, Parsadanian M, Sartorius LJ, Mackey B, Olney J, McKeel D, Wozniak D, Paul SM (2000) Apolipoprotein E isoform-dependent amyloid deposition and neuritic degeneration in a mouse model of Alzheimer's disease. Proc Natl Acad Sci U S A 97(6):2892-2897 (Pubitemid 30159268)
-
(2000)
Proceedings of the National Academy of Sciences of the United States of America
, vol.97
, Issue.6
, pp. 2892-2897
-
-
Holtzman, D.M.1
Bales, K.R.2
Tenkova, T.3
Fagan, A.M.4
Parsadanian, M.5
Sartorius, L.J.6
Mackey, B.7
Olney, J.8
McKeel, D.9
Wozniak, D.10
Paul, S.M.11
-
21
-
-
0032473596
-
Amyloid-beta peptide activates cultured astrocytes: Morphological alterations, cytokine induction and nitric oxide release
-
DOI 10.1016/S0006-8993(97)01318-8, PII S0006899397013188
-
Hu J, Akama KT, Krafft GA, Chromy BA, Van Eldik LJ (1998) Amyloid-beta peptide activates cultured astrocytes: morphological alterations, cytokine induction and nitric oxide release. Brain Res 785:195-206 (Pubitemid 28179382)
-
(1998)
Brain Research
, vol.785
, Issue.2
, pp. 195-206
-
-
Hu, J.1
Akama, K.T.2
Krafft, G.A.3
Chromy, B.A.4
Van Eldik, L.J.5
-
22
-
-
4143091289
-
Apolipoprotein E: Diversity of cellular origins, structural and biophysical properties, and effects in Alzheimer's disease
-
Huang Y, Weisgraber KH, Mucke L, Mahley RW (2004) Apolipoprotein E: diversity of cellular origins, structural and biophysical properties, and effects in Alzheimer's disease. J Mol Neurosci 23 (3):89-204
-
(2004)
J Mol Neurosci
, vol.23
, Issue.3
, pp. 89-204
-
-
Huang, Y.1
Weisgraber, K.H.2
Mucke, L.3
Mahley, R.W.4
-
23
-
-
0041816291
-
Cerebrovascular effects of amyloid-beta peptides: Mechanisms and implications for Alzheimer's dementia
-
Iadecola C (2003) Cerebrovascular effects of amyloid-beta peptides: mechanisms and implications for Alzheimer's dementia. Cell Mol Neurobiol 23(4-5):681-689
-
(2003)
Cell Mol Neurobiol
, vol.23
, Issue.4-5
, pp. 681-689
-
-
Iadecola, C.1
-
24
-
-
2342614850
-
Neurovascular regulation in the normal brain and in Alzheimer's disease
-
Iadecola C (2004) Neurovascular regulation in the normal brain and in Alzheimer's disease. Nat Rev Neurosci 5(5):347-360
-
(2004)
Nat Rev Neurosci
, vol.5
, Issue.5
, pp. 347-360
-
-
Iadecola, C.1
-
25
-
-
0035934250
-
Interleukin 1-induced cyclooxygenase and nitric oxide synthase gene expression in the rat dorsal root ganglia is modulated by antioxidants
-
DOI 10.1016/S0306-4522(01)00253-6, PII S0306452201002536
-
Igwe OJ, Murray JM, Moolwaney AS (2001) Interleukin 1-induced cyclooxygenase and nitric oxide synthase gene expression in the rat dorsal root ganglia is modulated by antioxidants. Neuroscience 105:971-985 (Pubitemid 32786810)
-
(2001)
Neuroscience
, vol.105
, Issue.4
, pp. 971-985
-
-
Igwe, O.J.1
Murray, J.N.2
Moolwaney, A.S.3
-
26
-
-
0033827557
-
Apolipoprotein e affects the amount, form, and anatomical distribution of amyloid beta-peptide deposition in homozygous APP(V717F) transgenic mice
-
Irizarry MC, Cheung BS, Rebeck GW, Paul SM, Bales KR, Hyman BT (2000) Apolipoprotein E affects the amount, form, and anatomical distribution of amyloid beta-peptide deposition in homozygous APP(V717F) transgenic mice. Acta Neuropathol 100(5):451-458
-
(2000)
Acta Neuropathol
, vol.100
, Issue.5
, pp. 451-458
-
-
Irizarry, M.C.1
Cheung, B.S.2
Rebeck, G.W.3
Paul, S.M.4
Bales, K.R.5
Hyman, B.T.6
-
27
-
-
0035082722
-
Amyloid beta40/42 clearance across the blood-brain barrier following intra-ventricular injections in wild-type, apoE knock-out and human apoE3 or E4 expressing transgenic mice
-
Ji Y, Permanne B, Sigurdsson EM, Holtzman DM, Wisniewski T (2001) Amyloid beta40/42 clearance across the blood-brain barrier following intra-ventricular injections in wild-type, apoE knock-out and human apoE3 or E4 expressing transgenic mice. J Alzheimers Dis 3(1):23-30 (Pubitemid 32238247)
-
(2001)
Journal of Alzheimer's Disease
, vol.3
, Issue.1
, pp. 23-30
-
-
Ji, Y.1
Permanne, B.2
Sigurdsson, E.M.3
Holtzman, D.M.4
Wisniewski, T.5
-
28
-
-
0037077284
-
Apolipoprotein E4 potentiates amyloid beta peptide-induced lysosomal leakage and apoptosis in neuronal cells
-
DOI 10.1074/jbc.M112109200
-
Ji ZS, Miranda RD, Newhouse YM, Weisgraber KH, Huang Y, Mahley RW (2002) Apolipoprotein E4 potentiates amyloid beta peptide-induced lysosomal leakage and apoptosis in neuronal cells. J Biol Chem 277(24):21821-21828 (Pubitemid 34952334)
-
(2002)
Journal of Biological Chemistry
, vol.277
, Issue.24
, pp. 21821-21828
-
-
Ji, Z.-S.1
Dennis, M.R.2
Newhouse, Y.M.3
Weisgraberyadong, H.K.H.4
Mahley, R.W.5
-
29
-
-
0027087234
-
Peroxynitrite, a cloaked oxidant formed by nitric oxide and superoxide
-
DOI 10.1021/tx00030a017
-
Koppenol WH, Moreno JJ, Pryor WA, Ischiropoulos H, Beckman JS (1992) Peroxynitrite, a cloaked oxidant formed by nitric oxide and superoxide. Chem Res Toxicol 5:834-842 (Pubitemid 23004874)
-
(1992)
Chemical Research in Toxicology
, vol.5
, Issue.6
, pp. 834-842
-
-
Koppenol, W.H.1
Moreno, J.J.2
Pryor, W.A.3
Ischiropoulos, H.4
Beckman, J.S.5
-
30
-
-
39749188810
-
Cyclooxygenase-2 inhibition improves amyloid-beta-mediated suppression of memory and synaptic plasticity
-
DOI 10.1093/brain/awn008
-
Kotilinek LA, Westerman MA, Wang Q, Panizzon K, Lim GP, Simonyi A, Lesne S, Falinska A, Younkin LH, Younkin SG, Rowan M, Cleary J, Wallis RA, Sun GY, Cole G, Frautschy S, Anwyl R, Ashe KH (2008) Cyclooxygenase-2 inhibition improves amyloid-beta-mediated suppression of memory and synaptic plasticity. Brain 131(Pt 3):651-664 (Pubitemid 351294724)
-
(2008)
Brain
, vol.131
, Issue.3
, pp. 651-664
-
-
Kotilinek, L.A.1
Westerman, M.A.2
Wang, Q.3
Panizzon, K.4
Lim, G.P.5
Simonyi, A.6
Lesne, S.7
Falinska, A.8
Younkin, L.H.9
Younkin, S.G.10
Rowan, M.11
Cleary, J.12
Wallis, R.A.13
Sun, G.Y.14
Cole, G.15
Frautschy, S.16
Anwyl, R.17
Ashe, K.H.18
-
31
-
-
0027931854
-
Isoform-specific binding of apolipoprotein e to betaamyloid
-
LaDu MJ, Falduto MT, Manelli AM, Reardon CA, Getz GS, Frail DE (1994) Isoform-specific binding of apolipoprotein E to betaamyloid. J Biol Chem 269(38):23403-23406
-
(1994)
J Biol Chem
, vol.269
, Issue.38
, pp. 23403-23406
-
-
LaDu, M.J.1
Falduto, M.T.2
Manelli, A.M.3
Reardon, C.A.4
Getz, G.S.5
Frail, D.E.6
-
32
-
-
0028906808
-
Purification of apolipoprotein e attenuates isoformspecific binding to beta-amyloid
-
LaDu MJ, Pederson TM, Frail DE, Reardon CA, Getz GS, Falduto MT (1995) Purification of apolipoprotein E attenuates isoformspecific binding to beta-amyloid. J Biol Chem 270(16):9039-9042
-
(1995)
J Biol Chem
, vol.270
, Issue.16
, pp. 9039-9042
-
-
LaDu, M.J.1
Pederson, T.M.2
Frail, D.E.3
Reardon, C.A.4
Getz, G.S.5
Falduto, M.T.6
-
33
-
-
0000448998
-
Alzheimer Aß neurotoxicity: Promotion by antichymotrypsin, ApoE4; inhibition by Aβ-related peptides
-
DOI 10.1016/0197-4580(96)00112-1
-
Ma J, Brewer BH, Potter H, Brewer HB Jr (1996) Alzheimer Aßneurotoxicity: promotion by antichymotrypsin, apoE4; inhibition by Aβ-related peptides. Neurobiol Aging 17:773-780 (Pubitemid 26348879)
-
(1996)
Neurobiology of Aging
, vol.17
, Issue.5
, pp. 773-780
-
-
Ma, J.1
Brewer Jr., H.B.2
Potter, H.3
-
34
-
-
0030795829
-
Nitric oxide donors activate the cyclo-oxygenase and peroxidase activities of prostaglandin H synthase
-
DOI 10.1016/S0014-5793(97)00643-1, PII S0014579397006431
-
Maccarrone M, Putti S, Finazzi Agro A (1997) Nitric oxide donors activate the cyclooxygenase and peroxidase activities of prostaglandin H synthase. FEBS Lett 410:470-476 (Pubitemid 27304119)
-
(1997)
FEBS Letters
, vol.410
, Issue.2-3
, pp. 470-476
-
-
Maccarrone, M.1
Putti, S.2
Finazzi, A.A.3
-
35
-
-
0031900411
-
Nonsteroidal anti-inflammatory drug use and Alzheimer-type pathology in aging
-
Mackenzie IR, Munoz DG (1998) Nonsteroidal anti-inflammatory drug use and Alzheimer-type pathology in aging. Neurology 50:986-990 (Pubitemid 28212826)
-
(1998)
Neurology
, vol.50
, Issue.4
, pp. 986-990
-
-
Mackenzie, I.R.A.1
Munoz, D.G.2
-
36
-
-
0032839621
-
Apolipoprotein E: From atherosclerosis to Alzheimer's disease and beyond
-
DOI 10.1097/00041433-199906000-00003
-
Mahley RW, Huang Y (1999) Apolipoprotein E: from atherosclerosis to Alzheimer's disease and beyond. Curr Opin Lipidol 10 (3):207-217 (Pubitemid 29405911)
-
(1999)
Current Opinion in Lipidology
, vol.10
, Issue.3
, pp. 207-217
-
-
Mahley, R.W.1
Huang, Y.2
-
37
-
-
67650076604
-
Alzheimer disease: Multiple causes, multiple effects of apolipoprotein E4, and multiple therapeutic approaches
-
Mahley RW, Huang Y (2009) Alzheimer disease: multiple causes, multiple effects of apolipoprotein E4, and multiple therapeutic approaches. Ann Neurol 65(6):623-625
-
(2009)
Ann Neurol
, vol.65
, Issue.6
, pp. 623-625
-
-
Mahley, R.W.1
Huang, Y.2
-
38
-
-
33645808672
-
Apolipoprotein E4: A causative factor and therapeutic target in neuropathology, including Alzheimer's disease
-
Mahley RW, Weisgraber KH, Huang Y (2006) Apolipoprotein E4: a causative factor and therapeutic target in neuropathology, including Alzheimer's disease. Proc Natl Acad Sci U S A 103 (15):5644-5651
-
(2006)
Proc Natl Acad Sci U S A
, vol.103
, Issue.15
, pp. 5644-5651
-
-
Mahley, R.W.1
Weisgraber, K.H.2
Huang, Y.3
-
39
-
-
2142771727
-
Prostanoids, Not Reactive Oxygen Species, Mediate COX-2-Dependent Neurotoxicity
-
DOI 10.1002/ana.20078
-
Manabe Y, Anrather J, Kawano T, Niwa K, Zhou P, Ross ME, Iadecola C (2004) Prostanoids, not reactive oxygen species, mediate COX-2-dependent neurotoxicity. Ann Neurol 55(5):668-675 (Pubitemid 38544327)
-
(2004)
Annals of Neurology
, vol.55
, Issue.5
, pp. 668-675
-
-
Manabe, Y.1
Anrather, J.2
Kawano, T.3
Niwa, K.4
Zhou, P.5
Ross, M.E.6
Iadecola, C.7
-
40
-
-
33645827104
-
Proinflammatory cytokines released from microglia inhibit gap junctions in astrocytes: Potentiation by beta-amyloid
-
DOI 10.1096/fj.05-4297fje
-
Même W, Calvo CF, Froger N, Ezan P, Amigou E, Koulakoff A, Giaume C (2006) Proinflammatory cytokines released from microglia inhibit gap junctions in astrocytes: potentiation by beta-amyloid. FASEB J 20(3):494-496 (Pubitemid 46671227)
-
(2006)
FASEB Journal
, vol.20
, Issue.3
, pp. 494-496
-
-
Meme, W.1
Calvo, C.-F.2
Froger, N.3
Ezan, P.4
Amigou, E.5
Koulakoff, A.6
Giaume, C.7
-
41
-
-
0029961125
-
Interferon-gamma and nitric oxide down-regulate lipopolysaccharide- induced prostanoid production in cultured rat microglial cells by inhibiting cyclooxygenase-2 expression
-
Minghetti L, Polazzi E,Nicolini A, Creminon C, Levi G(1996) Interferongamma and nitric oxide down-regulate lipopolysaccharide-induced prostanoid production in cultured rat microglial cells by inhibiting cyclooxygenase-2 expression. J Neurochem 66:1963-1970 (Pubitemid 26118786)
-
(1996)
Journal of Neurochemistry
, vol.66
, Issue.5
, pp. 1963-1970
-
-
Minghetti, L.1
Polazzi, E.2
Nicolini, A.3
Creminon, C.4
Levi, G.5
-
42
-
-
0029382468
-
Evidence for cyclooxygenase activation by nitric oxide in astrocytes
-
Molina-Holgado F, Lledo A, Guaza C (1995) Evidence for cyclooxygenase activation by nitric oxide in astrocytes. Glia 15:167-172
-
(1995)
Glia
, vol.15
, pp. 167-172
-
-
Molina-Holgado, F.1
Lledo, A.2
Guaza, C.3
-
43
-
-
0032740467
-
2 levels in patients with probable AD
-
Montine TJ, Sidell KR, Crews BC, Markesbery WR, Marnett LJ, Roberts LJ 2nd, Morrow JD (1999) Elevated CSF prostaglandin E2 levels in patients with probable AD. Neurology 53(7):1495-1498 (Pubitemid 29491943)
-
(1999)
Neurology
, vol.53
, Issue.7
, pp. 1495-1498
-
-
Montine, T.J.1
Sidell, K.R.2
Crews, B.C.3
Markesbery, W.R.4
Marnett, L.J.5
Roberts II, L.J.6
Morrow, J.D.7
-
44
-
-
20444377686
-
Regulation of the cyclooxygenase-2 system by interleukin-1beta through mitogen-activated protein kinase signaling pathways: A comparative study of human neuroglioma and neuroblastoma cells
-
DOI 10.1016/j.molbrainres.2005.03.010, PII S0169328X05001221
-
Moolwaney AS, Igwe OJ (2005) Regulation of the cyclooxygenase-2 system by interleukin-1beta through mitogen-activated protein kinase signaling pathways: a comparative study of human neuroglioma and neuroblastoma cells. Brain Res 137(1-2):202-212 (Pubitemid 40798903)
-
(2005)
Molecular Brain Research
, vol.137
, Issue.1-2
, pp. 202-212
-
-
Moolwaney, A.S.1
Igwe, O.J.2
-
45
-
-
0029161781
-
Glial cytokines in Alzheimer's disease: Review and pathogenic implications
-
Mrak RE, Sheng JG, Griffin WS (1995) Glial cytokines in Alzheimer's disease: review and pathogenic implications. Human Pathol 26:816-823
-
(1995)
Human Pathol
, vol.26
, pp. 816-823
-
-
Mrak, R.E.1
Sheng, J.G.2
Griffin, W.S.3
-
46
-
-
0027195977
-
Synthesis of nitric oxide in CNS glial cells
-
DOI 10.1016/0166-2236(93)90109-Y
-
Murphy S, Simmons ML, Agullo L, Garcia A, Feinstein DL, Galea E, Reis DJ, Minc-Golomb D, Schwartz JP (1993) Synthesis of nitric oxide in CNS glial cells. Trends Neurosci 16:323-328 (Pubitemid 23190649)
-
(1993)
Trends in Neurosciences
, vol.16
, Issue.8
, pp. 323-328
-
-
Murphy, S.1
Simmons, M.L.2
Agullo, L.3
Garcia, A.4
Feinstein, D.L.5
Galea, E.6
Reis, D.J.7
Minc-Golomb, D.8
Schwartz, J.P.9
-
47
-
-
0033622480
-
Exogenous A beta1-40 reproduces cerebrovascular alterations resulting from amyloid precursor protein overexpression in mice
-
Niwa K, Carlson GA, Iadecola C (2000) Exogenous A beta1-40 reproduces cerebrovascular alterations resulting from amyloid precursor protein overexpression in mice. J Cereb Blood Flow Metab 20(12):1659-1668
-
(2000)
J Cereb Blood Flow Metab
, vol.20
, Issue.12
, pp. 1659-1668
-
-
Niwa, K.1
Carlson, G.A.2
Iadecola, C.3
-
48
-
-
0034745636
-
Neurotoxic Abeta peptides increase oxidative stress in vivo through NMDA-receptor and nitric-oxide-synthase mechanisms, and inhibit complex IV activity and induce a mitochondrial permeability transition in vitro
-
DOI 10.1046/j.1471-4159.2001.00112.x
-
Parks JK, Smith TS, Trimmer PA, Bennett JP Jr, Parker WD Jr (2001) Neurotoxic Abeta peptides increase oxidative stress in vivo through NMDA-receptor and nitric-oxide-synthase mechanisms, and inhibit complex IV activity and induce a mitochondrial permeability transition in vitro. J Neurochem 76(4):1050-1056 (Pubitemid 32167378)
-
(2001)
Journal of Neurochemistry
, vol.76
, Issue.4
, pp. 1050-1056
-
-
Parks, J.K.1
Smith, T.S.2
Trimmer, P.A.3
Bennett Jr., J.P.4
Davis, P.W.Jr.5
-
49
-
-
51349156675
-
Amyloid plaque and neurofibrillary tangle pathology in a regulatable mouse model of Alzheimer's disease
-
Paulson JB, Ramsden M, Forster C, Sherman MA, McGowan E, Ashe KH (2008) Amyloid plaque and neurofibrillary tangle pathology in a regulatable mouse model of Alzheimer's disease. Am J Pathol 173(3):762-772
-
(2008)
Am J Pathol
, vol.173
, Issue.3
, pp. 762-772
-
-
Paulson, J.B.1
Ramsden, M.2
Forster, C.3
Sherman, M.A.4
McGowan, E.5
Ashe, K.H.6
-
50
-
-
0033041948
-
2 biosynthesis in macrophages
-
Perkins DJ, Kniss DA (1999) Blockade of nitric oxide formation down-regulates cyclooxygenase-2 and decreases PGE2 biosynthesis in macrophages. J Leukoc Biol 65:792-799 (Pubitemid 29279528)
-
(1999)
Journal of Leukocyte Biology
, vol.65
, Issue.6
, pp. 792-799
-
-
Perkins, D.J.1
Kniss, D.A.2
-
51
-
-
33751535253
-
Involvement of the nitric oxide pathway in synaptic dysfunction following amyloid elevation in Alzheimer's disease
-
Puzzo D, Palmeri A, Arancio O (2006) Involvement of the nitric oxide pathway in synaptic dysfunction following amyloid elevation in Alzheimer's disease. Rev Neurosci 17(5):497-523 (Pubitemid 44836221)
-
(2006)
Reviews in the Neurosciences
, vol.17
, Issue.5
, pp. 497-523
-
-
Puzzo, D.1
Palmeri, A.2
Arancio, O.3
-
52
-
-
0034704816
-
Apolipoprotein E and cognitive performance
-
Raber J, Wong D, Yu GQ, Buttini M, Mahley RW, Pitas RE, Mucke L (2000) Apolipoprotein E and cognitive performance. Nature 404 (6776):352-354 (Pubitemid 30164327)
-
(2000)
Nature
, vol.404
, Issue.6776
, pp. 352-354
-
-
Raber, J.1
Wong, D.2
Yu, G.-Q.3
Buttini, M.4
Mahley, R.W.5
Pitas, R.E.6
Mucke, L.7
-
53
-
-
0026076534
-
Functions and mechanisms of interleukin 1 in the brain
-
Rothwell NJ (1991) Functions and mechanisms of interleukin 1 in the brain. Trends Pharmacol Sci 12:430-436
-
(1991)
Trends Pharmacol Sci
, vol.12
, pp. 430-436
-
-
Rothwell, N.J.1
-
54
-
-
4344659648
-
A synthetic peptide blocking the apolipoprotein E/beta-amyloid binding mitigates beta-amyloid toxicity and fibril formation in vitro and reduces beta-amyloid plaques in transgenic mice
-
Sadowski M, Pankiewicz J, Scholtzova H, Ripellino JA, Li Y, Schmidt SD, Mathews PM, Fryer JD, Holtzman DM, Sigurdsson EM, Wisniewski T (2004) A synthetic peptide blocking the apolipoprotein E/beta-amyloid binding mitigates beta-amyloid toxicity and fibril formation in vitro and reduces beta-amyloid plaques in transgenic mice. Am J Pathol 165(3):937-948 (Pubitemid 39129300)
-
(2004)
American Journal of Pathology
, vol.165
, Issue.3
, pp. 937-948
-
-
Sadowski, M.1
Pankiewicz, J.2
Scholtzova, H.3
Ripellino, J.A.4
Li, Y.5
Schmidt, S.D.6
Mathews, P.M.7
Fryer, J.D.8
Holtzman, D.M.9
Sigurdsson, E.M.10
Wisniewski, T.11
-
55
-
-
0346386580
-
Widespread peroxynitrite-mediated damage in Alzheimer's disease
-
Smith MA, Richey Harris PL, Sayre LM, Beckman JS, Perry G (1997) Widespread peroxynitrite-mediated damage in Alzheimer's disease. J Neurosci 17(8):2653-2637
-
(1997)
J Neurosci
, vol.17
, Issue.8
, pp. 2653-12637
-
-
Smith, M.A.1
Richey Harris, P.L.2
Sayre, L.M.3
Beckman, J.S.4
Perry, G.5
-
56
-
-
0038176528
-
In vitro characterization of conditions for amyloid- peptide oligomerization and fibrillogenesis
-
DOI 10.1074/jbc.M210207200
-
Stine WB, Dahlgren KN, Krafft GA, LaDu MJ (2003) In vitro characterization of conditions for amyloid- peptide oligomerization and fibrillogenesis. J Biol Chem 278:11612-11622 (Pubitemid 36792723)
-
(2003)
Journal of Biological Chemistry
, vol.278
, Issue.13
, pp. 11612-11622
-
-
Stine Jr., W.B.1
Dahlgren, K.N.2
Krafft, G.A.3
LaDu, M.J.4
-
57
-
-
12044254746
-
Binding of human apolipoprotein E to synthetic amyloid peptide: Isoform-specific effects and implications for late-onset Alzheimer disease
-
Strittmatter WJ, Weisgraber KH, Huang D, Dong LM, Salvesen GS, Pericak-VanceM, SchmechelD, Saunders AM, Goldgaber D, Roses AD (1993) Binding of human apolipoprotein E to synthetic amyloid peptide: isoform-specific effects and implications for late-onset Alzheimer disease. Proc Natl Acad Sci USA 90:8098-8102 (Pubitemid 23260862)
-
(1993)
Proceedings of the National Academy of Sciences of the United States of America
, vol.90
, Issue.17
, pp. 8098-8102
-
-
Strittmatter, W.J.1
Weisgraber, K.H.2
Huang, D.Y.3
Dong, L.-M.4
Salvesen, G.S.5
Pericak-Vance, M.6
Schmechel, D.7
Saunders, A.M.8
Goldgaber, D.9
Roses, A.D.10
-
58
-
-
0033155382
-
Amyloid-beta peptide induced inflammatory reaction is mediated by the cytokines tumor necrosis factor and interleukin-1
-
Sutton ET, Thomas T, Bryant MW, Landon CS, Newton CA, Rhodin JA (1999) Amyloid-beta peptide induced inflammatory reaction is mediated by the cytokines tumor necrosis factor and interleukin-1. J Submicrosc Cytol Pathol 31(3):313-323 (Pubitemid 129553507)
-
(1999)
Journal of Submicroscopic Cytology and Pathology
, vol.31
, Issue.3
, pp. 313-323
-
-
Sutton, E.T.1
Thomas, T.2
Bryant, M.W.3
Landon, C.S.4
Newton, C.A.5
Rhodin, J.A.G.6
-
59
-
-
0029929872
-
Antioxidants inhibit interleukin-1-induced cyclooxygenase and nitric-oxide synthase expression in rat mesangial cells. Evidence for post-transcriptional regulation
-
Tetsuka T, Baier LD, Morrison AR (1996) Antioxidants inhibit interleukin-1-induced cyclooxygenase and nitric-oxide synthase expression in rat mesangial cells. Evidence for post-transcriptional regulation. J Biol Chem 271(20):11689-11693
-
(1996)
J Biol Chem
, vol.271
, Issue.20
, pp. 11689-11693
-
-
Tetsuka, T.1
Baier, L.D.2
Morrison, A.R.3
-
60
-
-
0035949620
-
Differential modulation of prostaglandin H synthase-2 by nitric oxide-related species in intact cells
-
DOI 10.1021/bi0108960
-
Vidwans AS, Uliasz TF, Hewett JA, Hewett SJ (2001) Differential modulation of prostaglandin H synthase-2 by nitric oxide-related species in intact cells. Biochemistry 40:11533-11542 (Pubitemid 32911296)
-
(2001)
Biochemistry
, vol.40
, Issue.38
, pp. 11533-11542
-
-
Vidwans, A.S.1
Uliasz, T.F.2
Hewett, J.A.3
Hewett, S.J.4
-
61
-
-
0030751783
-
Regulation of the inducible cyclo-oxygenase pathway in human cultured airway epithelial (A549) cells by nitric oxide
-
DOI 10.1038/sj.bjp.0701283
-
Watkins DN, Garlepp MJ, Thompson PJ (1997) Regulation of the inducible cyclo-oxygenase pathway in human cultured airway epithelial (A549) cells by nitric oxide. Br J Pharmacol 121:1482-1488 (Pubitemid 27317564)
-
(1997)
British Journal of Pharmacology
, vol.121
, Issue.7
, pp. 1482-1488
-
-
Watkins, D.N.1
Garlepp, M.J.2
Thompson, P.J.3
-
62
-
-
0024203298
-
Apolipoprotein E genotyping using the polymerase chain reaction and allele-specific oligonucleotide probes
-
DOI 10.1016/S0006-291X(88)81003-9
-
Weisgraber KH, Newhouse YM, Mahley RW (1988) Apolipoprotein E genotyping using the polymerase chain reaction and allelespecific oligonucleotide probes. Biochem Biophys Res Commun 157(3):1212-1217 (Pubitemid 19025986)
-
(1988)
Biochemical and Biophysical Research Communications
, vol.157
, Issue.3
, pp. 1212-1217
-
-
Weisgraber, K.H.1
Newhouse, Y.M.2
Mahley, R.W.3
-
63
-
-
0027970307
-
Acceleration of Alzheimer's fibril formation by apolipoprotein E in vitro
-
Wisniewski T, Castaño EM, Golabek AA, Vogel T, Frangione B, Acceleration of Alzheimer's fibril formation by apolipoprotein E in vitro (1994) Acceleration of Alzheimer's fibril formation by apolipoprotein E in vitro. Am J Pathol 145:1030-1035 (Pubitemid 24345650)
-
(1994)
American Journal of Pathology
, vol.145
, Issue.5
, pp. 1030-1035
-
-
Wisniewski, T.1
Castano, E.M.2
Golabek, A.3
Vogel, T.4
Frangione, B.5
-
65
-
-
47249129136
-
Cyclooxygenase-2 in synaptic signaling
-
DOI 10.2174/138161208784480144
-
Yang H, Chen C (2008) Cyclooxygenase-2 in synaptic signaling. Curr Pharm Des 14(14):1443-1451 (Pubitemid 351993045)
-
(2008)
Current Pharmaceutical Design
, vol.14
, Issue.14
, pp. 1443-1451
-
-
Yang, H.1
Chen, C.2
-
66
-
-
79955585471
-
Blocking the apolipoprotein E/amyloid-β interaction reduces fibrillar vascular amyloid deposition and cerebral microhemorrhages in TgSwDI mice
-
Yang J, Ji Y, Mehta P, Bates KA, Sun Y, Wisniewski T (2011) Blocking the apolipoprotein E/amyloid-β interaction reduces fibrillar vascular amyloid deposition and cerebral microhemorrhages in TgSwDI mice. J Alzheimers Dis 24(2):269-285
-
(2011)
J Alzheimers Dis
, vol.24
, Issue.2
, pp. 269-285
-
-
Yang, J.1
Ji, Y.2
Mehta, P.3
Bates, K.A.4
Sun, Y.5
Wisniewski, T.6
|