Purine salvage in Leishmania: Complex or simple by design?

Trends in Parasitology

Volumn 28, Issue 8, 2012, Pages 345-352

  Boitz, Jan M ^a   Ullman, Buddy ^a   Jardim, Armando ^b   Carter, Nicola S ^a  

^a OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^b MCGILL UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

PURINE;

CELL COMPARTMENTALIZATION; DRUG TARGETING; GENETIC ANALYSIS; LEISHMANIA; LEISHMANIA DONOVANI; NONHUMAN; NUCLEOTIDE TRANSPORT; NUTRITIONAL PARAMETERS; REVIEW; SYNTHESIS;

ANIMALS; LEISHMANIA; LEISHMANIASIS; PURINE NUCLEOTIDES;

HEXAPODA; MAMMALIA;

EID: 84863844968     PISSN: 14714922     EISSN: 14715007     Source Type: Journal    
DOI: 10.1016/j.pt.2012.05.005     Document Type: Review

References (64)

1. Marr J.J., et al. Purine metabolism in Leishmania donovani and Leishmania braziliensis. Biochim. Biophys. Acta 1978, 544:360-371.
2. LaFon S.W., et al. Purine and pyrimidine salvage pathways in Leishmania donovani. Biochem. Pharmacol. 1982, 31:231-238.
3. Looker D.L., et al. Purine metabolism in Leishmania donovani amastigotes and promastigotes. Mol. Biochem. Parasitol. 1983, 9:15-28.
4. Berens R.L., et al. Purine and pyrimidine metabolism. Biochemistry and Molecular Biology of Parasites 1995, 89-117. Academic Press. J.J. Marr, M. Muller (Eds.).
5. Tuttle J.V., Krenitsky T.A. Purine phosphoribosyltransferases from Leishmania donovani. J. Biol. Chem. 1980, 255:909-916.
6. Allen T., et al. Cloning and expression of the adenine phosphoribosyltransferase gene from Leishmania donovani. Mol. Biochem. Parasitol. 1995, 74:99-103.
7. Allen T.E., et al. Cloning and expression of the hypoxanthine-guanine phosphoribosyltransferase from Leishmania donovani. Mol. Biochem. Parasitol. 1995, 73:133-143.
8. Hwang H.Y., et al. Creation of homozygous mutants of Leishmania donovani with single targeting constructs. J. Biol. Chem. 1996, 271:30840-30846.
9. Hwang H.Y., Ullman B. Genetic analysis of purine metabolism in Leishmania donovani. J. Biol. Chem. 1997, 272:19488-19496.
10. Boitz J.M., et al. Adenine aminohydrolase from Leishmania donovani: unique enzyme in parasite purine metabolism. J. Biol. Chem. 2012, 287:7626-7639.
11. Boitz J.M., Ullman B. A conditional mutant deficient in hypoxanthine-guanine phosphoribosyltransferase and xanthine phosphoribosyltransferase validates the purine salvage pathway of Leishmania donovani. J. Biol. Chem. 2006, 281:16084-16089.
12. Boitz J.M., Ullman B. Leishmania donovani singly deficient in HGPRT, APRT or XPRT are viable in vitro and within mammalian macrophages. Mol. Biochem. Parasitol. 2006, 148:24-30.
13. Fulwiler A.L., et al. A rapid, efficient and economical method for generating leishmanial gene targeting constructs. Mol. Biochem. Parasitol. 2011, 175:209-212.
14. Jardim A., et al. Xanthine phosphoribosyltransferase from Leishmania donovani. Molecular cloning, biochemical characterization, and genetic analysis. J. Biol. Chem. 1999, 274:34403-34410.
15. Kidder G.W., Nolan L.L. Adenine aminohydrolase: occurrence and possible significance in trypanosomid flagellates. Proc. Natl. Acad. Sci. U.S.A. 1979, 76:3670-3672.
16. Aslett M., et al. TriTrypDB: a functional genomic resource for the Trypanosomatidae. Nucleic Acids Res. 2010, 38:D457-D462.
17. Logan-Klumpler F.J., et al. GeneDB - an annotation database for pathogens. Nucleic Acids Res. 2012, 40:D98-D108.
18. Ivens A.C., et al. The genome of the kinetoplastid parasite, Leishmania major. Science 2005, 309:436-442.
19. Peacock C.S., et al. Comparative genomic analysis of three Leishmania species that cause diverse human disease. Nat. Genet. 2007, 39:839-847.
20. Iovannisci D.M., Ullman B. Characterization of a mutant Leishmania donovani deficient in adenosine kinase activity. Mol. Biochem. Parasitol. 1984, 12:139-151.
21. Datta A.K., et al. Isolation and characterization of adenosine kinase from Leishmania donovani. J. Biol. Chem. 1987, 262:5515-5521.
22. Koszalka G.W., Krenitsky T.A. Nucleosidases from Leishmania donovani. Pyrimidine ribonucleosidase, purine ribonucleosidase, and a novel purine 2'-deoxyribonucleosidase. J. Biol. Chem. 1979, 254:8185-8193.
23. Cui L., et al. A nonspecific nucleoside hydrolase from Leishmania donovani: implications for purine salvage by the parasite. Gene 2001, 280:153-162.
24. Mauricio I.L., et al. Towards multilocus sequence typing of the Leishmania donovani complex: resolving genotypes and haplotypes for five polymorphic metabolic enzymes (ASAT, GPI, NH1, NH2, PGD). Int. J. Parasitol. 2006, 36:757-769.
25. Downing T., et al. Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance. Genome Res. 2011, 21:2143-2156.
26. Shi W., et al. Nucleoside hydrolase from Leishmania major. Cloning, expression, catalytic properties, transition state inhibitors, and the 2.5-a crystal structure. J. Biol. Chem. 1999, 274:21114-21120.
27. Debrabant A., et al. A unique surface membrane anchored purine-salvage enzyme is conserved among a group of primitive eukaryotic human pathogens. Mol. Cell. Biochem. 2001, 220:109-116.
28. Gottlieb M. The surface membrane 3'-nucleotidase/nuclease of trypanosomatid protozoa. Parasitol. Today 1989, 5:257-260.
29. Debrabant A., et al. Isolation and characterization of the gene encoding the surface membrane 3'-nucleotidase/nuclease of Leishmania donovani. Mol. Biochem. Parasitol. 1995, 71:51-63.
30. Gottlieb M., Dwyer D.M. Protozoan parasite of humans: surface membrane with externally disposed acid phosphatase. Science 1981, 212:939-941.
31. Shakarian A.M., et al. Molecular dissection of the functional domains of a unique, tartrate-resistant, surface membrane acid phosphatase in the primitive human pathogen Leishmania donovani. J. Biol. Chem. 2002, 277:17994-18001.
32. Wiese M., et al. Gene cloning and cellular localization of a membrane-bound acid phosphatase of Leishmania mexicana. Mol. Biochem. Parasitol. 1996, 82:153-165.
33. Carter N.S., et al. Purine and pyrimidine metabolism in Leishmania. Adv. Exp. Med. Biol. 2008, 625:141-154.
34. Landfear S.M., et al. Nucleoside and nucleobase transporters in parasitic protozoa. Eukaryot. Cell 2004, 3:245-254.
35. Carter N.S., et al. Nucleoside transporters of parasitic protozoa. Trends Parasitol. 2001, 17:142-145.
36. Liu W., et al. Functional characterization of nucleoside transporter gene replacements in Leishmania donovani. Mol. Biochem. Parasitol. 2006, 150:300-307.
37. Arastu-Kapur S., et al. Functional analysis of an inosine-guanosine transporter from Leishmania donovani. The role of conserved residues, aspartate 389 and arginine 393. J. Biol. Chem. 2003, 278:33327-33333.
38. Carter N.S., et al. Cloning of a novel inosine-guanosine transporter gene from Leishmania donovani by functional rescue of a transport-deficient mutant. J. Biol. Chem. 2000, 275:20935-20941.
39. Carter N.S., et al. Adaptive responses to purine starvation in Leishmania donovani. Mol. Microbiol. 2010, 78:92-107.
40. Sanchez M.A., et al. Functional expression and characterization of a purine nucleobase transporter gene from Leishmania major. Mol. Membr. Biol. 2004, 21:11-18.
41. Ortiz D., et al. An acid-activated nucleobase transporter from Leishmania major. J. Biol. Chem. 2009, 284:16164-16169.
42. Hart D.T., Opperdoes F.R. The occurrence of glycosomes (microbodies) in the promastigote stage of four major Leishmania species. Mol. Biochem. Parasitol. 1984, 13:159-172.
43. Opperdoes F.R. Compartmentation of carbohydrate metabolism in trypanosomes. Annu. Rev. Microbiol. 1987, 41:127-151.
44. Parsons M., et al. Biogenesis and function of peroxisomes and glycosomes. Mol. Biochem. Parasitol. 2001, 115:19-28.
45. Opperdoes F.R., Szikora J.P. In silico prediction of the glycosomal enzymes of Leishmania major and trypanosomes. Mol. Biochem. Parasitol. 2006, 147:193-206.
46. Gualdron-Lopez M., et al. When, how and why glycolysis became compartmentalised in the Kinetoplastea. A new look at an ancient organelle. Int. J. Parasitol. 2011, 42:1-20.
47. Shih S., et al. Localization and targeting of the Leishmania donovani hypoxanthine-guanine phosphoribosyltransferase to the glycosome. J. Biol. Chem. 1998, 273:1534-1541.
48. Zarella-Boitz J.M., et al. Subcellular localization of adenine and xanthine phosphoribosyltransferases in Leishmania donovani. Mol. Biochem. Parasitol. 2004, 134:43-51.
49. Dobie F., et al. Kinetic characterization of inosine monophosphate dehydrogenase of Leishmania donovani. Mol. Biochem. Parasitol. 2007, 152:11-21.
50. Cruz A., Beverley S.M. Gene replacement in parasitic protozoa. Nature 1990, 348:171-173.
51. Cruz A., et al. Double targeted gene replacement for creating null mutants. Proc. Natl. Acad. Sci. U.S.A. 1991, 88:7170-7174.
52. Allen T., et al. Purification and characterization of the adenine phosphoribosyltransferase and hypoxanthine-guanine phosphoribosyltransferase activities from Leishmania donovani. Mol. Biochem. Parasitol. 1989, 33:273-281.
53. Iovannisci D.M., et al. Genetic analysis of adenine metabolism in Leishmania donovani promastigotes. Evidence for diploidy at the adenine phosphoribosyltransferase locus. J. Biol. Chem. 1984, 259:14617-14623.
54. Freedman D.J., Beverley S.M. Two more independent selectable markers for stable transfection of Leishmania. Mol. Biochem. Parasitol. 1993, 62:37-44.
55. Goyard S., Beverley S.M. Blasticidin resistance: a new independent marker for stable transfection of Leishmania. Mol. Biochem. Parasitol. 2000, 108:249-252.
56. Beverley S.M. Protozomics: trypanosomatid parasite genetics comes of age. Nat. Rev. Genet. 2003, 4:11-19.
57. Boitz J.M., Ullman B. Amplification of adenine phosphoribosyltransferase suppresses the conditionally lethal growth and virulence phenotype of Leishmania donovani mutants lacking both hypoxanthine-guanine and xanthine phosphoribosyltransferases. J. Biol. Chem. 2010, 285:18555-18564.
58. Fulwiler A.L., et al. IMP dehydrogenase deficiency in Leishmania donovani causes a restrictive growth phenotype in promastigotes but is not essential for infection in mice. Mol. Biochem. Parasitol. 2011, 180:123-126.
59. Iovannisci D.M., Ullman B. Single cell cloning of Leishmania parasites in purine-defined medium: isolation of drug-resistant variants. Adv. Exp. Med. Biol. 1984, 165:239-243.
60. Stauber L.A. Characterization of strains of Leishmania donovani. Exp. Parasitol. 1966, 18:1-11.
61. Dwyer D.M. Leishmania donovani: surface membrane carbohydrates of promastigotes. Exp. Parasitol. 1977, 41:341-358.
62. Debrabant A., et al. Generation of Leishmania donovani axenic amastigotes: their growth and biological characteristics. Int. J. Parasitol. 2004, 34:205-217.
63. Goyard S., et al. An in vitro system for developmental and genetic studies of Leishmania donovani phosphoglycans. Mol. Biochem. Parasitol. 2003, 130:31-42.
64. Parsons M. Glycosomes: parasites and the divergence of peroxisomal purpose. Mol. Microbiol. 2004, 53:717-724.