RIM genes differentially contribute to organizing presynaptic release sites

Proceedings of the National Academy of Sciences of the United States of America

Volumn 109, Issue 29, 2012, Pages 11830-11835

  Kaeser, Pascal S ^a,b   Deng, Lunbin ^a,c   Fan, Mingming ^a   Südhof, Thomas C ^a  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c GENENTECH INC   (United States)

Author keywords

Exocytosis; Munc13; Synapse

Indexed keywords

CALCIUM CHANNEL;

ANIMAL CELL; ARTICLE; CELL STRAIN HEK293; CONTROLLED STUDY; GENE; GENE DELETION; GENE EXPRESSION; KNOCKOUT MOUSE; MOUSE; NERVE CELL CULTURE; NEUROTRANSMITTER RELEASE; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DOMAIN; PROTEIN FUNCTION; RIMS1 GENE; RIMS2 GENE;

ANIMALS; CALCIUM; CALCIUM CHANNELS; EVOKED POTENTIALS; GTP-BINDING PROTEINS; HEK293 CELLS; HIPPOCAMPUS; HUMANS; LIPIDS; MICE; MICE, KNOCKOUT; PATCH-CLAMP TECHNIQUES; PRESYNAPTIC TERMINALS; RAB3 GTP-BINDING PROTEINS;

MUS; RUMEX;

EID: 84863856685     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1209318109     Document Type: Article

References (31)

1. Gundelfinger ED, Fejtova A (October 24, 2011) Molecular organization and plasticity of the cytomatrix at the active zone. Curr Opin Neurobiol, 10.1016/j.conb.2011.10.005.
2. Kaeser PS (2011) Pushing synaptic vesicles over the RIM. Cell Logist 1:106-110.
3. Wang Y, Südhof TC (2003) Genomic definition of RIM proteins: Evolutionary amplification of a family of synaptic regulatory proteins (small star, filled) . Genomics 81:126-137. (Pubitemid 36298604)
4. Kaeser PS, et al. (2008) RIM1alpha and RIM1beta are synthesized from distinct promoters of the RIM1 gene to mediate differential but overlapping synaptic functions. J Neurosci 28:13435-13447.
5. Wang Y, Sugita S, Sudhof TC (2000) The RIM/NIM family of neuronal C2 domain proteins. Interactions with Rab3 and a new class of Src homology 3 domain proteins. J Biol Chem 275:20033-20044. (Pubitemid 30441612)
6. Schoch S, et al. (2002) RIM1alpha forms a protein scaffold for regulating neurotransmitter release at the active zone. Nature 415:321-326. (Pubitemid 34087553)
7. Weimer RM, et al. (2006) UNC-13 and UNC-10/rim localize synaptic vesicles to specific membrane domains. J Neurosci 26:8040-8047. (Pubitemid 44315128)
8. Gracheva EO, Hadwiger G, Nonet ML, Richmond JE (2008) Direct interactions between C. elegans RAB-3 and Rim provide a mechanism to target vesicles to the presynaptic density. Neurosci Lett 444:137-142.
9. Koushika SP, et al. (2001) A post-docking role for active zone protein Rim. Nat Neurosci 4:997-1005. (Pubitemid 32924139)
10. Schoch S, et al. (2006) Redundant functions of RIM1alpha and RIM2alpha in Ca(2+)-triggered neurotransmitter release. EMBO J 25:5852-5863. (Pubitemid 44967768)
11. Fourcaudot E, et al. (2008) cAMP/PKA signaling and RIM1alpha mediate presynaptic LTP in the lateral amygdala. Proc Natl Acad Sci USA 105:15130-15135.
12. Castillo PE, Schoch S, Schmitz F, Südhof TC, Malenka RC (2002) RIM1alpha is required for presynaptic long-term potentiation. Nature 415:327-330. (Pubitemid 34087554)
13. Chevaleyre V, Heifets BD, Kaeser PS, Südhof TC, Castillo PE (2007) Endocannabinoid-mediated long-term plasticity requires cAMP/PKA signaling and RIM1alpha. Neuron 54:801-812. (Pubitemid 46843526)
14. Kaeser PS, et al. (2011) RIM proteins tether Ca2+ channels to presynaptic active zones via a direct PDZ-domain interaction. Cell 144:282-295.
15. Kiyonaka S, et al. (2007) RIM1 confers sustained activity and neurotransmitter vesicle anchoring to presynaptic Ca2+ channels. Nat Neurosci 10:691-701. (Pubitemid 46828510)
16. Uriu Y, et al. (2010) Rab3-interacting molecule gamma isoforms lacking the Rab3-binding domain induce long lasting currents but block neurotransmitter vesicle anchoring in voltage-dependent P/Q-type Ca2+ channels. J Biol Chem 285:21750-21767.
17. Hibino H, et al. (2002) RIM binding proteins (RBPs) couple Rab3-interacting molecules (RIMs) to voltage-gated Ca(2+) channels. Neuron 34:411-423. (Pubitemid 34465499)
18. 2+ channel density and vesicle docking at the presynaptic active zone. Neuron 69:304-316.
19. Deng L, Kaeser PS, Xu W, Südhof TC (2011) RIM proteins activate vesicle priming by reversing autoinhibitory homodimerization of Munc13. Neuron 69:317-331.
20. Maximov A, Pang ZP, Tervo DG, Südhof TC (2007) Monitoring synaptic transmission in primary neuronal cultures using local extracellular stimulation. J Neurosci Methods 161:75-87. (Pubitemid 46349250)
21. Kaeser PS, et al. (2009) ELKS2alpha/CAST deletion selectively increases neurotransmitter release at inhibitory synapses. Neuron 64:227-239.
22. Ho A, et al. (2006) Genetic analysis of Mint/X11 proteins: Essential presynaptic functions of a neuronal adaptor protein family. J Neurosci 26:13089-13101. (Pubitemid 44954627)
23. Miki T, et al. (2007) Mutation associated with an autosomal dominant cone-rod dystrophy CORD7 modifies RIM1-mediated modulation of voltage-dependent Ca2+ channels. Channels (Austin) 1:144-147.
24. Fernández-Chacón R, et al. (2001) Synaptotagmin I functions as a calcium regulator of release probability. Nature 410:41-49. (Pubitemid 32225830)
25. Gerber SH, et al. (2008) Conformational switch of syntaxin-1 controls synaptic vesicle fusion. Science 321:1507-1510.
26. Pang ZP, et al. (2006) Synaptotagmin-2 is essential for survival and contributes to Ca2+ triggering of neurotransmitter release in central and neuromuscular synapses. J Neurosci 26:13493-13504. (Pubitemid 46026481)
27. Maximov A, Südhof TC (2005) Autonomous function of synaptotagmin 1 in triggering synchronous release independent of asynchronous release. Neuron 48:547-554. (Pubitemid 41654677)
28. Rosenmund C, Stevens CF (1996) Definition of the readily releasable pool of vesicles at hippocampal synapses. Neuron 16:1197-1207. (Pubitemid 26227241)
29. Lu J, et al. (2006) Structural basis for a Munc13-1 homodimer to Munc13-1/RIM heterodimer switch. PLoS Biol 4:e192.
30. Wang Y, Okamoto M, Schmitz F, Hofmann K, Südhof TC (1997) Rim is a putative Rab3 effector in regulating synaptic-vesicle fusion. Nature 388:593-598. (Pubitemid 27340010)
31. Yao I, et al. (2007) SCRAPPER-dependent ubiquitination of active zone protein RIM1 regulates synaptic vesicle release. Cell 130:943-957. (Pubitemid 47332568)