Boosting the sensitivity of ligand-protein screening by NMR of long-lived states

Journal of the American Chemical Society

Volumn 134, Issue 27, 2012, Pages 11076-11079

  Salvi, Nicola ^a   Buratto, Roberto ^a   Bornet, Aurélien ^a   Ulzega, Simone ^a,e   Rentero Rebollo, Inmaculada ^a   Angelini, Alessandro ^a,f   Heinis, Christian ^a   Bodenhausen, Geoffrey ^a,b,c,d  

^a EPFL   (Switzerland)

^b ECOLE NORMALE SUPÉRIEURE   (France)

^c CNRS   (France)

^d SORBONNE UNIVERSITÉ   (France)

^e BRUKER BIOSPIN AG   (Switzerland)

^f MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CANCER RESEARCH; DISSOCIATION CONSTANT; FREE LIGANDS; LIGAND-PROTEIN INTERACTION; SURFACE PLASMONS; UROKINASE-TYPE PLASMINOGEN ACTIVATOR (UPA);

DISSOCIATION; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PROTEINS;

LIGANDS;

GLYCINE GLYCINE ARGININE TRIPEPTIDE; PLASMINOGEN ACTIVATOR INHIBITOR; PROTON; TRIPEPTIDE DERIVATIVE; UK 18; UNCLASSIFIED DRUG; UROKINASE;

AMINO ACID SEQUENCE; ARTICLE; COMPLEX FORMATION; CONCENTRATION RESPONSE; DISSOCIATION CONSTANT; DRUG PROTEIN BINDING; DRUG SCREENING; ENZYME INHIBITION; LIGAND BINDING; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PROTEIN PROTEIN INTERACTION;

BINDING SITES; ENZYME INHIBITORS; HUMANS; LIGANDS; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, MOLECULAR; OLIGOPEPTIDES; PROTEIN BINDING; UROKINASE-TYPE PLASMINOGEN ACTIVATOR;

EID: 84863856503     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/ja303301w     Document Type: Article

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